Abstract
Introduction
Prior studies have shown beneficial effects of forehead cooling in insomnia patients using a device that circulates cooled fluids through a forehead pad. The current study aimed to determine if a device that cooled via direct thermoelectric contact to the forehead via a Peltier cooler would have similar effects in individuals with insomnia symptoms. Such a technology may allow for form factors that may have advantages for some individuals.
Methods
An intelligent, portable and battery-operated forehead cooling system using thermoelectric coolers (TECs) with a user selectable temperature range between 14C and 18C was used in the study. Individuals with insomnia symptoms (N=30, 25 female) were recruited and studied at 2 geographic locations. Each participant received pre- and post- treatment insomnia severity as well as daily sleep diary assessments over 1 week of baseline and 4 weeks of treatment.
Results
Participants’ insomnia symptoms improved over baseline in insomnia severity index (M + SD = 19.7 + 3.8 pre- vs 9.4 + 5.3 post-treatment, t = -9.3, p<0.00001), in sleep latency (M + SD = 43.0 + 40.8 minutes pre- vs 20.7 + 22.7 minutes post-treatment, t = 6.8, p<0.00001), in minutes awake after sleep onset (M + SD =63.0 + 59.2 minutes pre- vs 24.5 +34.5 minutes post-treatment, t = 8.0, p<0.00001) and in sleep quality (0-10 scale with 10 = best, M + SD = 4.1 + 1.9 pre- vs 6.8 + 2.2 post-treatment, t = -13.4, p<0.00001).
Conclusion
Forehead cooling via direct thermoelectric contact to the forehead via a Peltier cooler had beneficial effects on subjective insomnia symptoms. These promising preliminary data suggest the need for further large scale randomized controlled trials to establish the efficacy of forehead-cooling using direct thermoelectric contact to the forehead via a Peltier cooler on insomnia symptoms.
Support
Ebb Therapeutics, Pittsburgh, PA 15222