Effect of Spray-drying Condition and Surfactant Addition on Morphological Characteristics of Spray-dried Nanocellulose

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration

Pharmaceutics ◽

10.3390/pharmaceutics13050608 ◽

2021 ◽

Vol 13 (5) ◽

pp. 608

Author(s):

Csilla Bartos ◽

Patrícia Varga ◽

Piroska Szabó-Révész ◽

Rita Ambrus

Keyword(s):

Drug Delivery ◽

Spray Drying ◽

Process Parameters ◽

Sodium Tripolyphosphate ◽

Structural Characteristics ◽

Nasal Administration ◽

Drug Bioavailability ◽

Intranasal Application ◽

Spray Dried

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy. Thanks to the bonding of chitosan to the nasal mucosa and its permeability-enhancing effect, it is an excellent choice to formulate microspheres for the increase of drug bioavailability. The aim of our work includes the preparation of spray-dried cross-linked and non-cross-linked chitosan-based drug delivery systems for intranasal application, the optimization of spray-drying process parameters (inlet air temperature, pump rate), and the composition of samples. Cross-linked products were prepared by using different amounts of sodium tripolyphosphate. On top of these, the micrometric properties, the structural characteristics, the in vitro drug release, and the in vitro permeability of the products were studied. Spray-drying resulted in micronized chitosan particles (2–4 μm) regardless of the process parameters. The meloxicam (MEL)-containing microspheres showed nearly spherical habit, while MEL was present in a molecularly dispersed state. The highest dissolved (>90%) and permeated (~45 µg/cm2) MEL amount was detected from the non-cross-linked sample. Our results indicate that spray-dried MEL-containing chitosan microparticles may be recommended for the development of a novel drug delivery system to decrease acute pain or enhance analgesia by intranasal application.

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Staphylococcal Food Poisoning Associated with Spray-Dried Milk

Epidemiology and Infection ◽

10.1017/s0022172400000899 ◽

1955 ◽

Vol 53 (4) ◽

pp. 387-397 ◽

Cited By ~ 39

Author(s):

P. H. R. Anderson ◽

Doris M. Stone

Keyword(s):

Spray Drying ◽

Clinical Features ◽

Milk Powder ◽

Food Poisoning ◽

Skim Milk ◽

Skim Milk Powder ◽

Large Numbers ◽

Heat Treated ◽

Drying Chamber ◽

Spray Dried

SummaryEight explosive outbreaks of food poisoning, occurring in school canteens in England during 1953 and affecting 1190 known cases, are described. The clinical features were characteristic of the toxin type of illness. No deaths occurred.The food causing all of these outbreaks was prepared from spray-dried skim milk powder. It was not subsequently heat-treated and was usually consumed 3–4 hr. after preparation.The spray-dried milk powder proved to contain a high content of bacteria, including large numbers of Staph. aureus, of a phage pattern often associated with food poisoning. The assumption was therefore made that these outbreaks were caused by staphylococcal enterotoxin.Because the food was often consumed within 3–4 hr. of reconstitution of the milk powder—before, in fact, the staphylococci had had time to grow—it is concluded that the poisoning must have been due mainly to pre-formed toxin.Consideration is given to the opportunities for the formation of toxin in a spray-drying plant, and reasons are brought forward for believing that it is formed mainly in the balance tank where the warm milk is kept, sometimes for several hours, before passing into the final drying chamber.The processing of the milk and the precautions for preventing contamination of the finished product are discussed.

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Surface composition of industrial spray-dried milk powders. 2. Effects of spray drying conditions on the surface composition

Journal of Food Engineering ◽

10.1016/j.jfoodeng.2008.10.020 ◽

2009 ◽

Vol 94 (2) ◽

pp. 169-181 ◽

Cited By ~ 143

Author(s):

Esther H.-J. Kim ◽

Xiao Dong Chen ◽

David Pearce

Keyword(s):

Spray Drying ◽

Surface Composition ◽

Drying Conditions ◽

Spray Dried

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Inhalable Spray Dried Pro-Liposome Powder Containing Budesonide for Pulmonary Delivery

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2021.14.4.3 ◽

2021 ◽

Vol 14 (4) ◽

pp. 5538-5548

Author(s):

Aliasgar J Kundawala ◽

Khushbu S Chauhan ◽

Harsha V Patel ◽

Swati K Kurtkoti

Keyword(s):

Drug Release ◽

Spray Drying ◽

Entrapment Efficiency ◽

Geometric Standard Deviation ◽

Drying Method ◽

Dry Powder ◽

Liposomal Drug ◽

Vesicle Size ◽

Aerodynamic Properties ◽

Spray Dried

Budesonide is an anti-asthmatic agent which is used to control the symptoms of asthma like bronchospasm, oedema. Drug delivered to lung through inhalation will provide systemic and local drug delivery at lower dose in chronic and acute diseases. Dry powder inhalers are the best choice for targeting the anti-asthmatic drugs through pulmonary route. The objective of the present study is to prepare inhalable lipid coated budesonide microparticles by spray drying method so effective delivery of budesonide to the lungs can be achieved. The microparticles in the form of dry powder were obtained by either spray drying liposomal drug suspension or lipid drug suspension. The liposomes were initially prepared by solvent evaporation method using Hydrogenated Soyabean Phosphatidylcholine and Cholesterol (1:1, 1:2, 2:1) as lipid carrier and then spray dried later with mannitol as bulking agent at different lipid to diluent ratio (1:1.25, 1:2.5 & 1:5). The liposomes and liposomal dry powder were evaluated for vesicle size, % entrapment efficiency, in vitro drug release studies, powder characteristics, aerosol performance and stability studies. The liposomes prepared showed vesicle size (2-8 µm), Entrapment efficiency (92.22%) at lipid: drug ratio of (2.5:1) and observed 80.41 % drug release in 24 hrs. Pro-liposomes prepared by spray drying of liposomal drug suspension (LSD1) showed emitted dose, mean mass aerodynamic diameter, geometric standard deviation and fine particle fraction of 99.01%, 3.12 µm, 1.78 and 43.5% along with good powder properties. The spray dried powder was found to be stable at 4 ± 2 °C & 65% ± 5 % RH. The inhalable microparticles containing Budesonide containing lipid dry powder was successfully prepared by spray drying method that showed good aerodynamic properties and stability with mannitol as diluent. The microparticles produced with this novel approach could deliver drug on target via inhalation route and also ease manufacture process at large scale in fewer production steps.

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Enhancing antioxidant property of instant coffee by microencapsulation via spray drying

Proceedings of 21th International Drying Symposium ◽

10.4995/ids2018.2018.7520 ◽

2018 ◽

Author(s):

Chaleeda Borompichaichartkul ◽

Desi Sakawulan ◽

Richard Archer

Keyword(s):

Spray Drying ◽

Air Temperature ◽

Antioxidant Property ◽

Konjac Glucomannan ◽

Scavenging Activity ◽

Instant Coffee ◽

Dpph Scavenging Activity ◽

Dpph Scavenging ◽

Spray Dried ◽

Better Than

This study is aimed to improve the antioxidant property of instant coffee by using microencapsulation technique and spray drying. Concentrated coffee extract was mixed with Konjac glucomannan hydrolysate (KGMH) and Maltodextrin (MD). The mixture of coating material and coffee extract was then spray dried at 160 - 180 °C inlet air temperature and at 85-90 °C outlet air temperature. KGMH can preserve retention of phenolic compounds, DPPH scavenging activity and antioxidant activity of FRAP (p<0.05 of instrant coffee better than other treatment. Keywords: Hydrolysed Konjac Glucomannan; Spray Drying; Microencapsulation; Instant Coffee, Antioxidant

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Development and Evaluation of Nipa (Nypa Fruticans) Vinegar Powder

JPAIR Multidisciplinary Research ◽

10.7719/jpair.v32i1.578 ◽

2018 ◽

Vol 32 (1) ◽

pp. 110

Author(s):

Mario A. De Castro Jr.

Keyword(s):

Spray Drying ◽

Ph Value ◽

New Technology ◽

Production Quality ◽

Soluble Solids ◽

Organoleptic Evaluation ◽

Nypa Fruticans ◽

Three Samples ◽

Recovery Percentage ◽

Spray Dried

Due to emerging technologies, the improvization of products is a new trend. Spray drying is a new technology that transforms a product in liquid phase into a dry particulate powder. This study investigated the possibility of developing powder out of nipa vinegar with ideal physicochemical properties and high recovery percentage. A single process schedule design was applied in the nipa vinegar during spray drying. Three formulations of the added carrier were applied (F1- 50%, F2- 25% and F3-12.50%). The sensory characteristics of the spray-dried nipa vinegar in three formulations were analyzed and compared using organoleptic evaluation score card utilized by food experts. The pH level, total soluble solids (TSS) and solubility test of the three samples were also measured. Results showed that nipa vinegar with 12.50% of the added carrier is the preferred sample by the respondents and has the fastest solubility rate. However, it has the lowest recovery percentage. On the other hand, the nipa vinegar with 50% added carrier has the highest recovery percentage. The three samples have consistent pH value and changes were only observed in Nipa Vinegar with 50% added carrier. Further studies should be conducted to optimize the production quality of spray-dried nipa vinegar.

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EVALUACIÓN DE LA ESTABILIDAD DE CAROTENOIDES Y ACTIVIDAD ANTIOXIDANTE DE LA FLOR DE MASTUERZO (Tropaeolum majus L.) EN LA MICROENCAPSULACIÓN POR SPRAY-DRYING

Revista de la Sociedad Química del Perú ◽

10.37761/rsqp.v83i3.112 ◽

2017 ◽

Vol 83 (3) ◽

pp. 282-293

Author(s):

Luis Juscamaita Fabián ◽

Tiffany Pérez Salvatierra ◽

Clara Espinoza Silva ◽

Miguel Quispe Solano ◽

Greta Hinostroza Quiñónez ◽

...

Keyword(s):

Spray Drying ◽

Tropaeolum Majus ◽

Spray Dried

Se realizó la extracción de carotenoides de los pétalos de flores amarillas de mastuerzo (Tropaeolum majus L.) con hexano, cloroformo y éter de petróleo a 12, 24 y 48 horas; el mayor rendimiento se obtuvo con cloroformo a 24 horas, el que se purificó para ser solubilizado con aceite de oliva. Luego se microencapsuló con maltodextrina y goma arábiga. La dispersión se llevó a un Mini Spray Dried B-290 a temperaturas de secado de 130 °C, 150 °C y 170 °C; en el microencapsulado se evaluó el % de recuperación de carotenoides totales encontrándose diferencia (p<0,05) por efecto de la interacción del agente encapsulante y la temperatura de secado, los mayores % de recuperación fueron 74,10% y 83,76% a 130 ºC y 150 ºC, respectivamente, con goma arábiga; no se evidencia diferencia (p>0,05) en la actividad antioxidante las que van de 393,00 a 470,97 μmol-TE/g. de muestra. Con respecto al % de humedad, % de higroscopicidad, densidad aparente (g/cm3) y % de rendimiento se evidencia diferencia (p<0,05). En el % de solubilidad no se evidencia diferencia (p>0,05), la microcápsula de carotenoides puede ser usada como alimento funcional.

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Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material

10.20944/preprints202105.0358.v1 ◽

2021 ◽

Author(s):

Aleksandra A. Jovanović ◽

Steva M. Lević ◽

Vladimir B. Pavlovic ◽

Smilja B. Markovic ◽

Rada V. Pjanovic ◽

...

Keyword(s):

Spray Drying ◽

Dry Weight ◽

Drying Process ◽

Scanning Calorimetry ◽

Coating Agent ◽

Microwave Assisted ◽

Freeze Dried ◽

Wild Thyme ◽

The Impact ◽

Spray Dried

Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.

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