Analisis Performa Take Off Engine CFM56-7B Pada Thrust Tipe 26300 Lb

Penurunan performa engine dalam beberapa kondisi memungkinkan engine tidakdapat lagi di-maintain untuk mencapai performa yang disyaratkan. Menurut CFM masalah ini dapat diatasi dengan menurunkan versi (Thrust Rate) engine, dengan begitu engine tersebut tetap dapat beroperasi dengan standar performa yang lebih rendah dari versi awal.Dalam Tugas akhir ini penulis membahas perbandingan performa take-off engine CFM56-7B dengan konfigurasi thrust rating 26300 lbs. Perhitungan performa dilakukan dengan pengolahan data Test Cell Result menggunakan formula pada Engine Shop Manual – 003 untuk mengetahui seberapa besar perbedaan yang terjadi pada kedua konfigurasi thrust rating tersebut. Pada perhitungan performa take-off engine CFM56-7B dengan konfigurasi thrust rating 26300 lb berdasarkan formula dari Engine Shop Manual-003 Engine Acceptance Test adalah Konfigurasi thrust rating 26300 lb menghasilkan thrust sebesar 26920 lb. Nilai SFC yang didapatkan untuk thrust rating sebesar 0.3885 dengan SFC margin -5.3% dan 0.382. EGT yang dihasilkan engine sebesar 905.9 ºC dan EGT margin 17.1 ºC.

Propofol Inhibits Thyroid Cancer Cell Proliferation, Migration, and Invasion by Suppressing SHH and PI3K/AKT Signaling Pathways via the miR-141-3p/BRD4 Axis

Objective. This study explores the effect and mechanism of propofol for thyroid tumor. Methods. Culture human normal thyroid cells Nthy-ori 3-1 and thyroid cancer cell line TPC-1. TPC-1 cells were divided into the propofol group (treated with propofol), miR-141-3p group (transfected with the miR-141-3p mimic), negative control group (transfected with miR-NC), miR-141-3p + pcDNA-BRD4 group (transfected with the miR-141-3p mimic and pcDNA-BRD4), miR-141-3p + pcDNA group (transfected with the miR-141-3p mimic and pcDNA), siBRD4 group (transfected with siBRD4), and si-control group (transfected with si-control). The detection of miR-141-3p and BRD4 expression in cells was done by RT-qPCR, and the dual-luciferase reporter gene method and western blotting were used to verify the targeting relationship between miR-141-3p and BRD4. MTT method was used to test cell proliferation, transwell method was used to test cell migration and invasion, and western blotting was used to test SHH, GLI1, p-PI3K, and p-AKT protein expression. Results. Compared with Nthy-ori 3-1 cells, the expression of miR-141-3p in TPC-1 cells was markedly decreased. Propofol treatment and excessive expression of miR-141-3p could influence the phenotype of TPC-1 cells. BRD4 is one of the target genes of miR-141-3p, and its expression is negatively regulated by miR-141-3p. Overexpression of BRD4 can partially reverse the restraining effect of miR-141-3p on the TPC-1 cell phenotype. Both miR-141-3p and BRD4 can regulate the activity of SHH and PI3K/AKT signaling pathways. Conclusion. Propofol can inhibit the activity of SHH and PI3K/AKT pathways by targeting downregulating BRD4 through miR-141-3p, thereby inhibiting the phenotype of TPC-1 cells.

Loss of Liquid Lithium Coolant in an Accident in a DONES Test Cell Facility

A Demo-Oriented early NEutron Source (DONES) facility for material irradiation with nuclear is currently being designed. DONES aims to produce neutrons with fusion-relevant spectrum and fluence by means of D–Li stripping reactions occurring between a deuteron beam impacting a stable liquid lithium flowing film implementing the target. Given the hazard constituted by the liquid lithium inventory and the potential risk of reactions with water, air, and concrete eventually resulting in fire events, the Target Test Cell (TTC) is filled with helium and the reinforced concrete walls forming the bio-shield are covered with steel liners. A loss of Li in TTC, due to a large break in the Quench Tank, is postulated, and consequences are deterministically studied. With the TTC liner being water-cooled, the impact of the liner temperature rise following a leakage event is evaluated. Two separate MELCOR code models have been defined for the liquid lithium loop and water-cooled loop and are numerically coupled. The amount of leaked inventory dependent on the implemented safety logic and impact on TTC containment is evaluated. The water pressurization pattern within the liner cooling loop is studied to highlight possible risks of lithium–water/concrete reactions.

Serum lncRNA-ANRIL and SOX9 expression levels in glioma patients and their relationship with poor prognosis

Background lncRNA-CDKN2B antisense RNA 1 (ANRIL) and SRY-box transcription factor 9 (SOX9) has abnormal expression in many tumors including glioma, but the underlying molecular mechanism is unclear. This study set out to investigate the serum lncRNA-ANRIL and SOX9 levels in glioma patients and their effects on prognosis. Methods We enrolled 142 glioma patients admitted to our hospital from May 2014 to May 2016 into the research group (RG) and 120 healthy subjects receiving concurrent physical examinations into the control group (CG). Fasting peripheral blood (4 mL each) was sampled from subjects from the two groups. Using the quantitative real-time polymerase chain reaction (qRT-PCR), lncRNA-ANRIL and SOX9 were measured to explore their values in the early diagnosis of glioma. Patients from RG were followed up for 3 years to analyze the influence of lncRNA-ANRIL and SOX9 on patient prognosis. We purchased glioma cell lines U251 and U87 and grouped them according to the transfection of different plasmids. We conducted CCK8 assay to test cell proliferation, Transwell assay to test cell invasion, the flow cytometry to test cell apoptosis, and Western Blot assay to measure bcl-2 and bax protein levels. Results ANRIL and SOX9 were evidently higher in RG than in CG (P<0.01). The receiver operating characteristic (ROC) curve revealed that the diagnostic sensitivity of ANRIL combined with SOX9 for glioma was 81.62%, and the specificity was 90.83% (P<0.01). ANRIL and SOX9 were closely related to tumor grade, tumor diameter, distant metastasis, and family history of glioma (P<0.01). In total, 135 patients were successfully followed up (95.07%). Patients with high levels of ANRIL and SOX9 had a markedly poorer prognosis than those with low levels (P<0.05). ANRIL and SOX9 were markedly higher in glioma cell lines (U251 and U87) than in normal brain cells (P<0.01). The proliferation and invasion of U251 cells were notably reduced after the transfection of ANRIL and SOX9 inhibitory sequences (P<0.01), but the apoptosis was notably increased (P<0.01). Bcl-2 expression was markedly increased in lncRNA-ANRIL-inhibitor and SOX9-inhibitor (P<0.01), while bax expression was markedly reduced in lncRNA-ANRIL-inhibitor and SOX9-inhibitor (P<0.01). Conclusion lncRNA-ANRIL and SOX9 levels were higher in glioma patients than in healthy people. High-lncRNA-ANRIL and SOX9 levels were strongly associated with unfavorable prognosis of patients. The testing of biological behaviors revealed that lncRNA-ANRIL and SOX9 worked as tumor-promoting genes in glioma.

PEA Electromagnetic Distortion Reduction by Impedance Grounding and Pulsed Voltage Electrode Configurations

Space charges are one of the main challenges facing the constantly increasing use of extruded high voltage direct current (HVDC) cables. The Pulsed Electro-Acoustic (PEA) method is one of the most common procedures for space charge measurements of insulation. One issue with the PEA method is distortion due to the crosstalk between the applied voltage pulse and the acoustic sensor. This work analyzed two factors involved in the reduction in this distortion: the influence of the exposed semiconductor distance between the injection electrodes and PEA test cell, and the influence of adding a reactance at the grounding circuit of the PEA test cell. The interaction of these two factors with the distortion was analyzed through a series of experimental testing. Moreover, the performance regarding distortion after applying a developed coaxial injection was compared with the standard non-coaxial injection configuration. It was observed that these two factors had a direct impact on distortion and can be utilized for the reduction in distortion arising from the crosstalk of the applied pulsed voltage. The results can be utilized for the consideration of practical aspects during the construction of a PEA test setup for the measurement of full-size HVDC cables.

Turbine Inlet Temperature Measurements in A T 8200 KW Gas Turbine Using Water Vapor Emission

The measurement of turbine inlet temperature is challenging because of high temperatures and complicated physical access, but continuous measurement of the turbine inlet temperature is very important for maximizing turbine efficiency and increasing durability. This paper provides in-situ turbine rotor inlet temperature (TRIT) measurements in an 8200 kW operating gas turbine engine. The measurements were obtained using integrated spectral infrared (ISIR) emission from the water vapor of the combustion gases entering the turbine rotor. The method utilizes a sapphire optical fiber to convey the signal from the turbine wall to outside the turbine casing. All components are capable of long-term exposure to the turbine operating conditions. The temperature measurements were obtained at 6 operating conditions between 50% and full load. The TRIT temperature was also determined using more than 20 test cell inputs and Solar Turbine's commercial test cell engine model. The two temperatures (measured and modeled) were within 11 K (less than 1%) across the load sweep. Uncertainty calculations suggest that the uncertainty of the measurement can be expected to be ±2.9% within a confidence interval of 95%. The method also yields the nozzle guide vane surface temperature which was found to increase monotonically with increasing load.

Turbine Inlet Temperature Measurements in a T 8200 kW Gas Turbine Using Water Vapor Emission

The measurement of turbine inlet temperature is challenging because of high temperatures and complicated physical access, but continuous measurement of the turbine inlet temperature is very important for maximizing turbine efficiency and increasing durability. This paper provides in-situ turbine rotor inlet temperature (TRIT) measurements in an 8200 kW operating gas turbine engine. The measurements were obtained using integrated spectral infrared (ISIR) emission from the water vapor of the combustion gases entering the turbine rotor. The method utilizes a sapphire optical fiber to convey the signal from the turbine wall to outside the turbine casing. All components are capable of long-term exposure to the turbine operating conditions. The temperature measurements were obtained at 6 operating conditions between 50% and full load. The TRIT temperature was also determined using more than 20 test cell inputs and Solar Turbine’s commercial test cell engine model. The two temperatures (measured and modeled) were within 11 K (less than 1%) across the load sweep. Uncertainty calculations suggest that the uncertainty of the measurement can be expected to be ±2.9% within a confidence interval of 95%. The method also yields the nozzle guide vane surface temperature which was found to increase monotonically with increasing load.