Estimation of the application biopreparation of complex action “Agrophil” and the polyhumates of sapropel on the intensification of the physiological processes of alliumcepa growth in a magnetic hydroculture

The article deals with the influence of the biological product Agrophil (strains of Agrobacterium radiobacter) and ultrafine humate-sapropel suspension (UDGSS) obtained by alkaline extraction and ultrasonic cavitation of sapropel extract on the formation of economically valuable properties (length and biomass of leaves, pigment complex) of green onion leaves (Allium cepa L.) variety StuttgarterRiesen grown under intensive photoculture under conditions of hydroponic culture on a magnetized nutrient medium. The experiment was carried out in a multi-tiered hydroponic setup with full spectrum LED lamps. Magnetic processing was carried out in two different ways: by the method of electromagnetic influence with a variable frequency-modulated potential and a device with predominantly magnetic induction. The use of physical and biological factors, both individually and collectively, when forcing onion sets of the StuttgarterRiesen variety on a feather, contributed to an increase in plant biomass and the activity of the photosynthetic apparatus. The combined effect of polyhumates with a biopreparation and magnetic treatment had a static effect on the increase in leaf length. The maximum yield of leaf biomass was recorded for the TEMP + Polygumate variant. The highest levels of chlorophyll accumulation were recorded in the variant with the combined use of Agrophil and Polygumates. As a result of the combined influence of both biostimulants and the factor of magnetic irradiation, the plant-microbial system continued to develop freely, without damage in the morpho-physiological reactions of the plant culture, but the plants turned out to be shorter

A (supra)nationalist personality? The Big Five’s effects on political-territorial identification

Recent work suggests personality affects the subjective psychological weight one attaches to an identity. This study extends prior findings showing a static effect on European identification in a single country by investigating whether a similar systematic relationship exists for a wider range of political-territorial identities (regional, national, supranational, and exclusively nationalist) across different country contexts (Germany, Poland, and the United Kingdom) and over time (2012–2018). Original cross-national and panel survey data show that different traits predict both the type and degree of inclusivity of individuals’ identity attachments. These results contribute to the growing scholarship surrounding personality’s effects on EU support while underscoring the impact predispositions have on citizens’ sociopolitical orientations. They especially illuminate the contrasting profiles associated with those who identify as exclusively nationalist versus supranational European.

A More Efficient Observation Way With Electric Dipole Sources

The Ex and Hz amplitude are monotonic functions of the resistivity, and numerical algorithm can be utilized to obtain the high-precision apparent resistivity for all frequencies. On this basis, we focus on the comparative analysis of the resolution for Ex field, Hz field, and Cagniard apparent resistivity to conductive and resistance targets, which proves that the Ex field may have a better resolution for the resistance bodies, and the Hz field can better identify the conductive target. Besides, the electromagnetic data is often distorted by the static effect, which seriously affects the application effect of the electromagnetic method. The influence of the static effect on the Ex field, Hz field, is also analyzed. The apparent resistivity based on the Ex field and Cagniard apparent resistivity are severely affected by the static effect which can cover deep anomalous bodies, but the apparent resistivity based on the Hz field is almost unaffected by the static effect. At last, a more efficient observation way is provided for the resistance and conductive targets, respectively.

In vitro pharmacodynamics of omadacycline against Escherichia coli and Acinetobacter baumannii

Background The pharmacodynamics of omadacycline have been extensively studied against Gram-positive pathogens but less information is available for Gram-negative pathogens. We describe the pre-clinical pharmacodynamics of omadacycline against Escherichia coli and Acinetobacter baumannii. Methods An in vitro dilutional pharmacokinetic model was used. Exposure experiments with fAUC/MIC ratios ranging from 0 to 1200 were performed using five strains of E. coli and five strains of A. baumannii. Reduction in bacterial load and changes in population profiles were measured. Results The fAUC/MIC targets against E. coli for 24 h static and −1 log reduction in load were 25.3 ± 17.2 and 42.7 ± 32.5, respectively. For A. baumannii the fAUC/MIC for 24 h static effect was 108.1 ± 38.6. Changes in population profiles were observed for E. coli at fAUC/MIC ratios of ≤200 and for A. baumannii up to 1200. MICs were increased 2–32 fold. Conclusions fAUC/MIC targets for A. baumannii are greater than for E.coli and changes in population profiles more likely. E. coli fAUC/MIC targets align with in vivo data and will be useful in determining omadacycline dosing for this pathogen.

ANALYSIS OF STRUCTURAL TRANSFORMATION OF LABOR FROM AGRICULTURE TO NON-AGRICULTURE IN ASIA

Through the dataset from APO (Asian Productivity Organization) comprising 22 countries in Asia from 1980 to 2015, this study is to investigate the growth pattern, decomposition, and determinants of structural transformation in Asia. A decomposition method measuring within-effect, between-static-effect, and between-dynamic-effect was adopted to explain the structural change within sectors of agriculture, industry, and services. The results show that the agriculture sector of all countries in Asia declines slowly. The agriculture sector is no longer the largest contributor to GDP in all Asian countries even though it still has the largest labor in Asian developing countries. Workers moving from the agriculture sector to the services sector as the productivity of the service sector is higher than agriculture. The structural changes positively contribute to productivity growth in Asia as a result of the positive static reallocation effects and negative dynamic reallocation effects. Overall, the structural changes contribute to a large part of labor productivity growth. The important determinants of structural transformation are the employment share in agriculture and trade. Final, the policy implication was proposed for structural changes.

Morphology of Aluminum Oxide (Al₂O₃) Nanoparticles and Their Effect on the Micro Structural and Mechanical Properties of Carbon Fiber-Reinforced (CFR) Epoxy Nanocomposites

The main aim of this article is to investigate the effect of inclusion of Aluminum oxide (Al₂O₃) nano particles at varied percentage of weights into the carbon fiber-reinforced (CFR) epoxy composites, and evaluating the Mechanical properties for flexure, Impact and Tensile strength. The Aluminum oxide (Al₂O₃) is included into various percentages starting from 1 to 5 wt% and spread homogeneously throughout the epoxy resin by ultrasonication process. The CFR- Al₂O₃ nano composites are prepared through layup technique and healed by vacuum bagging method. The mechanical properties such for flexure and ultimate tensile strength showed better properties due to the presence of Al₂O₃ nanoparticles, while response for CFRAl₂O₃ nano composites increased at 2 wt% addition of Al₂O₃ nano particles, and further reduction has been seen at 5wt% due to an greater static effect.

Pharmacokinetics and Pharmacodynamics of Murepavadin in Neutropenic Mouse Models

ABSTRACT Murepavadin (POL7080) represents the first member of a novel class of outer membrane protein-targeting antibiotics. It specifically interacts with LptD and inhibits lipopolysaccharide (LPS) transport. Murepavadin is being developed for the treatment of serious infections by Pseudomonas aeruginosa. We determined the plasma protein binding and the pharmacokinetics of murepavadin in plasma and epithelial lining fluid (ELF; pulmonary) in infected animals, and we determined the exposure-response relationship. Treatment of CD-1 neutropenic mice was started 2 h after infection using murepavadin at different dosing frequencies for 24 h, and the number of CFU per lung was determined. The sigmoid maximum-effect model was used to fit the dose-response, and the pharmacodynamic index (PDI) response was used to determine the PDI values, resulting in a static effect and 1-log kill reduction. Using R2 as an indicator of the best fit, the area under the concentration-time curve for the unbound fraction of the drug (fAUC)/MIC ratio correlated best with efficacy. The mean AUC required to provide a static effect was 36.83 mg h/liter (fAUC = 8.25 mg h/liter), and that to provide a 1-log reduction was 44.0 mg h/liter (fAUC = 9.86 mg h/liter). The mean static fAUC/MIC was determined to be 27.78, and that for a 1-log reduction was 39.85. These data may serve to determine doses in humans that are likely to be efficacious.