scholarly journals Human Serum Albumin: A Novel Drug Delivery Carrier System

2021 ◽  
pp. 18-24
Author(s):  
Snehal Patel ◽  
Chintan Aundhia ◽  
Avinash Seth ◽  
Nirmal Shah ◽  
Dipti Gohil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Half Life ◽  
Therapeutic Potential ◽  
Specific Binding ◽  
Drug Carrier ◽  
Drug Molecules ◽  
Drug Delivery Carrier ◽  
Specific Binding Sites ◽  
Novel Drug

Serum albumin, often referred to simply as albumin, is a globular protein that in humans is encoded by the ALB gene. Albumin is a multifaceted, highly soluble, stable, nontoxic, non-poisonous, biocompatible and biodegradable plasma protein. Albumin has been widely studied as a protein carrier for drug delivery. Because of its versatile nature, it can also be used for the delivery of the hormones, metals and fatty acids by binding to its specific binding sites. Various studies revealed that albumin can be used to increase the circulating half-life and bioavailability of drug molecules which are smaller than the renal filtration threshold and are rapidly lost from the circulation leading to limiting therapeutic potential. This review article presents advantages, disadvantages, functions, importance, different nanoparticles that can be crowned with an albumin and the special features of albumin as a drug carrier, and how the understanding of these features is currently being employed to optimize the circulatory half-life albumin.

Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization

2019 ◽  
Vol 16 (3) ◽  
pp. 258-265
Author(s):  
Kei Takahashi ◽  
Tomomi Masuda ◽  
Mitsunori Harada ◽  
Tadashi Inoue ◽  
Shinsuke Nakamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Choroidal Neovascularization ◽  
Pigment Epithelium ◽  
Drug Carrier ◽  
Retinal Pigment ◽  
Laser Coagulation ◽  
Antiangiogenic Agents ◽  
Drug Carrier System ◽  
Novel Drug ◽  
Drug Delivery Devices

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

Herbal Liposomes: Natural Network for Targeted Drug Delivery System

2021 ◽  
pp. 31-41
Author(s):  
Vijay R. Salunkhe ◽  
Prasanna S. Patil ◽  
Ganesh H. Wadkar ◽  
Somnath D. Bhinge
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Lipid Solubility ◽  
Liposomal Formulations ◽  
Novel Drug ◽  
Herbal Formulations

Herbal medicines have tremendous therapeutic potential that can explored across various effective drug delivery system. Decoctions, herbal teas, tinctures, glyceritum, oxymel, and use much soap, herbal tablets, herbal capsules, and herbal cream, herbal books, and prepared the confection of the most commonly available forms of dosage. The less use of herbal formulations in recent decades due to their lack of standardization. It is possible to use plant extract and isolated constituents to overcome this problem. But these phytoconstituents are suffering from drawbacks, mostly due to problems with stability and low lipid solubility. Novel drug delivery such as liposomes plays an important role in problem solving. Infact, compliance with the patient also improves. The review article discusses the recent status of new herbal liposomal formulations and describes the different ways in which these formulations are prepared.

An Overview of Nanoparticles: Current Scenario

2021 ◽  
pp. 239-246
Author(s):  
Seema U. Shinde ◽  
Nikita D. Gidde ◽  
Pradnya P. Shinde ◽  
Akshay B. Kadam
Keyword(s):  
Drug Delivery ◽  
High Stability ◽  
Hydrophobic Drug ◽  
Preparation Methods ◽  
Routes Of Administration ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Current Scenario ◽  
Release Potential ◽  
Novel Drug

The simplest type of structures with sizes in the nm range will be nanoparticles. Any atom mean that is associated by intensity with other atoms within a 'limited' distance may be claimed to be a nanoparticle in principle. The creation of novel drug delivery systems using nanoparticles has seen an exponential interest in recent years. In terms of high stability, high precision, high drug carrying capability, managed release potential, the possibility of use in various routes of administration and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles may offer significant advantages over conventional drug delivery. The emphasis of this study is on classification, types, synthesis, preparation methods, characterization, use, nanoparticle advantages, and health perspectives.

scholarly journals The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

2015 ◽  
Vol 2015 ◽  
pp. 1-27 ◽  
Author(s):  
Karolina Werengowska-Ciećwierz ◽  
Marek Wiśniewski ◽  
Artur P. Terzyk ◽  
Sylwester Furmaniak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Physical Adsorption ◽  
Drug Carrier ◽  
Anticancer Therapy ◽  
Modern Drug ◽  
Polycyclic Groups ◽  
Novel Drug ◽  
Small Elements

Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the form of R-X-R the “click chemistry” groups is shown. Physical adsorption and chemical bonding of drug to nanocarrier surface involving drug on the internal or external surfaces of nanocarriers are described throughout possibility of the formation of the above-mentioned functionalities. Moreover, the most popular nanostructures (liposomes, micelles, polymeric nanoparticles, dendrimers, carbon nanotubes, and nanohorns) are characterized as nanocarriers. Building of modern drug carrier is a new method which could be effectively applied in targeted anticancer therapy.

A Novel Drug Delivery Carrier Based on α-eleostearic Acid Grafted Hydroxyapatite Composite

2014 ◽  
Vol 11 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Ting Cao ◽  
Weili Tang ◽  
Jingchan Zhao ◽  
Lulu Qin ◽  
Chunbo Lan
Keyword(s):  
Drug Delivery ◽  
Eleostearic Acid ◽  
Drug Delivery Carrier ◽  
Hydroxyapatite Composite ◽  
Novel Drug

scholarly journals Rapid identification of Human Serum Albumin binding peptides from a phage display library：a back-of-the-envelope assessment of positive binders using titer-based criteria

2015 ◽  
Author(s):  
Yi-Feng Shi ◽  
Min Li ◽  
Jia-Di Zhang ◽  
Lei Bian
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Phage Display ◽  
Human Serum ◽  
Half Life ◽  
Drug Carrier ◽  
Therapeutic Proteins ◽  
Blood Protein ◽  
Albumin Binding ◽  
Binding Peptides

Human serum albumin (HSA) is the most abundant protein in blood and has a 19-day in vivo half-life, the longest human blood protein. HSA has also been extensively studied as a drug carrier in a wide variety of clinical applications. HSA-binding, compared with HSA-fusion, is promising strategy for extending the plasma half-life of protein therapeutics. The construction of albumin-binding drugs requires assessment of a large enough quantity of HSA-binding peptide candidates for conjugation with therapeutic proteins. Here, we report a back-of-the-envelope assessment method to facilitate phage display selection of HSA-binding peptides. With an experimentally determined number of phage titers, we can calculate the specificity ratios and the recovery yields. The recovery yield is calculated using the titers of eluted phage divided by the titers of input phage. The specificity ratio is calculated using the titer of eluted phage from a target-coated plate divided by the titer of eluted phage from a blank-control plate. These parameters are defined as quantitative criteria for panning and characterization of binding phage clones. Consequently, this approach may enable more rapid and low-cost phage display screening of HSA-binding peptides, which could be used as candidates of HSA binders for conjugation with therapeutic proteins.

scholarly journals Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems

10.14311/1450 ◽  
2011 ◽  
Vol 51 (5) ◽  
Author(s):  
V. Petráková
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Electrical Potential ◽  
Diamond Surface ◽  
Attractive Alternative ◽  
Covalent Bonds ◽  
Detection Tool ◽  
Novel Drug ◽  
Work Done

This paper presents work done on developing optically-traceable intracellular nanodiamond sensors, where the photoluminescence can be changed by a biomolecular attachment/delivery event. Their high biocompatibility, small size and stable luminescence from their color centers make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery and cell-imaging applications. In our work, we study how surface modification of ND can change the color of ND luminescence (PL). This method can be used as a novel detection tool for remote monitoring of chemical processes in biological systems. Recently, we showed that PL can be driven by atomic functionalization, leading to a change in the color of ND luminescence from red (oxidized ND) to orange (hydrogenated ND). In this work, we show how PL of ND changes similarly when interacting with positively and negatively charged molecules. The effect is demonstrated on fluorinated ND, where the high dipole moment of the C-F bond is favorable for the formation of non-covalent bonds with charged molecules. We model this effect using electrical potential changes at the diamond surface. The final aim of the work is to develop a “smart” optically traceable drug carrier, where the delivery event is optically detectable.

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