scholarly journals Morphology Aspects of Hypothyroidism

2021 ◽  
Author(s):  
Fernando Candanedo-Gonzalez ◽  
Javier Rios-Valencia ◽  
Dafne Noemi Pacheco-Garcilazo ◽  
Wilfredo Valenzuela-Gonzalez ◽  
Armando Gamboa-Dominguez
Keyword(s):  
Autoimmune Disease ◽  
General Population ◽  
Morphological Features ◽  
Endocrine Disorders ◽  
Endocrine Disorder ◽  
New Class ◽  
Subclinical Disease ◽  
Hormonal Imbalance ◽  
Secondary Hypothyroidism ◽  
Serum Tsh

Hypothyroidism is a common endocrine disorder resulting of low levels of thyroid circulating hormones. The prevalence in the general population varies between 0.3% and 3.7%. Presents as clinical or subclinical disease based on presence of symptoms and levels of serum TSH and free thyroxine and T4, respectively. Hypothyroidism has numerous etiologies, some of them are originated on the thyroid itself and some others are of extrathyroid origin, with variable manifestations. Classified as primary, secondary, tertiary and peripheral. Thyroid autoimmune disease is the principal cause. A new class of drugs against cancer, like the anti-CTLA-4 and anti-PD-L1/PD1 therapies have been associated with primary or secondary hypothyroidism. Endocrine disorders can be difficult to diagnose based only on morphological features because endocrine manifestations are caused primarily by a hormonal imbalance. Hypothyroidism may have a higher risk of morbidity and mortality. Finally, myxedematous coma is the main complication of terminal stages hypothyroidism.

scholarly journals AB0533 ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA) IN GENERAL POPULATION WITHOUT ANCA ASSOCIATED VASCULITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1563.3-1563
Author(s):  
H. Tamaki ◽  
S. Fukui ◽  
T. Nakai ◽  
G. Kidoguchi ◽  
S. Kawaai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autoimmune Disease ◽  
General Population ◽  
Granulomatosis With Polyangiitis ◽  
Dietary Habits ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Anca Associated Vasculitis ◽  
The Mean

Background:Currently it is hypothesized that many systemic autoimmune diseases occur due to environmental risk factors in addition to genetic risk factors. Anti-Neutrophil Cytoplasmic Antibody (ANCA) is mainly associated with three systemic autoimmune disease including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA). It is known that ANCA can be positive before clinical symptoms in patients with known diagnosis of GPA and ANCA titers rise before clinical manifestations appear. However, prevalence of ANCA among general population is not well known. It has not been described as well how many of people with positive ANCA eventually develop clinical manifestations of ANCA associated Vasculitis.Objectives:This study aims to estimate prevalence of ANCA in general population without ANCA associated Vasculitis. It also describes natural disease course of people with positive ANCA without ANCA associated Vasculitis. Risk factors for positive ANCA are also analyzed.Methods:This is a single center retrospective study at Center for Preventive Medicine of St. Luke’s International Hospital in Tokyo. ANCA was checked among the patients who wished to between 2018 and 2019. St. Luke’s Health Check-up Database (SLHCD) was utilized to collect the data. The patients whose serum was measured for ANCA were identified. The data for basic demographics, social habits, dietary habits and laboratory data were extracted. The charts of the patients with positive ANCA were reviewed.Results:Sera of total 1204 people were checked for ANCA. Of these 1204 people, 587 (48.8%) are male and the mean age was 55.8 years (32.6 to 79). There were total 11 patients with positive ANCA. Myeloperoxidase ANCA (MPO-ANCA) was positive for 3 patients and proteinase 3 ANCA (PR3-ANCA) was positive for 8 patients. Of these 11 patients, 5 were male (45.5%) and the mean age was 54.6 years. Two patients had history of autoimmune disease (primary biliary cirrhosis and ulcerative colitis). Five patients were evaluated by rheumatologists with the median follow-up period of 274 days. None of them developed clinical signs and symptoms of ANCA associated Vasculitis. Four out of five patients had ANCA checked later, two of which turned negative. The prevalence of ANCA in this cohort was 0.9% (95% confidence interval [95% CI]: 0.5% to 1.6%). Univariate analysis was performed to identify risk factors of positive ANCA. The variables analyzed include age, gender, body mass index (BMI), smoking habits, alcohol intake, dietary habits (fruits, fish, red meat), hypertension, dyslipidemia, and laboratory data. None of these variables demonstrated statistically significant differences except for positive rheumatoid factor (ANCA positive group: 33 % vs ANCA negative group: 9.1%, p value = 0.044).Conclusion:The prevalence of ANCA in this cohort was 0.9% (95% CI: 0.5% to 1.6%). None of them who had a follow-up developed ANCA associated Vasculitis during the follow-up period. Longer follow-up and more patients are necessary to determine natural course of people with positive ANCA.Disclosure of Interests:None declared

The Symptoms of Depression in Endocrine Disorders

CNS Spectrums ◽  
1999 ◽  
Vol 4 (4) ◽  
pp. 51-61 ◽  
Author(s):  
Burton Hutto
Keyword(s):  
Differential Diagnosis ◽  
Clinical Picture ◽  
Depressive Disorders ◽  
Depressive Illness ◽  
Endocrine Disorders ◽  
Endocrine Disorder ◽  
Presenting Symptoms ◽  
Symptoms Of Depression

AbstractMany endocrine disorders present with symptoms of depression, thus differentiating primary depressive disorders from such endocrine conditions can be challenging. Awareness of the typical clinical picture of endocrine disorders is of primary importance. This article discusses a variety of common and uncommon endocrine disorders and the symptomatology that might suggest a depressive illness, and reviews literature on how endocrinopathies can mimic depression. Emphasis is also placed on the role that stress can play in the pathogenesis of endocrine disorders. Psychiatrists should be familiar with the range of presenting symptoms for endocrine disorders, and they should not rely on the presence or absence of stressors to guide their differential diagnosis between depression and endocrine disorder.

scholarly journals Correlation of Serum Prolactin and Thyroid Hormone in Female Infertility

2019 ◽  
Vol 17 (2) ◽  
pp. 32-34
Author(s):  
Fahat Banu
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Dysfunction ◽  
Female Infertility ◽  
Serum Prolactin ◽  
Psychological Consequences ◽  
Medical College ◽  
Hormone Profile ◽  
Hormonal Imbalance ◽  
High Incidence ◽  
Serum Tsh

Background: Infertility is a growing problem with adverse medical, social and psychological consequences globally. Apart from several causes of infertility, hormonal imbalance especially thyroid dysfunction and hyperprolactinemia can lead to female infertility. Both these conditions are treatable so Proper management of hormonal imbalance can result in restoration of normal fertility. Aims and objectives: Correlation of serum Prolactin and Thyroid hormone in female infertility. Materials and methods: Descriptive hospital based study was conducted at Nepalgunj medical college and teaching hospital, Nepalgunj, Banke, Nepal. The data was collected from September 2018 to August 2019. Total 30 cases of females of primary and secondary infertility attending outpatient department of gynecology department of Nepalgunj medical college were included in the study. A detailed history and clinical evaluation was done along with estimation of serum Prolactin and Thyroid hormone profile. Result: Hormonal status of subjects showed 15 i.e. 50% participants were thyroid whereas 11 (36.33%) were hypothyroid and 4 (13.33%) were hyperthyroid. Serum Prolactin was raised in 17 (57%) and normal in 13 (43%). Serum TSH and prolactin were found to be significantly positively correlated in female infertility (r=0.507, p =0.004). Conclusion: There is a high incidence of hyperprolactinaemia and thyroid dysfunction in female infertility.

scholarly journals Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

2012 ◽  
Vol 12 (4) ◽  
pp. 464-470 ◽  
Author(s):  
Apostolos Kontzias ◽  
Alexander Kotlyar ◽  
Arian Laurence ◽  
Paul Changelian ◽  
John J O'Shea
Keyword(s):  
Autoimmune Disease ◽  
Kinase Inhibitors ◽  
New Class

scholarly journals Analysis of Antibody Reactivity against Cysteine Sulfinic Acid Decarboxylase, A Pyridoxal Phosphate-Dependent Enzyme, in Endocrine Autoimmune Disease

2004 ◽  
Vol 89 (4) ◽  
pp. 1636-1640 ◽  
Author(s):  
Filip Sköldberg ◽  
Fredrik Rorsman ◽  
Jaakko Perheentupa ◽  
Mona Landin-Olsson ◽  
Eystein S. Husebye ◽  
...  
Keyword(s):  
Amino Acid ◽  
Autoimmune Disease ◽  
Pyridoxal Phosphate ◽  
Acid Decarboxylase ◽  
Endocrine Disorders ◽  
Sulfinic Acid ◽  
Cysteine Sulfinic Acid ◽  
Gad 65 ◽  
Cysteine Sulfinic Acid Decarboxylase ◽  
Group Ii

Abstract The structurally related group II pyridoxal phosphate (PLP)-dependent amino acid decarboxylases glutamic acid decarboxylase (GAD), aromatic l-amino acid decarboxylase (AADC), and histidine decarboxylase (HDC) are known autoantigens in endocrine disorders. We report, for the first time, the prevalence of serum autoantibody reactivity against cysteine sulfinic acid decarboxylase (CSAD), an enzyme that shares 50% amino acid identity with the 65- and 67-kDa isoforms of GAD (GAD-65 and GAD-67), in endocrine autoimmune disease. Three of 83 patients (3.6%) with autoimmune polyendocrine syndrome type 1 (APS1) were anti-CSAD positive in a radioimmunoprecipitation assay. Anti-CSAD antibodies cross-reacted with GAD-65, and the anti-CSAD-positive sera were also reactive with AADC and HDC. The low frequency of anti-CSAD reactivity is in striking contrast to the prevalence of antibodies against GAD-65, AADC, and HDC in APS1 patients, suggesting that different mechanisms control the immunological tolerance toward CSAD and the other group II decarboxylases. Moreover, CSAD may be a useful mold for the construction of recombinant chimerical antigens in attempts to map conformational epitopes on other group II PLP-dependent amino acid decarboxylases.

scholarly journals Effect of bromocriptine on serum TSH in euthyroid patients with endocrine disorders.

1985 ◽  
Vol 32 (5) ◽  
pp. 745-751 ◽  
Author(s):  
TAKASHI ISHIHARA ◽  
TORU MORI ◽  
NORIO WASEDA ◽  
KATSUJI IKEKUBO ◽  
TAKASHI AKAMIZU ◽  
...  
Keyword(s):  
Endocrine Disorders ◽  
Serum Tsh

Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study

2016 ◽  
Vol 34 (36) ◽  
pp. 4362-4370 ◽  
Author(s):  
Sarah C. Clement ◽  
Antoinette Y.N. Schouten-van Meeteren ◽  
Annemieke M. Boot ◽  
Hedy L. Claahsen-van der Grinten ◽  
Bernd Granzen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Tumor ◽  
Thyroid Stimulating Hormone ◽  
Endocrine Function ◽  
Hormone Deficiency ◽  
Study Cohort ◽  
Endocrine Disorders ◽  
Childhood Brain Tumor ◽  
Endocrine Disorder

Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders. Results After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency (9.2%), and thyroidal hypothyroidism (5.8%). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95% CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95% CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95% CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95% CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95% CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95% CI, 1.48 to 4.74) tumor site. Conclusion The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.

scholarly journals Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population

2017 ◽  
Vol 16 (4) ◽  
pp. 515-520
Author(s):  
Sri Suwarni ◽  
Cilmiaty Risya ◽  
Dono Indarto ◽  
Suradi Pulmonology
Keyword(s):  
Helicobacter Pylori ◽  
Serum Level ◽  
Elderly Population ◽  
Helicobacter Pylori Infection ◽  
Endocrine Disorders ◽  
World Population ◽  
Healthy Elderly ◽  
Cellular Inflammatory Response ◽  
Serum T3 ◽  
Serum Tsh

Background: Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal.Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori.Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R2 = 0,676. P < 0.001 ).Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.515-520

Comorbidities in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis versus the General Population

2016 ◽  
Vol 43 (8) ◽  
pp. 1553-1558 ◽  
Author(s):  
Martin Englund ◽  
Peter A. Merkel ◽  
Gunnar Tomasson ◽  
Mårten Segelmark ◽  
Aladdin J. Mohammad
Keyword(s):  
General Population ◽  
Statistical Significance ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Population Based ◽  
Endocrine Disorders ◽  
Comorbid Conditions ◽  
Southern Sweden ◽  
Cerebrovascular Accidents ◽  
Diagnostic Codes ◽  
Rate Ratios

Objective.To evaluate the consultation rates of selected comorbidities in patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV) compared with the general population in southern Sweden.Methods.We used data from a population-based cohort of patients with AAV diagnosed between 1998 and 2010 in Southern Sweden (701,000 inhabitants). For each patient we identified 4 reference subjects randomly sampled from the general population and matched for year of birth, sex, area of residence, and index year. Using the population-based Skåne Healthcare Register, we identified relevant diagnostic codes, registered between 1998 and 2011, for selected comorbidities assigned after the date of diagnosis of AAV or the index date for the reference subjects. We calculated rate ratios for comorbidities (AAV:reference subjects).Results.There were 186 patients with AAV (95 women, mean age 64.5 yrs) and 744 reference persons included in the analysis. The highest rate ratios (AAV:reference) were obtained for osteoporosis (4.6, 95% CI 3.0–7.0), followed by venous thromboembolism (4.0, 95% CI 1.9–8.3), thyroid diseases (2.1, 95% CI 1.3–3.3), and diabetes mellitus (2.0, 95% CI 1.3–2.9). For ischemic heart disease, the rate ratio of 1.5 (95% CI 1.0–2.3) did not reach statistical significance. No statistically significant differences were found for cerebrovascular accidents.Conclusion.AAV is associated with increased consultation rates of several comorbidities including osteoporosis and thromboembolic and endocrine disorders. Comorbid conditions should be taken into consideration when planning and providing care for patients with AAV.

17-KETOSTEROID FRACTIONATION STUDIES BY A MICRO-CHROMATOGRAPHIC TECHNIQUE IN ENDOCRINE DISORDERS

1954 ◽  
Vol 10 (3) ◽  
pp. 202-211 ◽  
Author(s):  
M. HELEN POND
Keyword(s):  
Clinical Medicine ◽  
Normal Subjects ◽  
Adsorption Chromatography ◽  
Endocrine Disorders ◽  
Chromatographic Technique ◽  
Endocrine Disorder ◽  
Adrenocortical Activity ◽  
Diagnostic Importance

SUMMARY Urinary 17-ketosteroids have been fractionated by adsorption chromatography on alumina into eight fractions, the main constituents of which are described. The patterns of 17-ketosteroid excretion in patients with various forms of endocrine disorder have been compared with those from normal subjects. The value of this investigation in clinical medicine is discussed. Although not of diagnostic importance, it is of use in the assessment of two aspects of adrenocortical activity, the excretion of the β-hydroxy-17-ketosteroids and the 11-oxy-17-ketosteroids.

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