Diagnostic Accuracy of Ultrasonography for Evaluation Solid Breast Lesions – A Systematic Review

2021 ◽  
Author(s):  
Syed Muhammad Yousaf Farooq ◽  
Guido C Robot ◽  
Syeda Khadija Tul Sughra Murrium ◽  
Aima Gilani ◽  
Hafiz Syed Arsalan Gilani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Public Health Problem ◽  
High Sensitivity ◽  
Breast Lesions ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Malignant Breast ◽  
The Mean ◽  
Methods Analytical ◽  
Key Terms

Breast cancer in women in both developed and developing countries is the most common cancer, and remains a major public health problem. Methods: Analytical cross-sectional studies and only highquality studies were included. The searched databases were: Pub Med (2008-2020), Google scholar (2008-2020) and science direct (20082020). The key terms searched were ultrasound imaging, Breast solid mass or lesions, papillary lesions, Fibro-adenoma, breast cancer. Using these key terms, researchers found total 101 studies from the above-mentioned databases. Among these researchers found 56 studies from Google scholars, 11 from science direct and 34 from Pub Med. After this, researchers separated the relevant and irrelevant data. Results: Table 1 shows the Descriptive results of age from 12 studies, 17641 individuals. The mean age was 46.14697 SD 10.56736. The mean Sensitivity was 91.0200 and mean specificity was 89.35. The pooled results of 8 studies and 2612 individuals, out of 2612 individuals we found 1220 (46.71) benign lesions and 1392 (53.29%) malignant lesions are also shown. Conclusions: In conclusion, Ultrasound can differentiate benign and malignant breast lesions to great extent. This technique has the potential ability to altering the handling of cases in where a biopsy may be recommended, but the risk of carcinoma is known to be relatively low. Ultrasound accuracy is recommended as the first option for follow-up examinations of lesions because of its high sensitivity and ability to detect lesions outside of breast density.

scholarly journals Factors influencing addiction in female population of an urban slum area

2020 ◽  
Vol 8 (3) ◽  
pp. 1038
Author(s):  
Ashwini Baburao Sapkal ◽  
Swati Rajesh Deshpande
Keyword(s):  
Age Of Onset ◽  
Harmful Effect ◽  
Public Health Problem ◽  
Urban Slum ◽  
Common Source ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Female Population ◽  
Factors Influencing ◽  
The Mean

Background: The use of certain licit substances like alcohol, tobacco and illicit substances like cocaine, amphetamine, cannabis, etc is termed as substance abuse. Globally, the most prevalent form of tobacco use in women is cigarette smoking. But, in low- and middle-income countries use of smokeless forms is quite common. Aim of the study was to study the factors influencing drug and tobacco addiction in the female population of an urban slum area.Methods: Community-based cross-sectional study conducted on 577 female participants in urban slums of a metropolitan city. A pre-validated semi-structured questionnaire was used. Data analysis was done in SPSS version 22.0 (IBM). Descriptive statistics and chi-square tests for associations were used.Results: The mean age of participants was 44.84±14.99 years and the mean age of onset of addiction was 21.51±6.47 years. Around 70.7% of women were tobacco chewers, 9.4% were smoking bidis and 15.8%were addicted to alcohol. Addiction is the subject of conflict in families of 70(12.1%) women. A most common source of information about the harmful effects of addiction was television and tobacco packets. Almost all women i.e. 555(96.2%) knew that oral cancer was a harmful effect of addiction. Willingness to quit an addiction was seen in 45.8%of women.Conclusions: Addiction in females is a major public health problem which is compounded by their lack of knowledge.

scholarly journals Prevalence and awareness of osteopenia in perimenopausal women in Navi Mumbai, Maharashtra, India

2019 ◽  
Vol 8 (2) ◽  
pp. 519
Author(s):  
Ajay Dodeja ◽  
Anushka Makhija ◽  
Ashita Rane ◽  
Meeta Dodeja
Keyword(s):  
Statistical Tests ◽  
Public Health Problem ◽  
World Health ◽  
Major Public Health Problem ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
The Mean ◽  
Level Of Significance ◽  
Health Organization

Background: Osteopenia is considered as precursor of osteoporosis. Osteoporosis is a major public health problem associated with substantial morbidity and socio-economic burden worldwide. Osteopenia occurs more frequently in most menopausal women. Early detection of the same can be beneficial to control prevalence of osteoporosis and also to reduce the fracture rates.Methods: A cross-sectional quantitative study using DEXA (Dual Energy X-ray Absorptiometry) was conducted on 80 women. A self-structured questionnaire was used to evaluate the level of awareness among the study subjects. The data was analyzed using statistical tests such as Chi-Square test for association. The level of significance was set at 5%.Results: The prevalence of osteopenia in the studied population was 63.75%. The mean age was recorded to be 40.35 years. The mean age of women with menopause in this study is 50.62 years. Out of the 51(63.75%) women diagnosed with osteopenia, 5.9% were underweight, 33.3% were normal and 49% were obese. Of the diseased, 37.3% experienced adequate amount sunlight exposure required while 62.7% did not. Out of the 80 women interviewed 43.75% were aware about osteopenia, its causes and complications; which 56.25% were unaware about the same.Conclusions: Women were screened for osteopenia with the help of DEXA scan according to the (World Health Organization) WHO, T-Score criteria-which may go undiagnosed otherwise and may experience the risk and complications of osteoporosis.

scholarly journals Concordance and Diagnostic Accuracy of Ultrasonography and Mammography Findings with Pathology Results in Breast Cancer

2020 ◽  
pp. 127-131
Author(s):  
Leila Ghafoor ◽  
Abbas Hajian ◽  
Yaser Hamidian ◽  
Seyed Hamed Rohani
Keyword(s):  
Breast Cancer ◽  
Medical Center ◽  
Malignant Lesion ◽  
Final Diagnosis ◽  
Screening Tools ◽  
Pathology Report ◽  
Breast Lesions ◽  
Cross Sectional ◽  
The Us ◽  
Malignant Breast

Background: Ultrasonography and mammography are two radiologic approaches for screening breast cancer; however, the pathology report is required for the ultimate diagnosis of malignancy. This study aimed to assess the concordance of ultrasonography (US) and mammography with the pathology in breast cancer.Methods: A cross-sectional study was conducted to assess the breast US and the mammography findings based on the BI-RADS model in comparison with the definitive pathology reports in a single medical center. The sensitivity, the specificity, positive (PPV) and negative predictive value (NPV) and also the concordance between the US and the mammography data were analyzed.Results: In this study, 126 patients were included. The sensitivity, specificity, PPV, and NPV for the US were 69.8, 71.9, 75.6 and 81.3 and for mammography were 91.9, 76.6, 80.8 and, 94.6 percent, respectively. The ROC-curve for either the US or the mammography showed that the BI-RADS 4 was accompanied with the highest sensitivity and specificity for the screening of the malignant breast lesions regarding the final diagnosis. Although an overall higher correlation between mammography report and presence of a malignant lesion was observed, the total relative concordance between the results of US and mammography as screening tools proved to be statistically significant (P<0.01).Conclusion: Both the US and the mammography were sensitive and specific screening tools, particularly for the malignant breast lesions. Furthermore, when evidence of the BI-RADS?4 in either the mammography or the US was present, utilization of the other test could be ignored before biopsy.

scholarly journals Comparison of LJ Medium and BACTEC MGIT 960 Culture System for the Diagnosis of Tuberculosis

2020 ◽  
Author(s):  
Pinki Kumari ◽  
Jiwesh Kumar Thakur ◽  
Prashant Kumar ◽  
Rakesh Kumar ◽  
Deval Parekh
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Public Health Problem ◽  
Categorical Variables ◽  
Clinical Samples ◽  
Sputum Smear ◽  
Major Public Health Problem ◽  
Continuous Variables ◽  
Cross Sectional ◽  
The Mean ◽  
Smear Negative

Introduction: Sputum negative pulmonary Tuberculosis (TB) is a major public health problem. So, the emergence of new techniques for a more precise and rapid microbiological identification of Mycobacterium tuberculosis in clinical samples is of great importance to improve the management of TB. Aim: To determine and compare the sensitivity and turnaround time for Mycobacterium tuberculosis detection by the BACTEC Mycobacteria Growth Indicator Tube (MGIT) 960 system, Lowenstein Jensen (LJ) medium and Ziehl-Neelsen (ZN) staining. Materials and Methods: An Institution based, observational, cross-sectional study was conducted at Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India, from July 2013-March 2016. Sputum, pericardial fluid, pleural fluid, peritoneal fluid, pus and endometrial tissue samples were collected from 80 patients of suspected TB cases. All were Acid-Fast stained by ZN staining method and cultured on solid culture LJ medium and on liquid medium (MGIT). Data was analysed using Statistical Package for the Social Sciences (SPSS) software, Version 20.0 (SPSS Inc, Chicago, IL, USA). Fisher’s-Exact test was used to show association of categorical variables. Non-parametric Mann-Whitney U test was used to show median difference of non-normally distributed continuous variables of two groups. Results: Out of the 80 samples, 41 cases were positive by either of the all methods. The positive specimen for ZN staining, LJ media and MGIT were 21, 29 and 41 cases respectively. The mean Time To Detection (TTD) was shorter for MGIT system than LJ media. Both LJ medium and MGIT 960 detected all cases of sputum smear positive cases and in addition significantly higher number than ZN stain in sputum smear negative cases. MGIT 960 detected significantly higher number of cases of sputum negative cases than LJ Media. The mean TTD was also significantly shorter in case of smear positive cases than the smear negative cases by both the solid and liquid culture mediums. Conclusion: The use of liquid media (MGIT) is more accurate and rapid method for the diagnosis of TB. The combination of more than one method is also highly recommended for rapid detection and early treatment of TB.

scholarly journals Validation and Psychometric Properties of the Spanish Version of the Hopkins Symptom Checklist-25 Scale for Depression Detection in Primary Care

2021 ◽  
Vol 18 (15) ◽  
pp. 7843
Author(s):  
María Rodríguez-Barragán ◽  
María Isabel Fernández-San-Martín ◽  
Ana Clavería-Fontán ◽  
Susana Aldecoa-Landesa ◽  
Marc Casajuana-Closas ◽  
...  
Keyword(s):  
Primary Care ◽  
Psychometric Properties ◽  
Public Health Problem ◽  
Composite International Diagnostic Interview ◽  
Spanish Version ◽  
Major Public Health Problem ◽  
Symptom Checklist ◽  
Validity And Reliability ◽  
Cross Sectional ◽  
Hopkins Symptom Checklist

Depression constitutes a major public health problem due to its high prevalence and difficulty in diagnosis. The Hopkins Symptom Checklist-25 (HSCL-25) scale has been identified as valid, reproducible, effective, and easy to use in primary care (PC). The purpose of the study was to assess the psychometric properties of the HSCL-25 and validate its Spanish version. A multicenter cross-sectional study was carried out at six PC centers in Spain. Validity and reliability were assessed against the structured Composite International Diagnostic Interview (CIDI). Out of the 790 patients, 769 completed the HSCL-25; 738 answered all the items. Global Cronbach’s alpha was 0.92 (0.88 as calculated for the depression dimension and 0.83 for the anxiety one). Confirmatory factor analysis (CFA) showed one global factor and two correlated factors with a correlation of 0.84. Area under the curve (AUC) was 0.89 (CI 95%, 0.86–0.93%). For a 1.75 cutoff point, sensibility was 88.1% (CI 95%, 77.1–95.1%) and specificity was 76.7% (CI 95%, 73.3–79.8%). The Spanish version of the HSCL-25 has a high response percentage, validity, and reliability and is well-accepted by PC patients.

scholarly journals Contrast-enhanced ultrasound of breast fibromatosis: a case report

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110106
Author(s):  
Shanhong Lin ◽  
Yong Cao ◽  
Libin Chen ◽  
Mei Chen ◽  
Shengmin Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Case ◽  
Common Type ◽  
Breast Lesions ◽  
Contrast Enhanced Ultrasound ◽  
High Similarity ◽  
Potential Value ◽  
Contrast Enhanced ◽  
Malignant Breast ◽  
Contrast Enhanced Ultrasonography

We herein present a rare case of breast fibromatosis, the contrast-enhanced ultrasonography (CEUS) findings of which we believe have never been described. The high similarity between the clinical and imaging manifestations of breast cancer makes its differential diagnosis difficult. In this report, we describe the CEUS findings of a less common type of fibromatosis, discuss the potential value of CEUS to differentiate it from malignant breast lesions, and briefly review the literature.

scholarly journals The prescription pattern and awareness about antibiotic prophylaxis and resistance among a group of Egyptian pediatric and general dentists: a cross sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mariam Mohsen Aly ◽  
Marwa Aly Elchaghaby
Keyword(s):  
Antibiotic Resistance ◽  
Antibiotic Prophylaxis ◽  
Antibiotic Prescription ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Major Public Health Problem ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
General Dentists

Abstract Background The use of antibiotics in dentistry as prophylaxis and treatment is frequent. Their misuse has led to a major public health problem globally known as antibiotic resistance. This study aimed to assess the pattern of antibiotic prescription and its prophylactic use for systemic conditions. Besides, this study evaluated the awareness and adherence to antibiotic prescription guidelines and antibiotic prophylaxis guidelines along with awareness of antibiotic resistance across pediatric and general dentists. Methods An overall of 378 pediatric and general dentists meeting the required eligibility criteria, fulfilled a pre-designed validated questionnaire. Data were collected, tabulated, and statistically analyzed. Results A significant statistical difference was found among the pediatric and general dentists regarding antibiotics prescription for most of the oral conditions where Amoxicillin with clavulanic acid was the most frequently prescribed antibiotic among the two groups (53% pediatric dentist and 52% general dentist). The majority of pediatric and general dentists, on the other hand, were aware of antibiotic resistance and prescribing recommendations. Conclusions The present study showed a tendency to overprescribe and overuse antibiotics in certain dental conditions among the participants. The vast majority of dentists, especially general dentists do not have adherence to professional guidelines for antibiotics prescription in children despite their awareness of antibiotic resistance and prescription guidelines.

scholarly journals Predictive risk factors towards liver fluke infection among the people in Kamalasai District, Kalasin Province, Thailand

2019 ◽  
Vol 7 ◽  
pp. 205031211984020 ◽  
Author(s):  
Woragon Wichaiyo ◽  
Wirat Parnsila ◽  
Wisit Chaveepojnkamjorn ◽  
Banchob Sripa
Keyword(s):  
Risk Factors ◽  
Liver Fluke ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
The People ◽  
Fluke Infection ◽  
Raw Fish ◽  
Predictive Risk ◽  
Liver Fluke Infection

Background: Liver fluke disease caused by Opisthorchis viverrini remains a major public health problem with its crucial risk factors caused by some individual habits or false beliefs among the people in northeastern Thailand concerning the consumption of raw fish meat dishes. Objectives: This study explores the predictive risk factors for the infection of liver fluke disease. Methods: The sample consisted of 400 people aged 30 years and above in Thanya sub-district, Kamalasai district, Kalasin province. A cross-sectional analytic study, using the χ2 test, odds ratio and 95% confidence interval, was used to find the influence of each variable, along with the use of multiple logistic regression (p = 0.05). A questionnaire form was used as the research instrument. Results: Factors found in the results are as follows: households with a cat were 7.00 times more at risk than households without a cat; eating raw fish dishes prepared by themselves increases the risk of infection by 2.58 times; eating raw fish dishes prepared by family members increases the risk by 4.74 times; and raw fish dishes bought from a community market increases the risk by 2.33 times. Conclusion: A campaign should be launched to educate people not to eat raw or undercooked fish dishes, but to fully cook fish dishes before eating, as the food is still delicious, but also safe, healthy, and free from liver fluke infection.

scholarly journals Blood levels of Polycyclic Aromatic Hydrocarbons in Women with Benign and Malignant Breast Lesions: A case-control study

2011 ◽  
Vol 1 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Vipul K Singh ◽  
M Anand ◽  
D Rawtani ◽  
Uday P Singh ◽  
DK Patel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Case Control Study ◽  
Case Control ◽  
Breast Lesions ◽  
Total Pahs ◽  
Polycyclic Aromatic ◽  
Malignant Breast ◽  
Control Study

Objective: As part of our program to investigate the possible role of environmental pollutants in the incidence of breast cancer in India, we conducted for the first time a hospital based case-control study where blood polycyclic aromatic hydrocarbons (PAHs) levels were determined in women suffering from benign and malignant breast lesions, and compared with those of disease free controls drawn from similar socioeconomic environment residing in and around New Delhi, India. Material & Methods: Anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo (a) pyrene, benzo (k) fluoranthene and dibenzo (a,h) anthracene were determined by HPLC-FD. Results: Level of total PAHs in control, benign and malignant groups (30 numbers in each) were 142.05 ± 50.84, 185.99 ± 61.97 and 200.74 ± 55.05 μg / L respectively. Mean levels of naphthalene, phenanthrene, pyrene and benzo (k) fluoranthene were higher in both malignant and benign groups than in control but the difference was not statistically significant. Of the total PAHs, 3–ringed compounds were found much higher (89%) in controls than in benign (52%) and malignant groups (54%). However, the percentage sum of 2, 4 and 5-ringed PAHs were much higher in malignant (46%) and benign (48%) groups when compared with those of controls (11%). Conclusion: Results of the present study indicate that higher levels of PAHs (especially non-carcinogenic), though statistically non-significant, were present in cases with benign and malignant breast lesions than in those of controls. Key Words: Polycyclic Aromatic Hydrocarbons; Breast cancer; Benign lesions; HPLC-FD  DOI: 10.3126/ajms.v1i2.2924Asian Journal of Medical Sciences 1 (2010) 80-86

Neoadjuvant Chemotherapy for Breast Cancer: Evaluation by PET / CT

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rania Ali Maarouf ◽  
Amgad S Abdel-Rahman ◽  
Samar Ibrahim Mohamed
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Therapeutic Response ◽  
Left Breast ◽  
Breast Lesions ◽  
Mean Values ◽  
Pet Ct ◽  
The Mean ◽  
Neo Adjuvant Chemotherapy ◽  
Fdg Pet Ct

Abstract Background Breast cancer (BC)is the most commonly occurring cancer in women and the second most common cancer overall.An increase in the rate of breast preservation has come to be expected because of tumor reduction using neo-adjuvant chemotherapy (NAC) for locally advanced cancer and it is important to accurately determine the effects of NAC. Patients and Methods This study was conducted on 30 female patients with histopathologically confirmed breast cancer referred for a PET/CT scan aiming to demonstrate the role of 18F-FDG PET/CT in detecting the pathological response to NAC in BC patients. Results No statistically significant differences were found between the baseline number of lesions and that after three cycles of chemotherapy. Also, no statistically significant differences were found between the mean values of baseline and after three cycles of chemotherapy of both liver activity and size of right breast lesions. Meanwhile, the mean values of SUV of right and left breast lesions as well as the size of left breast lesions were significantly lower after three cycles of chemotherapy when compared to their baseline values. And no statistically significant differences were found between complete and partial therapeutic response in the right breast lesions as well as between complete and no therapeutic response in the left breast lesions as regards baseline SUV and SUV after 3 cycles of chemotherapy. Conclusion It can be concluded that FDG-PET/CT is useful for evaluation of neo-adjuvant chemotherapy for breast cancer. However, more studies are needed to validate the results of the current study.

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