Surface composition of industrial spray-dried milk powders. 2. Effects of spray drying conditions on the surface composition

2009 ◽  
Vol 94 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Esther H.-J. Kim ◽  
Xiao Dong Chen ◽  
David Pearce
Keyword(s):  
Spray Drying ◽  
Surface Composition ◽  
Drying Conditions ◽  
Spray Dried

scholarly journals Optimization of Spray Drying Condition of Asparagus Powder Using Response Surface Methodology (P17-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jiseon Park ◽  
Soon Bae Kwon ◽  
Hye Jeong Kwon
Keyword(s):  
Spray Drying ◽  
Flow Rate ◽  
Air Flow ◽  
Absorption Index ◽  
Water Extraction ◽  
Inlet Temperature ◽  
Air Flow Rate ◽  
Independent Variables ◽  
Drying Conditions ◽  
Spray Dried

Abstract Objectives The purpose of this study was to investigate optimization of spray drying conditions for water-soluble powder using response surface methodology that is a statistical procedure used for optimization studies. Methods First, conditions of the extract used for spray drying were set. We compared heat water extraction (60–100 °C) with ethanol extraction (10–50%). After final selection of the method of extract used for spray drying, spray drying conditions were set. Independent variables included the additive contents of maltodextrin (X1), inlet temperature (X2), and air flow rate (X3). The dependent variables were yield, water absorption index (WAI) and total phenolic compounds. Results The yield was highest in 100 °C heat water extraction. The content of rutin was 29.77 mg/100 g in 90 °C heat water extraction, 28.07 mg/100 g in 100 °C heat water extraction and 24.24 mg/100 g in 10% ethanol extraction. The heat water extraction method at 100 °C was selected as an extract of the spray dryer. Statistical analysis revealed that independent variables significantly affected all the responses. A maximum yield was obtained at 15.55% of X1, 167.87 °C of X2 and 50.00 mL/min of X3. The water absorption index of asparagus increased with increasing MD ratio (X1), higher inlet temperature (X2) and higher air flow rate (X3). The total polyphenol contents of asparagus were higher when the MD addition ratio (X1) was 16.56%, the inlet temperature (X2) was higher and the air flow rate (X3) was higher. Conclusions In this study, extracts of asparagus using different extraction methods were compared for yield and spray-dried asparagus powders were investigated for their physicochemical characteristics. We were vary the range of the temperature, air flow rate, dextrin rate and set the best method for the functionality content of asparagus. Asparagus was spray - dried using 100 °C water extraction with high yield and high rutin content. The maximum spray drying yield was obtained at 15.55% of MD ratio, 167.87 °C of inlet temperature and 50.00 mL/min of air flow rate. There will be additional processed goods development made with what we have found. Funding Sources This study was supported by 2018 Regional Specialized Technology Development Project, Rural Development Administration, Republic of Korea. Supporting Tables, Images and/or Graphs

Effect of Formulations and Spray Drying Process Conditions on Physical Properties of Resveratrol Spray-Dried Emulsions

2019 ◽  
Vol 819 ◽  
pp. 246-251
Author(s):  
Pontip Benjasirimongkol ◽  
Suchada Piriyaprasarth ◽  
Pornsak Sriamornsak
Keyword(s):  
Particle Size ◽  
Moisture Content ◽  
Physical Properties ◽  
Spray Drying ◽  
Feed Rate ◽  
Water Soluble ◽  
Process Conditions ◽  
Box Behnken Design ◽  
Drying Conditions ◽  
Spray Dried

Spray-dried emulsion is one of the useful strategies to enhance dissolution properties of poorly water-soluble drug for example resveratrol. Physical properties i.e. particle size and moisture content of spray-dried emulsions could affect their quality attributes. In this study, Box-Behnken design was performed in order to determine effect of formulation and spray drying condition parameters i.e. feed rate on responses including particle size and moisture content of resveratrol spray-dried emulsions. The spray-dried emulsions were prepared by varying content of low-methoxyl pectin (LMP) and caprylic/capric glycerides (CCG) and sprayed at different feed rate. Box-Behnken design results reveled that the particle size of spray-dried emulsions was significantly influenced by the content of LMP, interactions between LMP and CCG, interactions between LMP and feed rate. LMP content showed positive relationships with the particle size. The content of CCG had negative significantly effect on moisture content of the spray-dried emulsion. Mathematical models describing the relationships between studied parameters and responses provided good predictability. Based on model, the optimal formulation was prepared using 2.6% w/w of LMP, 9% w/w of CCG, and feed rate of 6.8 mL/min and the small particle size (~5.9 μm) and low moisture content (~5.6%) were obtained. The spray-dried emulsions were successfully prepared with satisfy quality. The Box-Behnken design would be an effective tool to elucidate influence of formulation and spray drying conditions on particle size and moisture content of the spray-dried emulsions. Further, the design aided in developing and optimizing the spray-dried emulsions with specified quality.

Quality of spray dried soy beverage powder as affected by drying and feed parameters

2017 ◽  
Vol 47 (4) ◽  
pp. 567-577 ◽  
Author(s):  
Saroj Kumar Giri ◽  
Shukadev Mangaraj ◽  
Lalan Kumar Sinha ◽  
Manoj Kumar Tripathi
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Air Temperature ◽  
Feed Rate ◽  
Quality Parameters ◽  
Solid Content ◽  
Surface Model ◽  
Content Type ◽  
Drying Conditions ◽  
Spray Dried

Purpose Soy beverage is becoming more and more popular because it is touted as a healthy food containing useful phytochemicals and is free from lactose and cholesterol. The purpose of this paper is to optimize the spray drying process parameters for obtaining soy beverage powder with good reconstitution and handling properties. Design/methodology/approach Pre-concentrated soy beverage was dried in a laboratory model spray dryer, and the effects of inlet air temperature (180-220°C), feed rate (20-40 ml/min) and feed solid content (15-25 per cent) on some physical parameters and reconstitution properties (wettability and dispersibility) of spray-dried soy beverage powders were investigated. Second order polynomial response surface model was selected for the analysis of data and optimization of the process. Findings Spray drying of soy beverage at different processing conditions resulted in powders with particle size (volume mean diameter) in the range of 86 to 156 µm. Dispersibility and wetting time of the spray-dried soy beverage powders was found to be in the range of 56 to 78 per cent and 30 to 90 s respectively, under various drying conditions. Inlet air temperature was found to be the main factor affecting most of the quality parameters, followed by solid content of the feed. Temperature significantly affected the wettability, dispersibility, colour parameters, particle size and flowability of the powder at p ≤ 0.01. Lower temperature and higher feed solid content produced bigger-sized powder particles with better handling properties in terms of flowability and cohesiveness. A moderate inlet air temperature (196°C), higher feed solid content (24 per cent) and lower feed rate (27 ml/min) were found suitable for drying of soy beverage. Practical implications The study implied the possibility of producing powder from soy beverage using the spray-drying method and optimized drying conditions for obtaining soy beverage powder with good reconstitution properties. Originality/value The finding of this study demonstrated for the first time how the inlet air temperature, feed solid content and feed rate during spray-drying influenced different quality parameters of soy beverage powder. Further, an optimized drying condition has been identified.

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

Drug Research ◽  
2017 ◽  
Vol 68 (03) ◽  
pp. 168-173 ◽  
Author(s):  
Saeed Ghanbarzadeh ◽  
Hadi Valizadeh ◽  
Shadi Yaqoubi ◽  
Arash Asdagh ◽  
Hamed Hamishehkar
Keyword(s):  
Spray Drying ◽  
Good Condition ◽  
Flow Property ◽  
Angle Of Repose ◽  
Spherical Particles ◽  
Content Uniformity ◽  
Divalproex Sodium ◽  
Powder Flowability ◽  
Drying Conditions ◽  
Spray Dried

Abstract Background Tablets and capsules are the most accepted and widely used solid dosage forms in the medical therapy. Flow property of the powders is playing a key role in the various pharmaceutical fields especially in the fomulation of tablets and capsules. The high hygroscopic crystalline structure of anhydrous Divalproex sodium (DVX) makes it to be appear as waxy white flakes with almost no powder flowability which cause serious problems during the tabletting and capsule filling procedures. Purpose The main objective of this study was to improve the flowability of DVX powder. Methods DVX was mixed with mannitol or lactos in different ratios, dissolved in water and differet binary mixtures of ethanol:water, and finally spray dried with different spray drying conditions. Particle size and powders morphology were assessed by Scanning Electron Microscopy (SEM). The poweder flowability was assessed by measurmet of Hausner ratio (HR), Carr’s index (CI) and angle of repose (AOR) indexes. Furthermore, the content uniformity of DVX in spray-dried powders was determined by using a validated HPLC technique. Results The results showed that spray drying technique improved DVX flowability by forming spherical particles with narrow size distribution AOR value of DVX was decrease from not flowable to 36.1° in spray dried solid dispersion indicating the improvmet of powder flowability from very poor to fair/good condition. Conclusion Findings suggest that the spray drying technique improves DVX flowability and may pave the way for improvement in the tabletting procedure of DVX.

scholarly journals Spray drying of lipid nanosystems (SLN and NLC) loaded with Syzygium aromaticum essential oil

2018 ◽  
Author(s):  
Debora Morais Rosa ◽  
Wanderley Pereira Oliveira
Keyword(s):  
Oleic Acid ◽  
Essential Oil ◽  
Physicochemical Properties ◽  
Spray Drying ◽  
Quality By Design ◽  
Syzygium Aromaticum ◽  
Independent Variables ◽  
Quality By Design Approach ◽  
Drying Conditions ◽  
Spray Dried

A quality by design approach was used to investigate the influence of formulation composition and spray drying conditions on physicochemical properties of redispersable lipid based nanosystems loaded with Syzygium aromaticum essential oil. Four critical independent variables were studied: presence or absence of the liquid lipid oleic acid (0% - 1%), of the cationic surfactant CTAB (0% and 1%), inlet drying temperature (60 ºC -80 ºC), and ratio of the drying aids (ADJ) regarded to total formulation constituents weight (1:1 and 2:1). Resuls showed the production of spray dried redispersable  lipid systems loaded with essential is feasible under very restrict conditions. Keywords: Encapsulation; lipid systems; essential oil; spray drying; redispersable.

scholarly journals Changing spray-dried lactose-whey protein isolate particle structure with drying conditions

2018 ◽  
Author(s):  
Roger De Souza Lima ◽  
Gaëtan Gutierez ◽  
Patricia Arlabosse ◽  
Maria-Inês Re
Keyword(s):  
Whey Protein ◽  
Spray Drying ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Solid Content ◽  
Particle Structure ◽  
Total Solid Content ◽  
Solid Structure ◽  
Drying Conditions ◽  
Spray Dried

Spray drying has become not merely a drying process, but also an important tool for engineering solid structures, specially for multi-component feeds. In that way, it is important to know how the drying conditions and liquid formulations affect the particle final solid structure. In the present study, we investigated the changes on the solid structure of a spray-dried binary mixture of lactose and whey protein isolate under different process and formulation conditions. Particle morphology, diameter, porosity and occluded air were analyzed. Total solid content in the feed was the parameter of highest impact on the spray-dried particle’s occluded air volume.Keywords: spray drying; solid structure; porosity; hollow particless.  

Effects of Spray Drying Conditions on the Stability and Antioxidant Properties of Spray-Dried Soluble Maté

2014 ◽  
Vol 10 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Vanessa G. Hartwig ◽  
Peggy A. Ponce Cevallos ◽  
Miguel E. Schmalko ◽  
Luis A. Brumovsky
Keyword(s):  
Glass Transition ◽  
Spray Drying ◽  
Transition Temperatures ◽  
Polyphenol Content ◽  
Total Polyphenol ◽  
Glass Transition Temperatures ◽  
Total Polyphenol Content ◽  
The Stability ◽  
Drying Conditions ◽  
Spray Dried

Abstract The aim of this research was to evaluate the stability of spray-dried soluble maté (Ilex paraguariensis) and its total polyphenol content determined with the Folin–Ciocalteu assay, after it was elaborated with three different maltodextrin concentrations (0, 7.05 and 14.10% w/v) using experimental data of water activities and glass transition temperatures. Adsorption isotherms were determined for these three materials at 25°C between water activity values (aw) of 0.1 and 0.85 (resulting in values of water content between 0.04 and 0.33 g of water/g of dried solid). Glass transition temperatures varied from 15 to 52°C. At room temperature powder containing 14.10% of maltodextrin at aw=0.55 was below the glass transition temperature, while the two other compositions were below their Tg and stable at aw=0.40. In the spray drying conditions analyzed, the loss of polyphenolic compounds is negligible. The total polyphenol content varied between 28 and 45 chlorogenic acid equivalents (g % dry powder).

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

scholarly journals Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 608
Author(s):  
Csilla Bartos ◽  
Patrícia Varga ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Process Parameters ◽  
Sodium Tripolyphosphate ◽  
Structural Characteristics ◽  
Nasal Administration ◽  
Drug Bioavailability ◽  
Intranasal Application ◽  
Spray Dried

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy. Thanks to the bonding of chitosan to the nasal mucosa and its permeability-enhancing effect, it is an excellent choice to formulate microspheres for the increase of drug bioavailability. The aim of our work includes the preparation of spray-dried cross-linked and non-cross-linked chitosan-based drug delivery systems for intranasal application, the optimization of spray-drying process parameters (inlet air temperature, pump rate), and the composition of samples. Cross-linked products were prepared by using different amounts of sodium tripolyphosphate. On top of these, the micrometric properties, the structural characteristics, the in vitro drug release, and the in vitro permeability of the products were studied. Spray-drying resulted in micronized chitosan particles (2–4 μm) regardless of the process parameters. The meloxicam (MEL)-containing microspheres showed nearly spherical habit, while MEL was present in a molecularly dispersed state. The highest dissolved (>90%) and permeated (~45 µg/cm2) MEL amount was detected from the non-cross-linked sample. Our results indicate that spray-dried MEL-containing chitosan microparticles may be recommended for the development of a novel drug delivery system to decrease acute pain or enhance analgesia by intranasal application.

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