scholarly journals Wound Healing Efficacy of Guava Leaf Extract

2021 ◽  
pp. 27-35
Author(s):  
Sarah B. Delorino ◽  
Madeline L. Ogalesco ◽  
Kaye R. Rebadulla ◽  
Myrelle Tricia A. Rongcales ◽  
Joshua Ismael A. Salubre V ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Povidone Iodine ◽  
Biological Process ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Complex Process ◽  
Healing Wound ◽  
Guava Leaf ◽  
Scar Tissue Formation

A wound is a break in the continuity of the skin. The body’s response to injury and the restoration of the same is healing. Wound healing is a biological process that is initiated by trauma and often terminated by scar formation. In this research, guava leaf extract was used as antiseptic and its efficacy was tested to commercially available products. The result revealed that all mice which received guava leaf extract formed scar earlier as compared to povidone iodine and PNSS. Since maturation phase which also refers to remodeling phase is responsible for the new epithelium and final scar tissue formation, and as the development of these completes the complex process of wound healing, the researchers suggest that the use of guava leaf extract in comparison with povidone iodine and PNSS when it comes to wound healing is the most affordable in treatment and promoting normal and more rapid wound healing.

scholarly journals Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications

2006 ◽  
Vol 364 (1843) ◽  
pp. 1385-1405 ◽  
Author(s):  
Steven McDougall ◽  
John Dallon ◽  
Jonathan Sherratt ◽  
Philip Maini
Keyword(s):  
Wound Healing ◽  
Diffusion Coefficient ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Collagen Deposition ◽  
Dermal Wound Healing ◽  
Fibroblast Migration ◽  
Collagen Alignment ◽  
Dermal Wound ◽  
Scar Tissue Formation

The extent to which collagen alignment occurs during dermal wound healing determines the severity of scar tissue formation. We have modelled this using a multiscale approach, in which extracellular materials, for example collagen and fibrin, are modelled as continua, while fibroblasts are considered as discrete units. Within this model framework, we have explored the effects that different parameters have on the alignment process, and we have used the model to investigate how manipulation of transforming growth factor-β levels can reduce scar tissue formation. We briefly review this body of work, then extend the modelling framework to investigate the role played by leucocyte signalling in wound repair. To this end, fibroblast migration and collagen deposition within both the wound region and healthy peripheral tissue are considered. Trajectories of individual fibroblasts are determined as they migrate towards the wound region under the combined influence of collagen/fibrin alignment and gradients in a paracrine chemoattractant produced by leucocytes. The effects of a number of different physiological and cellular parameters upon the collagen alignment and repair integrity are assessed. These parameters include fibroblast concentration, cellular speed, fibroblast sensitivity to chemoattractant concentration and chemoattractant diffusion coefficient. Our results show that chemoattractant gradients lead to increased collagen alignment at the interface between the wound and the healthy tissue. Results show that there is a trade-off between wound integrity and the degree of scarring. The former is found to be optimized under conditions of a large chemoattractant diffusion coefficient, while the latter can be minimized when repair takes place in the presence of a competitive inhibitor to chemoattractants.

scholarly journals A review on Vranagranthi (Keloid) in Ayurvedic and Modern Aspect

2019 ◽  
Vol 7 (06) ◽  
Author(s):  
Abhijeet Suresh Shinde
Keyword(s):  
Wound Healing ◽  
Scar Tissue ◽  
Review Article ◽  
Tissue Formation ◽  
Pathological Study ◽  
Modern Aspect ◽  
Surgical Scar ◽  
Severe Acne ◽  
Scar Tissue Formation ◽  
Regressive Phase

Hypertrophic appearing scar tissue formation is known as Keloids. The growth of keloid is as compare to other raised scars is more rapid and progressive. If the keloid is formed then it grow much larger than the wound that caused the scar. Keloid is hypertrophic appearing scar that continue to evolve over the time without quiescent or regressive phase in the process of wound healing [1,2]    The certain communities e.g. Africans having Keloid-prone skin. The cut, burn, pin prick or severe acne are the some examples that causes Keloid. A keloid can also form as chickenpox clear. Sometimes, a surgical scar becomes a keloid. In very rare cases, keloids form when people do not injure their skin. These are called “spontaneous keloids.” A keloid usually takes time to appear. After an injury, months can pass before this scar appears. A keloid can also form more quickly. Once it begins, a keloid can enlarge slowly for months or years. Ayurveda Vagbhatacharya described it is as Vrunagranthi. This review article is a comparative pathological study of Vrunagranthi with special references to keloid is found that having direct and much more identical Causes, features, pathology and prognostic between these.

The Temporal Course of Adenovirus-Mediated Gene Transfer in the Rat Larynx

2002 ◽  
Vol 126 (3) ◽  
pp. 281-290
Author(s):  
Jacobs Ian N. ◽  
Tufano Ralph P. ◽  
Walsh Danielle S. ◽  
Crombleholme Timothy
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Gene Transfer ◽  
Recombinant Adenovirus ◽  
Marker Gene ◽  
Care Facility ◽  
Scar Tissue ◽  
Complete Disappearance ◽  
Tissue Formation ◽  
Scar Tissue Formation

OBJECTIVE: Polypeptide growth factors have important influences on wound-healing and scar tissue formation. Specific growth factors or their inhibitors may potentially decrease scar tissue formation and prevent subglottic stenosis. Gene transfer using recombinant adenovirus may be an ideal method to mediate endogenous production of growth factors to inhibit fibrosis. STUDY DESIGN: The study incorporated adenovirus-mediated transduction of normal and stenotic rat larynges and histologic analysis of the sequential expression of a β-galactosidase marker gene over time. SETTING: The study was conducted at the animal care facility of an academic children's hospital. RESULTS: We report successful transduction in normal and injured rat larynx with peak expression of β-galactosidase at 2 days after transduction and almost complete disappearance by 7 days. There appeared to be an early inflammatory response to the viral injection, but at 7 and 14 days after injection (transduction) the uninjured rat larynges resumed a normal histologic appearance. All distant sites stained negative for β-galactosidase. CONCLUSION: Recombinant adenovirus-mediated gene transfer is feasible in the rat larynx with transient duration and limited toxicity. SIGNIFICANCE: Adenovirus-mediated gene transfer has the potential to deliver growth factors that modulate wound healing and inflammation in the larynx by inhibiting fibrosis.

Influence of Scar Tissue Formation on the Early Wound Healing Process of Palate Bones in Rats

2005 ◽  
Vol 47 (3) ◽  
pp. 294-304
Author(s):  
Hitoshi Kawanabe ◽  
Shouichi Kinoshita ◽  
Yuichiro Hata ◽  
Hiroyuki Ishikawa ◽  
Kazuhiko Okamura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Scar Tissue ◽  
Wound Healing Process ◽  
Tissue Formation ◽  
Early Wound ◽  
Scar Tissue Formation

scholarly journals Experimental Methods to Simulate and Evaluate Postsurgical Peripheral Nerve Scarring

2021 ◽  
Vol 10 (8) ◽  
pp. 1613
Author(s):  
Alessandro Crosio ◽  
Giulia Ronchi ◽  
Benedetta Elena Fornasari ◽  
Simonetta Odella ◽  
Stefania Raimondo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Experimental Methods ◽  
Scar Tissue ◽  
Experimental Models ◽  
Tissue Formation ◽  
Surgical Interventions ◽  
Pubmed Database ◽  
Different Types ◽  
Scar Tissue Formation

As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complications of peripheral nerve scarring and also standard and quantitative parameters to evaluate perineural scars. So far, there are no standardized methods used in experimental research, and it is, therefore, difficult to compare the results of the different antiadhesion devices.

scholarly journals VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury

2018 ◽  
Vol 7 (8) ◽  
pp. 283-297 ◽  
Author(s):  
Lyn M. Wise ◽  
Gabriella S. Stuart ◽  
Nicola C. Real ◽  
Stephen B. Fleming ◽  
Andrew A. Mercer
Keyword(s):  
Scar Tissue ◽  
Vegf Receptor ◽  
Tissue Formation ◽  
Cutaneous Injury ◽  
Scar Tissue Formation
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