scholarly journals Observational Study to Evaluate the Lipid Profile Abnormalities among Newly Diagnosed Hypertensive Patients

2021 ◽  
Vol 8 (3) ◽  
pp. 5-8
Author(s):  
Sidhant Kumar ◽  
Manish Kumar
Keyword(s):  
Observational Study ◽  
Lipid Profile ◽  
Hdl Cholesterol ◽  
Study Groups ◽  
Control Group ◽  
Age Group ◽  
Newly Diagnosed ◽  
Hypertensive Patients ◽  
Patient Consent ◽  
Clinical Records

Objective and Aim: Variations from the norm of lipid profile and hypertension frequently coincide. The present study was conducted to evaluate the lipid profile abnormalities among hypertensive patients. Material and Method: This is a retrospective observational study conducted at a primary diabetes and cardiology clinic OPD among 200 patients whose clinical records are well maintained or fully available at the clinics registry. After getting individual patient consent the data collected and analysed to draw a study conclusion. Result: 48.4 ± 6.9 years was the mean average age of study group whereas for the control group it was 49.3± 5.9 years. In the age group 40-49 years occurrence of hypertension was seen in extreme as compare to other age group. In study groups total cholesterol, triglyceride, HDL Cholesterol and LDL Cholesterol were significantly higher as compared to control group (p<0.05). Among the hypertensive subjects most frequently occurring abnormality was elevated TC (78%), followed by elevated LDL (66%). Conclusion: Among newly diagnosed hypertensives lipid variations are highly prevalent as documented in this study. Hypertension is the one of the major risk factor for coronary artery disease and for this biologic interrelations between serum lipids and blood pressure further worsen the condition. Hence to prevent complications early detection and aggressive treatment of dyslipidemia in hypertensive patients should be carried out. Keywords: Hypertension, Lipid profile, Cardiovascular Diseases.

scholarly journals The Effect of Hibiscus Sabdariffa on Lipid Profile, Creatinine, and Serum Electrolytes: A Randomized Clinical Trial

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Abbas Mohagheghi ◽  
Shirin Maghsoud ◽  
Patricia Khashayar ◽  
Mohammad Ghazi-Khansari
Keyword(s):  
Medicinal Plant ◽  
Lipid Profile ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Black Tea ◽  
Hibiscus Sabdariffa ◽  
Upward Trend ◽  
Hypertensive Patients ◽  
To Receive

Background. Hibiscus Sabdariffa L. (HS), a member of malvaceae family, is a medicinal plant with a worldwide fame. Its effect on reducing serum lipids is mentioned in several studies. The purpose of this study was to assess the efficacy of this plant in reducing the serum's lipids in hypertensive patients. Materials and Methods. Ninety hypertensive patients were randomly assigned to receive Hibiscus Sabdariffa (HS) tea or black tea for 15 days. The patients were asked to drink the tea within 20 minutes following its preparation. This process had to be repeated two times, daily. Patient's FBS and lipid profile were collected at the first visit day (day 0) and on the day 30. Results. There was no significant differences between pre and post experiment values within the two groups. An upward trend in total cholesterol, HDL, and LDL cholesterol was evident in both groups. The increase in total and HDL cholesterol in both groups relative to their initial values were significant. Conclusion. Hibiscus Sabdariffa is probably a safe medicinal plant. No significant harmful changes in cholesterol, triglyceride, BUN, serum creatinine, Na and K levels were observed within 15 days after the discontinuation of the medication.

scholarly journals Pengaruh pemberian ekstrak tinta cumi (squid ink) terhadap aterosklerosis

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Fajar M. Nasution ◽  
Rina S. Mardia ◽  
Ayu Azri ◽  
Rido R. Hutabarat ◽  
Fadhila Al. Izza ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Foam Cells ◽  
Control Group ◽  
Test Design ◽  
Randomized Controlled ◽  
Post Test ◽  
Paired T Test

Abstract: Squid ink consists of DHI, DHICA, and 2-carboxyl indole that improve lipid profile and remove foam cells in blood vessel walls. This study was aimed to analyze the effect of squid ink on atherosclerosis-induced Wistar rats. This was an experimental study. We used randomized controlled trial with pre-post test design for lipid profile assessment and randomized post-test only control design for blood vessel evaluation (foam cells in layers of coronary artery). Samples were 27 Wistar rats, divided into three groups; all were atherosclerosis-induced with initial injection of 0.006mg iv adrenalin on day 1, followed by standard diet and egg yolk until day 30. Squid ink extract was given to group P1 and P2 on days 15-30 in different doses, but not to control group. Data were analyzed by using Saphiro-Wilk test and paired t-test. The results showed that P2 group had decreased means of total cholesterol (-33.62 mg/dl), triglyceride (-28.00 mg/dl), and LDL cholesterol (-28.16 mg/dl), but an increased mean of HDL cholesterol (11.60 mg/dl). There were decreased numbers of foam cells in the layers of coronary arteries of P1 and P2 group compared to the control group. Conclusion: Squid ink extract could lower total cholesterol, triglyceride, and LDL cholesterol levels, and increase HDL cholesterol level. Moreover, it could remove foam cells from the layers of coronary arteries.Keywords: squid ink, atherosclerosis, lipid profile, foam cells Asbtrak: Tinta cumi memiliki kandungan DHI, DHICA, dan 2-carboxyl indole yang dapat memperbaiki profil lipid dan mengurangi sel busa pembuluh darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak tinta cumi terhadap tikus yang diinduksi aterosklerosis. Jenis penelitian ialah eksperimental dengan randomized controlled with pre-post test design untuk penilaian profil lipid dan post test only design untuk penilaian pembuluh darah (sel busa dalam dinding arteri koronaria). Sampel terdiri dari 27 tikus Wistar jantan, dibagi secara random menjadi tiga kelompok; kesemuanya diberi induksi aterosklerosis dengan injeksi inisial adrenalin 0,006 mg iv pada hari ke-1, dilanjutkan diet standar dan diet kuning telur sampai hari ke-30. Tikus kelompok kontrol tidak diberikan ekstrak tinta cumi; tikus kelompok perlakuan 1 dan perlakuan 2 diberikan tambahan ekstrak tinta cumi pada hari ke 16 sampai hari ke 30 dengan dosis yang berbeda. Analisis data dengan uji Saphiro-Wilk dan uji paired t-test. Hasil penelitian memperlihatkan penurunan rerata setelah perlakuan pada kelompok P2 ialah kolesterol total (-33,62 mg/dl), trigliserida (-28,00 mg/dl), dan kolesterol LDL (-28,16 mg/dl), serta peningkatan rerata kolesterol HDL (11,60 mg/dl). Terdapat penurunan jumlah sel busa kelompok perlakuan P1 dan P2 dibandingkan kelompok kontrol. Simpulan: Pemberian ekstrak tinta cumi menurunkan kadar kolesterol total, trigliserida dan kolesterol LDL, meningkatkan kadar kolesterol HDL, serta menurunkan jumlah sel busa dalam dinding arteri koronaria.Kata kunci: tinta cumi, aterosklerosis, profil lipid, sel busa

scholarly journals Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

2020 ◽  
Vol 71 (7) ◽  
pp. 425-435
Author(s):  
Teim Baaj ◽  
Ahmed Abu-Awwad ◽  
Mircea Botoca ◽  
Octavian Marius Cretu ◽  
Elena Ardeleanu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Hypertension ◽  
Lipid Profile ◽  
Blood Pressure Monitoring ◽  
Hdl Cholesterol ◽  
Night Time ◽  
Hypertensive Patients ◽  
Lipid Disorders

Accelerated atherosclerosis and cardiovascular diseases are frequent complications in hypertensive patients with chronic kidney disease (CKD), being mainly driven by cardiovascular risk factors as lipid disorders and an unfavorable blood pressure profile. The objectives of the study were to evaluate the lipid profile and to assess the characteristics of blood pressure (BP) in patients with primary arterial hypertension associating chronic kidney disease (CKD) in a primary care population in Timis County, Romania. Lipid disorders were highly prevalent in hypertensive patients with CKD, consisting in hyper LDL-cholesterolemia in 50.3%, hypertriglyceridemia in 52%, low HDL-cholesterol levels in 35.8%. More than 2 lipid abnormalities were present in 68.8% of CKD hypertensive. CKD hypertensive patients, compared with those without CKD, presented a BP profile with higher systolic and diastolic office BP. On ambulatory blood pressure monitoring they also registred higher systolic and diastolic BP, the systolic BP (SBP), both for 24 h SBP, day-time and night-time SBP being statistically significant higher than in hypertensive patients without CKD. The circadian 24 h BP profile demonstrated in the CKD hypertensive population an unfavourable nocturnal profile in 67%, consisting of a high prevalence of the non-dipping profile and of nocturnal riser pattern.

scholarly journals EFFECT OF SELECTED YOGA TECHNIQUES ALONG WITH ASHWAGANDHA AND VACHA IN DEPRESSION IN THE AGE GROUP 65–75 YEARS

2021 ◽  
pp. 65-68
Author(s):  
SOUMYA MELEPPURAKKAL ◽  
SUNITHA K ◽  
JAYAN D
Keyword(s):  
Combined Therapy ◽  
Holistic Approach ◽  
Study Groups ◽  
Warm Water ◽  
Treatment Modalities ◽  
Control Group ◽  
Study Group ◽  
Age Group ◽  
Study Population

Objective: The study was done to compare the effect of selected yoga techniques, drugs, and combined therapy in depression in geriatrics. Methods: 75 patients between 65 and 75 years of age with depression were included in the study which was assessed by HAM D Score. The study population was randomly allocated to one control group and two study groups. The control group was given Aswangandha and Vacha churna with warm water as anupana after food, selected yoga techniques in the first study group, and combined yoga and the drug were given to the second study group. Outcome variables were assessed for the groups after the 30th day and follow-up after 45 days. Results: The results obtained in the study were analyzed using the ANOVA test. Yoga along with drug experienced a comparatively greater reduction in HAM-D score after treatment and follow-up (p<0.05) than other groups. Conclusion: Holistic approach can bring a better and static result than applying the treatment modalities alone.

scholarly journals Effect of Losartan and Amlodipine on Lung Function Status in Hypertensive Patients: A Randomized Control Trial

2020 ◽  
Vol 15 (1) ◽  
pp. 42-44
Author(s):  
Mst Nasrin Nahar ◽  
Shelina Begum ◽  
Sultana Ferdousi ◽  
Tamanna Habib
Keyword(s):  
Essential Hypertension ◽  
Lung Function ◽  
Antihypertensive Medication ◽  
Antihypertensive Drugs ◽  
Armed Forces ◽  
Control Group ◽  
Angiotensin Ii Receptor Blocker ◽  
Newly Diagnosed ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Patients

Introduction: Essential hypertension is associated with altered pulmonary function. Antihypertensive medication and lung function are also associated. Losartan (angiotensin II receptor blocker) and amlodipine (calcium channel blocker) are commonly used antihypertensive drugs. Objectives: To evaluate the effects of antihypertensive drugs on lung function status in patients with essential hypertension. Materials and Methods: This prospective observational study was carried out in the Department of Physiology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, from July 2012 to June 2013 on 100 newly diagnosed hypertensive patients without any antihypertensive medication (group B, age 30-55 years). They were selected from the Out Patient Department (OPD) of Cardiology, BSMMU, Dhaka. Age, sex and BMI matched 50 apparently healthy normotensive subjects were also studied as control (group A). Based on treatment, these study subjects were divided into two groups (B1 and B2). Group B1 included 50 patients received losartan 50 mg daily and B2 included 50 patients received amlodipine 5 mg daily. They were observed once before the treatment (B1a and B2a), after 3 months of medication (B1b and B2b) and after 6 months of medication (B1c and B2c). For assessing lung function status, Forced Vital Capacity (FVC), Forced Expiratory Volume in 1st second (FEV1) and Peak Expiratory Flow Rate (PEFR) were measured with a RMS computer based Spirometer. Results: Mean FVC, FEV1 and PEFR were significantly lower in newly diagnosed hypertensive patients in comparison with that of healthy normotensive. Mean FVC, FEV1 and PEFR were found significantly higher in the group taking losartan and amlodipine for 6 months when compared to newly diagnosed but lower than those of controls. Conclusion: Reduced lung function occurs in newly diagnosed hypertensive patients which was improved by treatment with losartan and amlodipine. Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 42-44

scholarly journals Effect of Wheatgrass (Triticum aestivum) Juice on High Density Lipoprotein (HDL) Level in Experimentally Induced Dyslipidaemic Male Long Evans Rat

2015 ◽  
Vol 3 (1) ◽  
pp. 18-24
Author(s):  
Rokhsana Dil Afroz ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Md Ismail Khan ◽  
Tuhin Jahan
Keyword(s):  
Triticum Aestivum ◽  
Lipid Profile ◽  
Cholesterol Level ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipid Lowering ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Long Evans ◽  
Experimentally Induced

Background: Evidence shows that high density lipoproteins (HDLs) may exert multiple anti-atherogenic and anti-thrombotic effects that together decrease the risk of cardiovascular morbidity in hyperlipidaemic state. Experimental studies showed that fresh wheatgrass (Triticum aestivum Linn.) juice exerts lipid lowering effect as well as increases HDL-cholesterol level in rats. Objective: The present study was done to observe the effect of wheatgrass juice on serum HDL-cholesterol on experimentally induced dyslipidaemic rats evident by reduced HDL-cholesterol level. Materials and method: This experimental study was carried out in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, from July 2009 to June 2010. A total number of 48 healthy adult male Long Evans rats, age ranging from 2-3 months, and weighing from 140-200 grams were used for the present study. Six rats were taken in each group of total 8 groups treated differently with 1 control group. Rats of the first 5 groups were sacrificed at 29th day and their lipid profile was measured. Rests of the rats were sacrificed at 57th day and their lipid profile was measured. Results: Mean HDL-cholesterol of the group of rats treated with 10 mL/kg grass juice and 1% cholesterol diet, with 10 mL/kg grass juice and with 20 mL/kg grass juice were significantly increased (P<0.05, P<0.05, P<0.01 respectively). The mean HDL-cholesterol of the group treated with Atorvastatin for 28 days were also significantly increased (P<0.001).Conclusion: The present experiment showed that HDL-cholesterol level is increased by ingestion of wheat grass juice in experimental animals. Therefore, it provides the initial step for demonstrating cardio-protective effect of wheatgrass juice by increasing HDL-cholesterol level in blood in dyslipidaemic state. DOI: http://dx.doi.org/10.3329/dmcj.v3i1.22235 Delta Med Col J. Jan 2015; 3(1): 18-24

scholarly journals Cardiovascular risk rate in hypertensive patients attended in primary health care units: the influence of pharmaceutical care

2015 ◽  
Vol 51 (3) ◽  
pp. 617-627 ◽  
Author(s):  
Paulo Yuri Milen Firmino ◽  
Tainá Osterno Vasconcelos ◽  
Caroline Carneiro Ferreira ◽  
Larissa Mendonça Moreira ◽  
Nirla Rodrigues Romero ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Pharmaceutical Care ◽  
Intervention Group ◽  
Study Groups ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Pharmacological Interventions ◽  
Hypertensive Patients ◽  
Clinical Assay ◽  
Risk Rate

Cardiovascular complications are relevant due to their frequency and severity on the hypertension scenario. Studies refer Pharmaceutical Care (PC) as capable of decreasing cardiovascular risk rate (%CVR) on hypertensive patients. This study aimed to investigate, through a randomized clinical assay, the influence of PC service on the %CVR of hypertensive patients assisted in a health primary care unit from Fortaleza-Ceará. Two study groups were formed: i. Intervention Group (IG), which received orientation about taking medicines, actions aiming to prevent/solve medicine interactions and adverse effects and non-pharmacological interventions for 9 months and, ii. Control Group (CG), which received traditional assistance of the unit and was monitored during the same period. It was observed a statistically significant reduction on %CVR (10.76 to 7.86; p=0.04) and systolic blood pressure levels (SBP) (137.69 to 131.54; p<0.01) in the IG, while, in the CG, there was no significant alteration. 151 Drug Related Problem (DRP) were identified and it was realized 124 pharmaceutical interventions, with 89.2% of them resulting on solution/prevention of the problem. Our findings indicated that the inclusion of the PC service in the hypertensive health assistance was more effective at the %CVR and the SBP reduction in comparison to the traditional assistance offered.

scholarly journals Serum Lipid Profile of Hypertensive Patients in the Northern Region of Bangladesh

1970 ◽  
Vol 14 ◽  
pp. 93-98 ◽  
Author(s):  
MS Saha ◽  
NK Sana ◽  
Ranajit Kumar Shaha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Northern Region ◽  
Serum Lipid Profile ◽  
Hypertensive Patients ◽  
Control Subjects

A prospective study was conducted in the Northern region of Bangladesh, to investigate the serum lipid profile viz the level of total cholesterol (TC), Triglyceride (TG), HDL-cholesterol and LDL-cholesterol of hypertensive patients and compares them with levels of control subjects. The results revealed that serum total cholesterol, triglyceride and LDL-cholesterol were significantly markedly raised (p>0.001) whereas the level of HDL-cholesterol was significantly lower (p>0.001) in hypertensive patients as compared to control subjects. No significant changes of serum lipid profile were found between male and female hypertensive patients, but in control subjects, markedly higher levels of serum lipid profile was observed in male compared to that of female. It was concluded that hypercholesterolaemia, hypertrigyceridaemia and low density lipoprotein are the main lipid abnormalities on the incidence of hypertension in the study area. Key words: Hypertension, Total cholesterol (TC), triglyceride (TG), HDL- cholesterol and LDL-cholesterol. J. bio-sci. 14: 93-98, 2006

scholarly journals Effects of Nigerian Piliostigma thonningii Species Leaf Extract on Lipid Profile in Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
O. M. Ighodaro ◽  
J. O. Omole
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Piliostigma Thonningii ◽  
Aqueous Leaf Extract

Cardiovascular complications and associated conditions remain a major cause of death, globally. Piliostigma thonningii has been used for different and several medicinal purposes. On this background, the effect of aqueous leaf extract of the plant on the lipid profile of physiologically normal rats was examined. Graded doses of the extract, 0.0, 0.2, and 0.4 g/kg of body weight (bwt) were orally administered to rats for a period of 14 days. The effect of the extract was assessed on the basis of comparative determinations of the evaluated indices in treated rats vis-à-vis the nontreated group as well as in respect to the differences between the basal and final concentrations of the indices in each group. The extract, especially at 0.2 g per kg body weight caused a significant decrease in the total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol in the treated rats when compared to the control group and basal concentrations. Though, the level of high-density lipoprotein (HDL) cholesterol increased in the treated rats, the increase was not significant when compared to the basal concentration. The LDL/HDL ratio in all the experimental groups was less than 0.9. The results obtained in this study suggest that P. thonningii aqueous leaf extract likely contains antilipidaemic and anticholesterolaemic substance(s), which may be useful in the prophylactic and curative management of lipid peroxidation, high blood pressure, and cardiovascular disorders.

scholarly journals Study of Lipid Profile in Newly Diagnosed Hypertensive Patients

2014 ◽  
Vol 6 (2) ◽  
pp. 112-115
Author(s):  
MAK Akanda ◽  
KN Choudhury ◽  
MZ Ali ◽  
LA Sayami ◽  
RM Huda
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Newly Diagnosed ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
The Mean ◽  
Lipid Parameters

Back ground: Hypertension is one of the most important modifiable risk factors for cardiovascular disease (CVD) and stroke. Dyslipidemia is closely associated with hypertension. Dyslipidemia and hypertension are the commonest risk factors for CVD. The aim of the present study was to compare different lipid parameters among newly diagnosed hypertensive patients with normotensive subjects in Bangladesh and find out the relationship. Methods: This study was a cross sectional study in which 42 newly diagnosed hypertensive patients who were on no antihypertensive medication and 42 subjects with normal blood pressure (normotensive) were enrolled for compare. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by Enzymatic colorimetric test. Results: The mean systolic blood pressure of hypertensive and normotensive were 154.6±22.5 vs111.50±3.42 mmof.Hg and mean diastolic blood pressure were 93.2±5.20 vs 71.44± 3.21mm of Hg. The mean of SBP and DBP of hypertensive patients was found to be higher than normotensive (p< 0.05). There was significant increase in different lipid levels namely TC 199.4±44.5 vs188.7±37.9 mg/dl, TG155.9±88.8 vs 121.9±73.2 mg/dl and LDLc 119.8±35.6 vs112.7±28.6 mg/dl in hypertensive patients as compared to normotensive (p<0.05). However there was no significant difference in HDLc level. BMI and waist circumference showed significant association in hypertensive patients (p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia, BMI and waist circumference. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/cardio.v6i2.18350 Cardiovasc. j. 2014; 6(2): 112-115

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