FORMULATION AND STANDARDIZATION OF AVALEHA PREPARATION FROM BENINCASA HISPIDA

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (06) ◽  
pp. 69-72
Author(s):  
S. V Patil ◽  
◽  
S. S. Patil ◽  
N. R. Inamdar ◽  
V. A Mahajan ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Stability Study ◽  
Control Procedure ◽  
Scientific Quality ◽  
Chronic Respiratory Diseases ◽  
Benincasa Hispida ◽  
Total Reducing Sugars ◽  
The Stability ◽  
Evaluation Parameters

Standardization of Ayurvedic formulation is essential in order to assess the quality of drugs. Avaleha is “a semisolid preparation which is prepared by reboiling of decoction etc., till it solidifies and attains signs of proper cooking and consistency. The present study deals with standardization of Avaleha from Benincasa hispida , known to be effective in caugh and chronic respiratory diseases. Avaleha formulation was prepared by reported traditional method of Ayurveda. Formulation was standardized by modern scientific quality control procedure for the finished products. Standardization of Avaleha was achieved by organoleptic study and by studing physicochemical parameters such as pH, TLC, Loss on drying, Extractive values, ash value, total reducing sugars and stability study. The results showed that the physicochemical parameters were well within the standard limits and the values could be used to establish and formulate procedures for standardization and quality controll of these ayurvedic formulations. The study revealed that the standardization parameters could be used at commercial level for such formulations. Also comparison with the marketed formulation with satisfactory evaluation parameters justifies the stability of the method.

FORMULATION AND STANDARDIZATION OF ASAVA OF SYZYGIUM CUMINI

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (08) ◽  
pp. 63-66
Author(s):  
S. V. Patil ◽  
◽  
V. R Aralelimath ◽  
V. A. Mahajan ◽  
N. R. Inamdar ◽  
...  
Keyword(s):  
Physicochemical Parameters ◽  
Acid Value ◽  
Total Solid ◽  
Stability Study ◽  
Solid Content ◽  
Control Procedure ◽  
Scientific Quality ◽  
Syzygium Cumini ◽  
Total Solid Content ◽  
Study Results

Asavas and Arishtaare alcoholic medicaments are prepared by allowing the herbal juices or their decoctions to undergo fermentation with the addition of sugar. Standardization of ayurvedic formulation is essential in order to assess the quality of drugs. In the present study standardization of asava from Syzygium cumini, known to be effective in diabetics, has been performed.Asava formulation was prepared by reported traditional method of ayurveda. Formulation has been standardized by modern scientific quality control procedure for the finished productas. Standardization of asava was achieved by organoleptic study, physicochemical parameters such as pH, specific gravity, total solid content, acid value, alcohol content, refractive index, total reducing sugars and stability study. results reveal that the physicochemical parameters were within the limits and the values could be used to establish and formulate procedures for standardization and quality controlling of these ayurvedic formulations.

scholarly journals Preservatives Stability: Stability Study of Parabens under Different Conditions of Stress Degradation

2020 ◽  
Vol 11 (3) ◽  
pp. 4187-4194
Author(s):  
Ismail Bennani ◽  
Madiha Alami Chentoufi ◽  
Miloud El Karbane ◽  
Ibrahim Sbai El Otmani ◽  
Amine Cheikh ◽  
...  
Keyword(s):  
Extreme Values ◽  
Stability Study ◽  
Wide Field ◽  
Direct Influence ◽  
Light Conditions ◽  
Influence Of Temperature ◽  
Stress Degradation ◽  
Quality Of Products ◽  
The Stability

Preservatives are used in a wide field of application to maintain the quality of products. They are used to deal with the chemical, physical and microbiological problems and the constraints of the development of several formulations. In this work, we tested the stability of antimicrobial preservatives which are the parabens under different stress degradation conditions to evaluate their degree of effectiveness. The tested parabens were incubated in different solutions at different pH, Temperatures, light conditions, and presence or absence of sucrose in solution (create a medium similar of syrups). The HPLC was used for the assay, by a validated method for the parabens assay and the statistical analysis of the data is carried out by JMP software. The results show a direct influence of temperature and pH on the level of parabens, while the influence of light remains negligible. The increase in temperature gives a degree of immunity of parabens levels, especially with the extreme values of pH. This study is one of the first studies of forced decomposition of parabens carried out under the various conditions suggested. The results give an idea of the stability profile of the tested parabens and suggest a model of the conditions of conservation and use of these products in different domains and under different conditions.

EVALUATION OF SHELF LIFE OF BHALLATAKA TAILA (OIL)

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (06) ◽  
pp. 36-41
Author(s):  
Anu Ruhila ◽  
◽  
Pramod R. Yadav ◽  
Galib R ◽  
Pradeep K. Prajapati
Keyword(s):  
Shelf Life ◽  
Fatty Acid Content ◽  
Stability Study ◽  
Polyunsaturated Fatty Acid Content ◽  
Accelerated Stability ◽  
Physico Chemical ◽  
Current Scenario ◽  
The Government ◽  
The Stability

Bhallataka Taila (Oil) is extracted with the help of Patala Yantra. It is one of the important formulations in Ayurveda pharmaceutics. Shelf life for various dosage forms are described in Ayurveda classics. In the current scenario, the amendment of Rule No. 161-B of the Drugs and Cosmetic Act 1940, specifies the maximum shelf life of Ayurvedic formulations. However, there is a lack of shelf life data for individual for-mulations. Thus, the present study is aimed to evaluate the shelf life of Bhallataka Taila (Oil). Bhallataka Taila (Oil) was extracted following classical guidelines. The sample was subjected to an accelerated stability study maintaining the temperature and humidity 40 +- 2 0C and 75 +- 5 %, respectively. Physico-chemical parameters were analysed at the initiation of the study and at an interval of 1, 3 and 6 months to check the degradation levels in the formulation. Tests for microbial limit and heavy metals were also conducted for the safety and quality of the product. On extrapolating the observations, the shelf life for Bhallataka Taila (Oil) was found to be 4.89 years, which exceeds the shelf life mentioned for Taila (Oil) in official gazettes of the Government of India. This oil preparation does not incorporate any liquid media such as Swarasa (Juice), Kwatha (decoction), etc. as required in any Taila Preparation, resulting in low degradation rate. The oil is rich in PUFA (polyunsaturated fatty acid) content and tocopherols, which may contribute to the stability of the oil.

scholarly journals The Effect of Initial Purity on the Stability of Solutions in Storage

2013 ◽  
Vol 19 (2) ◽  
pp. 308-316 ◽  
Author(s):  
Ioana Popa-Burke ◽  
Steven Novick ◽  
Charles A. Lane ◽  
Robin Hogan ◽  
Pedro Torres-Saavedra ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Physicochemical Parameters ◽  
Storage Conditions ◽  
Stability Of Solutions ◽  
Initial Compound ◽  
High Quality ◽  
Freeze Thaw ◽  
Compound Screening ◽  
The Stability

Many modern compound-screening technologies are highly miniaturized, resulting in longer-lasting solution stocks in compound management laboratories. As the ages of some stocks stretch into years, it becomes increasingly important to ensure that the DMSO solutions remain of high quality. It can be a burden to check the quality of a large library of compound solutions continuously, and so a study was devised to link the effects of initial compound purity and physicochemical properties of the compounds with the current purity of DMSO solutions. Approximately 5000 compounds with initial purity of at least 80% were examined. Storage conditions were held or observed to be relatively constant and so were eliminated as potential predictors. This allowed the evaluation of the effects of other factors on the stability of solutions, such as initial purity, number of freeze-thaw cycles, age of the solution, and multiple calculated physicochemical parameters. Of all the factors investigated, initial purity was the only one that had a clear effect on stability. None of the other parameters investigated (physicochemical properties, number of freeze-thaw cycles, age of solutions) had a statistically significant effect on stability.

scholarly journals Evolution of the Stabilis® Database: Creation of a Level of Evidence for Stability Studies

2018 ◽  
Vol 3 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Elise D’Huart ◽  
Pauline Lider ◽  
Jean Vigneron ◽  
Béatrice Demoré
Keyword(s):  
Analytical Method ◽  
Antiviral Drugs ◽  
Stability Study ◽  
Antifungal Drugs ◽  
Quality Level ◽  
Stability Studies ◽  
Level Of Evidence ◽  
Stability Data ◽  
The Stability

AbstractBackgroundStabilis®is an international database on stability and compatibility of drugs. The stability data comes mainly from publications of pharmaceutical journals. As the quality of the published stability studies is not equivalent, the objective of this work was to propose a level of evidence for the physico-chemical stability studies selected for the database.MethodsAt first, we evaluated the main pharmacological class consulted by the users. This work was then divided into 5 steps: (1) updating of the criteria to validate a stability study, (2) creating a grid rating articles, (3) rating of the articles of stability studies for anticancer, antifungal and antiviral drugs by 2 evaluators, (4) creation of new screens in the database to enter rating, to visualize the pictograms and commentaries by the users, (5) creation of a guideline to explain the different levels of evidence.ResultsThe main pharmacological class consulted by Stabilis®users is the anticancer drugs and then antiinfectives. We have selected anticancer, antifungal and antiviral drugs for our study. Two hundred and forty publications were evaluated. The highest level attributed was A for anticancer and antifungal drugs and C for antiviral drugs. This difference can be explained by the fact that the majority of publications about antiviral drugs were older.The most frequent anomalies in the rating of articles were an incomplete or imperfect validation of the analytical method (high value of the coefficient of variation) and a defect in the evaluation of the stability indicating capacity.It must be noted that the level of evidence is not the quality level of the analytical method but the mixture of the quality of the method validation and of the results. This aspect was a choice of the Stabilis®team and seems important because the security of the patient is impacted by both aspects.ConclusionsThis new function contributes to help the Stabilis®users to evaluate the stability data published and to take a decision for their use in daily practice. This function will be progressively extended to other pharmacological classes of injectable drugs and then for non-injectable preparations.

scholarly journals Bio-analytical Approach for Stability Studies of Bendroflumethiazide Materials

2021 ◽  
pp. 195-203
Author(s):  
B. Veeraswami ◽  
V. M. K. Naveen
Keyword(s):  
Stability Study ◽  
Stability Studies ◽  
Dry Extract ◽  
Long Term Stability ◽  
Analytical Stability ◽  
Ich Guidelines ◽  
The Stability ◽  
Efficacy Prediction

In this paper a comprehensive study of stability related, and evidence based best practices of Bio-analytical stability on Bendroflumethiazide drug samples are studied. The proposed approach is very significant and essential for the drugs development process address the specify the acceptancy, purity, efficacy, prediction of strength and quality of the drugs. The stability study constituents several methods like Bench-Top, Auto-sampler, Freeze-Thaw, Dry-extract, Wet-extract, Short-term, long-Term stability studies at relative intervals results the complete stability information about the drug under the proposed and validated method. There ported out comes of this methos shows this drug have good stability according to ICH guidelines.

STABILITY STUDY OF TRIPHALA CHURNA

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (05) ◽  
pp. 56-60
Author(s):  
A. Desai ◽  
◽  
M. Savardekar
Keyword(s):  
Physicochemical Parameters ◽  
Stability Study ◽  
Raw Material ◽  
Terminalia Chebula ◽  
Mechanical Mixing ◽  
Short Life ◽  
Over The Counter ◽  
Terminalia Belerica ◽  
Accelerated Studies ◽  
The Stability

Triphala Churna is an Ayurvedic preparation, prepared by mechanical mixing of three fruit pericarppowders, Emblica officinalis Gaertn., Terminalia belerica Roxb. and Terminalia chebula Retz. It is soldin the market as over the counter drug and mainly used for constipation problems. The raw material wascollected from the market, after confirming the appropriate time of collection, to get the fresh material.Triphala Churna was prepared as per the Ayurvedic Formulary of India, under the supervision of anAyurvedic manufacturer. In the present study the stability of the preparation was studied as per ICHguidelines. The samples were incubated in stability chamber for accelerated studies (A) and long termstudies (L). One set of samples was kept at ambient temperature and humidity for real time study (R).The samples were intermittently re-tested for organoleptic characters, physicochemical parameters andassay of the total tannins. It was observed that the results go along with the standard Ayurvedic text. Thepreparation has very short life when assessed on the basis of total tannins.

Criteria for evaluation of the coordinate measurements quality of parts geometric parameters at pilot-experimental production

2019 ◽  
pp. 3-8
Author(s):  
N.Yu. Bobrovskaya ◽  
M.F. Danilov
Keyword(s):  
Quality Indicators ◽  
Quality Management System ◽  
Technical Specification ◽  
Experimental Production ◽  
Technological Heredity ◽  
Coordinate Measurements ◽  
Reasonable Choice ◽  
The Stability ◽  
Geometric Elements

The criteria of the coordinate measurements quality at pilot-experimental production based on contemporary methods of quality management system and traditional methods of the measurements quality in Metrology are considered. As an additional criterion for quality of measurements, their duration is proposed. Analyzing the problem of assessing the quality of measurements, the authors pay particular attention to the role of technological heredity in the analysis of the sources of uncertainty of coordinate measurements, including not only the process of manufacturing the part, but all stages of the development of design and technological documentation. Along with such criteria as the degree of confidence in the results of measurements; the accuracy, convergence, reproducibility and speed of the results must take into account the correctness of technical specification, and such characteristics of the shape of the geometric elements to be controlled, such as flatness, roundness, cylindrical. It is noted that one of the main methods to reduce the uncertainty of coordinate measurements is to reduce the uncertainty in the initial data and measurement conditions, as well as to increase the stability of the tasks due to the reasonable choice of the basic geometric elements (measuring bases) of the part. A prerequisite for obtaining reliable quality indicators is a quantitative assessment of the conditions and organization of the measurement process. To plan and normalize the time of measurements, the authors propose to use analytical formulas, on the basis of which it is possible to perform quantitative analysis and optimization of quality indicators, including the speed of measurements.

FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - 58 С.

2018 ◽  
Author(s):  
Мария Григорьевна Алпатова ◽  
Мария Игоревна Щеглова ◽  
Elmira Kalybaevna Adil’bekova ◽  
Nuradin Alibaev ◽  
Arunas Svitojus
Keyword(s):  
Service Sector ◽  
Applied Research ◽  
Point Of View ◽  
Scientific Quality ◽  
Final Decision ◽  
Main Criterion ◽  
The Public ◽  
Peer Reviewers ◽  
Verification Process

The conference is a major international forum for analyzing and discussing trends and approaches in research in the field of basic science and applied research. We provide a platform for discussions on innovative, theoretical and empirical research. The form of the conference: in absentia, without specifying the form in the collection of articles. Working languages: Russian, English Doctors and candidates of science, scientists, specialists of various profiles and directions, applicants for academic degrees, teachers, graduate students, undergraduates, students are invited to participate in the conference. There is one blind verification process in the journal. All articles will be initially evaluated by the editor for compliance with the journal. Manuscripts that are considered appropriate are then usually sent to at least two independent peer reviewers to assess the scientific quality of the article. The editor is responsible for the final decision on whether to accept or reject the article. The editor's decision is final. The main criterion used in assessing the manuscript submitted to the journal is: uniqueness or innovation in the work from the point of view of the methodology being developed and / or its application to a problem of particular importance in the public sector or service sector and / or the setting in which the efforts, for example, in the developing region of the world. That is, the very model / methodology, application and context of problems, at least one of them must be unique and important. Additional criteria considered in the consideration of the submitted document are its accuracy, organization / presentation (ie logical flow) and recording quality.

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