scholarly journals HAEMATOLOGICAL PROFILE DERANGEMENTS IN PATIENTS DUE TO NON-RESISTANT AND RESISTANT TYPHOID FEVER

2021 ◽  
Vol 71 (5) ◽  
pp. 1615-18
Author(s):  
Sunila Tashfeen ◽  
Naveed Asif ◽  
Muhammad Farooq
Keyword(s):  
Typhoid Fever ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Haematological Parameter ◽  
Drug Resistant ◽  
Cross Sectional ◽  
First Line Therapy ◽  
Haematological Profile

Objective: To assess and compare the frequency of haematological parameter derangements in patients due to non-resistant and extended drug resistant (XDR) typhoid fever. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department of Combined Military Hospital Quetta, from Jan to Dec 2019. Methodology: A total number of 172 blood culture Salmonella positive patients irrespective of age and gender were included in this study. Salmonella strains were isolated and grouped further according to their drugs sensitivity. 3ml venous blood was collected from these patients in Ethylene diamine tetra acetic acid container and blood complete count was done by semiautomated haematology analyser XP-100. Results: There were 126 (73%) males and 46 (27%) females with mean age of 17.5 ± 10.3 years. Out of 172 subjects, 106 (61.6%) had non-resistant typhoid and rest 66 (38.4%) were diagnosed with extended drug resistant Typhoid. We compared anaemia, leucopenia and thrombocytopenia between two groups and found anaemia statistically significant with the p-value of 0.001. Conclusion: This study has documented that changes in haematological parameters are significant in typhoid fever and early patients diagnosis, management and disease course can be monitored with them. Patients with significant anaemia and not responding to first line therapy should be considered as a case of extended drug resistant (XDR) Salmonella.

scholarly journals EFFECT OF PREANALYTICAL VARIABLES ON SERUM THYROID STIMULATING HORMONE ANALYSIS BY CHEMILUMINESCENCE METHOD

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S102-05
Author(s):  
Ambreen Rehman ◽  
Naveed Asif ◽  
Saima Shakeel Malik ◽  
Waqas Sheikh ◽  
Quratulain . ◽  
...  
Keyword(s):  
Venous Blood ◽  
Armed Forces ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Cross Sectional ◽  
Specimen Handling ◽  
Tsh Levels ◽  
Stimulating Hormone

Objective: To identify effect of pre-analytical variables on serum thyroid stimulating hormone. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, Department of Chemical Pathology & Endocrinology, from Mar 2018 to Aug 2018. Methodology: Hundred subjects with ages ranging from 18 to 34 years, irrespective of gender, were randomly selected for this study. Five milliliters venous blood sample was collected from each subject in a serum separator and divided into two aliquots. First aliquot was centrifuged and analyzed immediately for TSH, while second aliquot was stored for 24 hours and was then analyzed. TSH was measured by third generation assay usingchemiluminescence technique on ADVIA Centaur® XP. Serum TSH levels were also analyzed twice daily; in the morning (0800 to 0900 hours) and afternoon (1400 to 1600 hours). Data was analyzed using SPSS version 24. Frequency and percentages were calculated for qualitative variables like gender and pre-analytical variables. Test of significance Mann-Whitney U-test was applied and p-value <0.05 was taken as significant. Results: Mean age of subjects was 23 ± 3.4 years. Change in circadian rhythm was observed in 17 (28%) males and 14 (36%) females. Statistically significant association was found between morning and evening TSH levels, while no change was observed in TSH level by early and late centrifugation of samples. Conclusion: TSH levels vary significantly between blood samples collected at different timings of the day from the same person. TSH is resistant to degradation, immunologically stable, and reasonably insensitive to potential problems associated with routine specimen handling, when measured by immunoassay technique. Therefore, it is helpful in large epidemiological studies and small size laboratory, which require long transportation time and storage.

scholarly journals MILK AGGRAVATES ASTHMA – THE TRUTH OR THE PERCEPTION

2020 ◽  
Vol 70 (6) ◽  
pp. 1691-95
Author(s):  
Muhammad Khalid Azam Khan ◽  
Shazia Naz ◽  
Abdul Latif Khattak ◽  
Nauman Kashif ◽  
Syed Karamat Hussain Shah Bukhari ◽  
...  
Keyword(s):  
Positive Response ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medicine Department ◽  
Milk Substitute ◽  
Dyspnea Score ◽  
Drinking Milk

Objective: To assess the notion that milk can cause or aggravate asthma and break this myth. Study Design: A cross sectional study. Place and Duration of Study: Medicine department, Combined Military Hospital Lahore, from Jan 2019 to Dec2020. Methodology: A survey was conducted whereby known asthmatics were questioned about their opinion weather milk aggravates their asthma. Those who confirmed their positive response were exposed to milk and some liquid resembling milk, and their Lung functions were tested after each drink. The 42 patients who considered milk as the primary aggravator were called for the study for spirometry Results: A total of 600 people from the general population were surveyed. Two hundred and six (34.3%) of them were illiterate, 394 (65.6%) were educated from middle to graduates. In the first milk/milk encounter, the combined dyspnea scale showed increase of 50.3% and improvement of 0.008% in FEVI/FVC. In the second substitute/milk encounter, the dyspnea score showed an increase of 61.8% and an increase of 0.90% in FEVI/FVC. In the third milk/substitute encounter the dyspnea score showed a decrease of 22.9% and the FEVI/FVC decreases by 5.5%. In the 4th substitute/substitute encounter, dyspnea scores decreased by 8.4% while the pre and postencounter FEVI/ FVC scores were 2726 and 2711 with 0.55% decrease with insignificant p-value >0.05. Conclusion: Drinking milk or milk substitute has negligible effect on the spirometric parameters.

scholarly journals COMPARISON OF MANIFESTATIONS OF GIARDIA AND ASCARIS INFESTATIONS BETWEEN BOTH GENDERS PRESENTING WITH DIARRHEA

2020 ◽  
Vol 70 (6) ◽  
pp. 1681-85
Author(s):  
Kanwal Jehanzeb ◽  
Zia Ul Haq ◽  
Saeed Zaman Khattak ◽  
Sajid Ali Shah ◽  
Munir Akmal Lodhi ◽  
...  
Keyword(s):  
Sampling Technique ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Common Symptom ◽  
Chi Square ◽  
Cross Sectional ◽  
Worm Infestation ◽  
Number Of Patients ◽  
Common Parasite

Objective: To assess the occurrence and intensity of Giardia and Ascaris infestations in children of both genders reporting with diarrhea. Study Design: Comparative cross sectional study. Place and Duration of Study: Paediatrics department, Combined Military Hospital, Gilgit, from Jul 2016 to Jul2018. Methodology: Patients of either gender with worm infestation were included in the study. Patients more than13 years old were excluded. The sampling technique used was non probability consecutive sampling. The stoolexamination (R/E) for the diagnosis of worm infestation was done. Stratification was done with regards to age,mother education, gender, type of water used and post stratification chi square test was applied. p-value was0.613 when calculated for the manifestation between both genders. p-value ≤0.05 was considered significant. Results: Total number of patients in our study was 100. Among them, males were 65 (65%) and females were 35(35%). Mean age of patients in our study was 4.20 ± 2.61 years (Mean ± SD). Abdominal pain being most common symptom in 43 (43%) of patients. Majority of the patients were from 2 to 10 years of age, 79 (79%). Helminthic infestation was the most common observed in 52 (52%) whereas Protozoal infestation was observed in 48 (48%) patients. The most common parasite isolated was Giardia 41 (41%) followed by Ascaris 36 (36%). p-value of 0.613 was found between both gender. Conclusion: In our study Helminthic infestation was more common. The most common parasite isolated wasGiardia followed by Ascaris.

scholarly journals COMPLIANCE TO SURVIVING SEPSIS CAMPAIGN HOUR–1 BUNDLE–A CROSS SECTIONAL STUDY AMONG PHYSICIANS INVOLVED IN CRITICAL CARE IN PAKISTAN

2021 ◽  
Vol 71 (1) ◽  
pp. 249-54
Author(s):  
Rehana Feroze ◽  
Muhammad Tariq ◽  
Abdul Wasay Toor
Keyword(s):  
Work Experience ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Sectional Study ◽  
Surviving Sepsis Campaign ◽  
Cross Sectional ◽  
Sepsis Bundles ◽  
Critical Patients ◽  
Sepsis Bundle

Objective: To determine physician’s compliance to surviving sepsis campaign updated Hour-one bundle incritically ill patients in Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Department of Anaesthesiology, Combined Military Hospital Lahore MedicalCollege, from Jun to Aug 2019. Methodology: This study was carried out among physicians managing critical patients in intensive care units.Participants were asked to fill out a 16-questions survey (work experience, qualification and individual components of surviving sepsis campaign hour-1 bundle. Data was collected using online access to survey and by sending hard copies. Results: Questionnaire was sent to 230 physicians while only 63 responses were received (response rate 27%).Only 45 (71%) respondents were aware of the updated Hour-1 bundle. There was no institutional protocolfor compliance to sepsis bundles in thirty three (55%) responses. 52% respondents used Systemic inflammatoryresponse syndrome (SIRS) criteria to diagnose sepsis while quick Sequential Organ Failure Assessment (qSOFA)was used by 36% respondents. Overall compliance to hour-1 bundle components was only 60%. Lactate levelswas not measured by 35 (55%) respondents while 24 (38%) did not obtain blood cultures before administeringantibiotics. Crystalloid and nor epinephrine was used by all respondents. Overall compliance with all the components of sepsis bundle had strong correlation with post-graduate qualification (p-value 0.001-0.049). Conclusion: Poor compliance to updated sepsis guidelines was one of the major reasons of high sepsis relatedmortality in Pakistan.

scholarly journals INCIDENCE AND FACTORS FOR MATERNAL SATISFACTION AFTER CAESAREAN SECTION: A CROSS-SECTIONAL STUDY

2020 ◽  
Vol 70 (6) ◽  
pp. 1717-22
Author(s):  
Mobeen Ikram ◽  
Saira Mahboob ◽  
Sadia Zaineb
Keyword(s):  
Patient Satisfaction ◽  
Cesarean Section ◽  
Final Analysis ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Patient Dissatisfaction

Objective: To evaluate the factors for perioperative patient satisfaction in parturient undergoing lower section cesarean section, with a view assess anesthesia quality. Study design: cross sectional, analytical study Place and Duration of study: Department of Anesthesiology and Gynecology & Obstetrics, Combined Military Hospital, Okara Cantt for 04 months from January to April 2019. Material and method: A total of 400 parturient undergoing cesarean section were included in our study. The patients were given a questionnaire to fill on discharge. Our outcomes were frequency of patient satisfaction and various factors affecting it. SPSS version 20 was used to analyze data. Mean ± SD was described for quantitative variables and frequency (percentage) for qualitative variables. T-test and chi square used to analyze significance. p-value ≤0.05 taken as significant. Results: A total of 400 questionnaires were assessed in final analysis. The overall patient satisfaction was 382 (95.5%) with 4 (1%) showing dissatisfaction; whereas 14 (3.5%) didn’t answer this question. 395 (98.8%) underwent LSCS under spinal anesthesia. There wasno difference in patient satisfaction in regards to intra-operative concern alleviation, discomfort, previous number of LSCS, parturient age, choice of anesthesia; p value > 0.05. There was higher dissatisfaction in patients who experienced post-operative complaints, most notably pain; p=0.000. Patient satisfaction was higher in mothers who experienced joy on hearing their newborns cries; p=0.000 Conclusion: The overall patient satisfaction in our study was high and only few factors causing patient dissatisfaction which included postoperative complaints most notably pain.

scholarly journals Thalassemia ENDOCRINOPATHIES IN THALASSEMIA PATIENTS

2021 ◽  
Vol 71 (6) ◽  
pp. 1958-61
Author(s):  
Umer Touheed ◽  
Samra Maryam ◽  
Hafiz Muhammad Murtaza ◽  
Muhammad Mujtaba Sabir ◽  
Lutfullah Goheer ◽  
...  
Keyword(s):  
Venous Blood ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Cross Sectional ◽  
Endocrine Profile ◽  
Duration Of Disease ◽  
The Common ◽  
Endocrine Complications

Objective: To determine the common endocrine complications found in children having thalassemia major. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pediatric Medicine, Combined Military Hospital Multan, from May to Nov 2019. Methodology: A total of 160 Children with thalassemia were taken in this study. Once registered, venous blood sample was taken and sent to the laboratory for endocrine profile. SPSS-21 was applied for analysis of collected data. Results: Out of 160 study cases, 100 (62.5%) were boys while 60 (37.5%) were female patients. Mean age of our study cases was 8.58 ± 1.98 years. Mean duration of disease was 5.28 ± 3.29 years. Parental consanguinity was positive in 122 (76.3%) and only 47 (29.4%) were taking chelation therapy. Mean HbA1C level was 6.23 ± 1.18% mg/dl and diabetes was noted in 41 (25.6%) of our study cases. Mean FT4 was 0.98 ± 0.13 ng/dl and hypothyroidism was noted in 24 (15%) of our study cases. Conclusion: Diabetes and hypothyroidism were the common endocrine complications noted in our study among children having thalassemia. All physicians treating such patients should always screen such patients for early diagnosis and timely management in order to reduce burden of related morbidities and enhance quality of life of these patients.

scholarly journals Maternal Education and Acute Diarrhea Among Children Aged 2-5 Years In Pakistan: Cross Sectional Study

2021 ◽  
Vol 15 (6) ◽  
pp. 1944-1947
Author(s):  
Fatima Ehsan ◽  
Ayesha Ehsan ◽  
Wajahat Ullah Khan ◽  
Rizwan Masud ◽  
Hamad Hanif ◽  
...  
Keyword(s):  
Acute Diarrhea ◽  
Maternal Education ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Ethical Review ◽  
P Value ◽  
Sectional Study ◽  
Childhood Diarrhea ◽  
Cross Sectional

Childhood diarrheal disease is the second leading cause of death globally. All over the world, children below five years of age experience, on average, 3.2 episodes of diarrhea per year. Objectives: To explore an association of maternal education with childhood diarrhea in Pakistan. Study Design: Cross sectional study. Methodology: This study was conducted from Aug 2016 to Jan 2017 in Combined Military Hospital (CMH), Peshawar following approval from ethical review board. Total children under study were 363 aged 2 to 5 years, amid whom 121 were acute diarrhea cases and 242 were healthy controls leading to cases control ratio as 1:2. Data collection was done through semi structured questionnaire asked from mothers. Statistical analysis: Data was analyzed by SPSS software, version 22. To compare the association of maternal education with acute diarrhea, chi square test was applied at 5% level of significance. Statistical significance was taken at p value <0.05. Results: In present study, there was significant association between formal education of mothers and acute diarrhea with a highly statistically significant association (p < 0.001) observed showing increased proportion of childhood diarrhea, with increasing levels of education in mothers. Conclusion: We concluded that a significant increase in childhood diarrhea with higher levels of maternal education refutes the commonly observed finding. We need to further probe the underlying causes to minimize this high observed morbidity. Key Words: Maternal Education, Child Health and Safety and Acute Childhood Diarrhea

scholarly journals Seroconfirmed Typhoid Fever and Knowledge, Attitude, and Practices among Febrile Patients Attending at Injibara General Hospital, Northwest Ethiopia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wondemagegn Mulu ◽  
Chalachew Genet Akal ◽  
Kidist Ababu ◽  
Solomon Getachew ◽  
Fenkil Tesfaye ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
General Hospital ◽  
Venous Blood ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Northwest Ethiopia ◽  
Health Facilities ◽  
World Health ◽  
Cross Sectional ◽  
Middle Income

Introduction. Typhoid fever (TF) is a febrile global health problem caused by Salmonella enterica serovar Typhi (S. Typhi) with relatively high prevalence in low- and middle-income countries including Ethiopia. Identifying local prevalence and gaps in knowledge, attitude, and practice (KAP) towards TF is recommended by the World Health Organization to implement preventive measures. Therefore, this study determined the prevalence of S. Typhi and KAP of febrile patients towards TF in Injibara General Hospital, Northwest Ethiopia. Methods. Hospital-based cross-sectional study was conducted from January to March 2020. A total of 237 patients were included conveniently. Data on KAP and demographic variables were collected using a structured questionnaire by face-to-face interview. After the interview, 5 ml venous blood was collected and processed using the Widal test following the manufacturer’s instruction. Mean scores and percentages were used to determine the level of KAP. Multivariable analysis was done to correlate KAPs with TF. P value < 0.05 was considered statistically significant. Results. The overall prevalence of S. Typhi was 25.7%. The highest seroprevalence was observed among the age group of 30-34 years (33.3%) and patients with no education. The majority of participants know the major ways of TF transmission (59.1-90.7%) and prevention (81.4%) methods. However, the misconception on the route of TF transmission was observed in 13.5-36.7% of participants. About 65.4% and 67.5% of study participants were considered knowledgeable and had good preventive practice towards TF, respectively. Being a student ( AOR = 0.227 , CI = 0.053 − 0.965 ) and considering mosquito bite as transmission routes ( AOR = 2.618 , CI = 1.097 − 6.248 ) were significantly associated with TF. Conclusion. High S. Typhi prevalence was observed in the study area. Moreover, the misconception on the transmission of typhoid fever and educational level was a risk factor for TF. Thus, health facilities should incorporate topics on typhoid fever as part of their health education system within health facilities and in the community.

scholarly journals MATERNAL C-REACTIVE PROTEIN IN PREGNANCY AND ITS RELATION WITH EARLY ONSET NEONATAL SEPSIS

2021 ◽  
Vol 71 (4) ◽  
pp. 1130-33
Author(s):  
Muhammad Zahid ◽  
Saeed Zaman ◽  
Sohail Shahzad ◽  
Sajid Ali Shah ◽  
Sana Javed ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Increased Risk

Objective:To determine association of early-onset neonatal sepsis (EONS) in newborns of serum C-reactive protein positive mothers. Study Design:  Cross sectional study Place and duration of study:  Department of Pediatrics, Combined Military Hospital Quetta, Pakistan from September 2016 to March 2018. Material and Methods: 105 neonates (both gender) of all mothers who were C - reactive protein positive were enrolled in this study using inclusion and exclusion criteria.Neonatal sepsis was diagnosed by clinical examination, which was carried out by senior pediatrician, blood complete picture and c reactive protein. Neonates were treated as per departmental protocol. Stratification was done in regard to gestational age, birth weight and age of neonates in hours. Post stratification chi square test was applied and p-value less than 0.05 was considered significant. Results:Out of total 105 patients, 46 (44%) were male and 59 (56%)were female neonates. Amongst the babies of 105 CRP positive mothers, 79 babies were having signs and symptoms of neonatal sepsis and 26 babies were having no signs and symptoms of neonatal sepsis with statistically significant relation between maternal CRP and neonatal sepsis of p value <0.05. Conclusion:Increased maternal CRP level is associated with increased risk of neonatal sepsis. Maternal CRP may be used as a good screening tool for early detection of neonatal sepsis.

scholarly journals Prevalence of Rubella Immunity among Women Seeking Antenatal Care in a Tertiary Institution, South-South, Nigeria

2021 ◽  
pp. 30-37
Author(s):  
J. E. Egbagba ◽  
A. O. Abdu ◽  
N. Osegi ◽  
S. C. Amadi ◽  
M. A. Alex-Wele ◽  
...  
Keyword(s):  
Demographic Data ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
P Value ◽  
Igg Antibodies ◽  
Tertiary Institution ◽  
Cross Sectional ◽  
Obstetrics And Gynaecology ◽  
And Control

Aims: To determine rubella sero-prevalence (IgG, IgM) and to describe its relation to socio-demographic data among pregnant women in a tertiary institution in Yenagoa, Bayelsa state, South-South, Nigeria. Study Design:  This was a descriptive cross sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology, Federal Medical Centre in Yenegoa, Bayelsa State, in South-South Nigeria between May 2020 and August 2020. Methodology: We included 398 women at various stages of pregnancy. An interviewer administered questionnaire was used to obtain socio demographic data. Ten ml of venous blood was then collected for serological assays.  Analyses of samples were done using an in-vitro on-site rubella IgG/IgM rapid diagnostic assay. P value were kept at 0.05. Results: A total of 209 (53.0%) of the 398 women had a positive IgG antibodies. None (0.0%) of the women had positive IgM antibodies. There were no significant associations between respondents socio-demographic characteristics and rubella immunity as the probability values observed were greater than 0.05 (p>0.05). Conclusion: Our study shows a moderately high sero-prevalence of IgG antibodies amongst the participants studied. This indicates that rubella infection is endemic in Nigeria and requires further surveillance and control.

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