scholarly journals Effects of nuciferine on Nrf2/HO-1 signaling pathway in adipose tissue of obesity model rats

2022 ◽  
Vol 4 (1) ◽  
pp. 2
Author(s):  
ZhiXia Yang ◽  
JiaBao Liao
Keyword(s):  
Adipose Tissue ◽  
Signaling Pathway

CXCL13 inhibits microRNA-23a through PI3K/AKT signaling pathway in adipose tissue derived-mesenchymal stem cells

2016 ◽  
Vol 83 ◽  
pp. 876-880 ◽  
Author(s):  
Zhen-Wei Li ◽  
Liang Zhao ◽  
Qi-Cai Han ◽  
Xu Zhu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals Omics multi-layers networks and identification of genes involved in fat storage and metabolism in poultry using interactomics approach

2020 ◽  
Author(s):  
abolfazl bahrami ◽  
Farzad Ghafouri ◽  
Mostafa Sadeghi ◽  
Seyed Reza Miraei-Ashtiani
Keyword(s):  
Adipose Tissue ◽  
Signaling Pathway ◽  
High Throughput Screening ◽  
Broiler Chickens ◽  
Unsaturated Fatty Acids ◽  
Holistic Approach ◽  
High Rate ◽  
Literature Mining ◽  
Ampk Signaling ◽  
Ppar Signaling

Abstract Background Fatty acid metabolism in animals has a major impact on production and disease resistance traits. According to the high rate of interactions between lipid metabolism and its regulating properties, a holistic approach is necessary. Methods To study multi-omics layers of adipose tissue and identification of genes involved in fat metabolism, storage and endocrine signaling pathways in two groups of broiler chickens with high and low abdominal fat, high-throughput screening (HTS) techniques were used. The Gene-miRNA interacting bipartite and metabolic-signaling networks were reconstructed using their interactions. Results In the analysis of microarray and RNA-Seq data, 1835 genes were detected by comparing the identified genes with significant expression differences. Then, by comparing, 34 genes and 19 miRNAs were detected as common and main nodes. The literature mining approach was used and 7 genes were identified and added to the common gene set. Module finding revealed three important and functional modules. The detected modules 1, 2, and 3 were involved in the PPAR signaling pathway, biosynthesis of unsaturated fatty acids, and Alzheimer's disease metabolic pathway, adipocytokine, insulin, PI3K-Akt, mTOR and AMPK signaling pathway. Conclusions This approach revealed a new insight for a better understanding of the biological processes associated with adipose tissue.

scholarly journals HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Zeid Khitan ◽  
Mohit Harsh ◽  
Komal Sodhi ◽  
Joseph I. Shapiro ◽  
Nader G. Abraham
Keyword(s):  
Adipose Tissue ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Metabolic Pathway ◽  
Lipid Droplets ◽  
Wnt Signaling Pathway ◽  
Human Mscs ◽  
Antioxidant Gene ◽  
High Fructose Diet ◽  
High Fructose

Background.Fructose metabolism is an unregulated metabolic pathway and excessive fructose consumption is known to activate ROS. HO-1 is a potent antioxidant gene that plays a key role in decreasing ROS and isoprostanes. We examined whether the fructose-mediated increase in adipocyte dysfunction involves an increase in isoprostanes and that pharmacological induction of HO-1 would decrease both isoprostane levels and adipogenesis.Methods and Results.We examined the effect of fructose, on adipogenesis in human MSCs in the presence and absence of CoPP, an inducer of HO-1. Fructose increased adipogenesis and the number of large lipid droplets while decreasing the number of small lipid droplets (P<0.05). Levels of heme and isoprostane in fructose treated MSC-derived adipocytes were increased. CoPP reversed these effects and markedly increased HO-1 and the Wnt signaling pathway. The high fructose diet increased heme levels in adipose tissue and increased circulating isoprostane levels (P<0.05versus control). Fructose diets decreased HO-1 and adiponectin levels in adipose tissue. Induction of HO-1 by CoPP decreased isoprostane synthesis (P<0.05versus fructose).Conclusion.Fructose treatment resulted in increased isoprostane production and adipocyte dysfunction, which was reversed by the increased expression of HO-1.

scholarly journals Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Huiying Cong ◽  
Wenxia Zhong ◽  
Yiying Wang ◽  
Shoichiro Ikuyama ◽  
Bin Fan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Apolipoprotein E ◽  
Signaling Pathway ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Mrna Level ◽  
Antioxidant Properties ◽  
Expression Of Genes ◽  
Beige Adipocytes ◽  
Deficient Mice

Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake. The morphology results showed that the size of the adipocytes in the PYC-treated mice was obviously smaller than that in the HCD-fed mice. Next, we found that PYC upregulated the expression of genes related to lipolysis (ATGL and HSL), while it decreased the mRNA level of PLIN1. PYC significantly increased the expression of UCP1 and other genes related to beige adipogenesis. Additionally, PYC increased the expression of proteins related to the protein kinase A (PKA) signaling pathway. The findings suggested that PYC decreased obesity by promoting lipolysis and WAT browning. Thus, PYC may be a novel therapeutic target for obesity.

scholarly journals Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway

Diabetes ◽  
2017 ◽  
Vol 66 (5) ◽  
pp. 1198-1213 ◽  
Author(s):  
Wen Meng ◽  
Xiuci Liang ◽  
Hongzhi Chen ◽  
Hairong Luo ◽  
Juli Bai ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Signaling Pathway ◽  
White Adipose Tissue

Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue

2017 ◽  
Vol 30 ◽  
pp. 92-103 ◽  
Author(s):  
Ruixin Sun ◽  
Yi Wu ◽  
Weihua Hou ◽  
Zujun Sun ◽  
Yuxiong Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Inflammatory Response ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway

β-Lapachone Regulates Obesity through Modulating Thermogenesis in Brown Adipose Tissue and Adipocytes: Role of AMPK Signaling Pathway

2019 ◽  
Vol 47 (04) ◽  
pp. 803-822 ◽  
Author(s):  
Hyun Jeong Kwak ◽  
Mi-Young Jeong ◽  
Jae-Young Um ◽  
Jinbong Park
Keyword(s):  
Adipose Tissue ◽  
Protein Kinase ◽  
Brown Adipose Tissue ◽  
Signaling Pathway ◽  
Uncoupling Protein ◽  
Therapeutic Implication ◽  
Mitogen Activated Protein Kinase ◽  
Ampk Signaling ◽  
Compound C ◽  
Brown Adipose

Activation of brown adipose tissue (BAT) has been proposed as a promising target against obesity due to its increased capacity for thermogenesis. In this study, we explored the effect of [Formula: see text]-Lapachone ([Formula: see text]L), a compound obtained from the bark of the lapacho tree, against obesity. In vivo administration of [Formula: see text]L into either high fat diet (HFD)-induced obese C57BL6 mice and genetically obese Lepr[Formula: see text] mice prevented body weight gain, which was associated with tissue weight loss of white adipose tissue (WAT). In addition, [Formula: see text]L elevated thermogenic proteins including uncoupling protein 1 (UCP1) and mitochondrial count in BAT and human adipose tissue-derived mesenchymal stem cells (hAMSCs). [Formula: see text]L also induced AMP-activated protein kinase (AMPK) phosphorylation, subsequent upregulation of acetyl-CoA carboxylase (ACC) and UCP1, and these effects were diminished by AMPK inhibitor compound C, suggesting that AMPK underlies the effects of [Formula: see text]L. Mitogen-activated protein kinase pathways participated in the thermogenesis of [Formula: see text]L, specifically p38, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2) were activated by [Formula: see text]L treatment in hAMSCs. Additionally, inhibitors of p38/JNK/ERK1/2 abrogated the activity of [Formula: see text]L. Taken together, [Formula: see text]L exerts anti-obese effects by inducing thermogenesis mediated by AMPK signaling pathway, suggesting that [Formula: see text]L may have a potential therapeutic implication of obesity. Taken together, [Formula: see text]L exerts anti-obese effects by not only inducing thermogenesis on brown adipocytes but also inducing the browning of white adipocytes. The anti-obese effect of [Formula: see text]L is mediated by AMPK signaling pathway, suggesting that [Formula: see text]L may have potential therapeutic implication of obesity.

scholarly journals Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance

2020 ◽  
Author(s):  
Yujeong Kim ◽  
Ok-Kyung Kim
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Metabolic Disorders ◽  
Extracellular Vesicle ◽  
Extracellular Mirnas

ABSTRACT Recently, extracellular microRNAs (miRNAs) from adipose tissue have been shown to be involved in the development of insulin resistance. Here, we summarize several mechanisms explaining the pathogenesis of obesity-induced insulin resistance and associated changes in the expression of obesity-associated extracellular miRNAs. We discuss how miRNAs, particularly miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, in extracellular vesicles secreted from the adipose tissue can affect the insulin signaling pathway in metabolic tissue. Understanding the role of these miRNAs will further support the development of therapeutics for obesity and metabolic disorders such as type 2 diabetes.

Linoelaidic acid enhances adipogenic differentiation in adipose tissue-derived stromal cells through suppression of Wnt/β-catenin signaling pathway in vitro

2016 ◽  
Vol 110 ◽  
pp. 1-7 ◽  
Author(s):  
Jihui Wang ◽  
Yuan Liang ◽  
Luyang Jian ◽  
Jingwei Zhang ◽  
Shuai Liang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Signaling Pathway ◽  
Stromal Cells ◽  
Adipogenic Differentiation ◽  
Linoelaidic Acid
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