STABILITY STUDY OF TRIPHALA CHURNA

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (05) ◽  
pp. 56-60
Author(s):  
A. Desai ◽  
◽  
M. Savardekar
Keyword(s):  
Physicochemical Parameters ◽  
Stability Study ◽  
Raw Material ◽  
Terminalia Chebula ◽  
Mechanical Mixing ◽  
Short Life ◽  
Over The Counter ◽  
Terminalia Belerica ◽  
Accelerated Studies ◽  
The Stability

Triphala Churna is an Ayurvedic preparation, prepared by mechanical mixing of three fruit pericarppowders, Emblica officinalis Gaertn., Terminalia belerica Roxb. and Terminalia chebula Retz. It is soldin the market as over the counter drug and mainly used for constipation problems. The raw material wascollected from the market, after confirming the appropriate time of collection, to get the fresh material.Triphala Churna was prepared as per the Ayurvedic Formulary of India, under the supervision of anAyurvedic manufacturer. In the present study the stability of the preparation was studied as per ICHguidelines. The samples were incubated in stability chamber for accelerated studies (A) and long termstudies (L). One set of samples was kept at ambient temperature and humidity for real time study (R).The samples were intermittently re-tested for organoleptic characters, physicochemical parameters andassay of the total tannins. It was observed that the results go along with the standard Ayurvedic text. Thepreparation has very short life when assessed on the basis of total tannins.

scholarly journals Stability Study of Darunavir Ethanolate Tablets Applying a New Stability-Indicating HPLC Method

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Josilene Chaves Ruela Corrêa ◽  
Cristina Helena dos Reis Serra ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Degradation Products ◽  
Hplc Method ◽  
Stability Study ◽  
Raw Material ◽  
Forced Degradation ◽  
The Novel ◽  
Stability Indicating ◽  
Stability Indicating Method ◽  
The Stability ◽  
Darunavir Ethanolate

Chemical and physical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the aim of this work was to study the stability of darunavir and to develop and validate a liquid chromatography (LC) method to determine darunavir in raw material and tablets in the presence of degradation products. The novel method showed to be linear from 6.0 to 21.0 μg/mL, with high precision (CV < 2%) and accuracy (recuperation of 99.64%). It is simple and reliable, free of placebo interferences. The robustness of the method was evaluated by a factorial design using seven different parameters. Forced degradation study was done under alkaline, acidic, and oxidative stress at ambient temperature and by heating. The LC method was able to quantify and separate darunavir and its degradation products. Darunavir showed to be unstable under alkaline, acid, and oxidative conditions. The novelty of this study is understanding the factors that affect darunavir ethanolate stability in tablets, which is the first step to unravel the path to know the degradation products. The novel stability-indicating method can be used to monitor the drug and the main degradation products in low concentrations in which there is linearity.

FORMULATION AND STANDARDIZATION OF AVALEHA PREPARATION FROM BENINCASA HISPIDA

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (06) ◽  
pp. 69-72
Author(s):  
S. V Patil ◽  
◽  
S. S. Patil ◽  
N. R. Inamdar ◽  
V. A Mahajan ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Stability Study ◽  
Control Procedure ◽  
Scientific Quality ◽  
Chronic Respiratory Diseases ◽  
Benincasa Hispida ◽  
Total Reducing Sugars ◽  
The Stability ◽  
Evaluation Parameters

Standardization of Ayurvedic formulation is essential in order to assess the quality of drugs. Avaleha is “a semisolid preparation which is prepared by reboiling of decoction etc., till it solidifies and attains signs of proper cooking and consistency. The present study deals with standardization of Avaleha from Benincasa hispida , known to be effective in caugh and chronic respiratory diseases. Avaleha formulation was prepared by reported traditional method of Ayurveda. Formulation was standardized by modern scientific quality control procedure for the finished products. Standardization of Avaleha was achieved by organoleptic study and by studing physicochemical parameters such as pH, TLC, Loss on drying, Extractive values, ash value, total reducing sugars and stability study. The results showed that the physicochemical parameters were well within the standard limits and the values could be used to establish and formulate procedures for standardization and quality controll of these ayurvedic formulations. The study revealed that the standardization parameters could be used at commercial level for such formulations. Also comparison with the marketed formulation with satisfactory evaluation parameters justifies the stability of the method.

scholarly journals A Novel Approach to Fabricate Foam Ceramics from Steel Slag

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yu Zheng ◽  
Xudong Luo ◽  
Jinlong Yang ◽  
Wenlong Huo ◽  
Chi Kang
Keyword(s):  
Compressive Strength ◽  
Ph Value ◽  
Steel Slag ◽  
Raw Material ◽  
Solid Loading ◽  
Insulation Material ◽  
Ceramic Foams ◽  
Novel Approach ◽  
The Stability ◽  
First Time

A novel approach is used for fabricating steel slag foam ceramics based on the particle-stabilized foaming method. In this work, steel slag was used as the raw material and propyl gallate (PG) was used as the surface modifier. For the first time, steel slag ceramic foams were successfully fabricated based on particle-stabilized foams. The results show that the stability of the ceramic foams was closely related to the pH value and PG concentration. The porosity and compressive strength could be controlled by changing the solid loading of steel slag and sintering temperature. The porosity of steel slag foam ceramics ranged from 85.6% to 62.53%, and the compressive strength was from 1.74 MPa to 10.42 MPa. The thermal conductivity of steel slag foam ceramics was only 0.067 W (m·K)−1, which shows that it could be used as a thermal insulation material.

Study on Influence of Silicate Morphology Based on pH Value

2012 ◽  
Vol 454 ◽  
pp. 324-328
Author(s):  
Yan He ◽  
Ya Jing Liu ◽  
Yong Lin Cao ◽  
Li Xia Zhou
Keyword(s):  
Silicic Acid ◽  
Ph Value ◽  
Colorimetric Method ◽  
Absorption Spectrometry ◽  
Degree Of Polymerization ◽  
Raw Material ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ph Values ◽  
The Stability

Infra-red absorption spectrometry, X-ray diffraction observations and characterization tests based on silicon molybdenum colorimetric method were used to investigate the optimal pH value controlling the stability of the silicic acid form. The experiment process was done by using sodium silicate as raw material. The results showed that the solution of silicate influenced the polymerization. The active silicic acid solution with a certain degree of polymerization was obtained by controlling the pH values.

ANALYSIS OF SCIENTIFIC DEVELOPMENTS IN THE FIELD OF FUNCTIONAL BEVERAGES FOR SPORTS NUTRITION BASED ON PATENT DATABASES

2020 ◽  
Author(s):  
А.О. ЕВСЮКОВА
Keyword(s):  
Russian Federation ◽  
Sports Nutrition ◽  
Raw Material ◽  
Physical Culture ◽  
Industrial Complex ◽  
Production Volume ◽  
Innovative Products ◽  
Functional Beverages ◽  
The Russian Federation ◽  
The Stability

Согласно данным проекта Стратегии развития физической культуры и спорта в Российской Федерации до 2030 года, в 2008–2019 гг. численность систематически занимающегося физической культурой и спортом населения выросла в 2,5 раза. Это обусловливает необходимость создания инновационных продуктов для людей занимающихся спортом. Для определения перспектив создания продуктов специального назначения, в частности функциональных напитков для спортивного питания, проведен анализ патентов в этой области. Объектом анализа были 59 патентов, опубликованных с 1995 г. по май 2020 г. и занесенных в отечественную – ФИПС и международные – EAPATIS, USPTO, EPO, CISPATANT базы данных. Проанализированы следующие подклассы изобретений по актуализированной версии МПК: A23C, A23D, A23F, A23G, A23J, A23K, A23L, A61K, A61P, C12G. Результаты исследований представлены на рисунках в виде диаграмм. Установлено, что производство функциональных напитков для спортивного питания активно развивается. Российская Федерация имеет преимущество по количеству зарегистрированных патентов в этой области, но по объему производства продукции уступает зарубежным странам. Поскольку продукция агропромышленного комплекса России вполне удовлетворяет требованиям потребителей к натуральности сырьевого состава продукта, для обеспечения стабильности внутреннего рынка перспективно развитие отечественного производства функциональных напитков для спортивного питания. According to the draft strategy for the development of physical culture and sports in the Russian Federation until 2030, in 2008–2019, the number of people systematically engaged in physical culture and sports increased by 2,5 times. This makes it necessary to create innovative products for people involved in sports. To determine the prospects for creating special-purpose products, in particular functional beverages for sports nutrition, an analysis of patents in this area was conducted. 59 patents published from 1995 to may 2020 and included in the national – FIPS and international – EAPATIS, USPTO, EPO, CISPATANT databases were the object of analysis. Subclasses of inventions according to the updated version of the IPC A23C, A23D, A23F, A23G, A23J, A23K, A23L, A61K, A61P and C12G are analyzed. The results of the research are presented in figures in the form of diagrams. It is established that the production of functional beverages for sports nutrition is actively developing. The Russian Federation has an advantage in the number of registered patents in this area, but in terms of production volume it is inferior to foreign countries. Since the products of the Russian agro-industrial complex fully meet the requirements of consumers for the naturalness of the raw material composition of the product, the development of domestic production of functional beverages for sports nutrition is promising to ensure the stability of the domestic market.

scholarly journals Development of methodologies for dimethylaminoethanol glycolate assay in association with sunscreens in dermocosmetic formulation

2010 ◽  
Vol 46 (4) ◽  
pp. 705-713 ◽  
Author(s):  
Daniela Soares Deccache ◽  
Elisabete Pereira dos Santos ◽  
Lúcio Mendes Cabral ◽  
Carlos Rangel Rodrigues ◽  
Valéria Pereira de Sousa
Keyword(s):  
Apparent Viscosity ◽  
Initial Conditions ◽  
Stability Study ◽  
Raw Material ◽  
Good Stability ◽  
Rapid Assay ◽  
End Point ◽  
Stability Performance ◽  
Rp Hplc ◽  
Cosmetic Formulations

DMAE glycolate (DG) and sunscreens have been used associated in anti-aging dermocosmetic formulations. Despite extensive use of these substances, methods for quantification of DG as raw material and in cosmetic formulations, especially when associated, are not described in the literature. RP-HPLC and non-aqueous titration methods, with determination potentiometric end-point (PT), were developed and validated for rapid assay of DG as raw material and in a topic emulsion in association with sunscreens. Both methods are simple, selective, linear, accurate and precise. The PT method was chosen for stability study of DG in the formulation developed. The proposed formulation presented good stability performance as regards aspect, pH, apparent viscosity, and SPF, with less than 5% of DG degradation compared to initial conditions.

scholarly journals THE ANALYSIS OF RAW MATERIAL INVENTORY OF DOHO SUWAR-SUWIR BUSINESS IN JEMBER REGENCY

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Ardhitya Alam Wiguna ◽  
Linda Ekadewi Widyatami
Keyword(s):  
Inventory Management ◽  
Raw Material ◽  
Processed Food ◽  
Order Quantity ◽  
Stock Management ◽  
Safety Stock ◽  
Typical Food ◽  
The Stability ◽  
Small Medium Enterprises ◽  
Medium Enterprises

Doho Suwar-Suwir is a Micro Small Medium Enterprises (UMKM) processing Fermented Cassava (Tape Singkong) to become a processed food in Jember, which is Suwar-Suwir. To maintain the stability of production process, needs a control for the stock management towards the raw material at Doho Suwar-Suwir UMKM. The raw material inventory management at Doho Suwar-Suwir UMKM is about fermented cassava raw material inventory which then are processed to become the typical food of Jember Regency, which is Suwar-Suwir. The goal of this research were to analyze the fermented cassava raw material inventory quantity and to analyze the safety stock quantity at Doho Suwar-Suwir UMKM. The method used in this research was stock management calculation or Economical Order Quantity (EOQ) where the result of this research was the quantity of fermented cassava raw material  needed using Economical Order Quantity (EOQ) method at Doho Suwar-Suwir business was 60,6 kg and the number of the safety stock which must exist was 5,5 kg.

scholarly journals Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

2021 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
Cristina Martín-Sabroso ◽  
Mario Alonso-González ◽  
Ana Fernández-Carballido ◽  
Juan Aparicio-Blanco ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Shelf Life ◽  
Stability Study ◽  
Eye Drops ◽  
Microbiological Analysis ◽  
Nitrogen Gas ◽  
Long Term Stability ◽  
Main Degradation Product ◽  
The Stability ◽  
Unstable Molecule

Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications. Cysteamine eye drop compounded formulations, commonly prepared by hospital pharmacy services, are meant to diminish the build-up of corneal cystine crystals. The objective of this work was to analyze whether the shelf life proposed for six formulations prepared following different protocols used in hospital pharmacies is adequate to guarantee the quality and efficacy of cysteamine eye drops. The long-term and in-use stabilities of these preparations were studied using different parameters: content of cysteamine and its main degradation product cystamine; appearance, color and odor; pH and viscosity; and microbiological analysis. The results obtained show that degradation of cysteamine was between 20% and 50% after one month of storage in the long-term stability study and between 35% and 60% in the in-use study. These data confirm that cysteamine is a very unstable molecule in aqueous solution, the presence of oxygen being the main degradation factor. Saturation with nitrogen gas of the solutions offers a means of reducing cysteamine degradation. Overall, all the formulae studied presented high instability at the end of their shelf life, suggesting that their clinical efficacy might be dramatically compromised.

scholarly journals FORMULATION, CHARACTERIZATION AND STABILITY STUDY OF FAST DISSOLVING THIN FILM CONTAINING ASTAXANTHIN NANOEMULSION USING HYDROXYPROPYLMETHYL CELLULOSE POLYMER

2021 ◽  
pp. 17-22
Author(s):  
LUSI NURDIANTI ◽  
IYAN SOPYAN ◽  
TAOFIK RUSDIANA
Keyword(s):  
Thin Film ◽  
Mechanical Characteristics ◽  
Storage Conditions ◽  
Stability Study ◽  
Matrix System ◽  
Stability Studies ◽  
Casting Method ◽  
Hydroxypropylmethyl Cellulose ◽  
The Stability ◽  
Physical And Mechanical Characteristics

Objective: The present study was conducted to formulate and characterize the thin film containing astaxanthin nanoemulsion (TF-ASN) using Hydroxypropylmethyl Cellulose (HPMC) polymer as a film matrix system. The stability studies in different storage conditions were also performed. Methods: Astaxanthin nanoemulsion (As-NE) was prepared by using self-nanoemulsifying method, followed by incorporation into the HPMC matrix system by solvent casting method to forming TF-ASN. Evaluation of TF-ASN was performed by physical and mechanical characterizations. Stability study was carried out in both of accelerated (temperature of 40±2 °C/75±5% RH) and non-accelerated (at ambient temperature) conditions. Assay of astaxanthin in individual TF-ASN was determined compared to pure astaxanthin. Results: TF-ASN had good physical and mechanical characteristics that suitable for intraoral administration. Conclusion: For the study of stability under different storage conditions, it was proven that nanoemulsion form was packed in a HPMC matrix could enhance the stability of the astaxanthin.

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