scholarly journals Program Studi Sarjana Fisioterapi, Universitas Muhammadiyah Pekajangan Pekalongan, Indonesia

2021 ◽  
Vol 1 ◽  
pp. 1250-1253
Author(s):  
Afan Saputra ◽  
Windha Widyastuti ◽  
I Isytiaroh
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Gestational Age ◽  
Full Text ◽  
First Trimester ◽  
Scientific Paper ◽  
Google Scholar ◽  
Common Complaint ◽  
Before And After

AbstractNausea and vomiting (emesis gravidarum) is a common complaint in the first trimester pregnant women. One of non-pharmacological therapies which are safe to give to pregnant women who experience emesis gravidarum is lemon aromatherapy. This scientific paper aims to investigate the effect of lemon aromatherapy to reduce emesis gravidarum in pregnant women in trimester I. It is a literature review with three articles taken from Google scholar. Emesis gravidarum, lemon therapy, and pregnant women in trimester I are the keywords. These articles are full-text, published in 2018-2019. The analysis result of respondents characteristics from 71 people, most of them (75%) are 20-35 years old, parity 65% of multigravida, gestational age 25% of weeks. Nausea score measurement was measured by RHODES Indeks score. The analysis result of the articles stated there is a significant different before and after intervention. The total score average before applying the intervention was 19.18 and it reduced into 10.63 after the process. It means there is a reduction for about 8.55 after the treatment. The conclusion is applying lemon aromatherapy has effectively reduced emesis gravidarum in pregnant women in trimester I. therefore, nurses were suggested to apply this therapy as an alternative ways to reduce the frequency of nausea.Keywords : emesis gravidarum lemon ; aromatherapy ; pregnant women in trimester I AbstrakMual muntah (Emesis gravidarum) merupakan keluhan yang sering terjadi pada ibu hamil trimester pertama. Salah satu terapi nonfarmakologi yang aman di berikan pada ibu hamil yang mengalami emesis gravidarum adalah aromaterapi lemon. Karya Tulis Ilmiah ini bertujuan untuk menggambarkan penerapan pengaruh aromaterapi lemon untuk mengurangi emesis gravidarum pada ibu hamil trimester I berdasarkan literature review. Desain Karya Tulis ilmiah ini berupa literature review dengan jumlah artikel tiga yang diambil dari laman jurnal google scolar dengan kata kunci “ emesis gravidarum” “Aromaterapi lemon” dan “ibu hamil trimester I,” berupa artikel fulltext, terbit tahun 2018-2019. Hasil analisa karakteristik responden dari tiga artikel menunjukan jumlah responden 71, sebagian besar 75.0 % umur 20-35 tahun, paritas 65% multigravida, usia kehamilan 25.0 % 9 minggu. Pengukuran skor mual di ukur dengan menggunakan skor Index RHODES. Hasil analisa dari tiga artikel menunjukan jumlah skor rata-rata sebelum intervensi 19,18 setelah intervensi 10,63, terdapat penurunan skor rata-rata setelah dilakukan pemberian aromaterapi lemon sebesar 8,55. Simpulan hasil menunjukan bahwa pemberian aromaterapi lemon efektif menangani emesis gravidarum pada ibu hamil trimester I. Saran bagi petugas kesehatan hendaknya bisa menerapkan aromaterapi lemon sebagai alternatif untuk mengurangi frekuensi mual.Kata Kunci : Emesis Gravidarum ; Aromaterapi Lemon ; Ibu hamil Trimester

scholarly journals Literature Review : Terapi Pijat Oksitosin Untuk Meningkatkan Produksi Asi Pada Ibu Post Partum

2021 ◽  
Vol 1 ◽  
pp. 2129-2133
Author(s):  
Yanuar Sultan Pramana ◽  
I Isytiaroh
Keyword(s):  
Breast Milk ◽  
Literature Review ◽  
Milk Production ◽  
Full Text ◽  
Post Partum ◽  
Scientific Paper ◽  
Google Scholar ◽  
Average Value ◽  
Increase Milk Production ◽  
Postpartum Mothers

AbstractOne way to increase milk production is by doing oxytocin massage. This scientific paper aims to find out the description of oxytocin massage therapy to increase breast milk in postpartum mothers. It is a literature review with 3 articles taken from google scholar. Oxytocin massage, postpartum, and breast milk are the keywords. All are full-text, the first article published in 2016, the second one was in 2019, and the latter was in 2020. The result shows before applying the therapy, the average value of milk breast production was 10.02 ml, and it was 17.2 after applying the therapy with difference of the production was 7.18 ml. It means there was an increasing in producing breast milk. Therefore, nurses are suggested to apply this therapy on postpartum mothers.Keywords: oxytocin massage, postpartum, breast milk producing AbstrakSalah satu cara untuk meningkatkan produksi ASI yaitu pijat oksitosin. Tujuan karya tulis ilmiah ini yaitu mengetahui gambaran terapi pijat oksitosin untuk meningkatkan produksi ASI pada ibu post partum. Berdasarkan literature review Metode dalam karya tulis ilmiah ini adalah literature review dengan subyek literature review yang digunakan yaitu 3 artikel yang diambil dari laman jurnal google scholar dengan kata kunci “pijat oksitosin”, “post partum” dan “produksi ASI”. Berupa fulltext dan pada artikel pertama terbit pada tahun 2016, artikel kedua 2019 dan artikel ketiga tahun 2020. Hasil dari ketiga artikel menunjukan bahwa sebelum dilakukan pijat oksitosin terdapat nilai rata-rata produksi ASI 10,02 ml dan setelah dilakukan pijat oksitosin didapatkan bahwa terdapat nilai rata-rata produksi ASI 17,2 ml dengan perbedaan produksi ASI 7,18 ml sehingga terdapat adanya peningkatan produksi ASI. Simpulannya adalah terapi pijat oksitosin dapat meningkatkan produksi ASI pada ibu post partum. Saran untuk tenaga kesehatan diharapkan dapat menerapkan terapi pijat oksitosin untuk meningkatkan produksi ASI pada ibu post partum.Kata kunci: pijat oksitosin, post partum, produksi ASI

Pengaruh Teknik Relaksasi Genggam Jari Terhadap Penurunan Nyeri Pasien Post Operasi Appendiktomi: Literature Review

2021 ◽  
Vol 1 ◽  
pp. 996-1004
Author(s):  
Octaviana Wafa ◽  
Firman Faradisi ◽  
Nuniek Nizmah Fajriyah
Keyword(s):  
Literature Review ◽  
Scientific Paper ◽  
Google Scholar ◽  
Pharmacological Intervention ◽  
Relaxation Techniques ◽  
Pain Scores ◽  
Before And After ◽  
The Mean ◽  
Grip Relaxation ◽  
Reduce Pain Intensity

Abstract Grip Finger relaxation is one of the non-pharmacological intervention to reduce pain in post appendectomy patients. The purpose of this study was to describe the application of grip finger relaxation techniques on reducing pain in post appendectomy patients. The design of this scientific paper is a literature review with three articles taken from the Google Scholar page. the keywords used are "Finger grip relaxation" and "Post appendectomy surgery". The article selection category is fulltex, published in 2011-2020. Analysis of the characteristics of the respondents showed from the three articles, the number of respondents was 61, most of them (59.6%) were male, 64.7% aged 20-55 years. The mean pain scores before and after the intervention was 5.5 and 2.2. The grip finger relaxation technique proved can reduce pain intensity in post appendectomy patients. In line with this, nurses can teach their post appendectomy patients to use finger grip relaxation techniques to reduce pain.Keywords: Appendectomy; grip finger relaxation; pain Abstrak Relaksasi genggam jari merupakan salah satu tindakan non farmakalogi untuk menurunkan nyeri pada pasien post operasi appendiktomi. Penelitian ini bertujuan untuk menggambarkan penerapan teknik relaksasi genggam jari terhadap penurunan nyeri pasien post operasi appendiktomi berdasarkan literature review. Desain karya tulis ilmiah ini adalah literature review dengan jumlah artikel tiga yang diambil dari laman google scholar. kata kunci yang digunakan adalah “Relaksasi genggam jari” dan “Post operasi appendiktomi”. Kategori pemilihan artikelnya adalah fulltex, terbit tahun 2011-2020. Analisis karakteristik responden menunjukan, dari tiga artikel menunjukkan jumlah responden responden sebesar 61, sebagian besar (59,6%) laki-laki, 64,7% umur 20-55 tahun. Nilai rata-rata nyeri responden sebelum intervensi 5,5 sesudah intervensi 2,2. Kesimpulannya adalah teknik relaksasi genggam jari dapat menurunkan intensitas nyeri pada pasien post operasi appendiktomi. Saran bagi tenaga keperawatan teknik relaksasi genggam jari dapat digunakan sebagai intervensi keperawatan terhadap penurunan nyeri pasien post operasi appendiktomi.Kata kunci: Appendiktomi; relaksasi genggam jari; nyeri

First trimester PAPP-A2, PAPP-A and hCGβ in small-for-gestational-age pregnancies

2016 ◽  
Vol 54 (1) ◽  
Author(s):  
Young Bae Hansen ◽  
Vibeke Myrhøj ◽  
Finn Stener Jørgensen ◽  
Claus Oxvig ◽  
Steen Sørensen
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
First Trimester ◽  
Altered Level ◽  
Igf System ◽  
Before And After ◽  
Maternal Hypertension ◽  
Normal Controls ◽  
Control Study

AbstractPregnancy-associated plasma protein-A2 (PAPP-A2) is a recently discovered protease that cleaves a subset of insulin-like growth factor binding proteins (IGFBP). The molecular function suggests its involvement in the IGF system that is vital for fetal growth and development. Our objectives were to establish first trimester median curves of PAPP-A2, PAPP-A and hCGβ for singleton normal pregnancies and to investigate whether an altered level of one or more of the biomarkers is associated with small-for-gestational-age (SGA) neonates before and after stratification according to maternal hypertension and/or proteinuria.This was a case-control study based on 985 pregnant women delivering normal-weighted neonates and 170 pregnant women delivering SGA neonates. PAPP-A2 was measured by ELISA. PAPP-A and hCGβ were measured by an automatic analyzer. Median curves from 8+1 to 14+0 were established and all concentration values were converted to multiples of the median (MoM) values.Before stratification the SGA cases had unaffected PAPP-A2 MoM and hCGβ MoM levels but lower PAPP-A MoM compared with normal controls. After stratification the SGA normotensive subgroup had lower PAPP-A2 MoM and PAPP-A MoM levels than the normal normotensive subgroup. Severe preeclamptic women delivering SGA neonates had higher PAPP-A2 MoM compared to the normotensive women delivering SGA neonates.Pregnant women delivering SGA neonates did not have altered levels of PAPP-A2 or hCGβ but had lower PAPP-A level in the first trimester compared with pregnant women delivering normal-weighted neonates. Pregnancies complicated with severe preeclampsia and SGA may be associated with high PAPP-A2 level.

Literature Review : Pemberian Posisi Miring Dan Setengah Duduk Terhadap Lama Persalinan Kala

2021 ◽  
Vol 1 ◽  
pp. 744-749
Author(s):  
Arsy Andriyanto ◽  
I Isytiaroh ◽  
Windha Widyastuti
Keyword(s):  
Literature Review ◽  
Full Text ◽  
Scientific Paper ◽  
Google Scholar ◽  
Sitting Position ◽  
Second Stage Of Labor ◽  
Second Stage ◽  
Labor Duration ◽  
Oblique Position ◽  
Speed Up

AbstractIn the delivery process, the position of the mother giving birth has an effect on the smoothness of the process. This scientific paper aims to determine the description of giving oblique position and half-sitting position to the duration of the second stage of labor based on a literature review. It has taken three articles from Google scholar with tilt nosition half cit-fino nosition and the second stncre as the kevwords A Il Are full-text the first article was published in 2014, the second one was in 2019, and the latter was in 2020. The analysis result showed from 206 respondents, the average of labor duration on the second stage was 23.786 minutes In tilt position. Meanwhile, In halt Sitting position, it was 43.34 minutes. Furthermore, the first position was 19.554 minutes faster than the second one. And. the result is the conclusion. Therefore- it is suggested for the birth attendant to recommend a maternity mother to apply tilt position to speed up the delivery processKeywords: Tilt position; halfsitting position; second stage. AbstrakPosisi pada ibu bersalin berpengaruh terhadap proses persalinan. Pemilihan posisi yang tepat dan benar akan berdampak pada jalannya proses persalinan. Karya tulis ilmiah ini bertujuan untuk mengetahui gambaran pemberian posisi miring dan posisi setengah duduk terhadap lama persalinan kala II berdasarkan literature review. Desain dalam karya tulis ilmiah ini adalah literature review dengan jumlah artikel tiga yang diambil dari laman jurnal google scholar dengan kata kunci “posisi miring”, “posisisetengahduduk” dan “lama kala II”, berupaartikel fultext. Artikel 1 terbit tahun 2019, artikel 2 tahun 2020 dan pada artikel 3 tahun 2014. Hasil analisis dari ketiga artikel menunjukan jumlah responden 206, rata-rata lama persalinan kala II menggunakan posisi miring adalah 23,786 menit dan posisi setengah duduk 43,34 menit. Poisisi miring 19,554 menit lebih cepat saat persalinan kala II dibandingkan posisi setengah duduk. Simpulannya adalah pada ibu bersalin persalinan kala II dengan posisi miring lebih cepat waktu persalinannya dibandingkan posisi setengah duduk. Saran bagi penolong persalinan dapat menganjurkan ibu bersalin menggunakan posisi miring pada proses persalinan kala II.Kata kunci: Posisi miring ;posisi setengah duduk; lama kala II.

Gambaran Kejadian Anemia Pada Ibu Hamil : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 464-469
Author(s):  
Kiki Utari ◽  
R Ratnawati
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Google Scholar ◽  
Iron Intake ◽  
Exclusion Criteria ◽  
Food Reserves ◽  
Descriptive Method ◽  
In Pregnancy

AbstractPregnant women are very susceptible to anemia due to lack of food reserves and before pregnancy they were already anemic. Pregnant women need more iron intake than before pregnancy. Problems in pregnant women are problems in pregnancy that can cause anemia. This literature review aims to determine the description of the incidence of anemia in pregnant women from various articles. This study uses a descriptive method with a literature review approach. Search articles through PubMed and Google Scholar according to keywords and then analyzed according to inclusion and exclusion criteria and found 5 articles and reviewed using the Joanna Instrument (JBI). The description of the incidence of anemia in pregnant women showed anemia as many as 258 respondents (35.3%) and those who experienced anemia were not as many as 472 respondents (64.7%). In this literature review, it was concluded that most pregnant women did not experience anemia.Keywords: Anemia, Pregnant Women AbstrakIbu hamil sangat rentan mengalami anemia karena cadangan makanan kurang dan pada saat sebelum hamil sudah mengalami anemia. Ibu hamil membutuhkan asupan zat besi yang lebih banyak dibandingkan saat sebelum hamil. Permasalahan pada ibu hamil adalah masalah – masalah dalam kehamilan yang dapat menimbulkan anemia. Literatur Review ini bertujuan untuk mengetahui Gambaran Kejadian Anemia Pada Ibu Hamil dari berbagai artikel. Penelitian ini menggunakan metode deskriptif dengan pendekatan literature review. Pencarian artikel melalui PubMed dan Google Scholar sesuai dengan kata kunci kemudian dianalisa sesuai dengan keriteria inklusi dan ekslusi dan ditemukan 5 artikel dan di review menggunakan Instrument Joanna (JBI). Gambaran kejadian Anemia pada ibu hamil didapatkan hasil anemia sebanyak 258 responden (35,3%) dan yang mengalami tidak anemia sebanyak 472 responden (64,7%). Dalam penelitian literature review ini disimpulkan bahwa sebagian besar ibu hamil tidak mengalami anemia.Kata kunci : Anemia, Ibu Hamil

scholarly journals The possibility of modifications methods of determine volume of amniotic fluid

2016 ◽  
Vol 65 (3) ◽  
pp. 12-17
Author(s):  
Viktor A Mudrov
Keyword(s):  
Body Mass Index ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Body Mass ◽  
Gestational Age ◽  
First Trimester ◽  
Fetal Weight ◽  
Abdominal Circumference ◽  
Pregnancy And Childbirth ◽  
Maternity Hospitals

Selection of the optimal tactics of pregnancy and childbirth significantly depends on the expected volume of amniotic fluid. The amount of amniotic fluid reflects a condition of a fetus and changes at pathological conditions of both a fetus, and an uteroplacental complex. The aim of the study was a modification of methods for determining the expected volume of amniotic fluid. On the basis of maternity hospitals Trans-Baikal Region in the years 2013-2015 was held retrospective and prospective analysis of 300 labor histories, which were divided into 3 equal groups: 1 group - pregnant women with a body mass index (BMI) for Quetelet less than 24, Group 2 - with a BMI from 24 to 30, group 3 - with a BMI more than 30. In order to determine the expected volume of amniotic fluid were used the subjective method, the Chamberlain’s and Phelan’s methods. The error in determining volume of amniotic fluid by the existing methods exceeds 10 %, that defined need of creation of a quantitative method. On the basis of mathematical and 3d-modeling of the volume of amniotic fluid and fetal weight determined pattern change, which is expressed by the formula: VAF = IAF × М × π / GA2, where IAF - index of amniotic fluid (mm), M - fetal weight (g), GA - gestational age (weeks). Through a comprehensive analysis of anthropometric research of the pregnant women defined formula’s volume of amniotic fluid: V = 0,017 × HUF × (AC - 25 × BMI / GA)2 - М, where GA - gestational age (weeks), AC - abdominal circumference of the pregnant women (cm), BMI - body mass index for Quetelet in the first trimester of pregnancy (kg/m2), HUF - height of an uterine fundus (cm), M - the estimated fetal weight (g). In calculating volume of amniotic fluid according to the proposed ultrasonic formula error does not exceed 5,3 %, anthropometric formula error does not exceed 10,2 %. Thus, the method has a smaller error compared to the standard, and can be used to reliably determine volume of amniotic fluid in II and III trimester of pregnancy.

scholarly journals Hubungan Psikologis Ibu Hamil dengan Kejadian Hiperemesis Gravidarum

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jessica F. Rorrong ◽  
John J. E. Wantania ◽  
Anastasi M. Lumentut
Keyword(s):  
Literature Review ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Nausea And Vomiting ◽  
Google Scholar ◽  
Psychological State ◽  
Psychological Conditions ◽  
Common Problems ◽  
The Relationship

Abstract: Nausea and vomiting are common problems in early pregnancy. Symptoms of nausea and vomiting in pregnant women that persist and get worse are called hyperemesis gravidarum. The causes of hyperemesis gravidarum are not exactly known, but it is supposed that they could be caused inter alia by psychological factors. This study was aimed to determine the relationship between the psychological state of pregnant women and the incidence of hyperemesis gravidarum. This was a literature review study by using three databases, namely Google Scholar, ClinicalKey, and Pubmed. The keywords used were psychological AND hyperemesis gravidarum. The result showed that the psychological conditions assessed in most literatures were anxiety disorders, depression, and stress. Pregnant women who suffered from anxiety and stress could trigger or worsen the depression. The higher level of anxiety would increase the chance of suffering from hyperemesis gravidarum. Therefore, pregnant women need additional psychological support during treatment and as a follow-up for pregnant women with hyperemesis gravidarum. In conclusion, the psychological state of pregnant women is related to the incidence of hyperemesis gravidarum.Keywords: psychological, hyperemesis gravidarum, nausea and vomiting Abstrak: Mual dan muntah merupakan masalah yang biasa terjadi pada awal kehamilan. Gejala mual dan muntah pada ibu hamil yang menetap dan bahkan bertambah berat disebut hiperemesis gravidarum. Faktor pemicu terjadinya hiperemesis gravidarum pada ibu hamil belum diketahui secara pasti, tetapi diperkirakan antara lain oleh faktor psikologis. Penelitian ini bertujuan untuk mengetahui hubungan keadaan psikologis ibu hamil dengan kejadian hiperemesis gravidarum. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu Google Scholar, ClinicalKey, dan Pubmed. Kata kunci yang digunakan yaitu psikologis /psychological AND hiperemesis gravidarum/hyperemesis gravidarum. Hasil penelitian mendapatkan bahwa kondisi psikologis yang dinilai pada sebagian besar literatur yang dikaji ialah mengenai gangguan kecemasan, depresi, dan stres. Ibu hamil yang mengalami cemas dan stres dapat memicu atau memperburuk terjadinya depresi. Tingkat kecemasan yang semakin tinggi akan meningkatkan peluang untuk mengalami hiperemesis gravidarum sehingga diperlukan dukungan psikologis tambahan selama perawatan dan sebagai tindak lanjut ibu hamil dengan hiperemesis gravidarum. Simpulan penelitian ini ialah keadaan psikologis ibu hamil berhubungan dengan kejadian hiperemesis gravidarum. Kata kunci: psikologis, hiperemesis gravidarum, mual dan muntah

Gambaran Frekuensi Napas Pasien Asma Dewasa: Literature review

2021 ◽  
Vol 1 ◽  
pp. 1103-1110
Author(s):  
Didi Rethodi ◽  
Dian Kartikasari
Keyword(s):  
Literature Review ◽  
Respiratory Rate ◽  
Full Text ◽  
Breathing Pattern ◽  
Google Scholar ◽  
Educational Institutions ◽  
Nursing Interventions ◽  
Shortness Of Breath ◽  
Difficulty Breathing ◽  
Review Study

AbstractAsthma causes narrowing of the airways, which leads to various symptoms such as whezzing, coughing, and shortness of breath (dyspnea) in sufferers. Patients with asthma often complain of experiencing sudden shortness of breath, difficulty breathing, and pain when taking a breath. These conditions can causes the patient to become stressed, anxious and the breathing pattern in no longer effective. As a result, the prognosis of disease is poor. The purpose of this literature review study was to picture the frequency of breathing in asthma patients.This literature review highlighted five articles searched from 2011-2021 throught Garba Garuda and Google Scholar. The obtained articles were apprassied using the JBI (Joanna Briggs Institute) instrument before being analyzed. This study revealed that the respiratory rate in patients with asthma increases over 20x/minutes.The conclusion from this literature review is that patients with asthma have tachypnea. This literature review may be used as a reference for hospitals, educational institutions, and other researchers to determine appropriate nursing interventions for asthma patients.Keywords:Asthma; respiratoryrate. AbstrakPenyakit asma dapat menyebabkan penyempitan pada saluran napas dan hal ini dapat menimbulkan gejala seperti mengi, batuk, dan sesak napas (dyspnea) pada penderitanya. Keluhan pasien asma yaitu sering mengalami sesak napas yang dating secara mendadak, sulit untuk bernafas, nyeri saat menarik napas. Hal ini dapat menyebabkan pasien menjadi stress, cemas dan pola napas tidak lagi efektif dan prognosis penyakitnya menjadi buruk. Tujuan dari penelitian literature review ini adalah untuk mengetahui Gambaran Frekuensi Napas Pada Pasien Asma. Metode penelitian menggunakan metode deskriptif dengan pengumpulan data literature review. Pencarian artikel dari tahun 2011-2021 melalui penelusuran Garba Garuda, dan Google Shcolar dengan kriteria inklusi populasi pasien asma dewasa, tahun artikel 2011-2021, penelitian kuantitatif. Hasil pencarian yang didapatkan berupa full text dan pdf, kemudian direview dengan menggunakan instrument JBI (Joanna Briggs Institute), didapatkan 5 artikel dari tahun 2012-2021, diekstraksi kemudian dibahas dan disimpulkan .Hasil penelitian literature review dari 5 atikel menunjukkan bahwa frekuensi napas pada pasien dengan kejadian asma mengalami peningkatan pernafasan >20x/menit. Simpulan dari literature review ini yaitu pasien dengan kejadian asma mengalami peningkatan frekuensi pernapasan. Penelitian literature review ini diharapkan dapat menjadi refrensi bagi pihak rumah sakit, institusi pendidikan maupun penelitilainnya sebagai pertimbangan untuk menentukan intervensi keperawatan yang tepat bagi pasien asma.Kata kunci : Asma, Respirasi

Gestational age-specific reference intervals for 15 biochemical measurands during normal pregnancy in China

2017 ◽  
Vol 55 (4) ◽  
pp. 446-452 ◽  
Author(s):  
Yanpeng Dai ◽  
Junjie Liu ◽  
Enwu Yuan ◽  
Yushan Li ◽  
Quanxian Wang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Parametric Method ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Reference Intervals ◽  
Specific Reference ◽  
Gamma Glutamyl Transpeptidase ◽  
Cross Sectional ◽  
Laboratory Results

Aims Physiological changes that occur during pregnancy can influence biochemical parameters. Therefore, using reference intervals based on specimens from non-pregnant women to interpret laboratory results during pregnancy may be inappropriate. This study aimed to establish the essential reference intervals for a range of analytes during pregnancy. Methods A cross-sectional study was performed in 13,656 healthy pregnant and 2634 non-pregnant women. Fifteen biochemical measurands relating to renal and hepatic function were analysed using an Olympus AU5400 analyzer (Olympus, Tokyo, Japan). All the laboratory results were checked for outliers using Dixon’s test. Reference intervals were established using a non-parametric method. Results Alanine aminotransferase, aspartate aminotransferase, albumin, cholinesterase, creatinine, direct bilirubin, gamma-glutamyl transpeptidase, total bilirubin, total bile acid and total protein showed a decrease during the whole gestational period, while alkaline phosphatase and uric acid increased. Urea nitrogen, β2-microglobulin and cystatin-C fell significantly during the first trimester and then remained relatively stable until third trimester. Reference intervals of all the measurands during normal pregnancy have been established. Conclusions The reference intervals established here can be adopted in other clinical laboratories after appropriate validation. We verified the importance, for some measurands, of partitioning by gestational age when establishing reference intervals during pregnancy.

scholarly journals Fetal haemoglobin and alpha 1 microglobulin as biochemical markers in predicting preeclampsia in late first trimester and early second trimester of pregnancy

2018 ◽  
Vol 7 (8) ◽  
pp. 3226 ◽  
Author(s):  
S. Vijaya ◽  
M. Mahalakshmi ◽  
I. Inbapriyanka
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Gestational Age ◽  
Subsequent Development ◽  
Fetal Hemoglobin ◽  
First Trimester ◽  
Antioxidant Property ◽  
Maternal Blood ◽  
Fetal Haemoglobin ◽  
System Disorder

Background: Preeclampsia is a multi system disorder with placenta as the organ of origin and maternal endothelium being the organ of target.  According to recent studies, the cell free haemoglobin induces oxidative stress mediated damage to the blood placenta barrier with consequently elevated levels of HbF in maternal blood. Alpha 1 microglobulin is an endogenous protein with antioxidant property, present in elevated levels in maternal blood in response to oxidative stress. This fact forms the basis for our study. The objective of the present study was to establish association between high levels of fetal hemoglobin and alpha 1 microglobulin in plasma of pregnant women between 10 to 16 weeks of gestational age and subsequent development of preeclampsia.Methods: This was a prospective cohort study undertaken in the Department of Obstetrics and Gynaecology, ISO -KGH, between December 2016 to November 2017. A total of 100 pregnant women were included in the study after getting informed written consent. Both primigravida and multigravida, belonging to age group of 20 to 35 years (singleton/ multiple) between 10 to 16 weeks GA and with BMI between 16 to 35 kg/m2 were included in the study. A woman with Diabetes mellitus, Hypertension, Renal disease, Epilepsy and Vascular disorders were excluded from the study.Results: The cut off value for alpha 1 microglobulin was 1.86ng/ml and the cut off value of fetal haemoglobin was 1.92ng/ml above which the pregnant women develop preeclampsia.Conclusions: Higher values of fetal hemoglobin and alpha 1 microglobulin in pregnant women between 10 to 16 weeks gestational age positively correlates with development of preeclampsia in those women.

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