ANSWER: Annotation Software for Electronic Reporting

PURPOSE To better use genetic testing, which is used by clinicians to explain the molecular mechanism of disease and to suggest clinical actionability and new treatment options, clinical next-generation sequencing (NGS) laboratories must send the results into reports in PDF and discrete data element format (HL7). Although most clinical diagnostic tests have set molecular markers tested and have a set range of values or a binary result (positive or negative), the NGS genetic test could examine hundreds or thousands of genes with no predefined list of variants. Although there are some commercial and open-source tools for clinically reporting genomics results for oncology testing, they often lack necessary features. METHODS Using several available software tools for data storage including MySQL and MongoDB, database querying with Python, and a web-based user application using JAVA and JAVA script, we have developed a tool to store and query complex genomics and demographics data, which can be manually curated and reported by the user. RESULTS We have developed a tool, Annotation SoftWare for Electronic Reporting (ANSWER), that can allow molecular pathologists to (1) filter variants to find those meeting quality control metrics in the genes that are clinically actionable by diagnosis; (2) visualize variants using data generated in the bioinformatics analysis; (3) create annotations that can be reused in future reports with association specific to the gene, variant, or diagnosis; (4) select variants and annotations that should be reported to match the details of the case; and (5) generate a report that includes demographics, reported variants, clinical actionability annotation, and references that can be exported into PDF or HL7 format, which can be electronically sent to an electronic health record. CONCLUSION ANSWER is a tool that can be installed locally and is designed to meet the clinical reporting needs of a clinical oncology NGS laboratory for reporting.

Review on Digital Transformation Policy of Directorate Generale of Taxes

The Covid-19 pandemic caused a reduction in face-to-face interaction between people. Changes in social interaction from offline to online need supporting facilities, both internet networks, computers, gadgets, and other items. The Directorate General of Taxes (DGT) as the government agency that collects state revenues from taxes, is constantly transforming towards improving public services, especially to taxpayers. Many applications of e-tax systems that have been developed by DGT are Nadine, e-faktur, e-billing, e-filling, and DJP Online. This electronic reporting has influenced the increase of Annual Tax Return reporting for the last three years.

Alternative Strategies for Controlling the Brown Locust, Locustana pardalina (Walker)

Regular and often intense outbreaks of the brown locust, Locustana pardalina (Walker), in the semi-arid Nama Karoo region of South Africa present a formidable pest control problem. Outbreak patterns over a 64-year period (1941–2005) were reviewed indicating a very high frequency of outbreak years with regular ‘plague’ periods being experienced, while a more detailed analysis of the numbers of locust targets controlled during a 22-year period (1983–2005) described the intensity and scale of the outbreaks. The operational constraints associated with the traditional ground-based control strategy employed against the thousands of individual roosting brown locust hopper band and swarm targets in the Karoo are discussed. A brief review of laboratory and field trials of alternative methods of controlling the brown locust, such as insecticide baits, barrier treatments and the Green Muscle® myco-insecticide, as an alternative to broad-spectrum pyrethroid insecticides are described. In addition, alternative control strategies to the current ‘Commando’ system of ground-based control operations are discussed. The recommendation is for a modernised and technology-equipped integrated brown locust management strategy (IPM), combining ground and aerial tactics that will have the flexibility and the capacity to deal effectively with outbreaks. The integrated management strategy should focus on ground-based control of hopper bands and fledgling swarms in the Upper and eastern Karoo, while outbreaks over most of the Central Karoo and arid Bushmanland areas should be left to fledge and coalesce into large-sized swarms that could then be targeted by spray aircraft as they migrate along their known swarm flight paths. The introduction of electronic reporting and GIS mapping technologies for brown locust campaign management is essential.

Mastering the content and aspect terminology of the French language on the basis of co-working with students of materials for distant content

Introduction. The relevance of the research is determined by the demand for the development of new content of training programs, including through the creation of educational and control materials based on them together with students in the process of mastering theoretical grammar. The purpose of the article is to optimize the process of teaching theoretical language disciplines using the capabilities of electronic resources, as well as to develop students' skills to create control and measurement materials, including those based on electronic constructors/products. Materials and methods. The study involved 45 students of the French-English department of the Faculty of Foreign Languages of the Bryansk State University in 2015/2016/2017. The dynamics of learning outcomes in the course of step-by-step training was established both on the basis of a subjective assessment of students ' responses by the teacher (I and II training models), and on the basis of electronic reports and training program schedules reflecting the assessments of subjects in different ranges (III training model). The results of the study. It is established that the interactive version of the study of thematic material in the electronic learning system (ESO) in the organizational mode "student – task co-developer" (model III-the creation of interactive tasks by students based on lecture material) is characterized by a fairly high level of indicators: 100% coverage of subjects and almost the same indicator of independence in the process of completing tasks. In accordance with the electronic reporting provided by the graphic material, 95-100% of the subjects have good and excellent indicators (4.5/5 – on a five-point scale; 8.5/10-on a ten-point scale). Discussion and conclusion. The peculiarities of mastering theoretical grammar on the basis of interactive resources of training programs can be taken into account by other researchers in the field of methods of teaching theoretical disciplines. In the future, the study of this topic can be continued in collaboration with developers of electronic products for philologists.

Factors Affecting the Adoption of Electronic Data Reporting and Outcomes Among Selected Central Cancer Registries of the National Program of Cancer Registries

PURPOSE The CDC's National Program of Cancer Registries has expanded the use of electronic reporting to collect more timely information on newly diagnosed cancers. The adoption, implementation, and use of electronic reporting vary significantly among central cancer registries. We identify factors affecting the adoption of electronic reporting among these registries. METHODS Directors and data managers of nine National Program of Cancer Registries took part in separate 1-hour telephone interviews in early 2019. Directors were asked about their registry's key data quality goals; staffing, resources, and tools used to aid processes; their definition and self-perception of electronic reporting adoption; key helpers and challenges; and cost and sustainability implications for adoption of electronic reporting. Data managers were asked about specific data collection processes, software applications, electronic reporting adoption and self-perception, information technology infrastructure, and helpers and challenges to data collection and processing, data quality, and sustainability of approach. RESULTS Larger registries identified organizational capacity and technical expertise as key aides. Other help for implementing electronic reporting processes came from partnerships, funding availability, management support, legislation, and access to an interstate data exchange. Common challenges among lower adopters included lack of capacity at both registry and data source levels, insufficient staffing, and a lack of information technology or technical support. Other challenges consisted of automation and interoperability of software, volume of cases received, state political environment, and quality of data received. CONCLUSION Feedback from the formative evaluation yielded several useful solutions that can guide implementation of electronic reporting and help refine the technical assistance provided to registries. Our findings may help guide future process and economic evaluations of electronic reporting and identify best practices to strengthen registry operations.

Integrated professional training of the music teacher by means of innovative artistic and pedagogical technologies

The aim of the research was to study features of integrated professional training of the music teacher by means of innovative artistic and pedagogical technologies. The results demonstrate the main features of the use of innovative artistic and pedagogical technologies in a pandemic: 1) the transition to information and communication means of communication and limited consultations in various disciplines; 2) independent processing of educational materials, which negatively affects practical skills of students; 3) electronic reporting is the most common form of control over the work of future music teachers; 4) partner innovative artistic and pedagogical technologies of vocational training are poorly integrated into the practice of teaching at the university; 5) the frequency of use of artistic and integrative tools is reduced due to the predominance of independent work of music teachers; 6) interactive tools of innovative artistic and pedagogical technologies are used to a lesser extent in the educational process.

Electronic reporting of integrated disease surveillance and response: lessons learned from northeast, Nigeria, 2019

Background Electronic reporting of integrated disease surveillance and response (eIDSR) was implemented in Adamawa and Yobe states, Northeastern Nigeria, as an innovative strategy to improve disease reporting. Its objectives were to improve the timeliness and completeness of IDSR reporting by health facilities, prompt identification of public health events, timely information sharing, and public health action. We evaluated the project to determine whether it met its set objectives. Method We conducted a cross-sectional study to assess and document the lessons learned from the project. We reviewed the performance of the local government areas (LGAs) on timeliness and completeness of reporting, rumors identification, and reporting on the eIDSR and the traditional paper-based system using a checklist. Respondents were interviewed online on the relevance, efficiency, sustainability, project progress and effectiveness, the effectiveness of management, and potential impact and scalability of the strategy using structured questionnaires. Data were cleaned, analyzed, and presented as proportions using an MS Excel spreadsheet. Responses were also presented as direct quotes. Results The number of health facilities reporting IDSR increased from 103 to 228 (117%) before and after implementation of the eIDSR respectively. The timeliness of reporting was 43% in the LGA compared to 73% in health facilities implementing eIDSR. The completeness of IDSR reports in the last 6 months before the evaluation was ≥85%. Of the 201 rumors identified and verified, 161 (80%) were from the eIDSR pilot sites. The majority of the stakeholders interviewed believed that eIDSR met its predetermined objectives for public health surveillance. The benefits of eIDSR included timely reporting and response to alerts and disease outbreaks, improved timeliness, and completeness of reporting, and supportive supervision to the operational levels. The strategy helped stakeholders to appreciate their roles in public health surveillance. Conclusion The eIDSR has increased the number of health facilities reporting IDSR, enabled early identification, reporting, and verification of alerts, improved timeliness and completeness of reports, and supportive supervision of staff at the operational levels. It was well accepted by the stakeholder as a system that made reporting easy with the potential to improve the public health surveillance system in Nigeria.

Use of the NINJA (Nephrotoxic Injury Negated by Just-in-Time Action) Program to Identify Nephrotoxicity in Pediatric Patients with Cystic Fibrosis

OBJECTIVE This study aims to use and evaluate the Nephrotoxic Injury Negated by Just-in-time Action (NINJA) program in hospitalized patients with cystic fibrosis (CF) at Children's Healthcare of Atlanta. METHODS This was a single-center study evaluating patients with CF who were hospitalized and admitted to the pulmonary service 4 months pre- and post-NINJA implementation. Postimplementation patients with high nephrotoxic medication (NTMx) exposure were identified using an electronic reporting tool that triggered the pharmacist to alert the medical team and recommend Monday/Wednesday/Friday serum creatinine (SCr) monitoring. High NTMx exposure was defined as 3 or more NTMxs given concurrently, or at least 3 consecutive days of IV aminoglycosides or vancomycin. Outcomes assessed were rate of SCr monitoring, NTMx exposure, and days of acute kidney injury (AKI) pre- and post-NINJA implementation. RESULTS A total of 19 patients and 25 high-NTMx exposures were identified both pre- and post-NINJA implementation. The SCr monitoring increased from 13% to 50% of NTMx exposure days in the pre- versus post-NINJA time frame. More NTMx exposure days occurred in the post-NINJA time frame, from 250 exposure days per 1000 patient days pre-NINJA to 521 post-NINJA. An increased incidence of AKI events and AKI days were noted post-implementation; however, these differences were not significantly different between the 2 groups. CONCLUSIONS Increased SCr monitoring for patients with NTMx exposure using NINJA uncovered more episodes of AKI. Increased prevalence of NTMx use was associated with increased rates of AKI. Increased SCr monitoring as a result of NINJA implementation may allow for earlier detection of AKI.