scholarly journals Research of the Autonomic Regulation in the Formation of the Brain Microwave Radiation Restoration Processes during Rehabilitation of the Stroke Patients - Study by Means of the Multifractal Analysis of the Radiophysical Complex MRTHR Signals

2017 ◽  
Author(s):  
Vladimir Kublanov ◽  
Vasilii Borisov ◽  
Yan Kazakov ◽  
Alexander Azin
Keyword(s):  
Microwave Radiation ◽  
Multifractal Analysis ◽  
Autonomic Regulation ◽  
Stroke Patients ◽  
The Brain

scholarly journals Cross-Modal Effect of Presenting Visual and Force Feedback That Create the Illusion of Stair-Climbing

2021 ◽  
Vol 11 (7) ◽  
pp. 2987
Author(s):  
Takumi Okumura ◽  
Yuichi Kurita
Keyword(s):  
Visual Information ◽  
Force Feedback ◽  
Activity Level ◽  
Experimental Results ◽  
Stair Climbing ◽  
Mirror Therapy ◽  
Visual Condition ◽  
Stroke Patients ◽  
Head Mount Display ◽  
The Brain

Image therapy, which creates illusions with a mirror and a head mount display, assists movement relearning in stroke patients. Mirror therapy presents the movement of the unaffected limb in a mirror, creating the illusion of movement of the affected limb. As the visual information of images cannot create a fully immersive experience, we propose a cross-modal strategy that supplements the image with sensual information. By interacting with the stimuli received from multiple sensory organs, the brain complements missing senses, and the patient experiences a different sense of motion. Our system generates the sense of stair-climbing in a subject walking on a level floor. The force sensation is presented by a pneumatic gel muscle (PGM). Based on motion analysis in a human lower-limb model and the characteristics of the force exerted by the PGM, we set the appropriate air pressure of the PGM. The effectiveness of the proposed system was evaluated by surface electromyography and a questionnaire. The experimental results showed that by synchronizing the force sensation with visual information, we could match the motor and perceived sensations at the muscle-activity level, enhancing the sense of stair-climbing. The experimental results showed that the visual condition significantly improved the illusion intensity during stair-climbing.

Abstract TP274: Orosomucoid-1 Protein Increases Following Ischemic Stroke in the Brain and Periphery

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Hetal Mistry ◽  
Madeline Levy ◽  
Meaghan Roy-O'Reilly ◽  
Louise McCullough
Keyword(s):  
Sex Differences ◽  
Ischemic Stroke ◽  
Rna Sequencing ◽  
Multiple Testing ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mrna Levels ◽  
Stroke Patients ◽  
Post Stroke ◽  
Protein Levels ◽  
The Brain

Background and Purpose: Orosomucoid-1 (ORM-1) is an abundant protein with important roles in inflammation and immunosuppression. We utilized RNA sequencing to measure mRNA levels in human ischemic stroke patients, with confirmation by serum ORM-1 protein measurements. A mouse model of ischemic stroke was then used to examine post-stroke changes in ORM-1 within the brain itself. Hypothesis: We tested the hypothesis that ORM-1 levels increase following ischemic stroke, with sex differences in protein dynamics over time. Methods: RNA sequencing was performed on whole blood from ischemic stroke patients (n=23) and controls (n=12), with Benjamini-Hochberg correction for multiple testing. Enzyme-linked immunosorbent assay was performed on serum from ischemic stroke patients (n=28) and controls (n=8), with analysis by T-test. For brain analysis, mice (n=14) were subjected to a 90-minute middle cerebral artery occlusion (MCAO) surgery and sacrificed 6 or 24 hours after stroke. Control mice underwent parallel “sham” surgery without occlusion. Western blotting was used to detect ORM-1 protein levels in whole brain, with analysis by two-way ANOVA. Results: RNA sequencing showed a 2.8-fold increase in human ORM-1 at 24 hours post-stroke (q=.0029), an increase also seen in serum ORM-1 protein levels (p=.011). Western blot analysis of mouse brain revealed that glycosylated (p=0.0003) and naive (p=0.0333) forms of ORM-1 were higher in female mice compared to males 6 hours post-stroke. Interestingly, ORM-1 levels were higher in the brains of stroke mice at 6 hours (p=.0483), while at 24 hours ORM-1 levels in stroke mice were lower than their sham counterparts (p=.0212). In both human and mouse data, no sex differences were seen in ORM-1 levels in the brain or periphery at 24 hours post-stroke. Conclusion: In conclusion, ORM-1 is a sexually dimorphic protein involved in the early (<24 hour) response to ischemic stroke. This research serves as an initial step in determining the mechanism of ORM-1 in the ischemic stroke response and its potential as a future therapeutic target for both sexes.

scholarly journals Association between serum lipid and ischaemic stroke in a tertiary hospital in Northern Andhra Pradesh, India

2020 ◽  
Vol 7 (7) ◽  
pp. 1078
Author(s):  
Tamminana Venugopala Rao ◽  
Budumuru Annaji Rao ◽  
Sreedevi Panchadi ◽  
K. Sudheer
Keyword(s):  
Risk Factor ◽  
Ischaemic Stroke ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Independent Risk Factor ◽  
Ldl Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Stroke Patients ◽  
The Brain

Background: The incidence of cerebrovascular disease increases with age and the number of strokes is projected to increase as the elderly population grows. A stroke occurs when blood vessels that carry blood to the brain suddenly blocked or burst, preventing blood flow to the brain. The most common cause of blood vessel blockages is thrombosis (a blood clot) or an embolism (floating clot). Blood clots may form in the arteries that are damaged by atherosclerosis. Atherosclerosis is an aging process but some factors (risk factor) precipitate it to occur earlier. To find out the risk factors properly are of tremendous importance as risk factor change could directly influence or indirectly affect case fatality by altering the natural history of the disease. Serum lipids are thought to interact with the pathogenesis of stroke through the atherosclerotic mechanism. Objective was to identify the high serum lipid as an independent risk factor of stroke.Methods: This is a hospital-based case-control study. Seventy cases of stroke patients and age, sex-matched 70 healthy control subjects were enrolled by non-random sampling. 12 hours of fasting plasma lipids were estimated in both cases and control subjects. Then it was compared between cases and controls.Results: Hypercholesterolemia was higher in the case group than control but not statistically significant. Mean LDL- cholesterol, and triglycerides were significantly higher in the case group than the control group. The mean value of serum HDL-cholesterol was not significantly lower in the case group than the control group.Conclusions: Serum lipids are significantly higher in ischaemic stroke patients than the control group (LDL cholesterol and triglyceride). So, it may be an independent risk factor of ischemic stroke.

Resting state functional magnetic resonance imaging processing techniques in stroke studies

2016 ◽  
Vol 27 (8) ◽  
pp. 871-885 ◽  
Author(s):  
Golrokh Mirzaei ◽  
Hojjat Adeli
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Resting State ◽  
Brain Connectivity ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Stroke Patients ◽  
Processing Techniques ◽  
The Brain

AbstractIn recent years, there has been considerable research interest in the study of brain connectivity using the resting state functional magnetic resonance imaging (rsfMRI). Studies have explored the brain networks and connection between different brain regions. These studies have revealed interesting new findings about the brain mapping as well as important new insights in the overall organization of functional communication in the brain network. In this paper, after a general discussion of brain networks and connectivity imaging, the brain connectivity and resting state networks are described with a focus on rsfMRI imaging in stroke studies. Then, techniques for preprocessing of the rsfMRI for stroke patients are reviewed, followed by brain connectivity processing techniques. Recent research on brain connectivity using rsfMRI is reviewed with an emphasis on stroke studies. The authors hope this paper generates further interest in this emerging area of computational neuroscience with potential applications in rehabilitation of stroke patients.

Electromyography-Based Functional Electrical Stimulation (FES) in Rehabilitation

2020 ◽  
pp. 833-851
Author(s):  
Poulami Ghosh ◽  
Ankita Mazumder ◽  
Anwesha Banerjee ◽  
D.N. Tibarewala
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Functional Electrical Stimulation ◽  
Muscle Activity ◽  
Small Amplitude ◽  
Electrical Current ◽  
Metabolic Responses ◽  
Stroke Patients ◽  
Cord Injury ◽  
The Brain

Loss or impairment in the ability of muscle movement or sensation is called Paralysis which is caused by disruption of communication of nerve impulses along the pathway from the brain to the muscles. One of the principal reasons causing paralysis is Spinal Cord Injury (SCI) and Neurological rehabilitation by using neuro-prostheses, based on Functional Electrical Stimulation (FES) is extensively used for its treatment. Impaired muscles are activated by applying small amplitude electrical current. Electromyography (EMG), the recording of biosignals generated by muscle activity during the application of FES can be used as the control signal for FES based rehabilitative devices. This method is predominantly used for restoring upper extremity functioning (wrist, hand, elbow, etc.), standing, walking (speed, pattern) in stroke patients. FES, collaborated with conventional methods, has the potential to be utilized as a useful tool for rehabilitation and restoration of muscle strength, metabolic responses etc. in paralyzed patients.

scholarly journals A Novel Singular Value Decomposition-Based Denoising Method in 4-Dimensional Computed Tomography of the Brain in Stroke Patients with Statistical Evaluation

Sensors ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 3063 ◽  
Author(s):  
WonSeok Yang ◽  
Jun-Yong Hong ◽  
Jeong-Youn Kim ◽  
Seung-ho Paik ◽  
Seung Hyun Lee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Image Processing ◽  
Image Quality ◽  
Statistical Evaluation ◽  
Processing Technique ◽  
Singular Value ◽  
Image Processing Technique ◽  
Stroke Patients ◽  
Value Decomposition ◽  
The Brain

Computed tomography (CT) is a widely used medical imaging modality for diagnosing various diseases. Among CT techniques, 4-dimensional CT perfusion (4D-CTP) of the brain is established in most centers for diagnosing strokes and is considered the gold standard for hyperacute stroke diagnosis. However, because the detrimental effects of high radiation doses from 4D-CTP may cause serious health risks in stroke survivors, our research team aimed to introduce a novel image-processing technique. Our singular value decomposition (SVD)-based image-processing technique can improve image quality, first, by separating several image components using SVD and, second, by reconstructing signal component images to remove noise, thereby improving image quality. For the demonstration in this study, 20 4D-CTP dynamic images of suspected acute stroke patients were collected. Both the images that were and were not processed via the proposed method were compared. Each acquired image was objectively evaluated using contrast-to-noise and signal-to-noise ratios. The scores of the parameters assessed for the qualitative evaluation of image quality improved to an excellent rating (p < 0.05). Therefore, our SVD-based image-denoising technique improved the diagnostic value of images by improving their quality. The denoising technique and statistical evaluation can be utilized in various clinical applications to provide advanced medical services.

A Mechanism For the Influence of Microwave Radiation on Serotonergic Receptors in the Brain

BIOPHYSICS ◽  
2019 ◽  
Vol 64 (4) ◽  
pp. 626-631
Author(s):  
E. B. Shadrin ◽  
V. O. Samoilov ◽  
A. V. Ilinskiy ◽  
Ya. S. Katsnelson
Keyword(s):  
Microwave Radiation ◽  
Serotonergic Receptors ◽  
The Brain

scholarly journals POST-STROKE PSYCHIATRIC DISORDERS: AN OVERVIEW ON ITS SCREENING AND MANAGEMENT

2019 ◽  
Vol 12 (1) ◽  
pp. 11
Author(s):  
Keerthana Chandrasekar ◽  
Nakka Gautam Sai ◽  
Princy Sabu John ◽  
Sruthi Ninan ◽  
Raja D ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Bipolar Disorders ◽  
Depression And Anxiety ◽  
Stroke Patients ◽  
Post Stroke ◽  
The Third ◽  
Insufficient Amount ◽  
Psychiatric Complications ◽  
The Brain

Stroke is the third leading cause of death. Stroke occurs when an insufficient amount of blood is supplied to the brain due to a thrombus or an emboli leading to permanent tissue damage. Lesions in the brain can lead to psychiatric complications. The prevalence of psychiatric complications after stroke is very common. Psychiatric complications such as depression, anxiety, apathy, pseudobulbar effects (laughing and crying), mania, psychosis, and bipolar disorders are seen after stroke. In this review, various psychiatric disorders are reported among post-stroke survivors in which depression and anxiety are common. Consequently, apathy, pseudobulbar effects, catastrophic reactions, psychosis, bipolar disorder, and mania are also observed after stroke. Therefore, early detection and management of psychiatric disorders prevent further complications and improve the quality of life in post-stroke patients.

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