scholarly journals Study of Estimation of Urinary Delta Aminolevulinic Acid Levels as an Indicator of Lead Exposure in Pottery Workers

2020 ◽  
pp. 58-63
Author(s):  
Neelam J. Patil ◽  
Sayali R. Kalokhe ◽  
Sachin A. Patharkar ◽  
Alka V. Nerurkar ◽  
Pradeep N. Surve ◽  
...  
Keyword(s):  
Human Body ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Surrogate Marker ◽  
Lead Toxicity ◽  
Urine Samples ◽  
Age Group ◽  
High Good ◽  
Very High ◽  
Ehrlich Method

Background: Lead toxicity is a significant environmental hazard and has widespread ill effects on human body. In this study we detected the lead exposure by measuring urinary delta aminolevulinic acid levels. The activity of delta aminolevulinic acid dehydratase enzyme is inhibited significantly by lead, which leads to an increase in urinary δ- ALA excretion. Hence we can use estimation of urinary δ-ALA levels as a surrogate marker of lead exposure in pottery workers. Aim: To estimate the urinary delta aminolevulinic acid levels in pottery workers as an index of lead exposure. Materials and Methods: The study was done on 85 pottery workers of age group between 18 to 50 years with their brief history related to lead exposure. Their urine samples were analysed for δ-ALA by Ehrlich method. Results: According to our observation, it was found that out of 85 urine samples; 58 samples showed increased urinary δ-ALA levels (68.23%). Conclusion: We conclude that the prevalence of lead exposure in pottery workers in Mumbai is very high. Good hygienic practices and necessary precautions should be followed to avoid its ill effects on human body.

scholarly journals Estimation of Urinary Delta Aminolevulinic Acid (δ-ALA) Levels in Students of Age Group 15 to 25 Years as an Index of Lead Exposure

2020 ◽  
pp. 12-16
Author(s):  
Sachin A. Patharkar ◽  
Suraj H. Jain ◽  
Alka V. Nerurkar ◽  
Neelam J. Patil ◽  
Pradeep N. Surve
Keyword(s):  
Lead Poisoning ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Cross Sectional Study ◽  
The Body ◽  
Urine Samples ◽  
Reference Level ◽  
Age Group ◽  
Cross Sectional ◽  
Group 15

Background: Lead poisoning is a serious and sometimes fatal condition. It occurs when lead builds up in the body. Students exposed to lead by eating junk foods wrapped in newspaper, the licking of fingers for turning the photocopies, book pages, printout etc. and use of same fingers for eating purpose. Additionally young population get exposed to lead by use of Kohl or Kajal eyeliners, some traditional ethnic medicines, time spent at firing ranges and some hobbies like wall paintings or jobs related to plumbing and soldering. Damage caused by lead poisoning cannot be reversed. Lead inhibits necessary enzymes required for heme synthesis, and this result in increased levels of delta-aminolevulinic acid (δ-ALA) excretion through urine. Aim: To Estimate the urinary δ-ALA levels in the students of age group 15 to 25 years as an index of lead exposure. Study Design: This is a cross-sectional study in Mumbai from a suburban locality. Methodology: The study was done on 70 students of age group between 15 years and 25 years with their brief history related to lead exposure. Their urine samples were analyzed for δ-ALA by using Ehrlich reagent. Results: According to our observation, out of 70 students 46 student’s (65.71%)urine samples shown δ-ALA level  above reference level and remaining 24 (34.28%) were considered as below reference level. Conclusion: The prevalence of lead exposure among our study population is 65.71%. Clinical Significance: We conclude that there is high prevalence of lead exposure in students of age group 15 to 25 years in Mumbai and necessary precautions need to be taken to avoid detrimental effects of lead poisoning.

scholarly journals Effects of deltaAminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

2019 ◽  
Vol 10 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Mona Sobhi Siha ◽  
Dalia Abdel-Hamid Shaker ◽  
Hebatalla Saad Teleb ◽  
Laila Ahmed Rashed
Keyword(s):  
Gene Polymorphism ◽  
Kidney Function ◽  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Hematological Parameters ◽  
Lead Level ◽  
Lead Toxicity ◽  
Effect Modifier ◽  
Acid Dehydratase ◽  
Exposed Workers

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

Thiamine and Zinc in Prevention or Therapy of Lead Intoxication

1989 ◽  
Vol 17 (1) ◽  
pp. 68-75 ◽  
Author(s):  
S. J. S. Flora ◽  
S. Singh ◽  
S. K. Tandon
Keyword(s):  
Urinary Excretion ◽  
Lead Exposure ◽  
Intestinal Tract ◽  
Aminolevulinic Acid ◽  
Lead Toxicity ◽  
Dietary Supplementation ◽  
Lead In Blood ◽  
Liver And Kidney ◽  
Gastro Intestinal Tract ◽  
Dehydratase Activity

Thiamine, zinc or their combination given through gastric gavage were investigated for their ability to prevent or treat experimental lead toxicity in rats. Simultaneous dietary supplementation with thiamine plus zinc was found to be the most effective way of reducing the lead-induced inhibition of δ-aminolevulinic acid dehydratase activity in blood, urinary excretion of δ-aminolevulinic acid and accumulation of lead in blood, liver and kidney. Prevention was more effective than post-lead exposure treatment which may be due mainly to the decrease in the absorption of lead in the gastro-intestinal tract in the presence of thiamine and/or zinc.

A study on the ALAD gene polymorphisms associated with lead exposure

2008 ◽  
Vol 24 (7) ◽  
pp. 501-506 ◽  
Author(s):  
AP Shaik ◽  
K Jamil
Keyword(s):  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
White Cell Count ◽  
Hematological Parameters ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Stripping Voltammetry ◽  
Genotype Group ◽  
Significant Difference ◽  
Occupationally Exposed

δ-aminolevulinic acid dehydratase (ALAD) plays an important role in lead poisoning, and polymorphisms in this gene may affect the response of individuals to lead toxicity symptoms. This study was carried out to examine the effects of ALAD gene polymorphism (G177C) on blood lead levels (BLL) and hematological parameters. In all, 113 battery manufacturing unit workers and 102 occupationally unexposed controls from Hyderabad, A.P, India formed the study group. Genotypes for the ALAD G177C polymorphism were determined by Polymerase chain reaction and restriction fragment length digestion. BLL were determined by anode stripping voltammetry using ESA Model 3010B Lead analyzer. Complete blood picture was analyzed using ADVIA cell counter for each sample. The frequencies for ALAD1 and ALAD2 alleles were 0.98 and 0.01, respectively. ALAD 1-2 and ALAD 2-2 genotypes together were considered as a single group and compared with the ALAD 1-1 genotype group. BLL did not differ significantly among ALAD1-1, 1-2, and 2-2 genotypes; however, subjects from the ALAD 1-2/2-2 genotype group showed higher BLL concentrations of 80.51 μg/dL when compared with subjects from the ALAD 1-1 genotype group (50.4 μg/dL). Approximately 29.2% volunteers ( n = 33) from the occupationally exposed group had hemoglobin levels below 10.0 g/dL. There was no significant difference in total white cell count and platelet count between occupational and non-exposed lead-exposed groups. BLL of occupationally exposed individuals were significantly high compared with the unexposed group. ALAD G177C polymorphism along with BLL and assessment of hematological parameters may play an important role in evaluation and better understanding of the consequences of lead exposure.

Estimation of urinary δ Aminolevulinic Acid Levels (δ-ALA) in children of age group 1 to 5 years as an index of lead exposure

2018 ◽  
Vol 6 (1) ◽  
pp. 16
Author(s):  
DK Bokankar ◽  
Sachin Patharkar ◽  
Shraddha Chavan ◽  
MS Phadke ◽  
Neelam Patil
Keyword(s):  
Lead Exposure ◽  
Aminolevulinic Acid ◽  
Age Group ◽  
Group 1

Role of Vasavaleha in the management of Covid19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 259-261
Author(s):  
Aamir Khan ◽  
Rajni K. Gurmule
Keyword(s):  
Immune System ◽  
Human Body ◽  
Respiratory Diseases ◽  
Spreading Rate ◽  
Host Immune System ◽  
Shortness Of Breath ◽  
Antitussive Effect ◽  
Corona Viruses ◽  
Very High

Vasavaleha is one of the best medicine given for respiratory diseases. Corona viruses typically affect the respiratory system, causing symptoms such as coughing, fever and shortness of breath. It also affects host immune system of human body. Spreading rate of this disease is very high. Whole world is seeking for the treatment which can uproots this diseases. There in no vaccine available till date against this pandemic disease. Ayurveda mainly focuses on prevention of diseases alongwith its total cure. Rajyakshma Vyadhi is MadhyamMarga Roga as per Ayurveda. It shows many symptoms such as Kasa, Shwasa etc. By overall view of Covid 19, shows its resemblance with Rajyakshma Vyadhi described in Ayurveda. Vasavaleha is a Kalpa which is described in Rogadhikara of Rajyakshma. It shows Kasahara, Shwashara properties. It consists of Vasa, Pipalli, Madhu and Goghrita. These components shows actions like bronchodilation, antitussive effect and many more other actions. Pipalli shows important Rasayana effect. So in present review, we have tried to focus on role of Vasavaleha in the management of Covid 19. This can be used as preventive as well as adjuvant medication in treating Covid 19. There is need of further clinical research to rule of exact action of Vasavaleha against Covid 19.

HIGH PREVALENCE OF MALNUTRITON AND WORM INFECTION AMONG VAN KIEU AND PAKOH CHILDREN AGED 12-36 MONTHS IN DAKRONG DISTRICT, QUANG TRI PROVINCE

2012 ◽  
pp. 129-134
Author(s):  
Thi Lan Tran ◽  
Thi Huong Le ◽  
Xuan Ninh Nguyen
Keyword(s):  
Cross Sectional Study ◽  
Age Group ◽  
Infection Status ◽  
Sectional Study ◽  
Group Recommendation ◽  
Related Factors ◽  
Normal Children ◽  
Cross Sectional ◽  
High Prevalence ◽  
Very High

Objectives: Assess the nutritional status, worm infection status and some related factors among children aged 12-36 months of Dakrong district, Quang Tri province. Subject and method: A cross sectional study was carried out in 2010, in 680 children aged 12-36 months in 4 communes of Dakrong district, Quang Tri province. Results: The malnutrition rate was 55.0% for underweight, 66.5% for stunting and 16.2% for wasting. The prevalence of malnutrition increases by age group. The prevalence of worm infection was 31.6%, the highest prevalence was belong to Ascaris infection (24.6%), followed by Hookworm and Trichuris (6.5% and 6.2%, respectively). The prevalence of worm infection among children under two is very high (27.0%). The prevalence of worm infection was distributed quite equally between the malnutrition children group and normal children group. Recommendation: Early deworming forchildren from 12 months should be considered as important strategy against the malnutrition of children in Dakrong district, Quang Tri province

scholarly journals Exercise Intensity during Olympic-Distance Triathlon in Well-Trained Age-Group Athletes: An Observational Study

Sports ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 18
Author(s):  
Atsushi Aoyagi ◽  
Keisuke Ishikura ◽  
Yoshiharu Nabekura
Keyword(s):  
Heart Rate ◽  
Observational Study ◽  
Exercise Intensity ◽  
Time Range ◽  
Age Group ◽  
Slow Group ◽  
H 41 ◽  
The Mean ◽  
Aerobic And Anaerobic ◽  
Very High

The aim of this study was to examine the exercise intensity during the swimming, cycling, and running legs of nondraft legal, Olympic-distance triathlons in well-trained, age-group triathletes. Seventeen male triathletes completed incremental swimming, cycling, and running tests to exhaustion. Heart rate (HR) and workload corresponding to aerobic and anaerobic thresholds, maximal workloads, and maximal HR (HRmax) in each exercise mode were analyzed. HR and workload were monitored throughout the race. The intensity distributions in three HR zones for each discipline and five workload zones in cycling and running were quantified. The subjects were then assigned to a fast or slow group based on the total race time (range, 2 h 07 min–2 h 41 min). The mean percentages of HRmax in the swimming, cycling, and running legs were 89.8% ± 3.7%, 91.1% ± 4.4%, and 90.7% ± 5.1%, respectively, for all participants. The mean percentage of HRmax and intensity distributions during the swimming and cycling legs were similar between groups. In the running leg, the faster group spent relatively more time above HR at anaerobic threshold (AnT) and between workload at AnT and maximal workload. In conclusion, well-trained male triathletes performed at very high intensity throughout a nondraft legal, Olympic-distance triathlon race, and sustaining higher intensity during running might play a role in the success of these athletes.

scholarly journals Mapping Groundwater Potential for Irrigation, by Geographical Information System and Remote Sensing Techniques: A Case Study of District Lower Dir, Pakistan

Atmosphere ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 669
Author(s):  
Abid Sarwar ◽  
Sajid Rashid Ahmad ◽  
Muhammad Ishaq Asif Rehmani ◽  
Muhammad Asif Javid ◽  
Shazia Gulzar ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Water Table ◽  
Groundwater Potential ◽  
Geographical Information ◽  
Groundwater Potential Zone ◽  
Potential Zone ◽  
Relative Significance ◽  
High Good ◽  
Groundwater Potentiality ◽  
Very High

The changing climate and global warming have rendered existing surface water insufficient, which is projected to adversely influence the irrigated farming systems globally. Consequently, groundwater demand has increased significantly owing to increasing population and demand for plant-based foods especially in South Asia and Pakistan. This study aimed to determine the potential areas for groundwater use for agriculture sector development in the study area Lower Dir District. ArcGIS 10.4 was utilized for geospatial analysis, which is referred to as Multi Influencing Factor (MIF) methodology. Seven parameters including land cover, geology, soil, rainfall, underground faults (liniment) density, drainage density, and slope, were utilized for delineation purpose. Considering relative significance and influence of each parameter in the groundwater recharge rating and weightage was given and potential groundwater areas were classified into very high, high, good, and poor. The result of classification disclosed that the areas of 113.10, 659.38, 674.68, and 124.17 km2 had very high, high, good, and poor potential for groundwater agricultural uses, respectively. Field surveys for water table indicated groundwater potentiality, which was high for Kotkay and Lalqila union councils having shallow water table. However, groundwater potentiality was poor in Zimdara, Khal, and Talash, characterized with a very deep water table. Moreover, the study effectively revealed that remote sensing and GIS could be developed as potent tools for mapping potential sites for groundwater utilization. Furthermore, MIF technique could be a suitable approach for delineation of groundwater potential zone, which can be applied for further research in different areas.

scholarly journals The Economic Impact of Inflammatory Bowel Disease in Canada

2004 ◽  
Vol 18 (4) ◽  
pp. 255-257
Author(s):  
Robert Hilsden
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Labour Force ◽  
Incidence Rates ◽  
Age Group ◽  
Group Level ◽  
The Past ◽  
Inflammatory Bowel ◽  
Using Data ◽  
Very High

Longobardi and colleagues examined the effect of inflammatory bowel disease (IBD) on employment, using data from 10,891 respondents aged 20 to 64 years from the 1998 cycle of the Canadian National Population Health Survey (NPHS) (1). This sample included 187 (1.7%) subjects who self-reported IBD or a similar bowel disorder. A significantly greater proportion of IBD than non-IBD respondents reported that they were not in the labour force (28.9% versus 18.5%). Even after adjusting for other factors (age group, level of pain, etc), subjects with IBD had a 2.9% higher nonparticipation rate (21.4%). For example, among people not hospitalized within the past year and with no limitation of activities due to pain, IBD subjects were 1.2 times more likely to be unemployed than those without IBD. Subjects who reported high levels of pain had a very high probability of being out of the labour force. Based on Canadian annual compensation data for all employed persons in Canada, and age- and sex-specific prevalence, and incidence rates for IBD, the authors estimated that there are 119,980 IBD patients between the ages of 20 and 64 years in Canada and that this group includes 3479 people who are not in the labour force. This translates into lost wages of $104.2 million, or $868 per IBD patient

Sign in / Sign up

Export Citation Format

Share Document