Risk factors associated with ifosfamide (IFOS)-induced encephalopathy in patients (pts) with metastatic (Met) sarcoma (Sarc).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22518-e22518
Author(s):  
Adebayo Ogunniyi ◽  
Anjali Varma Desai ◽  
Troy Z Horvat ◽  
Li-Xuan Qin ◽  
Ping Chi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Albumin ◽  
Retrospective Analysis ◽  
Potential Risk ◽  
Odds Ratio ◽  
Serum Alkaline Phosphatase ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Potential Risk Factors ◽  
Low Serum

e22518 Background: IFOS is commonly used in the treatment of met sarc. IFOS has been reported to cause encephalopathy in 5 - 30% of pts. Potential risk factors for IFOS-induced encephalopathy (IIE) include female gender, older age, route of administration of IFOS, low serum albumin, existence of pelvic disease and renal failure. Unfortunately, the majority of the data surrounding potential risk factors is from heterogeneous cohorts. Methods: The purpose of this single-center retrospective analysis was to identify risk factors for developing IIE in a homogenous cohort of met sarc pts treated at MSKCC between 1/2010 and 5/2015. Logistic regression was used to examine the univariate effect of baseline and treatment variables. Variables significant at the 0.05 level were entered into a multivariate model. Results: A total of 328 met sarc pts with a median age of 51 years were analyzed. Thirty-four pts (10%) developed IIE. Of those 34 pts, 88% developed encephalopathy with the first or second cycle of IFOS. Age at the time of treatment (p = 0.0037), low serum albumin (p < 0.0001), increased serum alkaline phosphatase (p = 0.0022), liver met disease (p = 0.0011) and more than 3 met sites at time of IFOS dose (p = 0.0008) were all identified as risk factors by univariate analysis. Only low serum albumin (p < 0.0001, odds ratio = 0.33) and more than 3 met sites at time of IFOS dose (p = 0.0068, odds ratio = 2.47) maintained statistical significance after multivariate analysis. Conclusions: To our knowledge, this is the largest retrospective analysis of risk factors for IIE in the met sarc population. This analysis identified low serum albumin and more than 3 met sites at time of IFOS as predictors of IIE. Our data would suggest that clinicians considering the option of IFOS in met sarc pts should give particular attention to these predictive risk factors when making their treatment decisions.

Avascular osteonecrosis after hyperthermia in children and adolescents with pelvic malignancies: A retrospective analysis of potential risk factors

2006 ◽  
Vol 22 (6) ◽  
pp. 451-461 ◽  
Author(s):  
S. Balzer ◽  
D. T. Schneider ◽  
M. B. Bernbeck ◽  
M. Jäger ◽  
O. Mils ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Retrospective Analysis ◽  
Potential Risk ◽  
Avascular Osteonecrosis ◽  
Pelvic Malignancies ◽  
Potential Risk Factors

scholarly journals C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Carly L. Botheras ◽  
Steven J. Bowe ◽  
Raquel Cowan ◽  
Eugene Athan
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Potential Risk ◽  
Univariate Analysis ◽  
Foot Ulcer ◽  
Entry Point ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Risk Factors ◽  
Portal Of Entry

Abstract Background Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care. Methods In this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset S. aureus bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results. Results We identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161 mg/L on the day of admission were all significantly associated with complications. Conclusions We conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of S. aureus bacteraemia.

Risk factors for significant prostate cancer in radical cystoprostatectomy specimen: A retrospective analysis.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 136-136
Author(s):  
Andrea Katharina Thissen ◽  
Daniel Porres ◽  
David J. K. P. Pfister ◽  
Axel Heidenreich
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Bladder Cancer ◽  
Retrospective Analysis ◽  
Potential Risk ◽  
Common Finding ◽  
Considerable Proportion ◽  
Radical Cystoprostatectomy ◽  
Potential Risk Factors

136 Background: Prostate cancer (Pca) has been found incidentally in radical cystoprostatectomy (RCP) specimens in 27-70%. We evaluated histopathological features and clinical outcome of patients with incidental Pca undergoing RCP for urothelial bladder cancer and identified potential risk factors for the presence of significant Pca, being defined as Gleason Score ≥7b, primary tumor ≥T2c or Pca volume ≥0.5cm3. Methods: A retrospective analysis of patients who underwent RCP between 01/2005-03/2015 was performed with regard to clinical data and pathohistological features. Whole mount serial sections of specimens were examined in the same urological and pathological institution. Pca grade, p-stage, cancer volume and surgical margins were recorded. Preoperative PSA values and follow-up were analysed. Results: We identified 71 patients with incidental Pca with a mean age of 71.7 years (47-84 years). 33/71 patients (46.5%) had significant Pca (28.2% ≥T2c, 4.2% GS ≥7b [+≥T2c], 14.1% cancer volume ≥0.5cm3[+≥T2c]). Other features were as follows: pT2a, n=36 (50.7%); pT2b, n=2 (2.8%); GS 6, n=50 (70.4%); GS 7a, n=18 (25,3%). All patients were R0 and N0 for Pca. Mean preoperative PSA level was 2.7ng/ml. None of the patients developed biochemical recurrence (median follow-up: 29.5 [1-124 months]). Patients with significant Pca were older than those with insignificant Pca (median age 71.2 years vs 70.1 years) and had higher preoperative PSA levels: 90% of patients with a PSA level of 4-10ng/ml had a ≥T2c Pca, while 81.5% of patients with PSA levels of 0-1ng/ml had a pT2a Pca. P-stages in patients with PSA values between 1-4ng/ml were found to be equally distributed between pT2a-pT2c. Conclusions: The occurence of incidental Pca is a common finding in patients undergoing RCP, with a considerable proportion having the characteristics of significant Pca. Potential risk factors for significant Pca are older age and PSA levels >4ng/ml. However, none of the patients experienced biochemical relapse or Pca-related death during the follow-up. In line with published data, incidental Pca does not impact on the oncological outcome of patients undergoing RCP. The prognosis is primarily determined by bladder cancer.

scholarly journals The Risk Factors for Nosocomial Infection in Chinese Patients with Active Rheumatoid Arthritis in Shanghai

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Wei-Lin Xie ◽  
Zhuo-Ling Li ◽  
Zhen Xu ◽  
Huan-Ru Qu ◽  
Luan Xue ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Serum Albumin ◽  
Potential Risk ◽  
Active Rheumatoid Arthritis ◽  
Chinese Patients ◽  
Reactive Protein ◽  
Cell Counts ◽  
Potential Risk Factors ◽  
White Blood Cell Counts

Objective. To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods. A total of 2452 active RA patients at Hospitals in Shanghai between January 2009 and February 2011 were analyzed. Their demographic and clinical characteristics were compared with those without infection, and the potential risk factors were determined by logistic regression analysis. Results. Multivariate analysis indicated the gender (OR=0.70, 95% CI 0.53–0.92), duration in hospital (OR=1.03, 95%CI 1.01–1.05), number of organs involved (OR=0.82, 95%CI 0.72–0.92), number of disease-modifying antirheumatic drugs ((DMARDs) (OR=1.22, 95%CI 1.061–1.40)), corticosteroid therapy (OR=1.02, 95%CI 1.01–1.03), peripheral white blood cell counts ((WBC) (OR=1.04, 95%CI 1.00–1.08)), levels of serum albumin (OR=0.98, 95%CI 0.97–0.99), and C-reactive protein ((CRP) (OR=1.03, 95%CI 1.01–1.04)) that were significantly associated with the risk of infections. Conclusion. The female patients, longer hospital stay, more organs involved, more DMARDs, corticosteroid usage, high counts of WBC, lower serum albumin, and higher serum CRP were independent risk factors of infections in active RA patients.

scholarly journals 2013. Blood Culture Contamination in the Emergency Department: A Risk Factor Analysis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S675-S676
Author(s):  
Justin Klucher ◽  
Mrinmayee Lakkad ◽  
Jacob Painter ◽  
Ryan K Dare
Keyword(s):  
Risk Factors ◽  
Emergency Department ◽  
Factor Analysis ◽  
Risk Factor ◽  
High Risk ◽  
Potential Risk ◽  
False Positive ◽  
Univariate Analysis ◽  
Sterile Technique ◽  
Potential Risk Factors

Abstract Background Blood cultures (BCx) guide treatment for hospitalized patients, yet contaminated BCx lead to clinical uncertainty, impacting care. The Clinical and Laboratory Standards Institute (CLSI) recommends contamination rates should be <3%, yet our Emergency Department (ED) rate is consistently above this benchmark. Reasons for this are unclear, thus it is imperative to investigate potential risk factors for BCx contamination. Methods We performed a retrospective case–control risk factor analysis of patients with BCx collected in our ED between 2014 and 2018. Contaminated BCx were identified by the microbiology laboratory per American Society of Microbiology recommendations. Demographics, comorbidities, and clinical characteristics were evaluated in patients with false-positive/contaminated BCx (cases) and patients with negative BCx (controls). Potential risk factors identified in univariate analysis were included in a logistic regression model. Unadjusted and adjusted analyses were performed using SAS 9.4. Results 25,668 BCx from 13,782 patients were included in analysis. 20,907 BCx from 11,266 (82%) patients were negative, 2,856 BCx from 1,504 (11%) patients were true positives, and 1,905 BCx from 1,012 (7%) patients were contaminated. Yearly ED contamination rates ranged from 5.0–9.3%. Collector contamination rates varied, though 38 (19%), 75 (35%), and 7 (3%) of 209 collectors had a contamination rate <3%, ≥ 10%, and ≥ 20%, respectively. Significant patient-specific risk factors identified in univariate analysis are listed in the attached table along with adjusted analysis. Conclusion In our analysis, we identified that older age, African American race, higher BMI, COPD, paralysis, and presenting in septic shock independently increases risk of having a contaminated BCx. Difficulty obtaining venipuncture in patients with these risk factors, often requiring multiple collection attempts, likely leads to decreased sterile technique. It is imperative to have a process assuring sterile technique in these high-risk individuals to minimize consequences associated with having a false-positive BCx result in these high-risk patients. Additionally, variable collector contamination rates seen in this study highlight the necessity for frequent technique in-service training. Disclosures All authors: No reported disclosures.

scholarly journals A prospective interventional study investigating sleep disorders prior to and during adjuvant radiotherapy for breast cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dirk Rades ◽  
Carlos A. Narvaez ◽  
Liesa Dziggel ◽  
Stefan Janssen ◽  
Denise Olbrich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Sleep Disorders ◽  
Potential Risk ◽  
Adjuvant Radiotherapy ◽  
Rating Scale ◽  
Statistical Significance ◽  
Link Type ◽  
Self Rating ◽  
Potential Risk Factors

Abstract Background Most breast cancer patients with non-metastatic disease receive adjuvant local or loco-regional radiotherapy. To be scheduled for irradiation may cause distress and fears that can lead to sleep disorders. Few reports focused on sleep problems in patients assigned to radiotherapy. This study evaluates the course of sleep disorders during adjuvant radiotherapy for primary breast cancer and potential risk factors including the use of smartphones or tablets at bedtime. Methods The main goal is the evaluation of sleep disorders prior to radiotherapy and after 15 fractions of radiotherapy. A potential effect of habituation to the procedure of radiotherapy can be assumed that will likely lead to improvement (decrease) of sleep disorders. Improvement of sleep disorders (compared to baseline before radiotherapy) is defined as decrease of the severity of sleep disorders by ≥2 points on a patient self-rating scale (0 = no problems; 10 = maximum problems) or decrease of distress caused by sleep disorders by ≥2 points on a self-rating scale (0 = no distress; 10 = maximum distress) or reduction of the dose of sleeping drugs by ≥25%. Additional endpoints include sleep disorders after 5 fractions and at the end of radiotherapy. Moreover, potential risk factors including the use of smartphones or tablets at bedtime are evaluated. Fifty-one patients (48 plus potential drop-outs) are required. With this sample size, a one-sample binomial test with a one-sided significance level of 2.5% has a power of 80% to yield statistical significance, if the rate of patients with improvement of sleep disorders is 25% (rate under the alternative hypothesis) and assuming that a decrease of ≤10% has to be judged as a random, non-causal change in this uncontrolled study setting (null hypothesis). Discussion If a decrease of sleep disorders during the course of radiotherapy is shown, this aspect should be included in the pre-radiotherapy consent discussion with the patients. Moreover, identification of additional risk factors will likely lead to earlier psychological support. If the use of smartphones or tablets at bedtime is a risk factor, patients should be advised to change this behavior. Trial registration clinicaltrials.gov (NCT04879264; URL: https://clinicaltrials.gov/show/NCT04879264); registered on 7th of May, 2021.

Potential Risk Factors and Prognostic Evaluation of Malignant Changes Following Congenital Choledochal Cyst: a Retrospective Analysis

2020 ◽  
Vol 82 (5) ◽  
pp. 835-840
Author(s):  
Huaqin Guan ◽  
Renpin Chen ◽  
Dan Li ◽  
Rukhsaar Hoosen ◽  
Saili Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Analysis ◽  
Choledochal Cyst ◽  
Potential Risk ◽  
Prognostic Evaluation ◽  
Congenital Choledochal Cyst ◽  
Potential Risk Factors ◽  
Malignant Changes

scholarly journals Prevalence and Risk Factors of Repeat Breeding in Commercial Dairy Farms of Chittagong District of Bangladesh

2016 ◽  
pp. 21-27
Author(s):  
BK Nath ◽  
BC Das ◽  
MS Bari ◽  
MA Rahman
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Univariate Analysis ◽  
Dairy Farms ◽  
Economic Loss ◽  
Farm Level ◽  
Bacillus Spp ◽  
Potential Risk Factors ◽  
Staphylococcus Spp ◽  
Antibiotic Agents

The study was conducted to measure the prevalence of repeat breeding cows and to identify the potential risk factors of Repeat breeding syndrome in commercial dairy farms at Chittagong of Bangladesh during July 2011 to October 2012. A total of 15 government registered dairy farms having 283 cows were surveyed for individual and farm level variables identified using preset questionnaire. Out of them 56 dairy cows was sampled for bacteriological exploration and culture sensitivity test. Overall prevalence of repeat breeder cow in commercial dairying of Chittagong was 11.3%. The univariate analysis screened potential cow level exposure high yielding cows (p=0.02) and cows having peripartum events (dystocia) in last calving (p=0.001). Among farm level exposures, owner educational level (p=0.05), nature of feed offer at farm (p=0.06) were evident to be potential screened factors for repeat breeding. From the 32 repeat breeders, Staphylococcus spp. 13 (40.6%) was isolated as predominant bacteria followed by Escherichia coli 8 (25%), Bacillus spp 6 (18.8%), Corynebacterium spp 6 (18.8%) and Pseudomonas spp 5 (15.6%). The isolates of bacteria were more or less effective against eight antibiotic agents. Gentamicin 36 (97.3%) showed higher sensitivity followed by ceftriaxone 33 (89.2%), chloramphenicol 33 (89.2%) indicates the effectiveness of these antibiotics in treating repeat breeding. Moreover, the identified potential risk factors should be controlled to minimize the economic loss of dairy farms.International Journal of Natural Sciences (2014), 4(1) 21-27

scholarly journals Serotype diversity and slaughterhouse-level risk factors related to Salmonella contamination on poultry carcasses in Algiers

2019 ◽  
Vol 13 (05) ◽  
pp. 384-393 ◽  
Author(s):  
Lynda Mezali ◽  
Faiza Mebkhout ◽  
Siham Nouichi ◽  
Sofiane Boudjellaba ◽  
Taha-Mossadak Hamdi
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Broiler Chickens ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Poultry Meat ◽  
Small Scale ◽  
Cross Sectional ◽  
High Prevalence ◽  
Potential Risk Factors

Introduction: In Algeria, the latest studies on Salmonella demonstrated warning contamination rates in farms and slaughterhouses. This pathogen can contaminate poultry meat and put humans at risk especially that such product is nowadays widely consumed. Methodology: a cross-sectional study was conducted in Algiers to evaluate prevalence, determine serotypes and quantify risk for Salmonella contamination in broiler chickens and turkeys at the post-chill stage of slaughter process. Results: batch prevalence was 63.1% for chickens and 34.9% for turkeys. Eleven serotypes were isolated from chickens and five from turkeys. The most predominant at both sample and batch levels was S. Kentucky either in chicken (65.1%) or in turkey carcasses (63.2%). Univariate analysis screened 3 variables for chickens and 5 variables for turkeys. Final multivariate regression models provided one potential risk factor for Salmonella contamination in each poultry species. Presence of less than 6 broilers simultaneously in the traditional scalding tank of small scale slaughterhouses had a significantly reduced contamination risk (OR = 0.31; p < 0.05). Slaughtering turkeys in sites processing only this specie than in mixed poultry slaughterhouses increased significantly the contamination probability (OR = 4.44; p < 0.05). Conclusions: Our study indicates a high prevalence of Salmonella-contaminated poultry carcass with wide diversity of serotypes. Moreover, two potential risk factors identified for the first time in Algeria are found to be associated with the lack in hygienic management on production sites. A real threat for consumers exists highlighting the imperative need for improved safety throughout the local poultry meat supply chain.

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