scholarly journals Study of Relation between Vitamin D Serum Level and Biomarkers of Human Sinonasal Fibroblast Proliferation in Patient with Chronic Rhinosinusitis with Nasal Polyposis

2020 ◽  
Vol 8 (1) ◽  
pp. 11
Author(s):  
Ali Reza Lotfi ◽  
Nikzad Shahidi ◽  
Tala Pourlak ◽  
Ladan Noori Bayat
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Control Group ◽  
Case Group ◽  
Therapeutic Effects ◽  
Relative Role ◽  
Ki 67 ◽  
Vitamin D Levels

Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease of paranasal sinuses and nasal coverage, which reduces the quality of life and overall health. Vitamin D regulates many cellular functions, including anti-inflammatory and immune-modulating functions. There is an increasing evidence of the relative role of fibroblasts in the accumulation of inflammatory cells in chronic rhinosinusitis. The aim of this study was to investigate the relationship between vitamin D levels and the proliferation of sinonasal fibroblasts in patients with chronic rhinosinusitis with nasal polyposis and its therapeutic role. Material and Method: In this case-control study blood and tissue samples were extracted from patients with CRSwNP (n=30). Control subjects with non-inflammatory conditions underwent endoscopic and non-endoscopic surgery (n=30). The serum level of 1,25 dihydroxyvitamin D (1,25(OH)2D) and proliferation of fibroblasts sampled from nasal and sinus tissue using ki 67 and vimentin were evaluated and analyzed using SPSS® 23 software. Results: The average level of vitamin D was 23.1±7.36 ng/ml in the case group and 31.19±7.02 ng/ml in control group, which was significantly lower in case group (P=0.008). The proliferation of sinonasal fibroblasts were positive in all cases patients and only in 20% of control patients using vimentin. The proliferation of sinonasal fibroblasts were negative in all control patients while only 10% of the case patients were negative using Ki 67. The level of vitamin D decreased with the increased rate of Ki 67. Conclusion: The results of this study indicate a reversed relation between vitamin D levels and the proliferation of sinonasal fibroblasts.Thus vitamin D has both prophylactic and therapeutic effects in chronic rhinosinusitis with nasal polyposis.

scholarly journals Relationship of vitamin D3 deficiency and chronic rhinosinusitis with nasal and sinus polyposis in patients referring to the Department of Ear, Nose, and Throat Diseases Department of Vali-asr Hospital in Brigand, Iran

2021 ◽  
pp. 99-104
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Vitamin D3 ◽  
Sinus Surgery ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Relationship Of ◽  
Vitamin D3 Deficiency ◽  
Nose And Throat

Introduction: Chronic rhinosinusitis may require referral to an ear, nose, and throat specialist for possible endoscopic sinus surgery if medical management fails. Vitamin D is one of the essential vitamins for the body that is effective in inflammatory processes. Therefore, it seems necessary to confirm the association between the deficiency of this vitamin and the occurrence of chronic rhinosinusitis with nasal polyposis. This study aimed to determine the relationship of vitamin D3 deficiency and chronic rhinosinusitis with nasal and sinus polyposis in patients referring to the Otorhinolaryngology Department of Valiasr Hospital, Birjand, Iran, in 2017. Methods: A case-control study was performed on individuals, including a group of patients with rhinosinusitis and a control group (n=20 each), referring to the Department of Ear, Nose, and Throat Diseases Department of Vali-asr Hospital. Among patients diagnosed with chronic rhinosinusitis, the cases that had polyps on endoscopic examination were included in the study. After completing the consent form, venous blood samples (10cc) were collected from the patients in fasting conditions. The electrochemical luminescence method was used for measuring the level of serum vitamin D. A questionnaire containing demographic information and clinical findings was completed by reviewing the patients' records. Data analysis was performed in SPSS software (Version. 22)using Chi-square and Mann-Whitney U-tests. Results: The mean and median scores of vitamin D level were obtained at14.13±12.99 and 10.25 in the case group, and 18.72±9.29 and 18.77 in the control group, respectively. The level of vitamin D was significantly higher in the control group than in the chronic group (P=0.04). In the case group, 16 (80%) patients lacked vitamin D and 3 patients had an insufficient level of vitamin D. In the control group, 13 (65%) patients lacked vitamin D and 4 cases had an insufficient level of vitamin D. There was no significant difference in vitamin D levels between the two groups (P=0.61). No significant difference was observed between the two clinical symptoms. Conclusion: It was revealed that the lack of vitamin D was likely to be an effective factor in the rhinosinusitis disease; therefore, proceedings need to be taken to cure the deficiency of this vitamin.

scholarly journals Vitamin D levels in epileptic children on long-term anticonvulsant therapy

2015 ◽  
Vol 55 (3) ◽  
pp. 164
Author(s):  
Fathy Pohan ◽  
Aryono Hendarto ◽  
Irawan Mangunatmadja ◽  
Hartono Gunardi
Keyword(s):  
Vitamin D ◽  
Valproic Acid ◽  
Vitamin D Deficiency ◽  
Anticonvulsant Therapy ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
The Mean

Background Long-term anticonvulsant therapy, especially with enzyme inducers, has been associated with low 25-hydroxyvitamin D [25(OH)D] levels and high prevalence of vitamin D deficiency. However, there have been inconsistent results in studies on the effect of long-term, non-enzyme inducer anticonvulsant use on vitamin D levels.Objective To compare 25(OH)D levels in epileptic children on long-term anticonvulsant therapy and non-epileptic children. We also assessed for factors potentially associated with vitamin D deficiency/insufficiency in epileptic children.Methods This cross-sectional study was conducted at two pediatric neurology outpatient clinics in Jakarta, from March to June 2013. Subjects in the case group were epileptic children, aged 6-11 years who had used valproic acid, carbamazepine, phenobarbital, phenytoin, or oxcarbazepine, as a single or combination therapy, for at least 1 year. Control subjects were non-epileptic, had not consumed anticonvulsants, and were matched for age and gender to the case group. All subjects’ 25(OH)D levels were measured by enzyme immunoassay.Results There were 31 epileptic children and 31 non-epileptic control children. Their mean age was 9.1 (SD 1.8) years. Most subjects in the case group were treated with valproic acid (25/31), administered as a monotherapy (21/31). The mean duration of anticonvulsant consumption was 41.9 (SD 20) months. The mean 25(OH)D level of the epileptic group was 41.1 (SD 16) ng/mL, lower than the control group with a mean difference of 9.7 (95%CI 1.6 to 17.9) ng/mL. No vitamin D deficiency was found in this study. The prevalence of vitamin D insufficiency in the epileptic group was higher than in the control group (12/31 vs. 4/31; P=0.020). No identified risk factors were associated with low 25(OH)D levels in epileptic children.Conclusion Vitamin D levels in epileptic children with long-term anticonvulsant therapy are lower than that of non-epileptic children, but none had vitamin D deficiency.

scholarly journals Association of serum vitamin D levels with gestational diabetes mellitus

2021 ◽  
Vol 10 (6) ◽  
pp. 2198
Author(s):  
Sharmeen Mahmood ◽  
Hasna Hena Pervin ◽  
Shereen Yousuf
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Status ◽  
Third Trimester ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: This study was done to evaluate the association of serum vitamin D level with GDM (n=30) and without GDM (n=30). The age and body mass index of the participants along with their gestational age, gravidity and parity were harmonized. The serum vitamin D levels and blood glucose were investigated. The results revealed that, normal pregnant women had significantly higher vitamin D level than their GDM counterparts.Methods: This case-control study was conducted on healthy pregnant women attending routine antenatal care at Bangabandhu Sheikh Mujib medical university from January 2019 to December 2019 recruited at third trimester of gestation. We measured maternal serum vitamin D status (25[OH]D) in third trimester of pregnancy. GDM was diagnosed according to the American diabetes association. guidelines. Vitamin D status was defined as, vitamin D sufficiency (≥30 or ≥75 nmol/L), insufficiency (20-30 and 50-75 nmol/L), were used to categories participants according to their 25[OH]D concentrations. We calculated adjusted odds ratios and 95% confidence intervals (CIs) using logistic regression.Results: The mean serum vitamin D level was lower in case group case 23.4 (17.4±35.1) compared to that in control group 29.7 (15.4±39.8) and the difference between the 2 groups was statistically significant (p≤0.001). Sufficient level of vitamin D was more in control group (66.7%) than that of case group (26.1%). Insufficient level of vitamin D was higher in case (73.3%) group than that of control (33.3%) group. These findings were significant (p=0.021). Respondents with insufficient level of vitamin D have 3.1 times more chance to develop GDM.Conclusions: Serum vitamin D level is reduced in pregnant women having GDM.

scholarly journals Serum vitamin D levels in girls with central precocious puberty

2018 ◽  
Author(s):  
Mohammadreza Rafati ◽  
Daniel Zamanfar ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Fatemeh Faramarzi ◽  
Mohsen Aarabi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Precocious Puberty ◽  
Serum Vitamin ◽  
Central Precocious Puberty ◽  
Control Group ◽  
Age Difference ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Stimulating Hormone

Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recent studies showed that low serum level of vitamin D might be associated with precocious puberty. The aim of this research was to investigate the association between serum vitamin D level and central precocious puberty in girls. Girls with central precocious puberty under the age of eight were enrolled in the study. Subjects with brain tumor, inherent adrenal hyperplasia, or thyroid dysfunction were excluded from the study. Age, weight, height, serum level of vitamin D, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, free thyroxin (FT4), bone age, thyroid-stimulating hormone (TSH), and Tanner stages were determined for all the subjects. Healthy girls with no precocious puberty were considered as the control group. Finally, 58 girls (28 with central precocious puberty and 30 healthy) were included in the study. The average levels of serum vitamin D were 12.9 ± 7.8 ng/mL and 15.2±5.9 ng/mL in the case and control groups, respectively (P = 0.02). We found that 37% of girls with precocious puberty were in Tanner stage 2 and 63% in stage 3. The serum vitamin D level had considerable relationship with chronologicalbone age difference (P < 0.01). Vitamin D deficiency was more common in girls with central precocious puberty than those with normal sexual maturation. Insufficiency and deficiency of vitamin D were more common in girls who were evaluated in this study in comparison with other studies.

scholarly journals Is There Relation Between 25(OH) Vitamin D and Chronic Obstructive Pulmonary Disease?

2017 ◽  
Vol 5 (2) ◽  
pp. 87-91
Author(s):  
Farshid Divani ◽  
Alireza zahedi ◽  
Maryam Vasheghani ◽  
Ebrahim Nadi ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Vitamin D level can affect pulmonary function in patient who have chronic obstructive pulmonary disease (COPD). Objectives: There are few studies that assess this subject, so we investigate the relation of Vitamin D and COPD. Materials and Methods: A case-control study was conducted among the patients referred to the pulmonology clinic of Shahid Beheshti hospital of Hamadan, in which 68 of patients were assigned into the case group with COPD and 68 patients into the control group. Both groups were evaluated for respiratory differences as clinical or laboratory and the blood level of vitamin D was measured. Results: Of 136 evaluated participants with the mean age of 58.83 years old, 68 patients were studied as case group consisting of 2 females and 66 males. The results suggested that the serum level of vitamin D in COPD patients and control group patients were 22.22 ± 15.83 ng/mL and 27.47 ± 21.43 ng/mL, respectively. It was also found that there was a positive correlation between lung function and serum level of vitamin D in COPD. The greater the severity of COPD (forced expiratory volume in the first second [FEV1] lower level) was, the more the vitamin D deficiency was seen. It was also clarified that there was an indirect correlation between the serum level of vitamin D in COPD patients and body mass index (BMI). Conclusions: Prevalence of vitamin D deficiency in COPD patients was more than that in control group patients. Due to the growing prevalence of vitamin D deficiency in such patients, any use of vitamin D maybe suggested.

scholarly journals Association of serum level of 25-hydroxy vitamin D with Oral Lichen Planus. A case-control study.

2020 ◽  
Vol 9 (5) ◽  
pp. 400-404
Author(s):  
Mostafa Sadeghi ◽  
◽  
Mahdieh Zarabadipour ◽  
Faezeh Azmodeh ◽  
Monirsadat Mirzadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Vitamin D Levels ◽  
Oral Lichen ◽  
Control Study

Introduction: Vitamin D deficiency is a global health problem that can be a risk factor for a broad range of diseases such as some autoimmune diseases. Due to the autoimmune base of lichen planus, it seems that a reduction of the serum level of vitamin D is related to lichen planus. In this study, we investigate the relation between serum level of vitamin D and oral lichen planus patients (OLP). Material and Methods: In this case-control study, 35 patients with OLP (including 15 men and 20 women) and 70 healthy volunteers (including 35 men and 35 women), aged between 30-60 years old, referred to Qazvin University of Medical Sciences were investigated. None of these volunteers had systemic diseases. Vitamin D levels were measured with ELFA (Enzyme Linked Fluorescent Assay) and the data was analyzed using the chi-squared test and t-test. Results: The mean serum level of vitamin D in the control group was 23.7±9ng/ml and in the case group was 18.12±8/7ng/ml. The results show that the serum level of vitamin D in patients with OLP is significantly less than in the control group (p<0.05). Conclusion: According to the results, the serum level of vitamin D in patients with OLP was significantly lower than that of healthy people.

scholarly journals Vitamin D Levels in Children and Adolescents with Cerebral Palsy: Cross-sectional Study / Níveis de Vitamina D em Crianças e Adolescentes com Paralisia Cerebral: Estudo Transversal

2021 ◽  
Vol 4 (3) ◽  
pp. 11938-11949
Author(s):  
Marcela Almeida Linden ◽  
Elizete Aparecida Lomazi ◽  
Gabriel Hessel ◽  
Maria Ângela Bellomo-Brandão
Keyword(s):  
Vitamin D ◽  
Cerebral Palsy ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Food Sources ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Vitamin D Levels

Aim: Tetraparetic Cerebral Palsy (TCP) patients may present risks factors for Vitamin D deficiency such as increased risk of malnutrition and possibly infrequent sun exposure. The present study aimed to compare the vitamin D status in this population of TCP pediatric patients (Case Group) and compare them with healthy children and adolescents (Control Group). Methods: The clinical data obtained were: gender, age, weight, height, nutritional status, consumption of vitamin D food sources, sun exposure and serum levels of vitamin D. Vitamin D deficiency was defined as 20 ng/mL or less of 25(OH)D; “insufficiency” was defined as between 21-29 ng/mL; “sufficiency” was defined as between 30-100 ng/mL.1 Results: Sixty patients aged 3 to 20 years old were divided into two groups: the Control Group (n=30) and the Case Group (n=30) composed of individuals with TCP. Vitamin D levels did not differ between groups; the mean levels were 26.65 ng/mL (SD: 10.51) in the Case Group and, 28.93 ng/mL (SD: 9.26) in the Control Group. Conclusion: There was no difference identified between vitamin D levels among TCP and control patients, and no relationship between risk factors and serum 25(OH)D levels was observed. Even though Brazil is a tropical country with abundant sunshine during most of the year, there is still a considerable number of individuals with vitamin D classifications of insufficiency and deficiency in our study (N= 34/60). This should be alarming for healthcare professionals who work with the pediatric population, which is a population at risk for the development of disability.

scholarly journals MRONJ and VIT D insufficiency

2021 ◽  
Author(s):  
Gholamreza Shirani ◽  
Arghavan Tonkaboni ◽  
Mina Mazani ◽  
Babak Mirzashahi ◽  
Abel Garcia Garcia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Osteonecrosis Of The Jaw ◽  
Control Group ◽  
Case Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Sex Type ◽  
The Mean

Background: medication related osteonecrosis of the jaw (MRONJ) is a chronic condition of the oral cavity resulting in mucosal ulceration and exposure of underlying necrotic bone, and the ensuing secondary complications. The aim of this study was to evaluate the relationship between vitamin D deficiency and osteonecrosis of the jaw related to bisphosphonates. Materials and methods: This was a case-control study. The samples were 20 patients taking bisphosphonates, that 10 of them were with MRONJ and 10 were non-MRONJ. Clinical examination of patients was performed to diagnose jaw osteonecrosis. Demographic data of the patients were recorded including age, sex, type of drug, duration and cause of drug intake, and measurement of serum vitamin D levels. Data were analyzed using SPSS software. Results: In the patients without MRONJ, the mean age was 60.60 (±14.975) years, and in the patients with MRONJ, the mean age was 68.30 (69.92) years. As a whole, of the 16 female patients in this study, 10 cases (62.5%) were non- MRONJ and 6 cases (37.5%) were suffered by MRONJ. All of the male patients presented with MRONJ. In control group mean of vitamin D was 63.990 ng/ml (±29.796) and in case group mean of vitamin D was 29.510 ng/ml (±23.723). The serum level of vitamin D (25-OHD) was significantly higher in control group than in the case group (p=0.010). Conclusion: According to our result, there were statistically significant relationship between age, sex, type of drug, vitamin D level, and MRONJ (p>0.05).

scholarly journals Vitamin D levels in systematic lupus erythematosus patients: association with disease activity index and interferon alpha

2018 ◽  
Vol 7 (10) ◽  
pp. 1940
Author(s):  
Afsaneh Enteshari-moghaddam ◽  
Gholamreza Ravaei ◽  
Ahad Azami
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Interferon Alpha ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Disease Activity Index ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Levels

Background: In different studies the correlation between systemic lupus erythematosus (SLE) and disease activity with vitamin D has been shown. The role of different interferons especially interferon alpha (IFN-α) in lupus pathogenesis have been previously shown. Considering the role of vitamin D and IFN-α, it is possible that these two could demonstrate the SLE activity. This study aimed to investigate the association between vitamin D levels and IFN-α with disease activity index in Ardabil city SLE patients.Methods: In this case control study, 50 SLE patients and 50 age and sex matched healthy subjects were recruited. Patients had serum 25-OH Vitamin D concentration and disease activity recorded. Vitamin D and IFN-α levels were compared between two groups and also, levels of anti-dsDNA, and SLEDAI in case group was measured. Statistical methods were used to determine the correlation between vitamin D and IFN-α with disease activity index at baseline.Results: Vitamin D deficiency (<40 nmol/L) was detected in 20% of SLE patients. Vitamin D level in case group significantly lower than control group (23.94±11.93 vs. 29.10±11.40 ng/ml, p=0.02). The IFN-α amount in case group significantly upper than control group (396.60±54.73 vs. 200.38±14.42, p=0.001). There was significantly negative correlation between vitamin D with IFN-α (r=-0.413, p=0.003), SLEDAI (r=-0.492, p<0.001) and anti-dsDNA (r=-0.417, p=0.003). There was positive correlation between IFN-α with SLEDAI (r=0.358, p=0.01) and anti-dsDNA (p=0.297, p=0.03).Conclusions: Results showed that the low vitamin D was associated with a higher disease activity in SLE patients. Also, it seems that, the improvement of vitamin D levels by decreasing IFN-α could help in controlling disease activity in future.

scholarly journals Determining the Predictive Power of Vitamin D Levels in Iron Deficiency Anemia

2019 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Sorush Niknamian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Levels ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Vitamin D Levels

Background:Iron deficiency anemia is one of the most common hypochromic microcytic anemias and nutritional disorders in today’s world. Vitamin D is an important steroid hormone for the metabolism of serum calcium and phosphorus and plays a major role in the function of various body systems. Evidence suggests that vitamin D deficiency is associated with iron deficiency anemia. We aimed to compare the serum level of vitamin D between children with iron deficiency anemia and healthy ones. Methods: This case-control study was conducted on 60 patients with iron deficiency anemia and 60 healthy ones who did not suffer from iron deficiency anemia. Patients participated in the study voluntarily. Vitamin D levels were measured using HPLC and ferritin by RIA method. To estimate the predictive value of vitamin D levels in iron deficiency anemia, ROC curve analysis was used.  Results: In this study, 120 children aged 6-144 months with mean age of 30.2±31.4 months were analyzed; 49.2% of them were boys and 50.8% were girls. Vitamin D levels varied from 4.8 to 63.2 ng/ml with a mean of 23.87±12.57 ng/ml in all patients (19.25±9.15 ng/ml in the case group and 28.48±13.84 ng/ml in the control group (P<0.001). In other words, patients with a vitamin D level <23.6 ng/ml should be investigated for iron deficiency anemia, and sufficient vitamin D had a protective effect on iron deficiency anemia and each unit increase in vitamin D decreased the chance of iron deficiency anemia by 7.8%. Conclusion: The prevalence of simultaneous iron deficiency anemia and vitamin D deficiency is very high in children and there is a significant relationship between serum levels of 25(OH)D and hemoglobin.

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