scholarly journals Oral, topical, and inhalation of Calcarea carbonica derivative complex (M8) to treat inflammatory mammary carcinoma in dogs

2021 ◽  
Vol 11 (40) ◽  
pp. 166-167
Author(s):  
Daniella Matos Da Silva ◽  
Eneida Janiscki Da Lozzo ◽  
Dorly de Freitas Buchi ◽  
Carolina De Oliveira ◽  
Simone Domit Guérios
Keyword(s):  
Mammary Carcinoma ◽  
Present Report ◽  
Biological Response ◽  
Small Animal ◽  
Mammary Glands ◽  
Routes Of Administration ◽  
Anticancer Properties ◽  
Conium Maculatum ◽  
Aconitum Napellus ◽  
Anti Inflammatory

Background: Inflammatory mammary carcinoma (IMC) is locally aggressive, fast growing, highly malignant tumor that affects humans and dogs. Affected dogs usually are presented with generalized edema, pain, erythema, and skin ulceration in mammary glands. Surgery is not recommended and an effective treatment has not been established [1]. Calcarea carbonica derivative complex (M8) has demonstrated anticancer properties in a murine model, by improving innate immune response against tumor cells [2]. M8 is a complex high diluted medication comprised of Calcarea carbonica 16x, Aconitum napellus 20x, Arsenicum album 18x, Asa foetida 20x, Conium maculatum 17x, Ipecacuanha 13x, Phosphorus 20x, Rhus toxicodendron 17x, Silicea 20x, Sulphur 24x, and Thuya occidentalis 19x, dilution procedures have followed standard methodology described at the Brazilian Homeopathic Pharmacopoeia. Aims: To describe different routes of M8 administration associated with oral pyroxican (non-steroidal anti-inflammatory drug) to treat dogs with IMC. Methodology: Three female dogs with 10 years old median age were presented to the Veterinary Teaching Hospital at Federal University of Parana, Curitiba (HV-UFPR) with cytological and clinical diagnosis of IMC. Patients were treated with oral (0.5 mL,q12h), topical (q12h) and inhalatory (2 mL, q24h, through an ultrasonic inhalation device) M8, and oral pyroxican (0.3mg/kg, q24h).Thoracic radiographs showed pulmonary metastasis in all dogs. Results: 7 days after initiating treatment all patients had clinical improvement. It was observed reduction on mammary glands inflammation and decreased pain sensitivity. One patient had 8 month of complete remission. The other two patients died 1 and 2 month after initial treatment. However none of the patients had pulmonary progressive disease, showed by radiographic examinations. Owners revealed treatment satisfaction in regards to quality of life improvement, easy M8 administration, good M8 palatability for dogs, and inflammation reduction. Conclusion: The present report suggests that M8 influenced positively the anti -inflammatory treatment. Keywords: Calcarea carbonica complex; inflammatory mammary carcinoma; routes of administration References [1] Sorenmo K. Canine mammary gland tumors. Veterinary Clinics of North America: Small Animal Practice. 2003 33(3):573-96. [2] Oliveira CC, Abud APR, Oliveira SM, Guimarães FSF, Andrade LF, Di Bernardi RP, Coletto ELO, Kuczera D, Da Lozzo EJ, Gonçalves JP, Trindade ES, Buchi DF. Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complementary and Alternative Medicine 2011, 11(101): 2-11.

scholarly journals Calcarea carbonica derivative complex (M8) as adjuvant treatment of inflammatory mammary carcinoma in a dog

2021 ◽  
Vol 10 (36) ◽  
pp. 268-270
Author(s):  
Daniella Matos Da Silva ◽  
Eneida Janiscki Da Lozzo ◽  
Carolina Camargo De Oliveira ◽  
Dorly de Freitas Buchi ◽  
Simone Domit Guérios
Keyword(s):  
Clinical Improvement ◽  
Mammary Carcinoma ◽  
Present Report ◽  
Clinical Signs ◽  
Abdominal Ultrasound ◽  
Fine Needle Biopsy ◽  
Mammary Glands ◽  
Response To Treatment ◽  
Cytologic Examination ◽  
Conium Maculatum

Background: Inflammatory mammary carcinoma (IMC) is locally aggressive, fast growing, highly malignant tumor that affects humans and dogs. Affected dogs usually are presented with generalized edema, pain, erythema, and skin ulceration in mammary glands. Surgery is not recommended and an effective treatment has not been established [1]. Calcarea carbonica derivative complex (M8) has demonstrated anticancer properties in a murine model, by improving innate immune response against tumor cells [2,3]. M8 is a complex high diluted medication comprised of a 10%-20% concentration of Calcarea carbonica, Aconitum napellus, Arsenicum album, Asa foetida, Conium maculatum, Ipecacuanha, Phosphorus, Rhus tox, Silicea, Sulphur, and Thuya occidentalis, all in decimal dilutions of Hahnemann in distilled water and submitted to vigorous shaking. Aim: Describe an association of M8 and piroxicam (Non-steroidal anti-inflammatory drug) to treat a dog with IMC. Discussion: A 7 years old, mixed breed intact female dog was presented to the Federal University of Parana - Veterinary Hospital, Curitiba (HV-UFPR) for mammary glands examination. The owners related inflammation of mammary glands with clinical course of approximately 10 days, which was treated for mastitis (cephalexin and metergoline) without clinical improvement. Clinical examination revealed erythema, increased skin warmth, pain on palpation, and plaque involving the 4th and 5th right mammary glands. Abdominal ultrasound and serum biochemistry were unremarkable. Thoracic radiographs showed suspicious images of pulmonary metastasis. Fine needle biopsy was taken for cytologic examination. Cytological interpretation was a malignant epithelial neoplasm, probably a mammary carcinoma. Diagnosis of IMC was based on clinical signs and cytopathology. Dog was treated with oral (0.5 mL) and topical M8 twice a day for 15 days, and pyroxican, 0.3mg/kg, PO, q24h. Clinical improvement was observed 7 days after starting treatment. Until present date (70 treatment days with M8), dog has no clinical signs of IMC, and does not show signs of disease progression. Conclusion: The present report suggests that M8 associated with piroxicam contributes to improvement of IMC dog’s quality of life and survival rate. However, further clinical studies are needed to evaluate response to treatment in patients diagnosed with IMC.

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

scholarly journals Recent Findings on Thymoquinone and its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 775
Author(s):  
Ravi Raj Pal ◽  
Vasundhara Rajpal ◽  
Priya Singh ◽  
Shubhini A. Saraf
Keyword(s):  
Rheumatoid Arthritis ◽  
Aqueous Solubility ◽  
Disease Modifying Antirheumatic Drugs ◽  
Antirheumatic Drugs ◽  
Anticancer Efficacy ◽  
Drug Deposition ◽  
Anticancer Properties ◽  
Enhanced Permeability And Retention ◽  
Anti Inflammatory ◽  
Energy Dependent

Cancer causes a considerable amount of mortality in the world, while arthritis is an immunological dysregulation with multifactorial pathogenesis including genetic and environmental defects. Both conditions have inflammation as a part of their pathogenesis. Resistance to anticancer and disease-modifying antirheumatic drugs (DMARDs) happens frequently through the generation of energy-dependent transporters, which lead to the expulsion of cellular drug contents. Thymoquinone (TQ) is a bioactive molecule with anticancer as well as anti-inflammatory activities via the downregulation of several chemokines and cytokines. Nevertheless, the pharmacological importance and therapeutic feasibility of thymoquinone are underutilized due to intrinsic pharmacokinetics, including short half-life, inadequate biological stability, poor aqueous solubility, and low bioavailability. Owing to these pharmacokinetic limitations of TQ, nanoformulations have gained remarkable attention in recent years. Therefore, this compilation intends to critically analyze recent advancements in rheumatoid arthritis and cancer delivery of TQ. This literature search revealed that nanocarriers exhibit potential results in achieving targetability, maximizing drug internalization, as well as enhancing the anti-inflammatory and anticancer efficacy of TQ. Additionally, TQ-NPs (thymoquinone nanoparticles) as a therapeutic payload modulated autophagy as well as enhanced the potential of other drugs when given in combination. Moreover, nanoformulations improved pharmacokinetics, drug deposition, using EPR (enhanced permeability and retention) and receptor-mediated delivery, and enhanced anti-inflammatory and anticancer properties. TQ’s potential to reduce metal toxicity, its clinical trials and patents have also been discussed.

scholarly journals Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4426 ◽  
Author(s):  
Ming-Shun Wu ◽  
Levent Bless B. Aquino ◽  
Marjette Ylreb U. Barbaza ◽  
Chieh-Lun Hsieh ◽  
Kathlia A. De Castro-Cruz ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Sesamum Indicum ◽  
The Body ◽  
Anticancer Activities ◽  
Anticancer Properties ◽  
Pharmacological Significance ◽  
Anti Inflammatory ◽  
Natural Medicines

The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

scholarly journals Antihyperglycemic and Anti-Inflammatory Effects of StandardizedCurcuma xanthorrhizaRoxb. Extract and Its Active Compound Xanthorrhizol in High-Fat Diet-Induced Obese Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Mi-Bo Kim ◽  
Changhee Kim ◽  
Youngwoo Song ◽  
Jae-Kwan Hwang
Keyword(s):  
High Fat Diet ◽  
Interleukin 1 ◽  
Liver Fat ◽  
Postprandial Blood Glucose ◽  
Obese Mice ◽  
High Fat ◽  
Necrosis Factor Alpha ◽  
Glucose Levels ◽  
Anticancer Properties ◽  
Anti Inflammatory

Xanthorrhizol, a natural compound isolated fromCurcuma xanthorrhizaRoxb. (Java turmeric), has been reported to possess antioxidant and anticancer properties; however, its effects on metabolic disorders remain unknown. The aim of the present study was to evaluate the effects of xanthorrhizol (XAN) andC. xanthorrhizaextract (CXE) with standardized XAN on hyperglycemia and inflammatory markers in high-fat diet- (HFD-) induced obese mice. Treatment with XAN (10 or 25 mg/kg/day) or CXE (50 or 100 mg/kg/day) significantly decreased fasting and postprandial blood glucose levels in HFD-induced obese mice. XAN and CXE treatments also lowered insulin, glucose, free fatty acid (FFA), and triglyceride (TG) levels in serum. Epididymal fat pad and adipocyte size were decreased by high doses of XAN (26.6% and 20.1%) and CXE (25.8% and 22.5%), respectively. XAN and CXE treatment also suppressed the development of fatty liver by decreasing liver fat accumulation. Moreover, XAN and CXE significantly inhibited production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β(IL-1β), and C-reactive protein (CRP) in adipose tissue (27.8–82.7%), liver (43.9–84.7%), and muscle (65.2–92.5%). Overall, these results suggest that XAN and CXE, with their antihyperglycemic and anti-inflammatory activities, might be used as potent antidiabetic agents for the treatment of type 2 diabetes.

scholarly journals Efecto de la inflorescencia de “coliflor” sobre síndrome caquéctico en Mus musculus var. swiss con cáncer inducido

2020 ◽  
pp. 53-57
Keyword(s):  
Body Weight ◽  
Mus Musculus ◽  
Redox Reactions ◽  
Antioxidant Properties ◽  
Body Weight Loss ◽  
Progressive Increase ◽  
Anticancer Properties ◽  
Progressive Loss ◽  
Metabolic Imbalance ◽  
Anti Inflammatory

The objective was to determine the effect of Brassica oleracea var Botrytis "cauliflower" inflorescences on cachectic syndrome in Mus musculus var. swiss with induced cancer. Cachectic syndrome is characterized by progressive loss of body weight, anorexia, asthenia, immunosuppression and metabolism of carbohydrates, lipids and proteins, with loss of muscle and adipose tissue. It used dry cauliflower inflorescence extract (ESC) and male mice 35-45 g with induced cancer, divided into groups: G1 untreated control, G2 and G3 treated with ESC, doses 10 and 20mg/kg/bw/vo and G4 treated with quercitin, dose 7.14mg/Kg/bw/vo for 90 days. Some manifestations of cachectic syndrome were determined. It was observed that G1 had thinning and progressive increase in alopecia, asthenia and conjunctival xerosis due to energy and metabolic imbalance compared to G2, G3 and G4 that had higher body weight and fewer cachectic manifestations, being significant by time and treatment group (P<0.01). It has been reported that cauliflower contains flavonoids quercitin and kaemferol, with anti-inflammatory properties for its action on cyclooxygenase, lipooxygenase, interleukins and chemosins, with antioxidant properties on intracellular glutathione, in redox reactions and favoring the expression of caspases in cell apoptosis. Therefore, it is concluded that cauliflower prevents body weight loss and decreases cachectic syndrome because it contains kaempferol and quercitin that act synergistically with anti-inflammatory, antioxidant and anticancer properties.

Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells

2018 ◽  
Vol 41 (5) ◽  
pp. 505-516 ◽  
Author(s):  
Carsten Pelz ◽  
Sonja Häckel ◽  
Geo Semini ◽  
Sandra Schrötter ◽  
Willem Bintig ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Biological Response ◽  
Biological Response Modifier ◽  
Carcinoma Cells ◽  
Response Modifier ◽  
Mammary Carcinoma Cells

scholarly journals Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Manon Cairat ◽  
Marie Al Rahmoun ◽  
Marc J. Gunter ◽  
Gianluca Severi ◽  
Laure Dossus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Prospective Cohort ◽  
Cox Regression ◽  
Insurance Plan ◽  
Anticancer Properties ◽  
Hazard Ratios ◽  
Reimbursement Database ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Background Although anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent. Methods We investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk. Results In the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before. Conclusion Only women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.

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