scholarly journals The Impact of Hyperthecosis on Sporting Performance of Female Players

2021 ◽  
pp. 93-101
Author(s):  
Syeda Maryam Zara ◽  
Sumera Sattar ◽  
Yasmeen Tabassum ◽  
Shagufta Akhtar ◽  
Mahnoor Shafqat
Keyword(s):  
Clinical Features ◽  
Female Athletes ◽  
Energy Levels ◽  
Descriptive Analysis ◽  
Psychological Impact ◽  
Sports Performance ◽  
Anabolic Hormone ◽  
Psychological Conditions ◽  
The Impact ◽  
Sporting Performance

Testosterone is an anabolic hormone that increases muscle mass and strength, stimulates erythropoiesis, promotes competitive behavior and enhances the sporting performance of female athletes. A comparative study was designed on forty female athletes who were selected from the three public and private sector universities of Lahore, they had been diagnosed with HTC by a qualified gynecologist based on clinical features and lab tests. At the same time, a healthy group of female athletes (n=40) was selected from participants of the same population and having regular menses and showed no clinical features of HTC. The main objectives of the study included: 1) to compare both the groups of female athletes on clinical features of HTC, and 2) to compare both the groups on self-perceived sports performance. Data collection was done using two different instruments involving the “Hyperthecosis Questionnaire (HTCQ)” and “Athlete’s Subjective Performance Scale (ASPS)”. Data analyses involved descriptive analysis followed by an “Independent Sample t test’ to compare the physical and psychological impact of HTC and ANOVA was applied to analyze the impact of HTC on sports performance. There were significant differences between female athletes with HTC and those with Non-HTC on physical and psychological conditions. It can be concluded that female athletes with HTC were more concerned about their physical and psychological conditions. Moreover, their sporting performance was statistically significantly higher than Non-HTC athletes, which is attributed to higher energy levels caused by HTC itself.

scholarly journals Características psicológicas relevantes para el rendimiento deportivo: diferencias de género en fútbol juvenil

2021 ◽  
Vol 21 (2) ◽  
pp. 127-137
Author(s):  
Aurelio Olmedilla ◽  
Marta Cánovas ◽  
Belén Olmedilla-Caballero ◽  
Enrique Ortega
Keyword(s):  
Female Athletes ◽  
Psychological Characteristics ◽  
Soccer Players ◽  
Sports Performance ◽  
Cross Sectional ◽  
Male And Female ◽  
Youth Soccer ◽  
Track Record ◽  
The One ◽  
The Impact

El estudio de los factores psicológicos relacionados con el rendimiento deportivo tiene un importante recorrido en la literatura científica. Conocer si existen diferencias entre hombres y mujeres deportistas, cuáles son estas, y en qué aspectos se manifiestan es una cuestión que podría ayudar a mejorar la labor de entrenadores y técnicos deportivos. El objetivo de este estudio es determinar si existen diferencias de género en el perfil psicológico de futbolistas juveniles relacionado con el rendimiento deportivo. Se utilizó un diseño descriptivo transversal. La muestra objeto de estudio estuvo formada por un total de 329 jugadores juveniles de fútbol (46.8% varones y 53,2% mujeres), con una edad media de 17.02 (±1.50) años;. Para la evaluación de las características psicológicas se utilizó el Cuestionario Características Psicológicas Relacionadas con el Rendimiento Deportivo (CPRD). Los resultados de este estudio indican que existen diferencias estadísticamente significativas entre chicos y chicas en control de estrés (CE), influencia de la evaluación del rendimiento (IER) y en cohesión de equipo (CH). Los jugadores chicos manifiestan puntuaciones mayores que las jugadoras chicas en CE, es decir, gestionan mejor el estrés propio de la competición, y en IER, es decir, los jugadores chicos gestionan mejor que las jugadoras chicas el impacto que supone la evaluación de su rendimiento, el que hacen los otros (entrenadores, compañeros, padres/madres, etc.) y el que se hace a sí mismo. Sin embargo, las jugadoras chicas presentan mejores puntuaciones en CH, es decir, manifiestan una mayor tendencia a trabajar en grupo y fortalecer el equipo. The study of psychological factors related to sports performance has an important track record in the scientific literature. Knowing if there are differences between male and female athletes, what they are, and in what aspects they manifest is an issue that could help improve the work of coaches and sports technicians. The aim of this study is to determine if there are gender differences in the psychological profile of youth soccer players related to sports performance. A descriptive cross-sectional design was used. The sample under study was formed by a total of 329 youth soccer players (46.8% male and 53,2% female), with an average age of 17.02 (± 1.50) years. The Psychological Characteristics Questionnaire Related to Sports Performance (CPRD) was used to evaluate psychological characteristics. The results of this study indicate that there are statistically significant differences between male and female in stress control (CE), influence of performance evaluation (IER) and in team cohesion (CH). The male players show higher scores than the female players in CE, that is, they better manage the stress of the competition, and in IER, that is, the male players manage better than the female players the impact of evaluating their performance, the one that others do (coaches, partners, fathers / mothers, etc.) and the one that makes itself. However, female players have better CH scores, that is, they show a greater tendency to work in groups and strengthen the team. O estudo de fatores psicológicos relacionados ao desempenho esportivo tem um histórico importante na literatura científica. Saber se existem diferenças entre atletas masculinos e femininos, o que são e em que aspectos eles se manifestam é uma questão que pode ajudar a melhorar o trabalho de treinadores e técnicos esportivos. O objetivo deste estudo é determinar se existem diferenças de gênero no perfil psicológico de jovens jogadores de futebol relacionados ao desempenho esportivo. Foi utilizado um desenho descritivo de corte transversal. A amostra estudada foi composta por um total de 329 jogadores de futebol juvenil (46,8% masculino e 53,2% feminino), com idade média de 17,02 (± 1,50) anos. O Questionário de Características Psicológicas Relacionadas ao Desempenho Esportivo (CPRD) foi utilizado para avaliar as características psicológicas. Os resultados deste estudo indicam que existem diferenças estatisticamente significantes entre meninos e meninas no controle do estresse (EC), influência da avaliação de desempenho (IER) e na coesão da equipe (HC). Os jogadores pequenos apresentam pontuações mais altas do que as jogadoras da CE, ou seja, administram melhor o estresse da competição, e no IER, ou seja, os jogadores pequenos gerenciam melhor do que as jogadoras o impacto de avaliar seu desempenho , o que os outros fazem (treinadores, parceiros, pais / mães, etc.) e o que se faz. No entanto, as jogadoras têm melhores pontuações no HC, ou seja, mostram maior tendência a trabalhar em grupo e fortalecer a equipe

scholarly journals The impact of COVID-19 pandemic on mental health & wellbeing among home-quarantined Bangladeshi students: A cross-sectional pilot study

2020 ◽  
Author(s):  
Abid Hasan Khan ◽  
Mst. Sadia Sultana ◽  
Sahadat Hossain ◽  
M Tasdik Hasan ◽  
Helal Uddin Ahmed ◽  
...  
Keyword(s):  
Mental Health ◽  
Descriptive Analysis ◽  
Psychological Impact ◽  
Cross Sectional Study ◽  
Physical Symptoms ◽  
Psychological Consequences ◽  
Physical And Mental Health ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
The Impact

Background: COVID-19 is imposing threat both on physical and mental health since its outbreak. Bangladesh adopted lockdown strategy with potential consequences on day to day life, mental and physical health and this study aims to explore the impact of COVID-19 on mental health and wellbeing among Bangladeshi students. Methods: A cross-sectional study was conducted between 9th and 23th April 2020 among 505 college and university students. Data was collected by using online questionnaire including DASS 21 and IES. Descriptive analysis and bivariate linear regression were performed to examine the association of variables. Results: 28.5 % of the respondents had stress, 33.3% anxiety, 46.92% depression from mild to extremely severe, according to DASS 21 and 69.31% had event-specific distress from mild to severe in terms of severity according to IES. Perceiving physical symptoms as COVID-19 was significantly associated with DASS stress subscale (B=3.71, 95% CI: 1.01 to 6.40), DASS anxiety subscale (B= 3.95, 95% CI: 1.95 to 5.96), DASS depression subscale (B=3.82, 95% CI: 0.97 to 6.67) and IES scale (B=7.52, 95% CI: 3.58 to 11.45). Additionally, fear of infection, financial uncertainty, inadequate food supply, absence of physical exercise and limited or no recreational activity had significant association with stress, anxiety, depression and post-traumatic symptoms. Conclusion: This COVID-19 outbreak imposes psychological consequences on people to a great extent which requires attention from the concerned authorities to cope with this situation mentally. The perception about the outbreak can also play a big role in psychological impact.

Impak Kerjasama Politik Umno-Pas Terhadap Perkembangan Islam Di Malaysia Dari Tahun 1973 Hingga 1978

Sains Insani ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 12-16
Author(s):  
Mohammad Tawfik Yaakub ◽  
Osman Md Rasip
Keyword(s):  
Descriptive Analysis ◽  
Historical Research ◽  
Radio Station ◽  
The Political ◽  
Coalition Government ◽  
Secondary Sources ◽  
Political Cooperation ◽  
Islamic Religion ◽  
Political Approach ◽  
The Impact

This article discusses impact of UMNO-PAS political cooperation towards Islamic development in Malaysia from 1973 until 1978. The success of political cooperation in 1973 was the result of both UMNO’s leader, Tun Abdul Razak and PAS’s leader, Asri Muda willingness to explore a new political approach compared to what was being practiced at that time. Both leaders then started the development of a government known as the ‘Cooperation Government’ with the combination of UMNO and PAS in 1973 and later on, the development of the National Front’s (BN) Coalition Government in 1974. The Islamic religion benefits the most from the development of the Coalition Government which is a favourable gain for the Malays in Malaysia. Henceforth, this article will discuss in detail on the impact of the political cooperation between UMNO and PAS within the cooperation period. The methods used for this research is by interview and also by referring to secondary sources which are analyzed in a historical descriptive manner that is normally practiced in historical research. At the end of this research it is established that there are profound impacts to the Islamic religion within the UMNO-PAS cooperation period within 1973 to 1978 for example, the television and radio station beginning starting their programmes with the recitation from Quranic verses, the promulgation of ‘Adhan, alcohols are no longer served in official government’s function, lottery companies are not allowed to promote and announce the lottery results in official government’s media, the establishment of Islamic institution, the strengthening of Islamic education and the appropriate change in the relevant ministry’s symbols. This article can be utilized by subsequent researchers who wish to study the impact of political cooperation between UMNO and PAS. Keywords: political cooperation, UMNO-PAS, cooperation government ABTRAK:Makalah ini membincangkan mengenai impak kerjasama politik UMNO-PAS terhadap perkembangan Islam di Malaysia dari tahun 1973 hingga 1978. Kerjasama politik yang berjaya dibentuk bermula pada tahun 1973 adalah hasil daripada kesediaan Tun Abdul Razak dengan Mohd Asri Muda yang menerajui UMNO dan PAS pada ketika itu mencetuskan perubahan corak berpolitik yang berbeza berbanding sebelumnya. Maka, kedua-dua pemimpin ini kemudiannya merintis pembentukan sebuah kerajaan yang menggabungkan UMNO dengan PAS menerusi Kerajaan Campuran pada tahun 1973 dan Kerajaan Gabungan Barisan Nasional (BN) pada tahun 1974. Hasil daripada kejayaan penubuhan kedua-dua kerajaan ini, perkembangan Islam di negara ini bertambah pesat dan dapat dimanfaatkan oleh keseluruhan orang Melayu di Malaysia. Justeru, artikel ini membincangkan secara terperinci impak kerjasama politik antara UMNO dengan PAS dalam tempoh kerjasama politik berkenaan. Penyelidikan ini menggunapakai kaedah temubual dan menyorot sejumlah sumber sekunder yang kemudiannya dianalisis secara deskriptif sejarah (historical descriptive analysis) yang lazimnya dipraktikkan dalam kajian sejarah. Hasil kajian ini mendapati terdapat impak-impak jelas terhadap perkembangan Islam di negara ini sepanjang tempoh kerjasama politik antara UMNO dengan PAS dari tahun 1973 hingga 1978. Antara impak-impak tersebut ialah permulaan siaran televisyen dan radio dengan bacaan ayat-ayat suci Al-Quran, mengumandangkan suara azan, penghapusan arak dalam majlis-majlis kerajaan, penghapusan promosi dan keputusan judi di media kerajaan, penubuhan institusi Islam, pemerkasaan pendidikan Islam dan penukaran simbol institisu kerajaan. Akhirnya, artikel ini dapat dimanfaatkan oleh penyelidik-penyelidik berikutnya untuk menilai impak kerjasama politik antara UMNO dengan PAS.Kata kunci: kerjasama politik, UMNO-PAS, kerajaan campuran

Perceived workplace gender-bias and psychological impact

2019 ◽  
Vol 43 (3/4) ◽  
pp. 339-353 ◽  
Author(s):  
Siham Lekchiri ◽  
Cindy Crowder ◽  
Anna Schnerre ◽  
Barbara A.W. Eversole
Keyword(s):  
Gender Bias ◽  
Critical Incident ◽  
Psychological Impact ◽  
Working Women ◽  
Content Type ◽  
Treatment Bias ◽  
Male Dominated ◽  
The Impact ◽  
Organizational Mechanisms ◽  
Practical Implications

Purpose The purpose of this paper is to explore the experiences of working women in a male-dominated country (Morocco) and unveil the unique challenges and everyday gender-bias they face, the psychological impact of the perceived gender-bias and, finally, identify a variety of coping strategies or combatting mechanisms affecting their motivation and retention in the workplace. Design/methodology/approach Empirical evidence was obtained using a qualitative research method. The Critical Incident Technique (CIT) was used to collect incidents recalled by women in the select institution reflecting their perceptions of their managers’ ineffective behaviors towards them and the impact of these behaviors. The critical incidents were inductively coded, and behavioral statements were derived from the coded data. Findings The qualitative data analysis led them to structure the data according to two theme clusters: The perceived gender-bias behaviors (Covert and evident personal and organizational behaviors) and Psychological impacts resulting from the perceived bias. These behavioral practices included abusive behaviors, unfair treatment, bias and lack of recognition. The psychological impact elements involved decreased productivity, depression, anxiety and low self-esteem. Practical implications Understanding these experiences can facilitate the identification of strategies geared towards the retention of women in the workforce, and Moroccan organizations can develop and implement strategies and policies that are geared towards eliminating gender-bias in the workplace and to retaining and motivating women who remain ambitious to work in male-dominated environments and cultures. Originality/value This paper provides evidence that sufficient organizational mechanisms to support women in male-dominated environments are still unavailable, leaving them to find the proper coping mechanisms to persevere and resist.

scholarly journals Psychological impact in the time of COVID-19: A cross-sectional population survey study during confinement

2021 ◽  
pp. 135910532098558
Author(s):  
Carmina Castellano-Tejedor ◽  
María Torres-Serrano ◽  
Andrés Cencerrado
Keyword(s):  
Chronic Conditions ◽  
Population Survey ◽  
Psychological Impact ◽  
Survey Study ◽  
Psychological Interventions ◽  
Community Based ◽  
Cross Sectional ◽  
Young Females ◽  
The World ◽  
The Impact

The transformation that COVID-19 has brought upon the world is unparalleled. The impact on mental health is equally unprecedented and yet unexplored in depth. An online-based survey was administered to 413 community-based adults during COVID-19 confinement to explore psychological impact and identify high risk profiles. Young females concerned about the future, expressing high COVID-related distress, already following psychological therapy and suffering from pre-existing chronic conditions, were those at highest risk of psychological impact due to the COVID-19 situation. Findings could be employed to design tailored psychological interventions in the early stages of the outbreak to avoid the onset/exacerbation of psychopathology.

scholarly journals COVID-19 Psychological Impact on Health Care Workers in Saudi Arabia

2021 ◽  
Vol 18 (11) ◽  
pp. 6076
Author(s):  
Hasan S. Alamri ◽  
Wesam F. Mousa ◽  
Abdullah Algarni ◽  
Shehata F. Megahid ◽  
Ali Al Bshabshe ◽  
...  
Keyword(s):  
Health Care ◽  
Saudi Arabia ◽  
Health Care Workers ◽  
Psychological Impact ◽  
Psychological Outcomes ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Care Workers ◽  
The Impact

Objective: Little is known about the impact of Coronavirus (COVID-19) among the health care workers in Saudi Arabia. Therefore, the present study aimed to assess the psychological impact of COVID-19 among the health care workers. Methods: A cross-sectional survey was conducted from May till mid-July among 389 health care workers from government and private hospitals in Saudi Arabia. Data was collected using a pre-structured online questionnaire that measured adverse psychological outcomes, including the Patient Health Questionnaire-9 (PHQ-9) scale and the Generalized Anxiety Disorder 7-item (GAD-7) scale. The Pearson chi-square test was used to assess the distribution of depression and anxiety among health care workers. Results: A high level of anxiety was recorded among the health care workers, and 69.3% of health care workers below the age of 40 were found to have depression. There was a significant increase in depression among staff with chronic health problems (72.1% vs. 61.9%; p = 0.048). High anxiety levels were detected among young staff compared to others (68.7% vs. 43.8%; p = 0.001). Moreover, 82.1% of the female staff were anxious, as compared to 55.6% of the males (p = 0.001). Conclusions: We found increased prevalence of adverse psychological outcomes among the health care workers in Saudi Arabia during the outbreak of COVID-19. Therefore, there is a need for proper screening and development of corresponding preventive measures to decrease the adverse psychological outcomes.

scholarly journals OP0082-PARE THE EFFECT COVID-19 HAS ON THE MENTAL HEALTH OF PEOPLE LIVING WITH RHEUMATIC DISEASES. FROM DATA TO INTERVENTIONS.

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 44-45
Author(s):  
S. Mingolla ◽  
A. Celano ◽  
M. Santopietro
Keyword(s):  
Mental Health ◽  
Rheumatic Diseases ◽  
Rare Diseases ◽  
Psychological Impact ◽  
Well Being ◽  
Total Sample ◽  
Support Service ◽  
Health Condition ◽  
National Association ◽  
The Impact

Background:Covid-19 has had an important impact on the mental health conditions of over 5 million Italians suffering from one of the over 150 rheumatic diseases. In order to understand the psychological impact of the Covid-19 emergency and the restrictions imposed to counter it, the Italian National Association of People with Rheumatic and Rare Diseases – APMARR APS launched the research “Living with a rheumatic pathology”.Objectives:Gather data directly from Italian patients about the impact of the COVID-19 and consequent restrictions on their mental health and feelings; evaluate the most effective intervention to be implemented to face the pandemic by Patients organization.Methods:A qualitative-quantitative survey was carried out through a questionnaire administered throughout the national territory to a sample of N = 1,001 people. The people invited to complete the questionnaire were women (55,9%) and men (44,1%), aged 18-85 years (age 18-41=26,7%; age 42-65=64%; age >65=9,3%) with at least one rheumatic pathology. The questionnaire was made up of 39 questions, of which 29 were closed and 10 were open. For the administration of the questionnaires, the CAWI (Computer Aided Web Interview) methodology of on-line survey was used. The 1,001 interviews were carried out from 7 to 14 August 2020.Results:More than 4 out of 10 people (total sample 44.2%; male 60%, female 35,7%; age 18-41=39,1%; age 42-65=45,9%; age >65 = 50%) declared that the emergency period has somehow caused a worsening of their health condition. People declared that the deterioration of their health is due to the emergency period for the following reasons: 1) Psychological: such as stress and anxiety: “Too much stress and anxiety made the symptoms worse.”; “The stress of the quarantine affected my problem”; “Insomnia. Nervousness. General ailments. Depression. Strong stress” 2) Inability to perform physiotherapy and motor activities due to the lockdown 3) Postponement of examinations, visits and checks 4) remote working, in some cases described as harmful for people’s mental and physical health: “Due to Covid19 I had to do remote working and I worked even 12 hours a day including holidays to the detriment of my family life”.Furthermore, from January 31, 2020 a significant increase emerged in communication problems with rheumatology specialist compared to the period before the emergency due to Covid-19. The sharp increase may be due to the situation of severe psychological stress to which also the doctors were subjected in the emergency phase: people could not find the comfort of being empathically listened to.Conclusion:The research shows that the most frequent symptoms among people with rheumatic diseases were depression and high levels of anxiety due to strong emotional stress. Psychological malaise caused direct effects in worsening the symptoms of rheumatic disease as well as other related effects, for example, insomnia. The forced isolation due to the lockdown has made people lack the social support that is fundamental for the psychological well-being especially for those suffering from some chronic pathology. Starting from the data collected, APMARR promptly activated a completely free psychological support service with 6 professional psychologists, two of them specialized in emergency psychology. The service is accessible online and is still going on for all who are not able to overcome the anxiety and fear related to the pandemic and its evolution. Thousands of accesses to the service have been measured to date.References:S Mingolla1, A Celano1, M Santopietro2[1]NATIONAL ASSOCIATION OF PEOPLE WITH RHEUMATIC AND RARE DISEASES - APMARR APS[2]WeResearch. Ricerche di marketingDisclosure of Interests:None declared

scholarly journals Evaluation of the effect of the capitation compensation mechanism among pulmonary tuberculosis patients with a full period of treatment

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Xing-Yu Hu ◽  
Guang-Ying Gao
Keyword(s):  
Pulmonary Tuberculosis ◽  
Patient Compliance ◽  
Quantitative Data ◽  
Financial Burden ◽  
Descriptive Analysis ◽  
Compensation Mechanism ◽  
Medication Costs ◽  
Implementation Time ◽  
Full Period ◽  
The Impact

Abstract Background PTB is an infectious disease, which not only seriously affects people’s health, but also causes a heavier disease economic burden on patients. At present, reform of the medical insurance payment can be an effective method to control medical expenses. Therefore, our study is to explore the compensation mechanism for pulmonary tuberculosis (PTB) patients with a full period of treatment, to alleviate the financial burden of PTB patients and provide a reference and basis for the reform of PTB payment methods in other regions and countries. Methods The quantitative data of PTB patients was collected from the first half of 2015 to the first half of 2018 in Dehui Tuberculosis Hospital in Jilin Province, and medical records of PTB patients registered in the first half of 2018 (n = 100) from the hospital was randomly selected. Descriptive analysis of these quantitative data summarized the number, cost, medication and compliance. Semi-structured in depth interviews with policymakers and physicians were conducted to understand the impact of interventions and its causes. Results After implementation of the compensation mechanism, the number of PTB patient visits in 2018 was increased by 14.2%, average medical costs for outpatients and inpatients were significantly reduced by 31.8% and 47.0%, respectively, and the auxiliary medication costs was reduced by 36.5%. Moreover, the hospital carried out standardized management of tuberculosis, and the patient compliance was very high, reaching almost 90%. Conclusions The capitation compensation mechanism with a full period of treatment was a suitable payment method for PTB, and it is worthy of promotion and experimentation. In addition, the model improved patient compliance and reduced the possibility of drug-resistant PTB. However, due to the short implementation time of the model in the pilot areas, the effect remains to be further observed and demonstrated.

scholarly journals Potentially Prolonged Psychological Distress from Postponed Olympic and Paralympic Games during COVID-19—Career Uncertainty in Elite Athletes

2020 ◽  
Vol 18 (1) ◽  
pp. 2
Author(s):  
Anders Håkansson ◽  
Karin Moesch ◽  
Caroline Jönsson ◽  
Göran Kenttä
Keyword(s):  
Psychological Distress ◽  
Female Athletes ◽  
Job Insecurity ◽  
Elite Athletes ◽  
Psychological Impact ◽  
Sporting Events ◽  
Travel Restrictions ◽  
Career Uncertainty ◽  
Paralympic Games

The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the world of sports due to periods of home quarantine, bans against public gatherings, travel restrictions, and a large number of postponed or canceled major sporting events. The literature hitherto is sparse, but early indications display signs of psychological impact on elite athletes due to the pandemic. However, beyond acute effects from lockdown and short-term interrupted athletic seasons, the postponed and still uncertain Olympic and Paralympic Games may represent a major career insecurity to many athletes world-wide, and may lead to severe changes to everyday lives and potentially prolonged psychological distress. Given the long-term perspective of these changes, researchers and stakeholders should address mental health and long-term job insecurity in athletes, including a specific focus on those with small financial margins, such as many female athletes, parasports athletes, athletes in smaller sports, and athletes from developing countries. Implications and the need for research are discussed.

scholarly journals 936. Evaluating the Impact of Polypharmacy on Virologic Success in People with HIV

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S501-S502
Author(s):  
Humberto R Jimenez ◽  
Naana Boachie ◽  
Sangwon Park ◽  
Jin Suh
Keyword(s):  
Hiv Transmission ◽  
Virologic Failure ◽  
Descriptive Analysis ◽  
Virologic Response ◽  
Transmission Risk ◽  
Pill Burden ◽  
Cross Sectional ◽  
Hiv Rna ◽  
Aids Diagnosis ◽  
The Impact

Abstract Background As people with HIV (PWH) have experienced reductions in antiretroviral pill burden, there has been an increase in medications to manage non-AIDS-related co-morbidities. Previous studies have linked virologic failure to an increased pill burden. This study assessed whether polypharmacy and other variables affect success of HIV management in our population. Methods A retrospective, cross-sectional analysis of PWH receiving care at a Ryan White-funded clinic in New Jersey was performed. Eligible patients were ≥18 years old, had ≥2 visits in 2019 and were receiving antiretroviral therapy (ART). The primary endpoints were to determine the effect polypharmacy (defined as 5 or more non-ART pills per day) on virologic response rates (HIV RNA < 200 copies/mL). Secondary endpoints accounted for the impact of age, gender, race/ethnicity, HIV transmission risk factor, and AIDS diagnosis on virologic response. A descriptive analysis of comorbidities and medication classes was also completed. Logistic regression, chi square and student’s t test were used for statistical analysis. Results 964 patients were included in the analysis, with 355 (37%) meeting the criteria for polypharmacy. Most patients were male (60%) and the mean age was 49 years of age. The racial/ethnic breakdown was 46% Hispanic, 45% Black and 8% White. Polypharmacy was associated with higher rates of virologic success compared to those with a lower pill burden: 94% vs 86% had an HIV RNA < 200 copies/mL (P=0.0003), respectively. ART pill burden was statistically, but not clinically higher among those with polypharmacy (1.34 vs 1.45, P=0.025). Virologic response was found to be higher among Hispanics and Whites in comparison to Black patients (OR 2.2, CI 1.4-3.5 and 3.0, CI 1.1-8.2). Patients with an AIDS diagnosis were less likely to achieve virologic response (OR 0.64, CI 0.42-0.99). Conclusion Patients with polypharmacy were more likely to achieve virologic success than paitents with a low pill burden in our population. Disclosures Humberto R. Jimenez, PharmD, BCPS, AAHIVP, Gilead (Speaker’s Bureau)

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