Studies on the equatorial spot of G-type contact binary UV Lyn

New CCD photometric observations of G-type contact binary UV Lyn were obtained in 2006 and 2020, when the light curves (LCs) show positive O'Connell effect and negative O'Connell effect, especially. From the previous studies, the LCs by other ground-based telescope are variable from 1973 to 2020, particularly the magnitude difference between the two maxima. These phenomena indicate that the component is active in the past 47 years. In addition, under the monitoring of the space telescope of Transiting Exoplant Survey Satellite (TESS) from January to March in 2020, we fortunately find the continuous variations of O'Connell effect in every circle for the first time. The analysis also shows that in a short time, the positive O'Connell effect has been transformed into the negative one, which proves that there are stronger magnetic activities on the surface of the component. By using the Wilson-Devinney code with a spot model, these photometric solutions confirm UV Lyn is a shallow W-subtype contact binary with a cool equatorial spot on the less massive component. The successive variability of O'Connell effect possibly result from one equatorial cool spot shifting gradually along with time. We also investigate its \emph{O-C} curve from these continuous LCs, there is not obvious variation in such short time. while, the O’Connell effect as the indicator of the magnetic activity are possibly undergoing a periodic trend of a period of nearly 38 days. Comparing \emph{O-C} curve, we could find there is not relation between the period variation and magnetic activity.

Sharing Personal Information is Discounted as a Function of Social Distance

Social discounting researchers have repeatedly shown that individuals discount sharing the amount of a monetary reward as a function of social distance, and that increasing the available monetary reward decreases sharing. However, no previous study has tested whether sharing nonmonetary commodities are discounted as a function of social distance. The current study tested whether sharing personal information would be discounted similarly to monetary rewards, as well as whether a magnitude effect occurred at a relatively small magnitude difference with 96 university students. A within-participant procedure showed that sharing personal information was discounted as a function of social distance, albeit with a steeper discounting rate relative to both monetary reward magnitudes. However, there was no significant association between personal information discounting rates and monetary discounting rates at either magnitude, suggesting that participants treated each commodity differently (i.e., commodity effect). Replicating previous non-U.S. samples, discounting rates for both monetary reward magnitudes were significantly positively associated with each other and showed a significant magnitude effect, with participants showing significantly steeper discounting rates for the relatively larger monetary rewards. The results for sharing personal information are important because many scams now target personal information in addition to money. Future research should examine what type of personal information is most likely to be shared as a function of social distance, and whether those participants who choose to share more personal information also are at greater risk for scams targeting personal information.

Bacteria modulate tamoxifen-induced death via host fatty acid metabolism

Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER positive breast cancer, but that at high doses kills both ER-positive and ER negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis elegans, which does not have an ER ortholog. We find that different bacteria dramatically modulate tamoxifen toxicity in C. elegans, with a three-order of magnitude difference between animals fed Escherichia coli, Comamonas aquatica, and Bacillus subtilis. Remarkably, host fatty acid (FA) biosynthesis mitigates tamoxifen toxicity, and different bacteria provide the animal with different FAs, resulting in distinct FA profiles. Surprisingly these bacteria modulate tamoxifen toxicity by different death mechanisms, some of which are modulated by FA supplementation and others by antioxidants. Together, this work reveals a complex interplay between microbiota, FA metabolism and tamoxifen toxicity that may provide a blueprint for similar studies in more complex mammals.

Comparison of computational and experimental saturation vapor pressures of α-pinene + O₃ oxidation products

Accurate information on gas-to-particle partitioning is needed to model secondary organic aerosol formation. However, determining reliable saturation vapor pressures of atmospherically relevant multifunctional organic compounds is extremely difficult. We estimated saturation vapor pressures of α-pinene ozonolysis derived secondary organic aerosol constituents using FIGAERO-CIMS experiments and COSMO-RS theory. We found a good agreement between experimental and computational saturation vapor pressures for molecules with molar masses around 190 g mol−1 and higher, most within a factor of 3 comparing the average of the experimental vapor pressures and the COSMO-RS estimate of the isomer closest to the experiments. Smaller molecules likely have saturation vapor pressures that are too high to be measured using our experimental setup. The molecules with molar masses below 190 g mol−1 that have several orders of magnitude difference between the computational and experimental saturation vapor pressures observed in our experiments are likely products of thermal decomposition occurring during thermal desorption. For example, dehydration and decarboxylation reactions are able to explain some of the discrepancies between measured and calculated saturation vapor pressures. Based on our estimates, FIGAERO-CIMS can best be used to determine saturation vapor pressures of compounds with low and extremely low volatilities.

Mechanical Properties of Porous Structures for Dental Implants: Experimental Study and Computational Homogenization

A combined experimental and numerical study on titanium porous microstructures intended to interface the bone tissue and the solid homogeneous part of a modern dental implant is presented. A specific class of trabecular geometries is compared to a gyroid structure. Limitations associated with the application of the adopted selective laser melting technology to small microstructures with a pore size of 500 μm are first examined experimentally. The measured effective elastic properties of trabecular structures made of Ti6Al4V material support the computational framework based on homogenization with the difference between the measured and predicted Young’s moduli of the Dode Thick structure being less than 5%. In this regard, the extended finite element method is promoted, particularly in light of the complex sheet gyroid studied next. While for plastic material-based structures a close match between experiments and simulations was observed, an order of magnitude difference was encountered for titanium specimens. This calls for further study and we expect to reconcile this inconsistency with the help of computational microtomography.

Partition Function Estimation: A Quantitative Study

Probabilistic graphical models have emerged as a powerful modeling tool for several real-world scenarios where one needs to reason under uncertainty. A graphical model's partition function is a central quantity of interest, and its computation is key to several probabilistic reasoning tasks. Given the #P-hardness of computing the partition function, several techniques have been proposed over the years with varying guarantees on the quality of estimates and their runtime behavior. This paper seeks to present a survey of 18 techniques and a rigorous empirical study of their behavior across an extensive set of benchmarks. Our empirical study draws up a surprising observation: exact techniques are as efficient as the approximate ones, and therefore, we conclude with an optimistic view of opportunities for the design of approximate techniques with enhanced scalability. Motivated by the observation of an order of magnitude difference between the Virtual Best Solver and the best performing tool, we envision an exciting line of research focused on the development of portfolio solvers.

Effects of Home Confinement on the Intensity of Physical Activity during the COVID-19 Outbreak in Team Handball According to Country, Gender, Competition Level, and Playing Position: A Worldwide Study

This study investigated effects of home confinement on physical activity (PA) in Team Handball during the COVID-19 outbreak. A total of 1359 handball players participated (age: 23 ± 6 years). Participants from Europe, Western Asia, and North Africa answered an online version of the International Physical Activity Questionnaire (IPAQ) considering “before” and “during” confinement. COVID-19 home confinement has had a negative effect on PA (vigorous, moderate, walking, and overall). The largest decrease was in the sum parameter “all PA” (MET (metabolic equivalent of task)-min/week, ηp2 = 0.903; min/week, ηp2 = 0.861). Daily sitting time increased from 2.7 to 5.0 h per weekday (p < 0.001, ηp2 = 0.669). For gender, continent, country, level of handball league, and playing position, no significant differences (group and interaction effects) were observed. The largest change in PA behavior was in walking (minutes per day: ηp2 = 0.755), with males displaying the greatest decrease (from 62 ± 11 to 30 ± 14 min per weekday; d = 2.67). In terms of magnitude, difference between genders was greatest for sitting time (difference in d = 1.20). In conclusion, while COVID-19 measures were essential to preserve public health, PA was compromised and sedentary behavior increased because of these public health measures regardless of gender, playing position, and competition level.

An elastic phenomenological material law of technical textile with a nonlinear shear behaviour

In technical textile engineering, macro-level phenomenological modelling effectively describes the material’s highly nonlinear behaviour. However, existing material laws concentrate on the normal stiffness in the orthotropic yarns and simplify the shear effect because of the two orders of magnitude difference between shear and normal stiffness. This article introduces an improved phenomenological model that includes nonlinear shear behaviour, and it determines the material parameters with a previously applied data fitting method for exponential functions. The nonlinear shear behaviour is valid for the elastic state, that is, at the service level of the loads. Time-dependent, cyclic loading or plastic behaviour is not considered.

Evaluating the temperature dependence of bedrock hillslope erosion in the Mont Blanc massif using in situ cosmogenic 3He-10Be-14C

&lt;p&gt;The erosion of cold bedrock hillslopes in alpine environments depends not only on rates of frost weathering and accumulated rock damage, but additionally on the removal of the weathered material from the bedrock surface. In the Mont Blanc massif, steep bedrock faces with exposure ages sometimes much older than 50,000 years sit in close proximity to actively-eroding rockwalls, suggesting a more complex relationship between temperature and erosion rates than encompassed by the proposed &amp;#8220;frost-cracking window.&amp;#8221; Stochastic events like rockfalls and rock avalanches, despite their rarity, contribute a non-trivial proportion of the total sediment budget in alpine permafrost regions, adding to the contribution from background &amp;#8220;steady-state&amp;#8221; erosion. Employing a methodology based on the combination of in-situ cosmogenic nuclides &lt;sup&gt;3&lt;/sup&gt;He -&lt;sup&gt;10&lt;/sup&gt;Be-&lt;sup&gt;14&lt;/sup&gt;C, we test the temperature-dependence of high-alpine erosion while taking into account erosional stochasticity.&lt;/p&gt;&lt;p&gt;From cosmogenic &lt;sup&gt;10&lt;/sup&gt;Be concentrations of amalgamated samples collected on the Aiguille du Midi (3842 m a.s.l.) in the Mont Blanc massif, we find an order of magnitude difference in erosion rate across the peak&amp;#8217;s surface. Our preliminary measured erosion rates, ranging between appx. 0.03 mm yr&lt;sup&gt;-1&lt;/sup&gt; and 1.0 mm yr&lt;sup&gt;-1&lt;/sup&gt;, correlate neither with modern temperature measurements from borehole thermistors, nor with our current estimates of bedrock cosmogenic &lt;sup&gt;3&lt;/sup&gt;He-derived paleotemperatures. The corresponding cosmogenic &lt;sup&gt;14&lt;/sup&gt;C/&lt;sup&gt;10&lt;/sup&gt;Be ratios (between 1.70 and 4.0) for these erosion rates indicate that our measurements are not biased by recent stochastic rockfall events. Our current results therefore suggest that on geomorphic timescales, bedrock hillslope erosion rates are not set solely by rates of frost-cracking, but rather by the combined effects of frost-cracking and permafrost thaw-induced rockfalls. These insights are relevant both for short-term monitoring of alpine permafrost and associated geohazards under a warming climate, as well as studies of proposed &amp;#8220;buzzsaws&amp;#8221; operating on glacial-interglacial timescales.&lt;/p&gt;

Triclosan tolerance is driven by a conserved mechanism in diverse Pseudomonas species

Perturbation of natural microbial communities by antimicrobials, such as triclosan, can result in selection for antibiotic tolerance, which is of particular concern when pathogens are present. Members of the genus Pseudomonas are found in many natural microbial communities and frequently demonstrate increased abundance following triclosan exposure. The pathogen and well-studied model organism Pseudomonas aeruginosa exhibits high triclosan tolerance; however, it is unknown if all Pseudomonas share this trait, or if there are susceptible strains. We characterized the triclosan tolerance phenotypes of diverse Pseudomonas obtained from triclosan-exposed built environments and identified both tolerant and sensitive strains. High tolerance is associated with carriage of the enoyl-acyl carrier reductase (ENR) isozyme fabV compared to the lesser protective effects of efflux or presence of ENRs. Given its unique importance, we examined fabV distribution throughout Pseudomonas using large scale phylogenomic analyses. We find fabV presence or absence is largely invariant at the species level but demonstrates multiple gain and loss events in its evolutionary history. We further provide evidence of its presence on mobile genetic elements. Our results demonstrate the surprising variability in triclosan tolerance in Pseudomonas and confirm fabV to be a useful indicator for high triclosan tolerance in Pseudomonas. These findings provide a framework for better monitoring of Pseudomonas in triclosan-exposed environments and interpreting effects on species and gene composition. Importance Closely related species are typically assumed to demonstrate similar phenotypes driven by underlying conserved genotypes. When monitoring for the effect of antimicrobials on the types of species that may be selected for, this assumption may prove to be incorrect, and identification of additional genetic markers may be necessary. We isolated several phylogenetically diverse members of Pseudomonas from indoor environments and tested their phenotypic tolerance toward the commonly used antimicrobial triclosan. Although Pseudomonas are broadly regarded to be highly triclosan tolerant, we demonstrate the presence of both triclosan tolerant and susceptible strains, separated by a nearly three orders of magnitude difference in tolerance. Bioinformatic and experimental investigation demonstrated that the presence of the gene fabV was associated with high tolerance. We demonstrate that fabV is not evenly distributed in all Pseudomonas, and that its presence could be a useful predictor of high triclosan tolerance suitable for antimicrobial monitoring efforts of triclosan.