scholarly journals Chloropyramine and Ranitidine as a combination of H1 and H2- antihistamines in the additive therapy of anaphylaxis

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Hajriz Alihodžić ◽  
Devleta Hadžić ◽  
Nada Mladina
Keyword(s):  
Diastolic Pressure ◽  
Cardiovascular Effects ◽  
Control Group ◽  
Rapid Progression ◽  
Prehospital Treatment ◽  
Arterial Blood ◽  
H1 Antihistamines ◽  
Life Threatening ◽  
Third Line ◽  
Experimental Group

Introduction: Current international guidelines recommend H1 and H2- antihistamines as a second or third- line drugs for the management of anaphylaxis. Aim: To present positive cardiovascular and dermatological effects of Chloropyramine and Ranitidine as the combination of H1 and H2- antihistamines in additive therapy of anaphylaxis. Patients and methods: In a retrospective study two groups of 146 patients who met the NIAID/FAAN criteria for the diagnosis of anaphylaxis were compared. Experimental group consisted of 62 patients who received combination of Chloropyramine H1- antihistamines and Ranitidine H2- antihistamines. Control group consisted of 84 patients who received only Chloropyramine H1- antihistamines. Results: A statistically significant differences of diastolic pressure and central pulse (p< 0.001), a higher values of diastolic pressure, and a lower values of central pulse in the experimental group of patients were recorded at the end of the prehospital treatment of anaphylaxis. The increase in the mean arterial blood pressure at the end of the treatment is higher in the experimental group compared to the initial values, with an average difference of 15 mmHg (%95 CI= 7,95-21,95). Total prehospital time and time recovery of the skin urticaria and itch was shorter in the experimental group for 18 minutes (95% CI= 11,95-25,95). Conclusion: Positive cardiovascular effects and a faster resolving of the skin symptoms justify the use of combination Chloropyramine and Ranitidine as an additive therapy of anaphylaxis that is not life- threatening, and of a rapid progression.

scholarly journals Effect of deep breathing exercises and incentive spirometry on respiratory distress scoring in second degree inhalational burn patients.

2019 ◽  
Vol 2 (1) ◽  
pp. 13-16
Author(s):  
Summiya Siddique Malik ◽  
Sadaf Saeed ◽  
Sumaira Kanwal
Keyword(s):  
Respiratory Distress ◽  
Vital Signs ◽  
Blood Gases ◽  
Sampling Technique ◽  
Control Group ◽  
Deep Breathing ◽  
Breathing Exercises ◽  
Arterial Blood ◽  
Experimental Group ◽  
Second Degree

Objective: Study was conducted for 6 months in PIMS Hospital Islamabad. Data was collected on self-structured Questionnaire, Respiratory distress scoring, Objective tools of Arterial blood gases and vital signs with signed consent. Methodology: The subjects were randomly allocated in experimental and control groups. Baseline data was collected and re-collected on Day 0 and Day 7 respectively and assessed using non-probability convenient sampling technique. Both groups were given standard medical and nursing care. Results: The experimental group was given single treatment regimen i.e. Deep breathing exercises (with 5-10 repetitions of each DBE being possible onto patient for 15-30 minutes twice daily). The control group was given 10-15 cycles of ISM with prior steam inhalation and nebulization with salbutamol for a period of 15-20 minutes for 35-45 minutes twice daily for a period of 07 days. Conclusion: The experimental group results show that deep breathing exercises are significantly effective in improving post burn complications like pneumonia in patients suffering from second degree inhalation burns.

scholarly journals High sodium intake during postnatal phases induces an increase in arterial blood pressure in adult rats

2014 ◽  
Vol 112 (12) ◽  
pp. 1923-1932 ◽  
Author(s):  
M. C. S. Moreira ◽  
E. F. da Silva ◽  
L. L. Silveira ◽  
Y. B. de Paiva ◽  
C. H. de Castro ◽  
...  
Keyword(s):  
Sodium Intake ◽  
Tap Water ◽  
Recovery Period ◽  
Control Group ◽  
Adult Rats ◽  
High Sodium ◽  
Arterial Blood ◽  
Hypertension Development ◽  
Lower Magnitude ◽  
Experimental Group

Epigenetic studies suggest that diseases that develop in adulthood are related to certain conditions to which the individual is exposed during the initial stages of life. Experimental evidence has demonstrated that offspring born to mothers maintained on high-Na diets during pregnancy have higher mean arterial pressure (MAP) in adulthood. Although these studies have demonstrated the importance of prenatal phases to hypertension development, no evidence regarding the role of high Na intake during postnatal phases in the development of this pathology has been reported. Therefore, in the present study, the effects of Na overload during childhood on induced water and Na intakes and on cardiovascular parameters in adulthood were evaluated. Experiments were carried out in two groups of 21-d-old rats: experimental group, maintained on hypertonic saline (0·3 m-NaCl) solution and food for 60 d, and control group, maintained on tap water and food. Later, both groups were given water and food for 15 d (recovery period). After the recovery period, chronic cannulation of the right femoral artery was performed in unanaesthetised rats to record baseline MAP and heart rate (HR). The experimental group was found to have increased basal MAP (98·6 (sem 2·6) v. 118·3 (sem 2·7) mmHg, P< 0·05) and HR (365·4 (sem 12·2) v. 398·2 (sem 7·5) beats per min, P< 0·05). There was a decrease in the baroreflex index in the experimental group when compared with that in the control group. A water and Na intake test was performed using furosemide. Na depletion was found to induce an increase in Na intake in both the control and experimental groups (12·1 (sem 0·6) ml and 7·8 (sem 1·1), respectively, P< 0·05); however, this increase was of lower magnitude in the experimental group. These results demonstrate that postnatal Na overload alters behavioural and cardiovascular regulation in adulthood.

scholarly journals PENGARUH MASSAGE AROMATHERAPHY LAVENDER TERHADAP PERUBAHAN TEKANAN DARAH PADA IBU HAMIL DENGAN PREEKLAMPSIA DI PBM. LILIS SURYAWATI DESA SAMBONG DUKUH KECAMATAN JOMBANG KABUPATEN JOMBANG

2019 ◽  
Vol 5 (2) ◽  
pp. 27-34
Author(s):  
Any Isro'aini
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Diastolic Pressure ◽  
Blood Pressure Reduction ◽  
Systolic Pressure ◽  
Pharmacological Therapy ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
Experimental Group

Hypertension in preeclampsia is found in pregnant women with gestational age> 20 weeks. Hypertension is defined where systolic pressure above 140 mmHg and diastolic pressure above 90 mmHg. Handling hypertension in pregnant women up to now is still using pharmacological therapy or drugs by 100%. One nonpharmacological therapy that can lower blood pressure is aromatherapy lavender massage therapy. The purpose of this study was to determine the effect of lavender aromatherapy massage on blood pressure reduction in pregnant women with preeclampsia.The design of this study used the Quasy Experiment Design with the Control Time Series Design research design, where the study used two groups divided into experimental groups and control groups. In this study both groups were pre-tested and after being given treatment in the experimental group a post-test was carried out in both groups. The research sample amounted to 50 respondents, of which 25 respondents became the experimental group and 25 became the control group. This research took place at PBM. Lilis Suryawati, Sambong village, Dukuh, Jombang District, Jombang Regency. This research was conducted from February to April 201.                    The results showed a significant difference between the blood pressure of the experimental group who were treated and the control group that was not treated. The systolic blood pressure of both groups p-value 0.003 and the value of Z -4.007. While diastolic blood pressure in both groups p-value 0,000 and Z value -5,559.                    It is expected that the midwifery profession can provide information about the importance of aromatherapy lavender massage to reduce blood pressure in pregnant women with preeclampsia, so that it can minimize the occurrence of complications in pregnant women with preeclampsia.

scholarly journals A prospective study of N-acetylcysteine treatment in drug-induced fulminant hepatic failure

2019 ◽  
Vol 8 (5) ◽  
pp. 1000
Author(s):  
Tauseef Nabi ◽  
Nadeema Rafiq ◽  
Quratul Ain Arifa
Keyword(s):  
Length Of Hospital Stay ◽  
Signs And Symptoms ◽  
Control Group ◽  
Rapid Progression ◽  
Drug Induced ◽  
Life Threatening ◽  
Baseline Characteristics ◽  
A Prospective Study ◽  
Tuberculosis Therapy ◽  
Control Study

Background: Acute liver failure (ALF) is a rare but severe, life-threatening, complex, multisystemic gastroenterological emergency. Its rapid progression and high mortality demand early diagnosis and expert management. Drug-induced ALF (DI-ALF) remains the uncommon cause of ALF in India. To date, there is no established treatment for DI-ALF other than liver transplantation and little is known about the use of N-acetylcysteine (NAC) in DI-ALF. A prospective case-control study was carried with the aim to determine the effect of NAC on mortality of DI-FHF patients and also to evaluate the safety and efficacy of NAC use.Methods: A total of 18 patients with a diagnosis of DI-FHF were included in the study. 10 patients received NAC infusion for 72 hours whereas the control group received placebo. The variables evaluated were demographic, signs and symptoms, biochemical parameters, outcome and length of hospital stay.Results: Out of 18 DI-FHF patients, 13 (72.2%) had anti-tuberculosis therapy (ATT) induced FHF and 5 (27.8%) patients had ayurvedic induced FHF. The two groups were comparable for the various baseline characteristics (age, INR, alanine aminotransferase, creatinine, albumin, grade of encephalopathy, etc.). The mortality decreased to 20% with the use of NAC versus 75% in the control group (P=0.023). Use of NAC was associated with a shorter length of hospital stay of survived patients (P=0.043). Moreover, the overall survival was improved by NAC (P=0.023) in DI-FHF. ATT induced FHF showed better outcome as compared to ayurvedic induced FHF use (P=0.019).Conclusions: Author recommended the use of NAC along with conventional treatments in patients with DI-FHF in non-transplant centers while awaiting referrals. ATT induced FHF showed better outcome as compared to ayurvedic induced FHF with NAC administration and its use was safe.

scholarly journals Observation on the Nursing Effect of Prone Position Ventilation Applied to Children with Respiratory Failure

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Aili Peng ◽  
Litao Guo ◽  
Jing Xu ◽  
Jingrong Fan
Keyword(s):  
Carbon Dioxide ◽  
Respiratory Failure ◽  
Partial Pressure ◽  
Prone Position ◽  
Pediatric Patients ◽  
Oxygenation Index ◽  
Control Group ◽  
Arterial Partial Pressure ◽  
Arterial Blood ◽  
Experimental Group

Objective — To compare the effects of two prone position ventilation methods on children with respiratory failure, to obtain a safer and more effective way to guide clinical nursing work. Methods — 48 cases of children who were admitted to the intensive care unit of our hospital from February 2018 to August 2019 and applied mechanical ventilation were divided into groups based on a random number table. The odd numbers were included in the experimental group (continuous prone position ventilation group, the duration of continuous prone position exceeded 12 hours, a total of 25 cases). The even numbers were included in the control group (intermittent prone position ventilation group, prone position for 3 hours at a time, alternating with supine position and lateral position, total prone position duration 12 hours, a total of 23 cases). Oxygenation index (OI), PH value, arterial partial pressure of carbon dioxide (PCO2), arterial partial pressure of oxygen (PO2) at 24h, 48h, 72h of the two groups of children, as well as their ventilator use time and ICU hospital stay were compared. Results — Continuous prone position ventilation and intermittent prone position ventilation have no statistical significance on arterial blood carbon dioxide partial pressure (PaCO2), arterial blood oxygen partial pressure (PaO2), ventilator duration, ICU length of stay in children with respiratory failure (P>0.05), but with the increase of the total length of the prone position, when reaching more than 36 hours, the trend of oxygenation index (OI) of the experimental group and the control group can be seen to decline.  Conclusion — In this study, by comparing the effects of two prone position ventilation modes, it was found that intermittent prone position ventilation and continuous prone position ventilation had no difference in the treatment of children with respiratory failure. When children are treated in continuous prone and intermittent prone positions, the total prone position can last up to 36 hours, which can effectively improve the clinical treatment effect. In view of the characteristics of pediatric patients and the difficulty in nursing critically ill patients with tracheal intubation, it is recommended that pediatric patients can use intermittent prone ventilation to complete treatment when the cumulative time in the prone position reaches more than 36 hours.

scholarly journals A Study on the Efficacy and Safety of a New Endoscopic Nasal Mask for Intravenous Anaesthesia With Respiratory Retention: a Randomized Controlled Trial

2021 ◽  
Author(s):  
Bin Yu ◽  
Mengying Wang ◽  
Xinyu Cheng ◽  
Haiyue Ma ◽  
Shuqi Xie
Keyword(s):  
Blood Gas Analysis ◽  
Day Surgery ◽  
Assisted Ventilation ◽  
Gas Analysis ◽  
Control Group ◽  
Nasal Mask ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Arterial Blood Gas Analysis ◽  
Experimental Group

Abstract Background: General anaesthesia is the most common choice for day surgery, and a laryngeal mask airway is the most commonly used airway management method in general anaesthesia. Many of the complications of laryngeal mask airways are not conducive to a rapid recovery and discharge. The main purpose of this study was to verify the effectiveness and safety of a new endoscopic nasal mask for anaesthesia for a short surgery.Methods: This is a randomized controlled study of 96 patients who were scheduled to undergo hysteroscopy, breast mass resection or great saphenous vein lesion resection. They were randomly divided into two groups. After entering the operating room, 48 patients in the control group were treated with LMA-assisted ventilation, and 48 patients in the experimental group were subjected to assisted ventilation with the new endoscopic nasal mask. Both groups were given dexmedetomidine combined with sufentanil, propofol, dexamethasone, parecoxib sodium, dezocine and ramosetron to complete the intravenous general anaesthesia.The main observation indexes included the occurrence of hypoxemia (SpO2<90%) after anaesthesia induction; the occurrence of hypercapnia (PetCO2>50 mmHg) due to respiratory depression and changes in the PaO2 and PaCO2 values in the arterial blood gas analysis (ABG) results.Results: The occurrence of hypoxemia (SPO2<90%) in the experimental group and the control group was not significantly different (P>0.05). The occurrence of hypercapnia (PetCO2>50 mmHg) in the experimental group was significantly reduced compared to that in the control group (P<0.05), and the difference was statistically significant. According to the results of the preoperative and postoperative arterial blood gas analysis, there was no statistically significant difference in PaO2 and PaCO2 between the two groups (P>0.05). Conclusion: Both methods are safe and effective for anaesthesia during a short operation. The new endoscopic nasal mask can quickly and effectively provide effective ventilation . It is convenient for anaesthesia airway management for clinical short day surgery.Trial registration: Trial Registration: www.chictr.org.cn; registration no.: ChiCTR2000032548; date of registration: 3rd May 2020

scholarly journals Are Physiological Changes Experienced by Healthy Subjects during Acu-Tens Associated with Acupuncture Point Sensations?

2014 ◽  
Vol 32 (1) ◽  
pp. 28-36 ◽  
Author(s):  
David T W Yu ◽  
Alice Y M Jones
Keyword(s):  
Placebo Group ◽  
Healthy Subjects ◽  
Massachusetts General Hospital ◽  
Physiological Responses ◽  
Acupuncture Point ◽  
Control Group ◽  
Acupuncture Points ◽  
Physiological Changes ◽  
Arterial Blood ◽  
Experimental Group

Background Transcutaneous electrical nerve stimulation over acupuncture points (acu-TENS) has been reported to improve clinical outcomes. The objectives of the present study were to investigate whether acupuncture point sensations were experienced during acu-TENS, and whether such sensations were associated with any concomitant changes in autonomic nervous system activity. Methods This study adopted a single-blinded, randomised, controlled trial methodology. A total of 36 healthy subjects were randomly assigned to an experimental group (acu-TENS on right LI4 and LI11 points); control group (acu-TENS to bilateral kneecaps); or placebo group (sham acu-TENS on right LI4 and LI11 points). Heart rate (HR), mean arterial blood pressure (MAP), SD of the NN interval (SDNN) and low frequency to high frequency ratio (LF/HF) were measured before, during and after intervention. The Hong Kong Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale (C-MMASS) index was used for quantifying the acupuncture point stimulation sensations. Results The experimental group showed a significant increase in HR (mean (SD) 73.5 (6.3) to 75.9 (6.7) bpm, p=0.027), MAP (88.5 (4.5) to 91.0 (4.1) mm Hg, p=0.004), SDNN (143.36 (8.58) to 153.69 (7.64) ms, p=0.002) and LF/HF (1.26 (0.19) to 1.31 (0.21), p=0.037) during the intervention. The control group showed a significant increase in SDNN (140.21 (8.72) to 143.39 (9.47) ms, p=0.009) and LF/HF (1.21 (0.09) to 1.23 (0.12), p=0.033). There were no significant physiological changes in the placebo group. Overall C-MMASS indices for the experimental, control and placebo groups were 3.23 (0.3), 2.14 (0.6) and 0.29 (0.32), respectively. The between-group difference was statistically significant (F=139.24, df=2, p<0.05). However, correlation analysis did not support any association between sensation intensity and physiological responses in any groups (γ ranged from −0.36 to 0.25). Conclusions This study showed that ‘acupuncture point sensations’ were experienced during acu-TENS to LI4 and LI11, but such sensations were not associated with physiological responses induced during the stimulation.

An ATP-sensitive potassium channel blocker decreases diaphragmatic circulation in anesthetized dogs

1994 ◽  
Vol 77 (1) ◽  
pp. 127-134 ◽  
Author(s):  
A. Comtois ◽  
C. Sinderby ◽  
N. Comtois ◽  
A. Grassino ◽  
J. M. Renaud
Keyword(s):  
Blood Flow ◽  
Phrenic Nerve ◽  
Spontaneous Breathing ◽  
Arterial Blood Flow ◽  
Control Group ◽  
Transdiaphragmatic Pressure ◽  
K Channels ◽  
Arterial Blood ◽  
Tension Time ◽  
Experimental Group

The goal of this study was to determine whether in the dog ATP-sensitive K+ channels blocked with glibenclamide affect diaphragmatic blood flow [phrenic arterial blood flow (Qpa)] during both spontaneous breathing at rest and increased diaphragmatic activity. A control group (no glibenclamide; n = 4) and an experimental group (50 mg/kg of glibenclamide; n = 5) were studied. During spontaneous breathing at rest, Qpa was 15.0 ml.min-1 x 100 g-1 and decreased by 5% in the presence of glibenclamide. Diaphragmatic pacing (30 min-1) generated by phrenic nerve pacing produced an initial diaphragmatic tension-time index of 0.25 in both groups. A 50% decay in transdiaphragmatic pressure was reached at 165 s in the experimental group compared with 421 s in the control group. Diaphragmatic pacing increased Qpa by 46% in the experimental group and 65% in the control group, yielding a 63% greater vascular resistance in the experimental group. Phrenic vein K+ content at rest was unchanged by the presence of glibenclamide, being 3.6 +/- 0.16 mmol/l compared with 3.5 +/- 0.19 mmol/l in the control group. Phrenic nerve pacing in the control group produced a 13% increase in phrenic vein K+ content, whereas in the experimental group a 16% decrease was observed. We suggest that ATP-sensitive K+ channels play an important role in the modulation of Qpa.

BIOMECHANICAL, PHYSIOLOGICAL AND AGE-RELATED FEATURES OF PERSONIFICATION AND INDIVIDUALIZATION DURING QUICKNESS AND SPEED-STRENGTH QUALITIES ENHANCEMENT IN YOUNG WEIGHTLIFTERS

2019 ◽  
Vol 19 (3) ◽  
pp. 28-35 ◽  
Author(s):  
A Isaev ◽  
R Khomenko ◽  
A Nenasheva ◽  
A Shevtsov ◽  
A Batueva
Keyword(s):  
Blood Flow ◽  
Body Composition ◽  
Stroke Volume ◽  
Performance Enhancement ◽  
Diagnostic System ◽  
The Body ◽  
Control Group ◽  
Arterial Blood ◽  
Age Related ◽  
Experimental Group

Aim. The article deals with studying biomechanical, physiological, and age-related features in young weightlifters during quickness and speed-strength qualities enhancement. Materials and methods. The study was conducted at the precompetitive stage of preparation. Weightlifters aged 14–15 and 16–17 years (n = 15) participated in the experiment. Body composition was studied with the Tanita BC-418AA computer analyzer. The spatial characteristics of spine segments were investigated with the help of the MBN-Scanner computer equipment. Postural studies were conducted with the stabilometric systems produced by MBN Russia. Blood flow spectral analysis was performed using impedance rheography (the Centaur diagnostic system). Results. The body composition of young weightlifters was varied in the following range: muscle mass – 52.4–53.9%, fat mass – 9.0–10.2%. BMI was equal 25.64 kg/m2. The data of the orthostatic test in young weightlifters revealed significant changes in HR, total spectrum power (TSP), and stroke volume regulation (SV) in the experimental group (p < 0.05). In the control group, HR changes were higher than in the experimental group. In 50% of athletes from the groups of sports performance enhancement, eukinetic blood flow was revealed, in 32% – hypokinetic, and in 18% – hypertonic. After a year of training, a consistent increase in stroke volume (SV) was registered, as well as a decrease in HR, peripheral vascular resistance (PVR), heart index, and arterial blood pressure. Conclusion. The control system allows revealing in time the problems connected with weightlifters’ preparation, offering rehabilitation measures, and transforming the training process itself (its orientation, volume, intensity) to optimize body functioning in young weightlifters.

Evaluation of the Effectiveness of a Youth Leadership Class in the Prevention of Depression in Adolescents

2001 ◽  
Vol 17 (4) ◽  
pp. 204-209 ◽  
Author(s):  
Jacqueline Oria ◽  
Virginia Young Cureton ◽  
Daryl Canham
Keyword(s):  
Adolescent Depression ◽  
Youth Leadership ◽  
Control Group ◽  
Control Group Design ◽  
8Th Grade ◽  
Equivalent Control ◽  
Life Threatening ◽  
Leadership Class ◽  
Experimental Group ◽  
Larger Sample

Depression in adolescence is a common and potentially life-threatening health problem. The purpose of this study was to evaluate the effects of prevention strategies on decreasing the rate of depression in adolescents. A class addressing specific skills identified as having an impact on adolescent depression was taught to youth participating in the program. The non-equivalent control group design was used. The sample consisted of 7th- and 8th-grade students in either the Youth Leadership class or a computer class of a California middle school. The Childhood Depression Inventory was the instrument used. Nine control group subjects and 11 experimental group subjects completed both the pretest and the posttest. The analysis of the data revealed no statistically significant differences between the control and experimental groups. This study should be repeated with larger sample sizes and with greater attention to the timing of pretests and posttests.

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