Vitamin D Deficiency and Adverse Results in COVID-19

2021 ◽  
Vol 15 (11) ◽  
pp. 3499-3501
Author(s):  
Maria Mehmood ◽  
Zobia Mubarak ◽  
Irum Javed ◽  
Sarah Arif ◽  
Sikandar Ali Khan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Virus Disease ◽  
Strong Association ◽  
Vitamin D Insufficiency ◽  
Negative Effects ◽  
Severe Vitamin ◽  
Severe Deficiency ◽  
Number Of Patients ◽  
Vitamin D Levels

Aim: The goal of this study is to find out how common vitamin D deficiency is in patients with corona virus disease and what the consequences are. Study Design: Observational /Prospective Place and Duration: Institute of Basic medical sciences, Khyber Medical University (KMU), Jan 2021-Oct 2021. Materials & Methods: This study included 120 patients of both genders who had been diagnosed with covid-19. Patients ranged in age from 15 to 75 years. After receiving written agreement, demographically detailed such as age, sex, and BMI were recorded. All of the patients had a 5 mL blood sample obtained to check their vitamin D levels. 25(OH)D < 25 nmol/L (10 ng/dL) was considered severe Vitamin D insufficiency. The prevalence of vitamin D insufficiency as well as negative effects were investigated. SPSS 23.0 was used to analyse the data. Results: The mean age of the 120 patients was 40.11±8.64 years, with 68 (56.7%) males and 52 (43.3%) females. There were 52 patients (43.3%) with severe vitamin D insufficiency. There were 17 deaths of the total number of patients in the study. Vitamin D deficiency was associated with a higher mortality rate in patients with covid-19 disease than in those who had normal levels of vitamin D, a finding that was statistically significant at the 0.05 level. Conclusion: It was found that severe deficiency of vitamin D and death in individuals with covid-19 illness had a strong association. Keywords: Mortality, Vitamin D Deficiency, Covid-19,

scholarly journals The link between vitamin D deficiency and Covid-19 in a large population

2020 ◽  
Author(s):  
Ariel Israel ◽  
Assi Albert Cicurel ◽  
Ilan Feldhamer ◽  
Yosef Dror ◽  
Shmuel M Giveon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Conditional Logistic Regression ◽  
Strong Association ◽  
Large Population ◽  
Population Based ◽  
Male Ratio ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
The Relationship

BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection. In our population we observe major differences in Covid-19 incidence in ethnic groups and genders in each group. METHODS We carried out a population-based study among 4.6 million members of Clalit Health Services (CHS). We collected results from vitamin D tests performed between 2010 and 2019 and used weighted linear regression to assess the relationship between prevalence of vitamin D deficiency and Covid-19 incidence in 200 localities. Additionally, we matched 52,405 infected patients with 524,050 control individuals of the same sex, age, geographical region and used conditional logistic regression to assess the relationship between baseline vitamin D levels, acquisition of vitamin D supplements in the last 4 months, and positive Covid-19. RESULTS We observe a highly significant correlation between prevalence of vitamin D deficiency and Covid-19 incidence, and between female-to-male ratio for severe vitamin D deficiency and female-to-male ratio for Covid-19 incidence in localities (P<0.001). In the matched cohort, we found a significant association between low vitamin D levels and the risk of Covid-19, with the highest risk observed for severe vitamin D deficiency. A significant protective effect was observed for members who acquired liquid vitamin D formulations (drops) in the last 4 months. CONCLUSION In this large observational population study, we show a strong association between vitamin D deficiency and Covid-19 occurrence. After adjustment for baseline characteristics and prior vitamin D levels, acquisition of liquid vitamin D formulations is associated with decreased risk for Covid-19 infection.

scholarly journals An audit of vitamin D monitoring and management of deficiency in women's secure services

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S12-S12
Author(s):  
Claire Bustin ◽  
Shay-Anne Pantall ◽  
Jeremy Rampling
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Maintenance Treatment ◽  
Vitamin D Insufficiency ◽  
Electronic Patient Records ◽  
Number Of Patients ◽  
Vitamin D Levels ◽  
African Caribbean ◽  
One Year ◽  
Sufficient Vitamin

AimsTo audit the investigation, identification and treatment of vitamin D deficiency within Women's Secure Services.BackgroundIt has been suggested that vitamin D and vitamin D deficiency may play a role in the pathogenesis of psychiatric illness. There is evidence that vitamin D inadequacy is prevalent among patients in long-term hospital settings. Patients within secure hospitals are considered to be at high risk due to their often lengthy admissions, having been transferred from other hospital or prison settings. Ardenleigh in Birmingham is a blended female secure unit. Here we present the findings of an audit, completed in 2019, of vitamin D monitoring and treatment in this service.MethodA retrospective review of electronic patient records, for all inpatients admitted within women's secure services at Ardenleigh as of 1st September 2019 (n = 27). Standards were based on the Trust accepted guidelines for management of vitamin D deficiency.ResultKey findings included:-The majority of inpatients were Caucasian (44%) and African-Caribbean (41%). Median age was 31 years (range 20–56).Approximately two-thirds (60%) had been in hospital for over a year.89% of patients had their vitamin D level checked at some point during admission.Of those checked, 25% were tested within 1 week of admission. Seven patients were tested after being in hospital for over one year (30%).Only 25% of patients tested were found to have adequate vitamin D levels. Nine patients were found to have insufficient levels of vitamin D (37.5%) or deficiency (37.5%).89% of those identified as requiring treatment were prescribed supplementation, of which the majority was prescribed at the correct dose for the appropriate duration (94%). One patient refused treatment. Of those with sufficient levels, 67% were prescribed ongoing maintenance treatment due to previously detected deficiency.Of those found to have sufficient vitamin D in the last 12 months (n = 14), 71% were continued on maintenance treatment.ConclusionWe identified a high prevalence of vitamin D insufficiency in women admitted to secure services. Testing was delayed for a number of patients from the point of admission. However, once identified, the vast majority of those in need of treatment were managed appropriately by the medical team. We advise that vitamin D be considered an essential routine blood test at the point of admission to minimise delays in identifying those with deficiency and establishing necessary supplementation.

scholarly journals Prevalence of vitamin D deficiency in patients attending outpatient clinic with thyroid disorders in Chitwan Medical College Teaching Hospital

2017 ◽  
Vol 7 (2) ◽  
pp. 7-10
Author(s):  
Bidhan Shrestha ◽  
Shital Adhikari ◽  
Rano Mal Piryani ◽  
Arun Sedhain ◽  
Suresh Deep ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Outpatient Clinic ◽  
College Teaching ◽  
Vitamin D Insufficiency ◽  
Thyroid Disorders ◽  
Medical College ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Global Health Problem

Objectives: Vitamin D deficiency is being studied all over the world and is a global health problem. Recent studies haveshown that Vitamin D may have a significant role in reducing the incidence of autoimmune diseases. This study was conducted to find out the level of Vitamin D in patients with thyroid disorders and compare Vitamin D levels in Anti Tpo positive and negative patients. Subject and Methodology: 60 patients from Chitwan Medical College outpatient clinic were included in the study from February to May 2016. A brief history and clinical examinations were taken from all patients along with laboratory tests for thyroid functions, TPO antibody level of 25(OH) Vitamin D3 level and Serum Calcium level. Results: Both patients of hypothyroidism (autoimmune and nonautoimmune) had severe Vitamin D deficiency. Most of the hyperthyroid cases had Vitamin D insufficiency. Anti TPO positive and negative patients both had Vitamin D deficiency. Conclusion: Our study shows there is significant Vitamin D deficiency in hypothyroidism and hyperthyroidism irrespective of its autoimmunity. This study certainly encourages us to screen Vitamin D and supplement Vitamin D to all thyroid disorders patients.

scholarly journals Vitamin D deficiency: how prevalent it is?

2019 ◽  
Vol 5 (2) ◽  
pp. 271
Author(s):  
Irwant V. Pallewad ◽  
Jayshree J. Upadhye
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Research Centre ◽  
Normal Body Mass Index ◽  
Medical Sciences ◽  
Number Of Patients ◽  
Vitamin D Levels

<p class="abstract"><strong>Background:</strong> Vitamin D deficiency is frequently seen nowadays due to inadequate exposure to sun and pollution. The present study was undertaken to evaluate the prevalence of vitamin D deficiency in patients presenting with suggestive complaints.</p><p class="abstract"><strong>Methods:</strong> The present study is a retrospective study done at Srinivas Institute of Medical Sciences and Research Centre, Mukka, Suratkal, Mangaluru. Patients who have musculoskeletal or other problem suggestive of vitamin D deficiency were advised vitamin D levels. We went through OPD papers of only those patients with reports of Vitamin D levels.<strong></strong></p><p class="abstract"><strong>Results:</strong> In present study, out of 100 patients, 42 (42%) patients had normal BMI, 23 (23%) patients were overweight, 24 (24%) patients were obese while 11 (11%) patients were underweight. 46 (46%) patients were having walk for exercise purpose, 21 (21%) were doing work out at gym while 33 (33%) patients were walking only for doing some work. 47 (47%) patients had normal levels of vitamin D, 31 (31%) had insufficient levels while 22 (22%) patients had deficient levels of vitamin D. So, prevalence of vitamin D deficiency was 22% and for vitamin D insufficiency was 31%.</p><p class="abstract"><strong>Conclusions:</strong> In present study, we conclude that irrespective of normal body mass index or physical activity, patients presented with various complaints. In them, vitamin D levels were either insufficient or deficient in large number of patients. So, vitamin D levels should be done as screening or at least when patients present with suggestive complaint. </p>

scholarly journals Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Jee Hye Wee ◽  
Sung Woo Cho ◽  
Jeong-Whun Kim ◽  
Chae-Seo Rhee
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Vitamin D Deficiency ◽  
House Dust Mites ◽  
Regression Analyses ◽  
Allergen Sensitization ◽  
Korean Adults ◽  
Simultaneous Test ◽  
Severe Deficiency ◽  
Vitamin D Levels

Abstract Background Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroallergens in Korean adults. Methods We retrospectively reviewed serum 25-hydroxyvitamin D (25[OH]D) measurements of participants (n = 57,467) in a healthcare center between May 2003 and June 2020. Serum 25(OH)D levels were categorized as follows: severe deficiency (< 10 ng/mL), deficiency (10 to < 20 ng/mL), insufficiency (20 to < 30 ng/mL), and sufficiency (≥ 30 ng/mL). Among all subjects, 1277 simultaneously underwent the multiple allergen simultaneous test. Multiple linear and logistic regression analyses were used to estimate coefficients and odds ratios (ORs) with 95% confidence interval (CI) for the association between serum vitamin D deficiency and aeroallergen sensitization after adjustment for potential confounders. Subgroup analyses were conducted for the types of aeroallergen (house dust mites, pollens, animal dander, foods, cockroach, and fungus). Results Vitamin D deficiency, defined as serum 25(OH)D level < 20 ng/mL, was noted in 56.4% of participants. There were significant differences in serum 25(OH)D levels according to sex, age, season, and bone mineral density (all P < 0.001). In multiple linear regression analyses, serum 25(OH)D levels were significantly lower in young subjects (adjusted coefficient [95% CI], 0.188 [0.101, 0.275]) and during winter (− 4.114 [− 6.528, − 1.699]). However, no significant association was observed between serum 25(OH)D levels and allergen sensitization (adjusted coefficients [95% CI], − 0.211 [− 1.989, 1.567], P = 0.816). In multivariate logistic regression analyses, male sex, young age, and winter season were significant risk factors for vitamin D deficiency. However, allergen sensitization showed no significant association with 25(OD)D levels after adjusting for confounders (adjusted OR [95% CI], 1.037 [0.642, 1.674] in insufficiency; 0.910 [0.573, 1.445] in deficiency; 0.869 [0.298, 2.539] in severe deficiency groups, P for trend = 0.334). There were consistent findings across subgroups regarding type of aeroallergen sensitized. Conclusion Vitamin D deficiency was prevalent but was not significantly associated with aeroallergen sensitization in Korean adults. To the best of our knowledge, this is the first large-scale study to evaluate the association between vitamin D deficiency and sensitization to 59 different aeroallergens.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

Effects of Stratified Vitamin D Supplementation in Middle-Aged and Elderly Individuals with Vitamin D Insufficiency

2018 ◽  
Vol 50 (10) ◽  
pp. 747-753
Author(s):  
Yanhui Lu ◽  
Xiaomin Fu ◽  
Lili Zhang ◽  
Minyan Liu ◽  
Xiaoling Cheng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Intervention Group ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Middle Aged ◽  
Oral Vitamin ◽  
Severe Vitamin

AbstractThe incidence of vitamin D deficiency is high globally, and vitamin D supplementation draws particular attention. The objective of this study was to investigate the effects of stratified vitamin D supplementation in middle-aged and elderly individuals with vitamin D insufficiency in Beijing. A total of 448 subjects aged over 40 years old were selected from a community in Beijing. Among them, 100 middle-aged and elderly people with vitamin D insufficiency were randomly selected on a voluntary basis. They were further divided into control group and intervention group. The control group received health education and lifestyle guidance, and the intervention group received lifestyle guidance and vitamin D supplementation for nine months. The doses were stratified as follows: for vitamin D insufficiency, oral vitamin D3 supplement was given at 5000 IU/w; for mild vitamin D deficiency, oral vitamin D3 supplement was given at 10 000 IU/w; for severe vitamin D deficiency, oral vitamin D3 supplement was given at 15 000 IU/w. Safety evaluation was conducted after three-month treatment. The intervention group consisted of 8%, 62%, and 30% of cases who had vitamin D insufficiency, mild vitamin D deficiency, and severe vitamin D deficiency, respectively, which were similar with the control group. It showed that the blood 25(OH)D level increased significantly in the intervention group, from 14.30±4.30 ng/ml to 33.62±6.99 ng/ml (p<0.001), in contrast to insignificant change in the control group. Stratified vitamin D supplementation effectively increased the blood 25(OH)D level, as well as the number of cases with corrected vitamin D insufficiency or deficiency.

Effect of Severe Vitamin D Deficiency at Admission on Shock Reversal in Children With Septic Shock: A Prospective Observational Study

2017 ◽  
Vol 34 (5) ◽  
pp. 397-403 ◽  
Author(s):  
Jhuma Sankar ◽  
Javed Ismail ◽  
Rashmi Das ◽  
Nishanth Dev ◽  
Anubhuti Chitkara ◽  
...  
Keyword(s):  
Vitamin D ◽  
Septic Shock ◽  
Multivariate Analysis ◽  
Vitamin D Deficiency ◽  
Univariate Analysis ◽  
Pediatric Intensive Care ◽  
Hydroxyvitamin D ◽  
Severe Vitamin ◽  
Severe Deficiency ◽  
Shock Reversal

Objectives: To evaluate the association of severe vitamin D deficiency with clinically important outcomes in children with septic shock. Methods: We enrolled children ≤17 years with septic shock prospectively over a period of 6 months. We estimated 25-hydroxyvitamin D [25 (OH) D] levels at admission and 72 hours. Severe deficiency was defined as serum 25 (OH) <10 ng/mL. We performed univariate and multivariate analysis to evaluate association with clinically important outcomes. Results: Forty-three children were enrolled in the study. The prevalence of severe vitamin D deficiency was 72% and 69% at admission and 72 hours, respectively. On univariate analysis, severe vitamin D deficiency at admission was associated with lower rates of shock reversal, 74% (23) versus 25% (3); relative risk (95% confidence interval [CI]): 2.9 (1.09-8.08), at 24 hours and greater need for fluid boluses (75 vs 59 mL/kg). On multivariate analysis, nonresolution of shock at 24 hours was significantly associated with severe vitamin D deficiency after adjusting for other key baseline and clinical variables, adjusted odds ratio (95% CI): 12 (2.01-87.01); 0.01. Conclusion: The prevalence of severe vitamin D deficiency is high in children with septic shock admitted to pediatric intensive care unit. Severe vitamin D deficiency at admission seems to be associated with lower rates of shock reversal at 24 hours of ICU stay. Our study provides preliminary data for planning interventional studies in children with septic shock and severe vitamin D deficiency.

scholarly journals Prevalence and Treatment of Vitamin D Deficiency in Young Male Russian Soccer Players in Winter

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2405 ◽  
Author(s):  
Bezuglov ◽  
Tikhonova ◽  
Zueva ◽  
Khaitin ◽  
Waśkiewicz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Young Male ◽  
Vitamin D Insufficiency ◽  
Soccer Players ◽  
Football Players ◽  
Duration Of Treatment ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Vitamin D (25(OH)D) insufficiency and deficiency are highly prevalent in adult soccer players and can exceed 80% even in regions with high insolation; however, the treatment of this condition is often complicated. The aim of the present study was to examine the prevalence of vitamin D insufficiency and deficiency in youth Russian soccer players and the efficacy of its treatment. Participants were 131 young male football players (age 15.6 ± 2.4 years). Low vitamin D levels (below 30 ng/mL) were observed in 42.8% of the analyzed participants. These athletes were split in two groups composed of persons with vitamin D deficiency (serum vitamin D below 21 ng/mL) and insufficiency (serum vitamin D in range of 21–29 ng/mL). A dietary supplement of 5000 IU cholecalciferol per day was administered for two months. After the treatment, an average 92% increase in vitamin D concentration was observed (before treatment—19.7 ± 5.4 ng/mL, after treatment—34.7 ± 8.6 ng/mL, p<0.001) and 74% of the post-treatment values were within the reference range (30–60 ng/mL). Serum concentration of vitamin D increased by 200% ± 98% (p<0.001) during the first month of treatment with vitamin D deficiency and insufficiency being successfully treated in 83% of the football players. In summary, the prevalence of vitamin D insufficiency and deficiency was high in young Russian soccer players. Furthermore, it was indicated that the daily usage of cholecalciferol in a dose 5000 IU was an effective and well-tolerated treatment for vitamin D insufficiency. No linear dependency between the duration of treatment and increase in vitamin 25(OH)D concentration was observed.

scholarly journals Prevalence and Correlation of Laryngopharyngeal Reflux in Females with Vitamin D Deficiency in a Multi-Specialty Polyclinic in New Delhi, India

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Sachin Saini ◽  
Rahul Pandey ◽  
Navdeep Singh ◽  
Surendra Kumar Pandey ◽  
Inam Danish Khan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tissue Injury ◽  
Laryngopharyngeal Reflux ◽  
New Delhi ◽  
Female Population ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
The Mean ◽  
Study Participants

Background: Laryngopharyngeal Reflux (LPR) is a condition in which gastric content reflux into the larynx and pharynx. It is one of the extraesophageal manifestations of gastroesophageal reflux disease (GERD), involving the laryngeal regio. The laryngopharyngeal epithelium is more susceptible to reflux-related tissue injury than the esophageal epithelium. Objectives: This study aimed to test the hypothesis of whether severe vitamin D deficiency results in increased Laryngopharyngeal reflux (LPR) symptoms in Indian females. The objective was to find out the prevalence of LPR in the severe vitamin D deficient Indian female population. Methods: A descriptive observational study was done at a multispecialty polyclinic in New Delhi, India, over a period of one year. Based on a pilot study, a sample size of 185 individuals was taken. All females referring to the general outpatient department (OPD) with vitamin D levels below 20 ng/ml were included. The frequency of LPR symptoms in the study participants was assessed using the reflux symptom index (RSI) and reflux finding score (RFS) given for all symptomatic patients using a validated scoring system. The data were analyzed descriptively with Microsoft Excel and SPSS version 21 using appropriate tests. Results: In this study, 92% of the subjects aged more than 25 years, and the mean vitamin D level was 9.87 (± 3.425) ng/ml. Moreover, 74% of study participants had severe vitamin D deficiency (≤ 10 ng/ml). The mean RSI for our study participants was 14.54 (± 10.353). Also, the mean RFS was 1.77 (± 3.069). No significant correlation was established between the severity of vitamin D deficiency and RSI as well as RFS. The prevalence of LPR was 43%. Conclusions: Hypovitaminosis D does not have any effect on LPR in the Indian female population.

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