scholarly journals The Role p53 Protein Expression in Urothelial Neoplasm

2021 ◽  
pp. 85-99
Author(s):  
Bijayalaxmi Sahoo ◽  
. Jayaraman ◽  
R. Govindharajan ◽  
Vindu Sivastava
Keyword(s):  
Bladder Carcinoma ◽  
Tumor Size ◽  
P53 Protein ◽  
Bladder Neoplasms ◽  
The Elderly ◽  
Clinical Parameter ◽  
Transitional Epithelium ◽  
Malignant Neoplasms ◽  
Elderly Age ◽  
Papillary Type

The urinary bladder had a line with transitional epithelium. Urothelial neoplasms are the majority among the bladder neoplasms. Urothelial neoplasms were more common in males than in females. Urothelial neoplasms usually occur in the elderly age group. The majority of the tumor size was more significant than 3 cm, and papillary type is majorly found among the tumors. The present study aimed to identify the grade and staging of the p53 in urothelial neoplasms. The bladder carcinoma (54) cases from Department of Pathology, Sree Balaji Medical College and hospital (during September 2015 to September 2017) were analysed. The median age for bladder carcinoma in the present study was 66 years. The clinical parameter studied was the size of the lesion based on the cytoscopic or radiological findings (31- 33). Based on tumor size, lesions were classified into two groups, less than equal to 3cm and greater than 3cm, which was found to be 42% and 58%, respectively This study concludes that p53 is useful in differentiating benign and malignant neoplasms in morphologically difficult cases. Immunohistochemistry for p53 is useful adjunct to histomorphology.

Hubungan Sikap dan Karakteristik Pasangan Usia Subur (PUS) dengan Keikutsertaan dalam Program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur

2020 ◽  
Vol 8 (2) ◽  
pp. 105-114
Author(s):  
Ainul Mardhiah ◽  
Nova Hasbani Prima Dewi ◽  
Aminy Aminy
Keyword(s):  
Family Planning ◽  
Family Planning Program ◽  
The Elderly ◽  
P Value ◽  
Planning Program ◽  
Elderly Age ◽  
Chi Square ◽  
Cross Sectional ◽  
The Family ◽  
Relationship Of

The family planning program also aims to improve the quality of the family in order to generate a sense of security, peace and hope of a better future in realizing the prosperity of birth and inner happiness. Allegedly the factor causing EFA participation in the family planning program is characteristic. The purpose of this research is to know the relationship of attitude and characteristic of Elderly Age Couple (PUS) with participation in family planning program at UPT Puskesmas Sungai Raya Sungai Raya District, East Aceh regency 2018. The research design used was analytic survey with cross sectional design. The population of this study is all Pairs Age of Fertile located in Work Area UPT Sungai Raya Public Health Service Center in January to December 2017 which amounted to 1897 people. Sampling using Slovin formula, obtained as many as 95 samples. The study was conducted from 7-17 July 2018 using questionnaires by interview. Statistical test using chi-square test. Result of research indicate that majority of fertile couple couples (PUS) participate in family planning program as much as 67 respondents (70,5%). Statistically there is relationship of attitude and characteristic of Elderly Age Couple (EFA) with non participation in family planning program in Working Area of UPT Puskesmas Sungai Raya Sungai Raya District of East Aceh Regency 2018 with p value <0,1. It is recommended that the family planning program holders in UPT Puskesmas Sungai Raya Sungai Raya District of East Aceh District to invite cross-sectoral figures to hold meetings to create mini workshop plans at least once a month to increase the participation of the Elderly Age Couple (PUS) in family planning programs. Keyword : Family Planning Program, Attitudes, CharacteristicsABSTRAKProgram KB juga bertujuan untuk meningkatkan kualitas keluarga agar dapat timbul rasa aman, tentram, dan harapan masa depan yang lebih baik dalam mewujudkan kesejahteraan lahir dan kebahagiaan batin. Diduga faktor yang menyebabkan ketidakikutsertaan PUS dalam program KB adalah karakteristik. Tujuan penelitian ini untuk mengetahui hubungan sikap dan karakteristik Pasangan Usia Subur (PUS) dengan keikutsertaan dalam program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur tahun 2018. Desain penelitian yang digunakan adalah survei analitik dengan rancangan bedah lintang. Populasi dari penelitian ini adalah seluruh Pasangan Usia Subur yang berada di Wilayah Kerja UPT Puskesmas Sungai Raya pada bulan Januari sampai dengan Desember tahun 2017 yang berjumlah 1.897 orang. Pengambilan sampel menggunakan rumus Slovin, didapatkan sebanyak 95 sampel. Penelitian dilaksanakan dari tanggal 7-17 Juli tahun 2018 menggunakan kuesioner dengan cara wawancara. Uji statistik menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa mayoritas Pasangan Usia Subur (PUS) ikut serta dalam program KB yaitu sebanyak 67 responden (70,5%). Secara statistik ada hubungan sikap dan karakteristik Pasangan Usia Subur (PUS) dengan ketidakikutsertaan dalam program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur tahun 2018 dengan p value < 0,1. Sebaiknya pemegang program KB di UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur agar mengajak tokoh lintas sektor agar mengadakan pertemuan untuk membuat rencana loka karya mini setidaknya satu bulan sekali untuk meningkatkan keikutsertaan Pasangan Usia Subur (PUS) dalam program KB.Kata Kunci : Program KB, Sikap, Karakteristik

scholarly journals Impact of Frailty on Medical and Long-Term Care Expenditures for the Elderly Age 75 or Over in Japan

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 176-176
Author(s):  
Hiroto Yoshida ◽  
Yuriko Kihara
Keyword(s):  
Long Term Care ◽  
The Elderly ◽  
Elderly Age ◽  
Term Care ◽  
Intentional Weight Loss ◽  
Long Term Care Insurance ◽  
And Gender ◽  
The Impact

Abstract This study examined the impact of frailty on medical and long-term care expenditures in an older Japanese population. The subjects were those aged 75 years and over who responded to the survey (March 2018) in Bibai, Hokkaido, Japan (n=1,203) and have never received certification of long-term care insurance at the survey. We followed up 867 individuals (72.1%) until the end of December 2018 (10 month-period). We defined frailty as a state in performing 4 items and over of 15 items which were composed of un-intentional weight loss, history of falls, etc. Among 867 subjects, 233 subjects (26.9%) were judged to be frailty group, and 634 subjects (73.1%) non-frailty group. We compared period to the new certification of long-term care insurance (LTCI), accumulated medical and long-term care expenditures adjusted for age and gender between the two groups during the follow-up period. Cox proportional hazard models were used to examine the association between baseline frailty and the new certification of LTCI. The relative hazard ratio (HR) was higher in frailty group than non-frailty group (HR=3.51, 95% CI：1.30-9.45, P=.013). The adjusted mean accumulated medical and long-term care expenditures per capita during the follow-up were significantly (P=.002) larger for those in the frailty group (629,699 yen), while those in the non-frailty group were 450,995 yen. We confirmed strong economic impact of frailty in the elderly aged 75 or over in Japan.

Abstract P614: Effect Sizes of Vascular Risk Factors for Stroke Occurrence by Age Among West Africans

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Mayowa Owolabi ◽  
FRED S SARFO ◽  
Onoja Akpa ◽  
Joshua Akinyemi ◽  
Albert Akpalu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Middle Age ◽  
Meat Consumption ◽  
The Elderly ◽  
Vascular Risk Factors ◽  
Effect Sizes ◽  
Modifiable Risk Factors ◽  
Age Group ◽  
Vascular Risk ◽  
Elderly Age

Background: Age is a non-modifiable risk factor for stroke occurrence due its influence on vascular risk factor acquisition. In sub-Saharan Africa, the effect sizes of vascular risk factors for stroke occurrence by age is unknown. Objective: To quantify the magnitude and direction of the effect sizes of key modifiable risk factors of stroke according to three age groups: <50years(young), 50-65 years(middle age) and >65 years(elderly) in West Africa. Methods: The Stroke Investigative Research and Educational Network (SIREN) is a multicenter, case-control study involving 15 sites in Ghana and Nigeria. Cases include adults aged ≥18 years with evidence of an acute stroke. Controls were age-and-gender matched stroke-free adults. Detailed evaluations for vascular, lifestyle, stroke severity and outcomes were performed. We used conditional logistic regression to estimate adjusted odds ratios (aOR) of vascular risk factors of stroke. Results: Among 3,553 stroke cases, 813(22.9%) were young, 1441(40.6%) were middle-aged and 1299(36.6%) were elderly. Five modifiable risk factors were consistently associated with stroke occurrence regardless of age namely hypertension, dyslipidemia, diabetes mellitus, regular meat consumption and non-consumption of green vegetables. Among the 5 co-shared risk factors, the effect size, aOR(95%CI) of dyslipidemia, 4.13(2.64-6.46), was highest among the young age group, hypertension, 28.93(15.10-55.44) and non-consumption of vegetables 2.34(1.70-3.23) was highest among the middle-age group while diabetes, aOR of 3.50(2.48-4.95) and meat consumption, 2.40(1.76-3.26) were highest among the elderly age group. Additionally, among the young age group cigarette smoking and cardiac disease were associated with stroke. Furthermore, physical inactivity and salt intake were associated with stroke in the middle-age group while cardiac disease was associated with stroke in the elderly age group. Conclusions: Age has a profound influence on the profile, magnitude and direction of effect sizes of vascular risk factors for stroke occurrence among West Africans. Population-level prevention of stroke must target both co-shared dominant risk factors as well as factors that are unique to specific age bands in Africa.

The vertical vestibulo-ocular reflex, and its interaction with vision during active head motion: Effects of aging

2001 ◽  
Vol 11 (1) ◽  
pp. 3-12
Author(s):  
Ji Soo Kim ◽  
James A. Sharpe
Keyword(s):  
Smooth Pursuit ◽  
Low Frequency ◽  
The Elderly ◽  
Head Motion ◽  
Head Tracking ◽  
Elderly Age ◽  
Ocular Reflex ◽  
Visual Enhancement ◽  
Vestibulo Ocular Reflex ◽  
Effects Of Aging

The effects of aging on the vertical vestibulo-ocular reflex (VOR), and its interactions with vision during active head motion had not been investigated. We measured smooth pursuit, combined eye-head tracking, the VOR, and its visual enhancement and cancellation during active head motion in pitch using a magnetic search coil technique in 21 younger (age < 65) and 10 elderly (age ⩾ 65) subjects. With the head immobile, subjects pursued a target moving sinusoidally with a frequency range of 0.125 to 2.0 Hz, and with peak target accelerations (PTAs) ranging from 12 to 789Âř/s 2 . Combined eye-head tracking, the VOR in darkness, and its visual enhancement during fixation of an earth-fixed target (VVOR) were measured during active sinusoidal head motion with a peak-to-peak amplitude of 20Âř at frequencies of 0.25, 0.5, 1.0 and 2.0 Hz. The efficacy of VOR cancellation was determined from VOR gains during combined eye-head tracking. VOR and VVOR gains were symmetrical in both directions and did not change with aging, except for reduced gains of the downward VOR and VVOR at low frequency (0.25 Hz). However, in the elderly, smooth pursuit, and combined eye-head tracking gains and the efficacy of cancellation of the VOR were significantly lower than in younger subjects. In both the young and elderly groups, VOR gain in darkness did not vary with the frequency of active head motion while the gains of smooth pursuit, combined eye-head tracking, and VVOR declined with increasing target frequency. VOR and VVOR performance in the elderly implicates relative preservation of neural structures subserving vertical vestibular smooth eye motion in senescence.

Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men

1997 ◽  
Vol 272 (1) ◽  
pp. E139-E146 ◽  
Author(s):  
A. A. Portale ◽  
E. T. Lonergan ◽  
D. M. Tanney ◽  
B. P. Halloran
Keyword(s):  
Parathyroid Hormone ◽  
Young Men ◽  
The Elderly ◽  
Ionized Calcium ◽  
Elderly Men ◽  
Elderly Age ◽  
Healthy Men ◽  
Age Related ◽  
Serum Pth ◽  
The Relationship

We examined the effect of aging on the relationship between the concentrations of blood ionized calcium and of serum parathyroid hormone (PTH) in 22 healthy men [9 elderly (age 74 +/- 2 yr) and 13 young (age 39 +/- 1 yr)] in whom the glomerular filtration rate was > 70 ml/min. Throughout a 24-h period, serum concentrations of PTH in the elderly men were twice those in the young men, whereas blood ionized calcium did not differ between the two groups. With intravenous infusion of calcium gluconate, the minimum PTH concentration was two- to threefold higher in the elderly men. With infusion of NaEDTA. the maximum PTH concentration was 20% higher in the elderly men. The calcium set point for PTH release was higher in the elderly than in the young men (4.71 +/- 0.04 vs. 4.54 +/- 0.03 mg/dl, respectively, P < 0.005). In these healthy men, the age-related increase in serum PTH could not be attributed to a sustained decrease in concentration of either blood ionized calcium or 1,25-hydroxyvitamin D. These findings suggest that, with aging, the relationship between calcium and PTH is altered such that at any given level of calcium, the concentration of PTH is higher.

scholarly journals Indirect impact of Covid-19 on hospital care pathways in Italy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Teresa Spadea ◽  
Chiara Di Girolamo ◽  
Tania Landriscina ◽  
Olivia Leoni ◽  
Silvia Forni ◽  
...  
Keyword(s):  
The Elderly ◽  
Malignant Neoplasms ◽  
Italian Population ◽  
Hospital Discharges ◽  
Effective Response ◽  
St Segment Elevation ◽  
Care Services ◽  
Italian Regions ◽  
And Performance ◽  
Set Up

AbstractEarlier in 2020, seven Italian regions, which cover 62% of the Italian population, set up the Mimico-19 network to monitor the side effects of the restrictive measures against Covid-19 on volumes and quality of care. To this aim, we retrospectively analysed hospital discharges data, computing twelve indicators of volume and performance in three clinical areas: cardiology, oncology, and orthopaedics. Weekly indicators for the period January–July 2020 were compared with the corresponding average for 2018–2019; comparisons were performed within 3 sub-periods: pre-lockdown, lockdown, and post-lockdown. The weekly trend of hospitalisations for ST-segment elevation myocardial infarction (STEMI) showed a 40% reduction, but the proportion of STEMI patients with a primary PTCA did not significantly change from previous years. Malignant neoplasms surgery volumes differed substantially by site, with a limited reduction for lung cancer (< 20%) and greater declines (30–40%) for breast and prostate cancers. The percentage of timely surgery for femoral neck in the elderly remained constantly higher than the previous 2 years whereas hip and knee replacements fell dramatically. Hospitalisations have generally decreased, but the capacity of a timely and effective response in time-dependent pathways of care was not jeopardized throughout the period. General trends did not show important differences across regions, regardless of the different burden of Covid-19. Preventive and primary care services should adopt a pro-active approach, moving towards the identification of at-risk conditions that were neglected during the pandemic and timely addressing patients to the secondary care system.

scholarly journals THE DISABILITY OF CITIZEN OF ELDERLY AGE IN THE RUSSIAN FEDERATION

2019 ◽  
Vol 61 (6) ◽  
pp. 292-299
Author(s):  
Marina A. Shurgaya
Keyword(s):  
Social Support ◽  
Health Care ◽  
Russian Federation ◽  
Disabled Persons ◽  
Regional Differentiation ◽  
Malignant Neoplasms ◽  
Urogenital System ◽  
Elderly Age ◽  
Gender Characteristics ◽  
The Russian Federation

During the period of health care reforming, study of a true picture of population health and medical social needs in particular age-gender groups, including elderly age, is a necessary condition for planning development of health care, social support and scientific substantiation of prevention programs. The article presents the results of comparative analysis of indices of disability of main age groups of adult population of the Russian Federation during 2005-2016. The methods of study: documentary, data sampling, statistical and graphic techniques. The volume of study made up to 34,840,933 individuals aged from 18 years and older, recognized as disabled, including disabled persons of elderly age - 12,971,062 individuals. The established characteristics of primary and repeated disability of citizen of elderly age in the Russian Federation (gender characteristics, nosological structure, regional differentiation) are covered that reflect demographic tendencies of aging of population. The dynamics of disability of citizen of elderly age during long term period (2005-2016) testifies alteration of ratio between primary and repeated established cases of disability. In 2005 overwhelming exceeding of primary recognized as disabled persons over repeatedly recognized was marked: 81.2% against 18.9%. In 2016 in total contingent of the examined the disabled persons with repeatedly established disability prevailed: 62.7% against 37.3%. During the period of observation, the level of repeatedly established disability among citizen of elderly age increased up to 74,5% (R2 = 0,546), whereas in contingents of young and middle age is marked a stable tendency to decreasing of value of indicator (R2 = 0,934, R2 = 0,5873 correspondingly). The citizen of elderly age prevails in the structure of disability due to malignant neoplasms, diseases of blood circulation system, diseases of musculoskeletal system and connective tissue, diseases of eye, ear and mastoid bone, diseases of endocrine, nervous and urogenital system. In connection with high invalidation, the elderly category of population is in need of significant medical social support. The development of activities targeted to medical social rehabilitation of citizen of elderly age it is appropriate considering regional differentiation of the subjects in the Russian Federation related to prevalence of disability and also gender characteristics of disability.

scholarly journals MEMBANGUN PENDIDIKAN KARAKTER DALAM MASYARAKAT

2013 ◽  
Vol 13 (1) ◽  
pp. 1
Author(s):  
Sri Suyanta
Keyword(s):  
Early Childhood ◽  
Character Education ◽  
The Elderly ◽  
Social Environments ◽  
Human Beings ◽  
Elderly Age ◽  
The Past ◽  
Three Stages ◽  
At Home

Character education is a necessity across the area, time and age. Character education is absolutely necessary not only in school, but also at home and in other social environments. It was prioritized since the past, present and future. Even today the students in character education is no longer for an early childhood but also adult and even the elderly age. Therefore character education should be designed and implemented systematically and simultaneously to help the students understand the human behavioral values which are associated with someoneself, fellow human beings, the environment and his or her Lord. Character education can be reached through three stages, namely socialization of the introduction, internalization, application in life.

scholarly journals Subjectively perceived change in consumption along the living standards in old ages

2021 ◽  
Vol 55 (Különszám 2) ◽  
pp. 21-31
Author(s):  
Réka Hegedüs ◽  
Klaudia Rádóczy
Keyword(s):  
Human Resource Development ◽  
Old Age ◽  
Financial Management ◽  
Cluster Formation ◽  
The Elderly ◽  
Pension Scheme ◽  
Age Group ◽  
Elderly Age ◽  
New Findings ◽  
Financial Awareness

THE AIMS OF THE PAPER The aim of our research is to provide a picture of the conditions for providing the income background necessary for old age, the spending habits of the 50 plus age group, and to illustrate how the old ages goup of our survey, the elderly age group we survey perceives changes in their spending in the last 10-year. METHODOLOGY We used a representative personal survey with 500 Hungarian people. This survey was made in February 2020 on a targeted sample of the Hungarian population aged 50-70. In the analysis method, we used cluster formation, because we tried to identify groups showing different consumption changes based on the consumption categories of the Hungarian Central Statistical Office. MOST IMPORTANT RESULTS, NEW FINDINGS The results show that the people who participated in the survey had little perception of a change in their spending compared to their life 10 years before. On the other hand, our retirement income in old age may lag far behind the income in active, working years, so we can assume that if the significant decline in income did not affect consumption patterns, old-age income may be supplemented by savings in old age. EMPIRICAL IMPLICATIONS OF THE RESEARCH The clusters that we made shows well that the spendings of the 50-plus age group are also significant for the economy as a whole. The types of their expenditures is diverse and there is a lot of items that they would not necessarily be able to afford from an average income funded by the pension scheme. The characteristics of the clusters also show that there is a positive relationship between financial awareness (planning spending, exploring sales) and age. In our oppinion this is the reason why financial awareness education, the communications about this is very important. The financial management of households can be incorporated into the education of children from an early age. Acknowledgments: This research was partially supported by the Human Resource Development Operational Programme, grant No.: EFOP-3.6.1-16-2016-00004 “Comprehensive developments at the University of Pécs for the implementation of intelligent specialization”

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