scholarly journals Gastroenterological symptoms and diet therapy in children with autism

Author(s):  
И.А. Бавыкина

Целью данного исследования было выявление различий в наличии и тяжести гастроэнтерологических жалоб у пациентов с расстройствами аутистического спектра в зависимости от стиля питания. В исследование включены родители 138 детей с данным диагнозом, 30 из которых привержены к соблюдению безглютеновой диеты более 6 месяцев. Возраст детей составлял от 3 до 15 лет. Дети были разделены на 2 группы в зависимости от стиля питания. Первую группу составили 30 пациентов, придерживающихся безглютеновой диеты, во вторую включены 108 человек, не имеющих ограничений в питании. У каждого второго ребенка с расстройствами аутистического спектра выявлены значимые рецидивирующие гастроэнтерологические жалобы (52,8%, 73 из 138). Дети, соблюдающие безглютеновую диету, имеют меньше гастроэнтерологических жалоб, и они являются более редкими, кратковременными, эпизодическими, не нарушающими состояния ребенка, в то время как у детей, не приверженных к использованию диетотерапии, жалобы чаще носят персистирующий и рецидивирующий характер. Диарея и вздутие живота беспокоят детей на безглютеновой диете чаще. Наиболее распространенной жалобой в обеих группах является наличие тошноты (63,3% vs 62,9%). Дети, не имеющие ограничений в питании, имеют более широкий круг жалоб, среди них: избирательность в еде, запах изо рта, наличие непереваренных частиц пищи в кале. Перед включением безглютеновой диеты в курс терапевтических мероприятий при расстройствах аутистического спектра необходимы консультация гастроэнтеролога и проведение клинического обследования с целью уточнения наличия пищевой непереносимости у ребенка. Objective. To identify differences in the presence and severity of gastroenterological complaints in patients with ASD, depending on the eating style. Methods. The study included parents of 138 children diagnosed with ASD, 30 of whom are committed to HD for more than 6 months. The children ranged in age from 3 to 15 years. The children were divided into 2 groups depending on their eating style. The first group consisted of 30 patients who adhere to HD, the second included 108 people who do not have dietary restrictions.Results. Every second child with ASD had significant recurrent gastroenterological complaints (52,8%, 73 out of 138). Children who adhere to HDG have fewer gastroenterological complaints, and they are more rare, short-term, episodic, not violating the child's condition, while children who are not committed to using diet therapy, complaints are more often persistent and recurrent. Diarrhoea and bloating bother children on HD more often. The most common complaint in both groups is nausea (63,3% vs 62,9%). Children who do not have dietary restrictions have a wider range of complaints, among them: selectivity in food, bad breath. The presence of undigested food particles in the feces. Conclusion. Before including HD in the course of therapeutic measures for ASD, it is necessary to consult a gastroenterologist and conduct a clinical examination to clarify the presence of food intolerance in the child.

2021 ◽  
Vol 20 (1) ◽  
pp. 5-10
Author(s):  
Alla Borshulyak ◽  
Oksana Andriyets ◽  
Svitlana Pryimak ◽  
Anatoliy Andriyets

Based on the literature datа and the results of our studies, menstrual dysfunction in teen girls leads to disorders of the reproductive system in fertile age. Establishment of normal menstrual function in teen girls is an eff ective measure for the prevention of future reproductive health disorders, which leads to improved methods of menstrual disorders diagnostics in overweight girls by analyzing clinical and anamnestic data, biochemical markers, development of diagnostic algorithm and pathogenetically based correction of menstrual disorders. To gain this aim, it was proposed to include to the complex of conventional therapy, diet therapy and drugs myo-inositol (inofolic softgel) and metformin. Evaluation of the treatment eff ectiveness was performed on the regression dynamics of the disease main clinical symptom and the normalization of hormonal status indicators. The result of treatment was considered satisfactory when the patient had regular menstruation for 12 months on the background of the therapy, and the maintenance of irregular menstruation with a cycle duration of more than 38 days was unsatisfactory. As a result of treatment the body mass index has decreased in all the patients which received our complex of therapeutic measures, especially for obesity of the second and third degree what proves the eff ectiveness of complex treatment. The appointment of proposed complex of treatment measures for patients is pathogenetically based, because after treatment, previously detected insulin resistance decreased signifi cantly in all groups, but most and reliably in groups with obesity of the second and third degree and became almost within normal limits.


2020 ◽  
Vol 4 (1) ◽  
pp. 36
Author(s):  
Alifah Fajriyyatul Izzah ◽  
Widati Fatmaningrum ◽  
Roedi Irawan

Background: Autism disorders can disrupt the quality of life of autism children. One popular diet therapy for children with autism is a gluten and casein free diet. Gluten and casein free diet based on opioid theory are still pros and cons.Objective: To determine the difference of symptoms in autistic children who are free from gluten and casein and those who are not.Method: An observational analytic cross-sectional study was conducted at several autistic therapy centers in Surabaya. The study was carried out in children with autism aged 3-12 years and was diagnosed by a specialist. The research subjects were selected by purposive sampling method. Data collected, including data on the child's identity, data on the identity of parents, data on gluten and casein implementation were obtained through the FFQ questionnaire and data on symptoms of autistic children were obtained from the ATEC questionnaire.Results: Autistic symptom scores were good for communication skills, social interactions, cognitive responses, and behavioral disorders in autistic children on diets rather than those who did not. Bivariate test results showed that there were significant differences in the variable behavior disorder (p=0.021) and the total score (p=0.018).Conclusion: There are differences in symptoms in autistic children who are free from gluten and casein and those who are not especially on behavioral disorders.ABSTRAKLatar Belakang: Gangguan autisme dapat mengganggu kualitas hidup anak autis. Salah satu terapi diet populer bagi anak autis adalah diet bebas gluten dan kasein. Diet bebas gluten dan kasein yang didasari oleh teori opioid masih menjadi pro kontra.Tujuan: Mengetahui perbedaan gejala pada anak autis yang diet bebas gluten dan kasein dengan yang tidak diet.Metode: Penelitian analitik observasional rancangan cross sectional dilakukan di beberapa pusat terapi autis di Surabaya. Penelitian dilakukan pada anak autis berusia 3 – 12 tahun dan telah didiagnosis oleh dokter ahli. Subyek penelitian dipilih dengan metode purposive sampling. Data yang dikumpulkan, meliputi data identitas anak, data identitas orang tua, data pelaksanaan diet bebas gluten dan kasein diperoleh melalui kuesioner FFQ serta data gejala pada anak autis diperoleh dari kuesioner ATEC.Hasil: Gambaran gejala pada anak autis yang diet bebas gluten dan kasein lebih ringan daripada yang tidak diet berupa gangguan kemampuan komunikasi, interaksi sosial, respon kognitif dan gangguan perilaku. Hasil uji bivariat menunjukkan ada perbedaan yang signifikan pada variabel gangguan perilaku (p=0,021) dan skor ATEC total (p=0,018).Kesimpulan: Ada perbedaan gejala pada anak autis yang diet bebas gluten dan kasein dengan yang tidak diet terutama pada gangguan perilaku.


2017 ◽  
Vol 7 (4) ◽  
pp. 63 ◽  
Author(s):  
Lázaro Gómez ◽  
Belkis Vidal ◽  
Carlos Maragoto ◽  
Lilia Morales ◽  
Sheyla Berrillo ◽  
...  

Autism is a representation, a general characterized by "a bunch of failure" to describe and categorize individuals behavior describing failures in social relationships, communication, and imagination ability. To develop ability on children with autism to be close to normal, diagnosis methods through early, integrated and intensive treatment were used. One type of therapy for children with autism is through food or the so-called Gluten Free Casein Free (GFCF) diet therapy. The type of this research was descriptive with cross sectional design. The population in the study were all students with autism who were still active following treatment with a sample of 36 people who were taken by using purposive sampling. Results showed that mostly there are 80.6% parents who have knowledge, 55.6% samples never eat foods containing gluten, 50% samples never eat foods containing casein, 77.8% samples have a good energy intake, 100% samples have good protein intake, and 80.6% samples have mild autistic behavior. From the results of the study, it is expected that the parents can increase knowledge about the GFCF diet in order to improve their diet and reduce behavior disorders in autism children


2020 ◽  
Vol 15 (4) ◽  
pp. 40-46
Author(s):  
I.A. Bavykina ◽  
◽  
A.A. Zvyagin ◽  
K.Yu. Gusev ◽  
A.V. Pochivalov ◽  
...  

Objective. To analyze correlation between the level of intestinal fatty-acid binding protein (I-FABP) and concentration of serological markers of gluten and casein intolerance in children with autism spectrum disorder (ASD). Patients and methods. This study included 55 children aged between 3 and 15 years diagnosed with ASD. Twenty of them followed a gluten-free diet (GFD). All patients were tested for their serum levels of anti-gliadin IgG, anti-deamidated gliadin peptide IgA, anti-casein IgG, and anti-I-FABP IgG using enzyme-linked immunosorbent assay (ELISA). To exclude selective immunodeficiency, we also measured total IgA level. Statistical analysis was performed using the Statistica 10.0 software. We have constructed a three-dimensional surface using paired samples correlations. Results. The level of I-FABP varied between 1.63 and 209 pg/mL (mean 63.54 ± 48.5 pg/mL); its concentration decreased with age (r = -0,786). Increased levels of anti-gliadin antibodies were observed in 17.1% of children with ASD; 73.5% of patients had elevated levels of anti-casein antibodies; none of participants had anti-I-FABP antibodies. Conclusion. After constructing a multidimensional surface for three parameters, we have found certain correlations between the parameters examined, which reflects the existing relationships between them. We suggest using multidimensional descriptive statistics as the basis for constructing relationship functions in further research. Key words: autism, diet therapy, serological markers, leaky gut syndrome, gluten intolerance


1964 ◽  
Vol 206 (6) ◽  
pp. 1430-1436 ◽  
Author(s):  
Paul N. Rozin ◽  
Jean Mayer

Goldfish press a lever in order to receive a food pellet during 1-hr sessions at the same time each day. They eat much less in 1 hr than when allowed to press the lever for a full day. The day-to-day 1-hr intake is stable. The intake in 1 hr is about the same when the fish have been deprived from 4 to 47 hr. This constancy cannot be accounted for by assuming a steady state in the gut. Four hours postfeeding virtually all undigested food from the previous feeding session remains in the gut; by 47 hr most or all has been excreted.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Daniel S. R. Angrimani ◽  
Maíra M. Brito ◽  
Bruno R. Rui ◽  
Marcílio Nichi ◽  
Camila I. Vannucchi

Abstract Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment.


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