Isoprophylaxis is neither homeoprophylaxis nor homeopathic immunization, but isopathic immunization unsupported by the homeopathic epistemological model: A response to Golden

Homeopathy might be employed for the prevention of epidemic diseases (homeoprophylaxis) provided remedies are selected on an individual basis in compliance with the ‘principle of symptom-based similitude’ and according to the totality of symptoms peculiar to a given epidemic (remedy of the ‘epidemic genius’ or ‘genus epidemicus), as countless examples in the literature show. The use of nosodes for the prevention of epidemic diseases (isoprophylaxis), i.e., selected based on the ‘principle of etiological identity’ with full neglect of symptom-based individualization and pathogenetic trials, is not supported by the homeopathic epistemological model. As long as there are no reliable scientific evidences attesting to its efficacy and safety, ‘isopathic immunization’ might not be indicated as a regular replacement of classical immunization, as it would mean a transgression of the bioethical principles of beneficence and non-maleficence. Although many homeopathic practitioners systematically indicate that practice, it is condemned by homeopathic institutions worldwide. In this article, I elaborate on epistemological, ethical and scientific features of these disparate approaches to prophylaxis, which I had summarily addressed in a previous review.

The psychological impact of prostate cancer after treatment: a critical review of the literature

Aim: This critical review of the literature seeks to understand the psychological impact that treatment interventions may have on prostate cancer (PC) survivors. Materials and Methods: A literature search was conducted using databases of peer-reviewed literature. The search terms used were devised using the building-blocks technique to divide the query into facets. The articles were manually assessed for relevance and appraised using the relevant Critical Appraisal Skills Programme (CASP) tool. Government guidelines and regulations were also used following a manual search on the National Institute for Health and Care Excellence (NICE) website. This process resulted in a total of 12 sources being included in the critical review. Results: The key themes that arose from the review were masculinity, depression, anxiety and psychological implications related to sexual functioning. Psychological impact varies on an individual basis and is influenced by the quality of a patient’s experience during and after treatment in relation to sufficient information giving and support. Findings: Open communication should be encouraged by healthcare professionals to assess patient mental wellbeing. The extent of psychological impact varies on an individual basis; however, there are predictive factors that can make an individual more at risk of being affected psychologically post-PC treatment.

Fertőzésekhez kapcsolódó immunológiai jelenségek: a szürkezóna jelentősége

Összefoglaló. A fertőzésekhez kapcsolódó immunológiai kórképekre különösen jellemző, hogy mind etiológiai tényezőikben, mind klinikai képükben rendkívül heterogének. Az átfedő és inkomplett megjelenési formák nem ritkák, ami a diagnosztika standardizálását nehezíti. Egyes, a fertőzésekhez opcionálisan kapcsolódó tünetek megfigyelése már több mint egy évszázaddal ezelőtt elvezetett a gócelmélet megszületéséhez, amely eredeti formájában leginkább elnagyolt és naiv feltételezéseken alapult. Folyamatosan bővülő ismereteink ugyanakkor egyre több esetben támasztják alá, hogy az átvészelt, esetleg krónikus vagy perzisztáló fertőzések, illetve a mikrobiom összetétele számos ponton lehet befolyással immunológiai, metabolikus és endokrin homeosztázisunkra. A jelen munkában az ismert összefüggéseket, illetve a meghaladott feltételezéseket is röviden érintve megkíséreljük a rendelkezésre álló ismereteken keresztül áttekinteni a fertőzésekhez kapcsolódó immunológiai jelenségek szürkezónáját, azon kórtani folyamatokat és tüneteket, amelyek létezése igazolható, de terápiás következményeik az egyén szintjén egyelőre bizonytalanok. Orv Hetil. 2021; 162(38): 1526–1532. Summary. Immunologic phenomena related to infections are well known to be truly heterogeneous, both regarding their etiology and the clinical picture. Overlapping symptoms and incomplete presentations are not seldom, which often constitute diagnostic challenge. Certain, optional complications of infectious diseases led to the creation of the focal infection theory more than a century ago, although only on the basis of assumptions derived from elusive and naive theories. However, an expanding body of evidence ever since did underline the impact of previous and persistent infections on the immunologic, metabolic and endocrine homeostasis. Besides briefly touching the well-defined diseases, as well as the outdated theories of this field, we aim to provide an overview of the grey zone of infection-related immunologic phenomena, the existence of which is biologically well established, however, their true significance on an individual basis remains uncertain. Orv Hetil. 2021; 162(38): 1526–1532.

Article 12—Collective Licensing with an Extended Effect

This chapter talks about collective licensing with an extended effect, which is outlined in Article 12 of Directive 2019/790 on copyright in Europe. It cites the task of Member States to ensure that the licensing mechanism is only applied within well-defined areas of use. It considers how authorisations from rightholders can be obtained on an individual basis, which is typically onerous and impractical to a degree that makes the required licensing transaction unlikely. The chapter points out how Article 12 does not affect the application of collective licensing mechanisms with an extended effect in accordance with other provisions of Union law. It looks at the requirement of Member State to inform about the scope of corresponding national provisions on the purposes and types of licences that may be introduced about the contact details of organisations issuing licences.

SOCIAL SKILLS OF PEOPLE WITH DISABILITIES

The problem of people with disabilities is quite serious in Russia. Disabled people do not have equal opportunities for education and employment with other people. Due to the established norms and attitudes towards people with disabilities, their social interaction with other people has a negative character for them; they cannot live and take care of themselves on an individual basis. The State should support and develop the social skills of people with disabilities from early childhood and throughout their lives, so that they can be independent and not deprived.

The Effects of a Nutrition Education Intervention on Sports Nutrition Knowledge during a Competitive Season in Highly Trained Adolescent Swimmers

The aim of this study was to evaluate the effects of a seven-week nutrition education intervention on the sports nutrition knowledge (SNK) of highly trained UK adolescent swimmers. Fifteen national and international adolescent swimmers (males = 5; females = 10, 15.5 ± 1.1 years, 170.2 ± 7.5 cm, 60.3 ± 5.7 kg) participated in the study during seven consecutive weeks of the competitive swimming season. The participants received 30 min of nutrition education once per week in a classroom-based setting after they had completed their regular swim training. An undergraduate sports nutrition student delivered all nutrition education sessions and SNK questionnaires were administered to the participants pre- and post-intervention. The mean total SNK score improved by 8.3% (SD = 8.4%, 95% CI = 4.1–12.6; p = 0.006; ES = 1.0) following the nutrition education sessions. On an individual basis, ten swimmers significantly improved their total SNK score, whereas four swimmers did not improve, and one swimmer performed significantly worse after the intervention. Moreover, the swimmers’ knowledge of hydration improved by 22.2% (SD = 20.6%, 95% CI = 11.8–32.6, p = 0.004, ES = 1.1) over the seven-week timeframe, which was the only nutrition topic to have a significantly increased knowledge score. The current study therefore suggests that a nutrition education intervention can positively influence the SNK of highly trained adolescent swimmers.

Understand My Language, to Understand My Pain: Challenges of Neurological Evaluation Among Refugees

The increasing number of migrants and refugees entering Albania during the last decade has been a challenge to the medical service of the country. Many of the migrants arrive from remote areas of Middle East or other Asian regions, heading toward northern Europe, deprived from medical assistance during their tormenting journey. An exacerbation of previous medical conditions is expected and is related to the hardship of traveling conditions. The medical professionals working in migration medicine have little, if any, training on the field and need to familiarize themselves with a variety of previously unknown conditions. Empathy, necessary on an individual basis, may not be sufficient in itself; the burden of medically treating migrants needs a holistic and multidisciplinary approach.

Individual DNA Methylation Pattern Shifts in Nanoparticles-Exposed Workers Analyzed in Four Consecutive Years

A DNA methylation pattern represents an original plan of the function settings of individual cells and tissues. The basic strategies of its development and changes during the human lifetime are known, but the details related to its modification over the years on an individual basis have not yet been studied. Moreover, current evidence shows that environmental exposure could generate changes in DNA methylation settings and, subsequently, the function of genes. In this study, we analyzed the effect of chronic exposure to nanoparticles (NP) in occupationally exposed workers repeatedly sampled in four consecutive years (2016–2019). A detailed methylation pattern analysis of 14 persons (10 exposed and 4 controls) was performed on an individual basis. A microarray-based approach using chips, allowing the assessment of more than 850 K CpG loci, was used. Individual DNA methylation patterns were compared by principal component analysis (PCA). The results show the shift in DNA methylation patterns in individual years in all the exposed and control subjects. The overall range of differences varied between the years in individual persons. The differences between the first and last year of examination (a three-year time period) seem to be consistently greater in the NP-exposed subjects in comparison with the controls. The selected 14 most differently methylated cg loci were relatively stable in the chronically exposed subjects. In summary, the specific type of long-term exposure can contribute to the fixing of relevant epigenetic changes related to a specific environment as, e.g., NP inhalation.

Mani’s Metivta: Manichaean Pedagogy in its Late Antique Mesopotamian Context

This article investigates the nature of Manichaean pedagogy as expressed through the late antique codices known as the Kephalaia of the Teacher and the Kephalaia of the Wisdom of my Lord Mani. By paying attention to a range of contextual cues that frame each moment of instruction, it first argues that much like their rabbinic and Christian neighbors, Mesopotamian Manichaeans did not study in academic institutions. Rather, instruction took place on an ad-hoc, individual basis, often based on happenstance events; there is no mention of a building dedicated to learning, a standard curriculum, or a semester schedule. This article then contextualizes this form of non-institutionalized Manichaean instruction by comparing three formulae found in the Kephalaia codices that have parallels in the Babylonian Talmud: the formula of Mani “sitting among” his disciples (or of his disciples “sitting before” Mani), of Mani’s disciples “standing before” Mani, and of various people “coming before” Mani. In so doing, this article ultimately argues that the Babylonian Rabbis and Syro-Mesopotamian Manichaeans shared a common pedagogical habitus, one expressed through bodily comportment and hierarchy rather than through the imposition of institutional norms.

ACCIDENTAL INGESTION OF CYLINDRICAL BATTERIES IN CHILDREN – INTERVENTIONAL OR CONSERVATIVE MANAGEMENT?

Ingestion of cylindrical batteries is a rare condition in children. There are no clear guidelines regarding the appropriate management of this condition. We present 2 such cases; one patient required endoscopic removal of the battery, while in the other one the battery passed spontaneously. We recommend that such cases be admitted for monitoring and treated on an individual basis, according to the clinical picture, X-ray data and the availability of pediatric emergency endoscopy.