scholarly journals Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

2021 ◽  
pp. 310-316
Author(s):  
T. Mitila ◽  
P. S. Muthu Subramanian ◽  
Chitra Srinivasan ◽  
Vimal Chander
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Blood Group ◽  
Histological Grade ◽  
Tertiary Care ◽  
Blood Type ◽  
Early Screening ◽  
Tertiary Care Centre ◽  
Abo Blood Grouping ◽  
Blood Grouping

Background: Globally, breast cancer contributes to 27.7% of the newly diagnosed cases of cancer among women. Early screening and timely diagnosis of the lesions of breast help in alleviating the anxiety among patients. Histopathology is the gold standard in diagnosing the lesions, assessing the adequacy of treatment, and in disease prognosis. Studies have shown that ABO blood type has been associated with risk and survival for several malignancies. However, data for an association with breast cancer are inconsistent. Aim: To study the histopathological spectrum breast carcinomas and to investigate the presence of a possible association between breast cancer in women and ABO blood group and Rh factor. Materials and Methods: This retrospective descriptive study was done for a period of 4 years on 110 mastectomy specimens histopathologically diagnosed as breast cancers, and clinico-pathological data collected and analysed with records from the Department of Pathology, Saveetha Medical College. Association of breast cancer with ABO blood grouping and Rh typing was studied.  Results: Left breast was involved in most cases (96.4%). The mean age was 50.86 years, with 41-50 years age group showing peak incidence. Infiltrating breast carcinoma, no special type (89.6%) was the most common histological type. ER and PR positivity was seen in 46.4% and 41.8% of cases respectively. A statistically significant association was seen between hormone receptor status and histological grade. 39.1% cases belonged to O blood group, and Rh positivity was seen in 96.4% of the cases. No association was found between breast cancer and ABO/Rh blood grouping.

Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study

2011 ◽  
Vol 126 (2) ◽  
pp. 180-184 ◽  
Author(s):  
S I Adam ◽  
K M Wilson ◽  
S M Overholser ◽  
E Khabbaz ◽  
K Moreno ◽  
...  
Keyword(s):  
Head And Neck ◽  
Blood Group ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Laryngeal Carcinoma ◽  
Survival Rates ◽  
Blood Type ◽  
Advanced Stage Cancer ◽  
Abo Blood Grouping ◽  
Blood Grouping

AbstractObjective:Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality.Methods:Of 271 patients treated for squamous cell laryngeal carcinoma (1997–2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared.Results:There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001).Conclusion:Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.

scholarly journals Resolving blood group discrepancy in patients of tertiary care centre in Odisha, India

2018 ◽  
Vol 6 (7) ◽  
pp. 2348 ◽  
Author(s):  
Debasish Mishra ◽  
Pankaj Parida ◽  
Smita Mahapatra ◽  
Binay Bhusan Sahoo
Keyword(s):  
Blood Group ◽  
Tertiary Care ◽  
Group Testing ◽  
Antigen Expression ◽  
Tertiary Care Centre ◽  
Medical College ◽  
Cell Testing ◽  
A Prospective Study ◽  
Positive Results ◽  
Blood Grouping

Background: Blood grouping consists of both forward grouping; reverse grouping and both procedures should agree with each other.A blood group discrepancy exists when results of red cell testing do not agree with serum testing, usually due to unexpected negative or positive results in either forward or reverse typing. ABO and Rh blood group discrepancy is associated with incompatible transfusion reaction.Blood group discrepancy should be resolved before transfusion and blood group to be properly labeled to prevent transfusion reaction.Methods: A prospective study was carried in SCB blood bank which is under the Department of Transfusion Medicine, SCB Medical College and Hospital, Cuttack, Odisha from January 2015 to October-2016. Total 25,559 blood samples of patients were included in the study and hemolysed samples excluded. The ABO and Rh D typing was done by tube technique using monoclonal IgM (Tulip Diagnostic P Ltd.) Anti-A, Anti-B, Anti-D and pooled A, B and O cell.Results: A total of 25,559 blood group testing were done where we found 57 blood group discrepancies with overall frequency was 0.22%. Out of 57 discrepancies we were found 20 (35.09%) cases of technical error and 37 (64.91%) cases of sample related error. Among these sample related problems, we found weak/missing antibody, weak antigen expression, rouleaux, cold autoantibodies, cold alloantibodies, Bombay phenotype with the frequency of 13.51%, 2.70%, 2.70%, 54.06%, 8.11%, 18.92% respectively.Conclusions: Mistyping either a donor or a recipient can lead to transfusion with ABO-incompatible blood, which can result in severe hemolysis and may even result in the death of the recipient. Any discrepancy between forward and reverse blood grouping methods should be resolved before transfusion of blood components.

scholarly journals PROFILE OF BREAST CANCER PATIENTS ATTENDING A TERTIARY CARE CENTRE: A CROSS-SECTIONAL STUDY

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Ganpat Singh Choudhary ◽  
Man Singh Bairwa
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Rural Areas ◽  
Tertiary Care ◽  
Nipple Discharge ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Medical College

Background: World-wide breast cancer is the most frequent type of cancer among females with increasing incidence. Methods: This study was retrospective and prospective both. Total 40 Female patients of Breast cancer, from all age group admitted in Department of Surgery, Dr. S.N. Medical College, Jodhpur were included. Results: Lump was presenting feature in all cases 100%. The next most common presenting feature was pain, which was present in 62.5% cases. 10%, 17.5% and 2.5% cases had nipple discharge, nipple retraction and skin ulceration. Conclusion: The highest incidence of breast carcinoma was in 4th, 5th and 6the decades.Majority of the patients was Hindus and of rural areas and all the patients were married female. Keywords: Breast Carcinoma, Histopathologically Positive, Metastasis

scholarly journals PREVALENCE OF BOMBAY BLOOD GROUP AMONGST THE HEALTHY BLOOD DONORS AT A TERTIARY CARE CENTRE IN WESTERN RAJASTHAN, INDIA

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Kaluram Meghwal ◽  
N.L. Mahawar ◽  
Dev Raj Arya ◽  
Arun Bharti ◽  
Shailendra Vashistha ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Indirect Antiglobulin Test ◽  
Donor Population ◽  
Study Population ◽  
Clinically Significant ◽  
Group B ◽  
Blood Grouping

Introduction: The prevalence of Bombay (Oh Phenotype) is not precisely known in Rajasthan state. Because of the fact that Bombay blood group is clinically significant, we decided to conduct a study at our centre to determine the prevalence of Bombay blood group among blood donor population in Western Rajasthan. Methodology: This blood bank based prospective study was carried out amongst the blood donors over a period of 11 months, i.e., from February 2019 to December 2019. Total 30,000 donor samples were screened for ABO-RhD blood grouping and antibody screening. Auto control, indirect antiglobulin test (IAT) and Bombay blood group (Anti-H lectin) tests were run on all the O blood group samples showing agglutination with O reagent cells (in reverse grouping). Donors negative on Anti-H testing were tested for saliva A, B and H antigens and interpreted. Results: Out of the total 30,000 donors, the maximum number of donors had blood group B+ (32.76%), followed by O+ (29.9%), A+ (20.41%), AB+ (8.06%), B- (3.11), O- (3.02%), A- (1.93%) and AB- (0.8%). Prevalence of Bombay blood group among study population was calculated to be 0.003%. Conclusion: Bombay phenotype is a rare blood group but not uncommon. If serum grouping is not performed, it is misdiagnosed as blood group O. Therefore both forward and reverse blood grouping should be done on 100% samples. Keywords: Bombay, Anti-H lectin, Serum grouping, Blood donors.

scholarly journals Male breast carcinoma: study from a tertiary care centre in North India

2021 ◽  
Vol 9 (10) ◽  
pp. 3163
Author(s):  
Sant Prakash Kataria ◽  
Pinki Devi ◽  
Sanjay Kumar ◽  
Gajender Singh ◽  
Sonia Chhabra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Male Breast Cancer ◽  
Tertiary Care ◽  
Needle Aspiration ◽  
Male Breast ◽  
North India ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Fine Needle

Male breast cancer is a rare malignancy. In recent years a rise in the number of male breast cancer cases has been seen. Due to rarity of the disease the reporting of such cases is important to support the present status of this aggressive malignancy. Fine needle aspiration method for breast FNA is an invasive procedure but can provide a diagnosis without causing much morbidity to the patient. Hence, objective of the present work was to report and study the clinico-pathological behaviour of male breast cancer at a tertiary care centre in North India using fine needle aspiration-based diagnosis. Present study includes cytologically diagnosed male breast carcinoma cases over a period of 4 years. Eleven cases of male breast cancer were identified. Median age of presentation was 57years. All the eleven patients presented with main complaint of swelling in breast (100%), nine (81.8%) patients presenting in left breast and two (18.2%) in right breast. Four cases presented with nipple retraction. Also, axillary lymphadenopathy was evident in four (34.4%) patients. Male breast cancer an aggressive disease having distinct clinical presentation, can be cytologically diagnosed easily as other benign conditions are rare in male breast.  

scholarly journals Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mindaugas Morkunas ◽  
Dovile Zilenaite ◽  
Aida Laurinaviciene ◽  
Povilas Treigys ◽  
Arvydas Laurinavicius
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cox Regression ◽  
Regional Lymph Node ◽  
Histological Grade ◽  
Biological Information ◽  
Lymph Node Status ◽  
Bright Field

AbstractWithin the tumor microenvironment, specifically aligned collagen has been shown to stimulate tumor progression by directing the migration of metastatic cells along its structural framework. Tumor-associated collagen signatures (TACS) have been linked to breast cancer patient outcome. Robust and affordable methods for assessing biological information contained in collagen architecture need to be developed. We have developed a novel artificial neural network (ANN) based approach for tumor collagen segmentation from bright-field histology images and have tested it on a set of tissue microarray sections from early hormone receptor-positive invasive ductal breast carcinoma stained with Sirius Red (1 core per patient, n = 92). We designed and trained ANNs on sets of differently annotated image patches to segment collagen fibers and extracted 37 features of collagen fiber morphometry, density, orientation, texture, and fractal characteristics in the entire cohort. Independent instances of ANN models trained on highly differing annotations produced reasonably concordant collagen segmentation masks and allowed reliable prognostic Cox regression models (with likelihood ratios 14.11–22.99, at p-value < 0.05) superior to conventional clinical parameters (size of the primary tumor (T), regional lymph node status (N), histological grade (G), and patient age). Additionally, we noted statistically significant differences of collagen features between tumor grade groups, and the factor analysis revealed features resembling the TACS concept. Our proposed method offers collagen framework segmentation from bright-field histology images and provides novel image-based features for better breast cancer patient prognostication.

scholarly journals DISTRIBUTION OF ABO AND RH (D) BLOOD GROUPS AMONG BLOOD DONORS IN DISTRICT MARDAN, PAKISTAN

1969 ◽  
Vol 3 (2) ◽  
pp. 318-322
Author(s):  
MUHAMMAD KHALID ◽  
NAILA ASLAM ◽  
MUHAMMAD SIYAR ◽  
RASHID AHMAD
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Local Community ◽  
Healthy Adult ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Cross Sectional ◽  
Group B ◽  
Abo Blood Grouping ◽  
Blood Grouping

OBJECTIVE: To find out the distribution of ABO and Rh (D) blood groups among blood donors in districtMardan and to help transfusion services in the area.STUDY DESIGN: Cross sectional descriptive study.MATERIALS AND METHODS: The study was conducted in DHQ Hospital Mardan from 1st January2012 to 31st December 2012. A total of 2893 healthy adult, blood donors (both volunteer and directed) fromdistrict Mardan were included. Two ml of blood anti-coagulated with EDTA was taken and both ABO andRh (D) blood groups were determined using commercially available anti-sera of Biolaboratories. Thedistribution ofABO and Rh blood groups in the local community were then calculated.RESULTS: Among ABO blood groups “ B” (27.97%) was the most prevalent, followed by “0” (27.93%),“ A” (24.75%) and “ AB” (19.36%). Group Rh positive (94.30%) was more prevalent than Rh negative(5.70%). Similarly 0+ve (26.65%) was most frequent followed by B+ve (26.17%), A+ve (23.16%), AB+ve(18.32%), B've(1.80%),Ave(l.59%),O ve( 1.28%) and ABve( 1.04%).CONCLUSION: Blood group 'B' was most frequent among the ABO blood groups and Rh (D) positiveamong Rh blood groups while0+vewas the most frequent blood group in the study population.KEYWORDS: ABO Blood grouping, Rh (D) blood grouping, Mardan.

Blood group discrepancies at a tertiary care centre - analysis and resolution

2013 ◽  
Vol 36 (4) ◽  
pp. 481-487 ◽  
Author(s):  
G. Kaur ◽  
P. Kaur ◽  
S. Basu ◽  
R. Kaur
Keyword(s):  
Blood Group ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre

CLINICAL AND HISTOPATHOLOGICAL REVIEW OF INVASIVE BREAST CARCINOMA IN A TERITARY CARE CENTRE.

2021 ◽  
pp. 18-21
Author(s):  
A. Gomathy ◽  
Muruganantham Arunagirinathan ◽  
I. Nithya
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Survival ◽  
Histological Grade ◽  
Lymph Node Involvement ◽  
Left Breast ◽  
Invasive Breast Carcinoma ◽  
Indian Women ◽  
Node Involvement ◽  
Grade Ii

BACKGROUND: Breast cancer accounts for 14% of all cancers in Indian women, that can occur at any age. Cancer survival becomes more difcult in higher stages of tumour, hence in order to improve the survival of affected persons, early diagnosis of breast cancer is critical. METHODS: Retrospective study of 48 mastectomy specimens with relevant clinical details and respective H&E stained slides were reviewed. CONCLUSION: This review showed that occurrence of Invasive Breast Carcinoma(IBC) peaks in the age group of 41-50years (35.4% ) with right and left breast being affected equally in the ratio of R:L – 1 : 1. Most of the IBC (91.6%) were of No Special Type (NST), with 75% of tumours were of Histological Grade II. 58.3% of tumours were of tumour stage T along with lymph node involvement in equal number of cases.

Sign in / Sign up

Export Citation Format

Share Document