scholarly journals The Risk Factors for Nosocomial Infection in Chinese Patients with Active Rheumatoid Arthritis in Shanghai

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Wei-Lin Xie ◽  
Zhuo-Ling Li ◽  
Zhen Xu ◽  
Huan-Ru Qu ◽  
Luan Xue ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Serum Albumin ◽  
Potential Risk ◽  
Active Rheumatoid Arthritis ◽  
Chinese Patients ◽  
Reactive Protein ◽  
Cell Counts ◽  
Potential Risk Factors ◽  
White Blood Cell Counts

Objective. To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods. A total of 2452 active RA patients at Hospitals in Shanghai between January 2009 and February 2011 were analyzed. Their demographic and clinical characteristics were compared with those without infection, and the potential risk factors were determined by logistic regression analysis. Results. Multivariate analysis indicated the gender (OR=0.70, 95% CI 0.53–0.92), duration in hospital (OR=1.03, 95%CI 1.01–1.05), number of organs involved (OR=0.82, 95%CI 0.72–0.92), number of disease-modifying antirheumatic drugs ((DMARDs) (OR=1.22, 95%CI 1.061–1.40)), corticosteroid therapy (OR=1.02, 95%CI 1.01–1.03), peripheral white blood cell counts ((WBC) (OR=1.04, 95%CI 1.00–1.08)), levels of serum albumin (OR=0.98, 95%CI 0.97–0.99), and C-reactive protein ((CRP) (OR=1.03, 95%CI 1.01–1.04)) that were significantly associated with the risk of infections. Conclusion. The female patients, longer hospital stay, more organs involved, more DMARDs, corticosteroid usage, high counts of WBC, lower serum albumin, and higher serum CRP were independent risk factors of infections in active RA patients.

scholarly journals C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Carly L. Botheras ◽  
Steven J. Bowe ◽  
Raquel Cowan ◽  
Eugene Athan
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Potential Risk ◽  
Univariate Analysis ◽  
Foot Ulcer ◽  
Entry Point ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Risk Factors ◽  
Portal Of Entry

Abstract Background Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care. Methods In this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset S. aureus bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results. Results We identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161 mg/L on the day of admission were all significantly associated with complications. Conclusions We conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of S. aureus bacteraemia.

Udder shape and teat-end lesions as potential risk factors for high somatic cell counts and intra-mammary infections in dairy cows

2010 ◽  
Vol 183 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Abdul L. Bhutto ◽  
Richard D. Murray ◽  
Zerai Woldehiwet
Keyword(s):  
Risk Factors ◽  
Dairy Cows ◽  
Somatic Cell ◽  
Potential Risk ◽  
Somatic Cell Counts ◽  
Cell Counts ◽  
Potential Risk Factors

P1206Some potential risk factors for thromboembolic stroke in patients with rheumatoid arthritis and paroxysmal atrial fibrillation

EP Europace ◽  
2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i235-i235
Author(s):  
D Bublikov ◽  
A P Momot ◽  
M G Nicolaeva ◽  
I E Babushkin
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Atrial Fibrillation ◽  
Potential Risk ◽  
Paroxysmal Atrial Fibrillation ◽  
Thromboembolic Stroke ◽  
Potential Risk Factors

scholarly journals Risk Factors for In-Hospital Complications of Fall-Related Fractures among Older Chinese: A Retrospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Hong-Ying Pi ◽  
Yuan Gao ◽  
Jing Wang ◽  
Meng-Meng Hu ◽  
Dan Nie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Potential Risk ◽  
Preventive Measures ◽  
Chinese Patients ◽  
Potential Risk Factors ◽  
Older Chinese ◽  
Individual Complication ◽  
The Impact ◽  
Univariate Analyses

Purpose. The aim of this study was to investigate the risk factors and the efficacy of the preventive measurements for the in-hospital complications of fall-related fractures. Methods. The data on older Chinese patients with fall-related fractures were collected, including information on the patients, diseases, and preventive measurements. The potential risk factors for the in-hospital complications included health status on admission, comorbidity, fractures, preventive measures of the complications, and drugs use for the comorbidity. After univariate analyses, multivariate logistic regression analyses were applied to investigate the impact of the potential risk factors on the number of the complications and each individual complication, respectively, and the efficacy of the preventive measurements. Results. A total of 525 male and 1367 female were included in this study. After univariate analyses, multiple logistic regression showed that dementia, pneumonia, antidepressant, postural hypotension, and cerebral infarction could increase the incidence and number of comorbidities. Meanwhile, dementia has shown the strongest association with each individual complication. Conclusions. Different combinations of comorbidity, medication use, and preventive measurements were related to the in-hospital complications of fall-related fractures. Dementia emerged as the most important risk factor for these complications, while most of the preventive measurements could not reduce their incidences.

scholarly journals Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records

RMD Open ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. e000700 ◽  
Author(s):  
Rebecca M Joseph ◽  
David W Ray ◽  
Brian Keevil ◽  
Tjeerd P van Staa ◽  
William G Dixon
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Electronic Health Records ◽  
Potential Risk ◽  
Salivary Cortisol ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health Records ◽  
Potential Risk Factors

BackgroundGlucocorticoids (GCs) suppress endogenous cortisol levels which can lead to adrenal insufficiency (AI). The frequency of GC-induced AI remains unclear. In this cross-sectional study, low morning salivary cortisol (MSC) levels were used as a measure of adrenal function. The study aim was to investigate the prevalence of low MSC in patients with rheumatoid arthritis (RA) currently and formerly exposed to oral GCs, and the association with potential risk factors.MethodsSample collection was nested within UK primary care electronic health records (from the Clinical Practice Research Datalink). Participants were patients with RA with at least one prescription for oral GCs in the past 2 years. Self-reported oral GC use was used to define current use and current dose; prescription data were used to define exposure duration. MSC was determined from saliva samples; 5 nmol/L was the cut-off for low MSC. The prevalence of low MSC was estimated, and logistic regression was used to assess the association with potential risk factors.Results66% of 38 current and 11 % of 38 former GC users had low MSC. Among former users with low MSC, the longest time since GC withdrawal was 6 months. Current GC dose, age and RA duration were significantly associated with increased risk of low MSC.ConclusionThe prevalence of low MSC among current GC users is high, and MSC levels may remain suppressed for several months after GC withdrawal. Clinicians should therefore consider the risk of suppressed cortisol and remain vigilant for symptoms of AI following GC withdrawal.

scholarly journals Rheumatoid Arthritis and its treatment: potential risk factors of osteonecrosis of the jaw besides bisphosphonates

2021 ◽  
Author(s):  
Carolina Teixeira Cidon ◽  
Thais Helena Bonini Gorayeb ◽  
Maria Eugênia Teixeira Bicalho ◽  
Renata Lys Pinheiro de Mello ◽  
Victor Caires Tadeu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Potential Risk ◽  
Osteonecrosis Of The Jaw ◽  
Potential Risk Factors

scholarly journals Prevalence, potential risk factors and mortality rates of acute respiratory distress syndrome in Chinese patients with sepsis

2020 ◽  
Vol 48 (2) ◽  
pp. 030006051989565 ◽  
Author(s):  
Shilei Li ◽  
Danna Zhao ◽  
Jie Cui ◽  
Lizeng Wang ◽  
Xiaohua Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Potential Risk ◽  
Distress Syndrome ◽  
Mortality Rates ◽  
Chinese Patients ◽  
Potential Risk Factors

Risk factors associated with ifosfamide (IFOS)-induced encephalopathy in patients (pts) with metastatic (Met) sarcoma (Sarc).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22518-e22518
Author(s):  
Adebayo Ogunniyi ◽  
Anjali Varma Desai ◽  
Troy Z Horvat ◽  
Li-Xuan Qin ◽  
Ping Chi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Albumin ◽  
Retrospective Analysis ◽  
Potential Risk ◽  
Odds Ratio ◽  
Serum Alkaline Phosphatase ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Potential Risk Factors ◽  
Low Serum

e22518 Background: IFOS is commonly used in the treatment of met sarc. IFOS has been reported to cause encephalopathy in 5 - 30% of pts. Potential risk factors for IFOS-induced encephalopathy (IIE) include female gender, older age, route of administration of IFOS, low serum albumin, existence of pelvic disease and renal failure. Unfortunately, the majority of the data surrounding potential risk factors is from heterogeneous cohorts. Methods: The purpose of this single-center retrospective analysis was to identify risk factors for developing IIE in a homogenous cohort of met sarc pts treated at MSKCC between 1/2010 and 5/2015. Logistic regression was used to examine the univariate effect of baseline and treatment variables. Variables significant at the 0.05 level were entered into a multivariate model. Results: A total of 328 met sarc pts with a median age of 51 years were analyzed. Thirty-four pts (10%) developed IIE. Of those 34 pts, 88% developed encephalopathy with the first or second cycle of IFOS. Age at the time of treatment (p = 0.0037), low serum albumin (p < 0.0001), increased serum alkaline phosphatase (p = 0.0022), liver met disease (p = 0.0011) and more than 3 met sites at time of IFOS dose (p = 0.0008) were all identified as risk factors by univariate analysis. Only low serum albumin (p < 0.0001, odds ratio = 0.33) and more than 3 met sites at time of IFOS dose (p = 0.0068, odds ratio = 2.47) maintained statistical significance after multivariate analysis. Conclusions: To our knowledge, this is the largest retrospective analysis of risk factors for IIE in the met sarc population. This analysis identified low serum albumin and more than 3 met sites at time of IFOS as predictors of IIE. Our data would suggest that clinicians considering the option of IFOS in met sarc pts should give particular attention to these predictive risk factors when making their treatment decisions.

scholarly journals Prevalence and risk factors of depression in Chinese patients with type 2 diabetes mellitus: a protocol of systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaobo Liu ◽  
Chao Dong ◽  
Hong Jiang ◽  
Dongling Zhong ◽  
Yuxi Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Systematic Review ◽  
Potential Risk ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Chinese Patients ◽  
Prevalence Of Depression ◽  
Potential Risk Factors

Abstract Background The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in patients with T2DM are essential and effective. Therefore, we plan to conduct a systematic review and meta-analysis to evaluate the prevalence of depression in Chinese patients with T2DM and explore potential risk factors of depression in T2DM. Methods We will search literatures recorded in MEDLINE, EMBASE, the Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and WanFang Database from their inception onwards. We will manually search gray literatures, reference lists of identified studies, relevant websites, and consult experts in this field. We will include population-based, cross-sectional surveys that investigated the prevalence of depression in Chinese patients with T2DM or/and the possible risk factors of depression in T2DM. Two reviewers will screen studies, extract data, and evaluate risk of bias independently. Agency for Healthcare Research and Quality methodology checklist will be used to assess the risk of bias. If feasible, we will conduct random effects meta-analysis of observational data to summarize the pooled prevalence, and use odds ratio for categorical data to explore potential risk factors. Prevalence estimates will be stratified according to age, gender, and other factors. Statistical heterogeneity will be estimated using Cochran’s Q and I2 index. We will conduct meta-regression to investigate the potential sources of heterogeneity, sensitivity analyses to assess robustness of the synthesized results, and funnel plots and Egger’s test to assess publication bias. Discussion This systematic review and meta-analysis will provide comprehensive evidence of the prevalence and potential risk factors of depression in Chinese patients with T2DM. We expect to provide evidence for healthcare practitioners and policy makers to pay attention to the mental health of patients with T2DM. Our data will highlight the need and importance of early detection and intervention for depression in patients with T2DM. Systematic review registration PROSPERO CRD42020182979.

Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

1990 ◽  
Vol 63 (01) ◽  
pp. 013-015 ◽  
Author(s):  
E J Johnson ◽  
C R M Prentice ◽  
L A Parapia
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Potential Risk ◽  
Antithrombin Iii ◽  
Arterial Disease ◽  
Coagulation System ◽  
Early Age ◽  
Arterial Thromboembolism ◽  
Potential Risk Factors ◽  
Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

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