Cortisol – inspection in the physiology and stress

2018 ◽  
Vol 54 (1) ◽  
pp. 29-36
Author(s):  
Nikola Musiała ◽  
Iga Hołyńska-Iwan ◽  
Dorota Olszewska-Słonina
Keyword(s):  
Wide Spectrum ◽  
Hormone Secretion ◽  
Laboratory Diagnosis ◽  
The Body ◽  
Stress Hormone ◽  
Renal Handling ◽  
Peripheral Tissues ◽  
Neurotransmitter Secretion ◽  
Fatty Acids Metabolism ◽  
System Functioning

Cortisol, also called “the” stress hormone is a glucocorticoid secreted by the adrenal cortex. This hormone plays a significant role in maintaining homeostasis, according to the body’s total stress. Cortisol interferes with many organs, affects glucose and fatty acids metabolism and neurotransmitter secretion. Predominantly, cortisol influences the carbohydrate metabolism, stimulating gluconeogenesis in the liver and inhibiting glucose utilization in peripheral tissues. As it is an element “fight or flight” it also stimulates central nervous system and enhances blood flow. To some extent cortisol influences also the renal handling of electrolytes, namely: increasing sodium resorption, and renal excretion of potassium, calcium and phosphates. Through its anti-inflammatory and immunosuppressive character this glucocorticoid modulates the immune system functioning. Cortisol has a circadian rhythm following ACTH (adrenocorticotropic hormone) secretion. Increased cortisol levels are observed physiologically during stress and pathologically in Cushing’s syndrome. Chronic hypercortisolism is harmful or the body, and its effects present an extremely wide spectrum, including insulin resistance, obesity, insomnia and even depression. Thus, laboratory diagnosis of cortisol level is important for the diagnosis, monitoring and evaluate the effectiveness of hypercortisolism treatment.

The Basics of Microbiology

2021 ◽  
Author(s):  
Werner Solbach
Keyword(s):  
Infectious Diseases ◽  
Defense Mechanisms ◽  
Wide Spectrum ◽  
Severe Disease ◽  
Laboratory Diagnosis ◽  
Asymptomatic Infection ◽  
The Body ◽  
Sufficient Evidence ◽  
Effective Measure ◽  
Hygiene Measures

Microorganisms constitute 70 percent of the biomass on Planet Earth. Comparatively few species are adapted to colonize human surfaces and form a complex Meta-Organism with manyfold mutual benefits. Occasionally, microorganisms may overcome the barriers of the skin and mucosal surfaces and may multiply locally or in multiple sites inside the body. This process is called infection. Infections can be caused by bacteria, viruses, parasites, helminths, and fungi. Immediately after infection, numerous defense mechanisms of the immune system are activated to combat replication of the microbes. There is a balance between microorganism and human defense mechanisms, which may lead to either asymptomatic infection or result in a wide spectrum of symptoms from mild to severe disease and even death. The most important factors in the diagnosis of infectious diseases are a careful history, physical examination and the appropriate collection of body fluids and tissues. Laboratory diagnosis requires between 2 and 72 hours. Wherever possible, antibiotics should only be used when sufficient evidence of efficacy is available. Then, however, they should be used as early as possible and in high doses. In addition to everyday hygiene measures, vaccination is the most effective measure to prevent infectious diseases.

scholarly journals Cortisol Secretion and Subsequent Impaired Lymphopoiesis after Starvation Can Be Reduced by Moxibustion Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Kyung Ho Hwang ◽  
Kiyoung Jang ◽  
Sang-Yun Nam ◽  
Yong Ju Kim
Keyword(s):  
Bone Marrow ◽  
Progenitor Cell ◽  
Steroid Hormone ◽  
Hormone Secretion ◽  
The Body ◽  
Cortisol Secretion ◽  
Stress Hormone ◽  
Immunomodulatory Effects ◽  
Enhanced Resistance ◽  
Resistance To Stress

As a known steroid hormone, cortisol is involved in gluconeogenesis. Uninterrupted cortisol secretion has fatal effects, both physically and psychologically, because cortisol counteracts the immune response. Moxibustion (Mox) treatment is a traditional technique used in East Asia, which therapeutically transfers heat to certain points on the body surface. In the present study, the effect of Mox treatment on stress hormone secretion was investigated using a mouse model of starvation, in which Mox was applied on the Zhongwan acupoint (CV12). First, high cortisol levels induced by starvation were dose-dependently reduced by Mox treatment. In addition, the stress-induced decline in lymphoid progenitor cell production accompanied by altered cellularity in the thymus, bone marrow, and spleen was also significantly recovered by Mox treatment. Taken together, these findings indicated that Mox treatment reduces stress hormone secretion, which may rescue stress-induced lymphopoiesis impairment. These observations also suggested that enhanced resistance to stress may be one of the mechanisms underlying the immunomodulatory effects of Mox treatment.

scholarly journals Anionic fatty acids content in carp gills at different copper and zinc concentration in the water

2016 ◽  
Vol 18 (2) ◽  
Author(s):  
Y. F. Rivis ◽  
N. E. Yanovych
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Wide Spectrum ◽  
Total Concentration ◽  
Acyl Chain ◽  
Essential Elements ◽  
Copper And Zinc ◽  
Fatty Acids Metabolism ◽  
System Functioning

Copper and Zinc belongs to essential elements with wide spectrum of physiological and biochemical action in fishes organism. In particular, the role of Zinc in growth, development and reproduction of fishes is established, both as its influence on protein and nucleic acids metabolism and genes activity regulation. Zinc, as well as Copper, is involved in enzyme link of antioxidant system. Besides, Copper takes part in erythropoiesis, energetic metabolism and immune system functioning. Abovementioned elements also influence on desaturases activity. The desaturases are catalyzing transformation of single bond between Carbon atoms in acyl chain into double unsaturated bond. At the same time, Zinc and Copper influence on fatty acids metabolism in fishes body and its tissue and organic specificity remains insufficiently explored. Presented results testified, that at concentration of Zinc and Copper in the water, equated to 1 MPL (maximum permitted level), Zinc accumulates in the gills in greater extend, than Copper. In its turn, at two maximum permitted levels in the water, Copper accumulates in the gills more, than Zinc. Increasing of Zinc and Copper concentration in carp’s gills has led to the increasing of total concentration of anionic forms of fatty acids, those are barely metabolically active. The increasing of anionic fatty acids was caused by saturated, monounsaturated and polyunsaturated fatty acids. Wherein, the ratio of anionic polyunsaturated fatty acids of ω–3 family to anionic polyunsaturated fatty acids of ω–6 family didn’t changed.

Renal filtration and excretion of aluminium in the rat: dose-response relationships and effects of aluminium speciation

1995 ◽  
Vol 14 (6) ◽  
pp. 494-499 ◽  
Author(s):  
CJ Lote ◽  
JA Wood ◽  
A. Thewles ◽  
M. Freeman
Keyword(s):  
Filtration Rate ◽  
Rat Plasma ◽  
Tubular Reabsorption ◽  
The Body ◽  
Aluminium Sulphate ◽  
Renal Handling ◽  
Aluminium Speciation ◽  
Aluminium Citrate ◽  
Aluminium Species ◽  
Filtered Load

The known toxicity of aluminium, and the toxicity of agents (such as desferrioxamine) used to remove alumini um from the body, has prompted us to investigate whether there may be ways of enhancing aluminium excretion by exploiting the normal renal handling of aluminium. Aluminium (as sulphate or citrate) was administered intravenously to conscious rats at doses ranging from 25 μg (0.93 μmol) to 800 μg (29.6 μmol) aluminium, and alu minium excretion was monitored over the following 2 h. Measurements of the filterability of aluminium from the rat plasma, and the glomerular filtration rate (inulin clearance), enabled us to calculate the filtered load of alu minium, and hence determine aluminium reabsorption. At all doses of administered aluminium, that adminis tered as sulphate was excreted less effectively than that administered as citrate. This difference was attributable to the much greater filterability of aluminium administered as citrate. However, for any given filtered load, the excre tion of aluminium administered as citrate was not signifi cantly different (in either fractional or absolute terms) from the excretion of aluminium administered as sulphate. It seems likely that, following aluminium sulphate administration, the filtered aluminium may be an alumini um citrate form which is then reabsorbed in the same way as aluminium administered as citrate. It is thus apparent that aluminium removal from the body could be further enhanced if it were possible to pre vent the tubular reabsorption of the aluminium species which is so effectively filtered following aluminium citrate administration.

Some aspects of hemostasis in the tactics of the ophthalmologist. Literature review

2021 ◽  
pp. 265-270
Author(s):  
O.M. Stanishevskaya ◽  
◽  
M.A. Safronova ◽  
G.V. Bratko ◽  
I.Y. Efremova ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Vascular Diseases ◽  
Laboratory Diagnosis ◽  
The Body ◽  
Vascular Pathology ◽  
Treatment Result ◽  
Important Place ◽  
Correct Orientation ◽  
Pathological Conditions ◽  
Wide Range

Disorders of hemostasis occupy an important place in the structure of vascular diseases and are one of the most frequent pathological conditions encountered in practical medicine. The hemostasis system is naturally the most vulnerable system of the body. Violations of its balance are found in a wide variety of physiological and pathological conditions of the body. It is not uncommon for the first debut of decompensation to lead to an ophthalmologist. In the practice of an ophthalmologist, there are diseases when it is necessary to pay close attention to thrombophilic conditions. Changes in the hemostatic system, affect a wide range of vascular diseases of the eyeball. Recognition of the type of thrombophilia and its timely laboratory diagnosis in patients with vascular diseases of the retina and optic nerve are important in achieving the best treatment results. Multidisciplinary approach to the treatment of vascular diseases of the eyeball and modern diagnostics, including the study of hemostasis, is necessary and relevant to achieve the best clinical and functional treatment result. Timely and correct orientation of patients in vascular pathology is extremely important due to the fact that concomitant systemic pathology can aggravate the course of the disease, therefore, the choice of treatment tactics for this category of patients should be carried out in conjunction with a therapist, cardiologist, hematologist and endocrinologist. Key words: hemostasis, thrombosis CVS, diabet, primary open-angle glaucoma thrombodynamica, cardiovascular pathology.

A Review on Meropenem

2021 ◽  
pp. 5034-5038
Author(s):  
Mohsina Abed ◽  
Sara Yousuf
Keyword(s):  
Intravenous Administration ◽  
Wide Spectrum ◽  
Gastrointestinal Haemorrhage ◽  
The Body ◽  
Antibacterial Drug ◽  
Bacterial Strains ◽  
Enhanced Absorption ◽  
Bacterial Cell Death ◽  
Wide Range ◽  
Synthetic Derivative

Meropenem is a new Carbapenem antibacterial agent with wide spectrum of activity for intravenous administration. It is synthetic derivative of Thienamycin. Three analogues of Meropenem are evaluated and active against 18 bacterial strains. Meropenem causes rapid bacterial cell death by covalently binding to penicillin binding proteins (PBS). Structural modification at C-2 position, produced double promoiety prodrug of Meropenem and increases bioavailability of oral administration. Other forms of drug such as liposome and nanoparticles are also available with enhanced absorption. 14C labelled Meropenem prepared from 14C Dimethylamine hydrochloride is used for the analysis of M. tuberculosis transpeptidase. ICI213,689 is the only metabolite of Meropenem and it is inactive. Meropenem penetrates well into the body fluids and tissues including cerebrospinal fluid. Its bioavailability is 100% on intravenous administration. Hence it is used in the treatment of meningitis, febrile neutropenia, anthrax and various other skin and skin structure infections. Dosage reduction is required in patient with reduced renal function but not in hepatic impairment. Seizures, gastrointestinal haemorrhage are observed in patients. Vabmoere is the combination of Meropenem and Vaborbactam which is active against the Carbapenem resistant Enterobacteriacea. Meropenem is an effective broad-spectrum antibacterial drug for the treatment of wide range of infection including polymicrobial infection in both children and adult.

scholarly journals The effects of sweeteners and sweetness enhancers on obesity and diabetes: a review

2018 ◽  
Vol 4 ◽  
Author(s):  
Yanli Jiao ◽  
Yu Wang
Keyword(s):  
Metabolic Regulation ◽  
Hormone Secretion ◽  
Taste Receptor ◽  
Caloric Intake ◽  
Sweet Taste ◽  
The Body ◽  
Incretin Hormone ◽  
Obesity And Diabetes ◽  
Sweet Taste Receptors

Sweet taste, one of the five basic taste qualities, is not only important for evaluation of food quality, but also guides the dietary food choices of animals. Sweet taste involves a variety of chemical compounds and structures, including natural sugars, sugar alcohols, natural and artificial sweeteners, and sweet-tasting proteins. The preference for sweetness has induced the over-consumption of sugar, contributing to certain prevailing health problems, such as obesity, diabetes and cardiovascular disease. Non-nutritive sweeteners, including natural and synthetic sweeteners, and sweet-tasting proteins have been added to foods to reduce the caloric intake from sugar, but many of these sugar substitutes induce an off-taste or after taste that negatively impacts any pleasure derived from the sweet taste. Sweet taste is detected by sweet taste receptor, that also play an important role in the metabolic regulation of the body, such as glucose homeostasis and incretin hormone secretion. In this review, the role of sweet tastants and the sweet taste receptors involved in sweetness perception, and their effect on obesity and diabetes are summarized. Sweet taste enhancement, as a new way to solve the over-consumption of sugar, is discussed in this contribution. Sweet taste enhancers can bind with sweet tastans to potentiate the sweetness of food without producing any taste by itself. Various type of sweet taste enhancers, including synthetic compounds, food-processed substances and aroma compounds, are summarized. Notably, few natural, non-volatile compounds have been identified as sweetness enhancers.

scholarly journals Increasing the biological value of the curd product

2018 ◽  
Vol 80 (3) ◽  
pp. 124-127
Author(s):  
E. I. Dobriyan ◽  
A. M. Ilina ◽  
T. A. Medvedeva
Keyword(s):  
Carbohydrate Metabolism ◽  
Milk Fat ◽  
Nutritive Value ◽  
Wide Spectrum ◽  
Whey Proteins ◽  
Milk Proteins ◽  
The Body ◽  
Diabetic Patients ◽  
Biological Value ◽  
Test Intensity

The article is devoted to the improvement of quark product biological value in order to impart the properties adequate to specifity and nutrient status for the group of population with abnormal carbohydrate metabolism. Diabetes comprises the most widespread chronic diseases in the world. The reason for the number of diabetic patients growth bears the complex character but this growth is conditioned mainly by malnutrition. Correctly chosen diet adequate to the level and character of metabolic disorders is the important prophylactic factor. Milk products among which quark and quark products due to high amount of easily digestible protein are very Important in nutrition of the patients suffering from abnormal carbohydrate metabolism. The marketing analysis of this group nutritive value presented in the marked has been carried out. The obtained results show that the manufactures quark products are characterized by low amount of crude protein (from 4.5 to 6.0%) and high carbohydrates content ( from 13,0 to 18.0%) including sucrose (from 7,5 to 12,0%. One of the main requirements to dietetic therapy of the patients suffering from diabetes is drastic restriction and exclusion from food allowance easily digestible refined carbohydrates. The aim of the work is to improve biological value of the quark product by replacement of sucrose by stevia and enrichment it by whey protein. Among sugar substitute of natural origin is stevia, which besides the ability to reduce sugar possesses the wide spectrum of positive physiological impact on the body. The influence of milk components on the expressed after-taste of stevia and the possibility to level it has been studied. It was stated that protein has no impact on stevia after-taste but milk fat partially levels metallic taste and promotes the test intensity. It was stated that the best product organoleptic indices were fixed after introduction of 0.027% of stevia. Milk proteins are food irreplaceable components and mainly whey proteins characterized by high biological value conditioned by their specificity and balanced amino acid composition. But meanwhile commercial samples of quark products contained not more than 0,05% of whey proteins . The possibility to improve the biological value of the product by enrichment with whey proteins has been studied.

scholarly journals Changes in Adult Rats’ Testis structure Induced by Hypothyroidism and Alleviating Role of L-Carnitine

2019 ◽  
Vol 1 (4) ◽  
pp. 13-28
Author(s):  
Abdelmonem Awad Hegazy ◽  
Manal Mohammad Morsy ◽  
Rania Said Moawad ◽  
Gehad Mohammad Elsayed
Keyword(s):  
Fatty Acids ◽  
Semen Analysis ◽  
Protective Role ◽  
The Body ◽  
Albino Rats ◽  
Adult Rats ◽  
Fatty Acids Metabolism ◽  
Group 3 ◽  
Group 2

Background Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidative stress. L-carnitine (LC) regulates long chain fatty acids metabolism; and is considered a valuable antioxidant factor. Aim It was to evaluate the effect of hypothyroidism induced by propylthiouracil (PTU) on rats’ testes and the possible protective role of LC. Methods Forty-eight adult male albino rats were used in this work. The animals were divided into three groups with sixteen animals in each. Group 1 (Control): Animals were kept without medications. Group 2 (PTU-treated): was subjected to administration of PTU; while group 3 (PTU and LC) received both PTU and LC. By the end of the experiment “30 days”, blood samples were taken for hormonal assay; then animals were anaesthetized and sacrificed. Specimens were homogenized for biochemical analysis; epididymal content of each rat was obtained immediately for semen analysis. Testes’ specimens were harvested, prepared and examined by light microscope examination. Results Induced hypothyroidism was noticed to cause histopathological, morphometric and biochemical changes in rat’s testes. LC protected the testicular specimens against such changes; it also improved the seminal quality and quantity as well as testicular structure and biochemistry. Conclusion Hypothyroidism could result in hazards to the structure of testis. Fortunately co-administration of LC might reduce such hazards.

scholarly journals Parasitic Lesions in Fish in the Federal District, Brazil

2021 ◽  
Vol 49 ◽  
Author(s):  
Jair Alves Ferreira Junior ◽  
Saulo Pereira Cardoso ◽  
Nathália Dela-Sávia Da Fonseca ◽  
Karla Alvarenga Nascimento ◽  
Fábio Rodrigues ◽  
...  
Keyword(s):  
Water Quality ◽  
Federal District ◽  
Laboratory Diagnosis ◽  
Skin Lesions ◽  
Climatic Conditions ◽  
The Body ◽  
Nutritional Deficiencies ◽  
Small Fish ◽  
Cell Degeneration ◽  
Pathology Laboratory

Background: Brazil has a vast territory and favorable climatic conditions that allow the cultivation of freshwater fish. The intensification of the productive system can cause an imbalance in the aquatic environment as a result of poor water quality, nutritional deficiencies and infectious or parasitic diseases. The laboratory diagnosis and the determination of the prevalence of the main lesions, which occur in a certain region, help to guide towards the etiological diagnosis. This study aimed to describe the main parasitic lesions in fish in the routine at the Veterinary Pathology Laboratory of the Universidade de Brasília. Material, Methods & Results: All records of fish with parasitic lesions were recovered. Those cases in which there was an intralesional parasite and which presented lesions compatible with the parasite were included. The screening of ectoparasites was done by scraping the superficial mucus from the gills and skin. Organ sections were routinely processed for histopathologyand stained with hematoxylin-eosin (HE). In some records, parasitological identification was carried. The information was divided into the species of the affected fish, epidemiology of the outbreak (water quality, temperature, type of breeding), lesion distribution, etiology and macroscopic and microscopic changes. The resulting data was organized in absolute frequency and percentage. In this study, 22 cases were counted, between individual deaths and outbreaks, totaling 83 necropsied teleost fish.Inflammatory changes of parasitic origin were seen in 13/22 (59%) of the cases had lesions of parasitic origin. Skin lesions and gills were the most relevant. Macroscopically, red areas or spots of hyperemia or hemorrhage on the body surface were the most prevalent findings. Under microscopy, proliferative gill inflammation was the most relevant diagnosis. Pscinoodinium pilullare (Dinoflagellida), Ichthyophthirius multifiliis (Ciliophora), and monogenetic worms (Monogenea) were the main parasites found. Trichodina sp. (Ciliophora), Ichtyobodo sp. (Kinetoplastida), Amoebas, and Chilodonella sp. (Ciliophora), were seen in fewer numbers. An unusual case suggestive of parasitism by Eustrongylides sp. (Nematoda), in a pirá-brasília (Simpsonichthys boitonei), specimen has been recorded.Discussion: The diagnoses were based on epidemiology, anatomopathological and parasitological findings. The most frequent and significantly lethal lesion in the study was proliferative and / or hyperplastic branchitis. Proliferative branchitis with lamellar epithelial hyperplasia (LEH) is a response to some type of chemical or mechanical injury to the gill epithelium in order to protect the capillaries from further damage or microbial penetration. However, it also increases the diffusion distance between capillaries and the environment and, therefore, hinders breathing, excretory and osmoregulatory functions. Protozoan infections and monogenetic worms in general generated LEH and skin lesions of mechanical origin. Secondary bacterial infection, were observed in this parasitosis determining the cause of death of the fish. Its pathogenicity comes from the lesions caused by the colonization and histophagy of the epithelial surfaces, mainly gills and skin, causing epithelial proliferation, lamellar cell fusion, epithelial cell degeneration and necrosis forming several ulcers in the epithelium after the release of mature trophies. The pathogenesis of parasitism by Eustrongylides spp. is considerable when there is a large quantity of these larvae that can cause intestinal obstruction, rupture and compression of viscera, of greater importance in small fish. The main parasites of necropsied fish were protozoa and monogenetic worms, which mainly cause branquitis and dermatitis in varying grades.

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