Gender-related incidence, risk factors exposure and survival rates of laryngeal cancers – the 10-years analysis of trends from one institution

Objectives: The aim of the study was the analysis of the epidemiology of laryngeal cancer over 10 years in relation to known risk factors and to assess the current survival rates in this group of patients. Methods: The data were retrospectively collected from patients’ medical records, then entered in the database using dedicated software and a statistical analysis was performed. Results: 512 subjects - 443 men (86.5%) and 69 women (13.5%) were enrolled into the study. The male-to-female ratio was 6.4:1. There were 97.1% smoking women and 98% smoking men, however the history of more than 20 cigarettes per day smoking admitted 81.1 % of women and 94.6% of men. Heavy alcohol consumption was the case in 14 (20.3%) women and in 307 (69.3%) men. For both the size of heavy alcohol consumption and the size of excessive tobacco use, there was found statistically significant difference between women and men with laryngeal cancer (p<0.05). In the majority of male and female subjects, the tumour was located in the supraglottis/glottis area. Apparently this tumour location was much more common among women, accounting for 60.9% of cases , while in men was confirmed in 39.3% of cases. The stages of the laryngeal cancer were similarly of high advancement for both the men and women - stages III and IV were confirmed in 82.6% of women and in 77.6% of men. The over 5-year survival rate was 39.1% among women and 37.2% among men. Conclusions Contradictory to decreased exposure to risk factors and the shorter period for diagnosis, the higher stages of cancer were observed in women. Although in women the advancement was higher and the majority of cases were located in unfavourable supraglottic area, the survival rates were higher. Key words: laryngeal cancer, epidemiology, men and women, risk factors

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Laryngeal Cancer Attributable Factors and the Influence on Survival Rates: A Single Brazilian Institution Experience

International Archives of Otorhinolaryngology ◽

10.1055/s-0039-1687909 ◽

2019 ◽

Vol 23 (03) ◽

pp. e299-e304

Author(s):

Lara Maria Alencar Ramos Innocentini ◽

Alisson Henrique Teixeira ◽

Luciana Assirati Casemiro ◽

Matheus Carrijo Andrade ◽

Tatiane Cristina Ferrari ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Consumption ◽

Laryngeal Cancer ◽

Smoking Habit ◽

Tertiary Care ◽

Survival Rates ◽

Disease Free Survival ◽

Care Hospital ◽

Disease Evolution ◽

Risk Of Death

Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19–81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.

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A Dose-Response Meta-Analysis on the Association Between Alcohol Consumption and Incidence of Atrial Fibrillation

10.21203/rs.3.rs-89496/v1 ◽

2020 ◽

Author(s):

Haifu Zhang ◽

Qinxia Zhang ◽

Dong Yang ◽

Zhao Xu ◽

Xingwei Zhang

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Dose Response ◽

Meta Analysis ◽

Cochrane Library ◽

Response Curves ◽

Female Population ◽

Men And Women ◽

Heavy Alcohol ◽

Heavy Alcohol Consumption

Abstract Background: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. Alcohol consumption has been linked to the occurrence of AF.Methods: A comprehensive search of electronic databases (PubMed, Cochrane Library, OVID, Google scholar, and Web of Science) was performed. The search yielded a total of 1177 articles, and 12 cohort studies from the total were included in the meta-analysis. The effects of different doses of alcohol consumption on the risk of AF in men and women were compared using hierarchical analysis. Dose-response curves of alcohol consumption and risk of AF were plotted for the two groups according to sex.Results: The risk of AF increased with increased alcohol consumption in both men and women. In the male population, light-moderate alcohol consumption did not increase the risk of AF (HR: 1.07, 95%CI: 0.92-1.23, P=0.38), while heavy alcohol consumption significantly increased the risk of AF (HR: 1.38, 95%CI: 1.23-1.54, P<0.01). In the female population, the risk of AF was not significantly increased by either light-moderate or heavy alcohol consumption (light- moderate drink: HR: 1.00, 95%CI: 0.92-1.10, P=0.95; heavy drink: HR: 1.05, 95%CI: 0.90-1.23, P=0.55).Conclusions: In women, the risk of AF was not associated with any degree of alcohol consumption while high levels of alcohol consumption significantly increased the risk of AF in men.

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Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals

Liver Cancer ◽

10.1159/000513705 ◽

2021 ◽

pp. 1-11

Author(s):

Tatsuya Minami ◽

Ryosuke Tateishi ◽

Naoto Fujiwara ◽

Ryo Nakagomi ◽

Takuma Nakatsuka ◽

...

Keyword(s):

Risk Factors ◽

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Alcohol Consumption ◽

Chronic Hepatitis C ◽

Incidence Rates ◽

Multicenter Cohort Study ◽

Heavy Alcohol ◽

Heavy Alcohol Consumption

Background and Aims: It remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy. Methods: In this multicenter cohort study, we enrolled patients with chronic hepatitis C who achieved SVR with interferon (IFN)-based therapy (IFN group) or direct-acting antiviral (DAA) therapy (DAA group) between January 1, 1990, and December 31, 2018. The patients underwent regular surveillance for HCC. Cumulative incidence of and the risk factors for HCC development after SVR were assessed using the Kaplan-Meier method and Cox proportional hazard regression analysis, respectively. Results: Among 2,055 patients (840 in the IFN group and 1,215 in the DAA group), 75 developed HCC (41 in the IFN group and 34 in the DAA group) during the mean observation period of 4.1 years. The incidence rates of HCC at 1, 2, and 3 years were 1.2, 1.9, and 3.0%, respectively. Multivariate analysis revealed that in addition to older age, lower albumin level, lower platelet count, higher alpha-fetoprotein level, and absence of dyslipidemia, obesity (body mass index ≥25 kg/m2) and heavy alcohol consumption (≥60 g/day) were independent risk factors for HCC development, with adjusted hazard ratio (HR) of 2.53 (95% confidence interval [CI]: 1.51–4.25) and 2.56 (95% CI: 1.14–5.75), respectively. The adjusted HR was not significant between the 2 groups (DAA vs. IFN; HR 1.19, 95% CI: 0.61–2.33). Conclusions: Obesity and heavy alcohol consumption increased the risk of HCC development after SVR.

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Prospective Associations Between Alcohol Consumption and Psychological Well-being in Midlife

10.21203/rs.3.rs-743633/v1 ◽

2021 ◽

Author(s):

Marie Grønkjær ◽

Cathrine Lawaetz Wimmelmann ◽

Erik Lykke Mortensen ◽

Trine Flensborg-Madsen

Keyword(s):

Alcohol Consumption ◽

Binge Drinking ◽

Satisfaction With Life ◽

Well Being ◽

Psychological Well Being ◽

Men And Women ◽

Heavy Alcohol ◽

Alcohol Abstinence ◽

Heavy Alcohol Consumption

Abstract Background: Alcohol consumption potentially influences psychological well-being in beneficial and harmful ways, but prospective studies on the association show mixed results. Our main purpose was to examine prospective associations between alcohol consumption and psychological well-being in middle-aged men and women. Methods: The study sample included 4,148 middle-aged individuals (80% men) from the Copenhagen Aging and Midlife Biobank who reported their alcohol consumption (average weekly consumption and frequency of binge drinking) at baseline in 2004 or 2006 and reported their psychological well-being (satisfaction with life and vitality) at follow-up in 2009–2011. Analyses were adjusted for sociodemographic factors, lifestyle, social relations, and morbidity.Results: For satisfaction with life at follow-up, lower scores were observed in men and women who were alcohol abstinent at baseline as well as in men with heavy alcohol consumption compared with moderate alcohol consumption at baseline. Moreover, men with moderate frequency of binge drinking (1–3 times/month) at baseline had higher satisfaction with life scores at follow-up than men with less and more frequent binge drinking. In relation to vitality at follow-up, alcohol abstinence at baseline in men and women and heavy alcohol consumption at baseline in men were associated with lower scores compared with moderate alcohol consumption. Conclusions: Alcohol abstinence seems to be prospectively associated with adverse psychological well-being in men and women, while heavy alcohol consumption seems to be prospectively associated with adverse psychological well-being in men. Finally, an inverse u-shaped prospective association between binge drinking and life satisfaction was observed in men.

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Aflatoxin B1 exposure and liver cirrhosis in Guatemala: a case–control study

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2020-000380 ◽

2020 ◽

Vol 7 (1) ◽

pp. e000380

Author(s):

Christian S Alvarez ◽

Elisa Hernández ◽

Kira Escobar ◽

Carmen I Villagrán ◽

María F Kroker-Lobos ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Hepatitis B Virus ◽

Alcohol Consumption ◽

Hepatitis B ◽

Significant Positive Association ◽

Cross Sectional ◽

Heavy Alcohol ◽

B Virus ◽

Heavy Alcohol Consumption

ObjectiveIn Guatemala, cirrhosis is among the 10 leading causes of death, and mortality rates have increased lately. The reasons for this heavy burden of disease are not clear as the prevalence of prominent risk factors, such as hepatitis B virus, hepatitis C virus and heavy alcohol consumption, appears to be low. Aflatoxin B1 (AFB1) exposure, however, appears to be high, and thus could be associated with the high burden of cirrhosis. Whether AFB1 increases the risk of cirrhosis in the absence of viral infection, however, is not clear.DesignCirrhosis cases (n=100) from two major referral hospitals in Guatemala City were compared with controls (n=200) from a cross-sectional study. Logistic regression was used to estimate the ORs and 95% CIs of cirrhosis and quintiles of AFB1 in crude and adjusted models. A sex-stratified analysis was also conducted.ResultsThe median AFB1 level was significantly higher among the cases (11.4 pg/mg) than controls (5.11 pg/mg). In logistic regression analyses, higher levels of AFB1 was associated with cirrhosis (quintile 5 vs quintile 1, OR: 11.55; 95% CI 4.05 to 32.89). No attenuation was observed with adjustment by sex, ethnicity, hepatitis B virus status, and heavy alcohol consumption. A significantly increasing trend in association was observed in both models (p trend <0.01). Additionally, the cirrhosis–AFB1 association was more prominent among men.ConclusionsThe current study found a significant positive association between AFB1 exposure and cirrhosis. Mitigation of AFB1 exposure and a better understanding of additional risk factors may be important to reduce the burden of cirrhosis in Guatemala.

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The Genesis of Intracranial Aneurysms

JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA ◽

10.22290/jbnc.v21i3.847 ◽

2018 ◽

Vol 21 (3) ◽

pp. 162-167

Author(s):

Camila Flores ◽

Leonardo C. Welling ◽

Eberval G. Figueiredo ◽

Manoel J. Teixeira

Keyword(s):

Risk Factors ◽

Alcohol Consumption ◽

Cigarette Smoking ◽

Intracranial Aneurysm ◽

Intracranial Aneurysms ◽

Epidemiological Studies ◽

Endogenous Factors ◽

Heavy Alcohol ◽

Arterial Blood ◽

Heavy Alcohol Consumption

Introduction: The pathogenesis of intracranial aneurysms remains unclear in spite of its great importance. Besides the “classical” saccular aneurysms, there are other, such as the traumatic, infectious or fusiform ones. This study aims at reviewing the genesis of intracranial aneurysms. Method: This review was focused on the Medline/Pubmed data, with the keywords “intracranial” and “aneurysms” from 1990 to 2009. Conclusions: The epidemiological studies have identified the endogenous factors such as the elevated arterial blood pressureand the exogenous risk factors (cigarette smoking, heavy alcohol consumption or certain medications) that may lead to the formation, growth and rupture of the intracranial aneurysms. However, its etiology remains unclear and sometimes fatal to those who harbor an intracranial aneurysm. More evidence is needed to establish definitively what factors are responsible for causing intracranial aneurysms.

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AB0923 DIETARY FACTORS AND TOPHI: A FOOD INTAKE FREQUENCY SURVEY IN CHINESE GOUT PATIENTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4007 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1762.2-1762

Author(s):

Q. H. LI ◽

Y. F. Bi ◽

X. H. Lin ◽

H. B. Wang ◽

C. Y. Wu ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Consumption ◽

Multivariate Logistic Regression Analysis ◽

Red Meat ◽

Dietary Factors ◽

Multivariate Logistic Regression ◽

Urine Ph ◽

Heavy Alcohol ◽

Dependent Variables ◽

Heavy Alcohol Consumption

Background:Tophi is a cardinal sign of advanced gout. Risk factors of gout are also closely related to the formation of tophi, such as impaired kidney function and serum uric acid (sUA). Several dietary factors, such as alcohol, fructose-containing beverage, red meat, sea foods have been confirmed increasing the risk of gout. Diet patterns vary widely in different countries. Dietary factors’ association with tophi formation remain elusive in Chinese gout patients.Objectives:This study aimed to study whether dietary factors were risk factors for tophi.Methods:We recruited consecutive gout patients who fulfilled the 2015 Gout Classification Criteria of ACR/EULAR and collected demographic data, gout disease characteristics and comorbidities. Tophi was evaluated by physical examination and/or musculoskeletal ultrasound. All gout patients completed 10-items food intake frequency questionnaire which included red meat, animal offal, seafood, alcohol, fructose-containing beverages, milk and dairy products, coffee, hotpot, slow-cooking soup and tea. Patients were advised to report the average frequency of food consumption in the preceding year of first gout attack. Multivariate logistic regression analysis was performed to evaluate risk factors of tophi. Dependent variables were those met p values less than 0.1 on univariate analysis.Results:a)There were 682 gout patients recruited with 94% male, mean age 44±16 years, and median gout duration 4 (2,7) years. The mean sUA was 9.0±2.3mg/dl. Tophi presented in 166 (24.3%) patients with 31 (4.5%) patients diagnosed by ultrasound. In patients with gout duration <3 years, 3~4.9 years, 5~9.9 years and ≥10 years, the prevalence of tophi were 6.7%, 19.4%, 38.8%, and 49.6%, respectively. b)Tophus patients were characterized by older age (48±16 vs. 42±15 years), longer gout duration [7(4, 10) vs. 3(1, 5) years], more ever involved joints [11(4, 24) vs. 3(2, 5)] and more flare times in the last year [11(4, 24) vs. 3(2, 6)]. For comorbidities, tophus patients presented higher prevalence of urolithiasis (36% vs. 23%), hypertension (54% vs.40%,) and diabetes (20% vs. 11%) but less hypertriglyceridemia (19% vs. 32%, all P<0.05). c)Compared with patients without tophi, tophus gout patients consumed more red meat (>300g/d: 12% vs. 6%), seafood (>2 times/w: 18% vs.13%), hotpot (≥1 time/w: 17% vs. 10%) and alcohol (>84g/d: 23% vs. 9%). d)Dependent variables of multivariate logistic regression analysis included age, gender, gout duration, diuretics, BMI, sUA, serum creatinine, urine pH, hypertriglyceridemia, hypertension, diabetes, coronary heart disease, urolithiasis, alcohol consumption, hotpot, red meat, and seafoods. Gout duration, sUA, serum creatinine and urine pH were positively correlated with tophi, while hypertriglyceridemia was negatively associated with tophi. For dietary factors, heavy alcohol consumption (> 84g/ day vs. < 1g/ day OR=2.624, 95%CI: 1.437-4.793) and hotpot (≥ 1 time/w vs. <1 time/w, OR=2.164, 95%CI: 1.217-3.847) were positively correlated with tophi.Conclusion:Our data suggest tophi should not be ignored in gout patients with short duration. Heavy alcohol consumption and hotpot are associated with the formation of tophi.Disclosure of Interests:None declared

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Coronary deaths during Midsummer festival in Finland: miseries of long, light nights

European Journal of Epidemiology ◽

10.1007/s10654-021-00744-6 ◽

2021 ◽

Author(s):

Simo Näyhä

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Alcohol Consumption ◽

Negative Binomial ◽

Negative Binomial Regression ◽

Adverse Consequence ◽

Heavy Alcohol ◽

Summer Peak ◽

Binomial Regression ◽

Heavy Alcohol Consumption

AbstractThis paper examines whether the anomalous summer peak in deaths from coronary heart disease (CHD) in Finland could be attributed to adverse effects of the Midsummer festival and alcohol consumption during the festival. Daily deaths from CHD and alcohol poisoning in Finland, 1961–2014, that occurred during the 7 days centering on Midsummer Day were analysed in relation to deaths during 14 to 4 days before and 4 to 14 after Midsummer Day. Daily counts of deaths from CHD among persons aged 35–64 years were regressed on days around the Midsummer period by negative binomial regression. Mortality from CHD was highest on Midsummer Day (RR 1.25 (95% confidence interval 1.12–1.31), one day after the peak in deaths from alcohol poisonings. RR for CHD on Midsummer Day was particulary high (RR = 1.43; 1.09–1.86) in the 2000s, 30% of deaths being attributable to that day. In conclusion, the anomalous and prominent summer peak in deaths from CHD in Finland is an adverse consequence of the Midsummer festival. The most likely underlying reason is heavy alcohol consumption during the festival period, especially on Midsummer Eve. In the 2000s, one third of deaths from CHD on Midsummer Day are preventable.

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Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults

Alcoholism Clinical and Experimental Research ◽

10.1111/acer.13211 ◽

2016 ◽

Vol 40 (11) ◽

pp. 2435-2444 ◽

Cited By ~ 33

Author(s):

Adam J. Woods ◽

Eric C. Porges ◽

Vaughn E. Bryant ◽

Talia Seider ◽

Assawin Gongvatana ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Alcohol Consumption ◽

Heavy Alcohol ◽

Heavy Alcohol Consumption

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Abstract P002: Heavy Alcohol Consumption Increases the Risk of Atrial Fibrillation -Circulatory Risk in Communities Study(CIRCS)

Circulation ◽

10.1161/circ.127.suppl_12.ap002 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Fumihiko Sano ◽

Tetsuya Ohira ◽

Akihiko Kitamura ◽

Hironori Imano ◽

Renzhe Cui ◽

...

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Medical History ◽

Moderate Alcohol Consumption ◽

Heavy Alcohol ◽

Ethanol Drinking ◽

Wide Range ◽

Detailed Medical History ◽

Heavy Alcohol Consumption

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

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