Liminality as a condition for changing of the level of subjective vitality of a professional

The article analyzes the scientific literature on the problem of liminality as a condition for the dynamics of subjective vitality in conjunction with professional activity. The phenomenon of subjective vitality is defined as the subject's level of vital forces, which exist in him as an adaptive and personal potential, the realization of which is necessary for a person to realize his uniqueness and integrity in order to establish a correspondence between various states in the person himself, as well as with the systems surrounding him. The article substantiates its actual role in professional activity, preservation of mental and physical health, in increasing the level of psychological well-being. Taking into account the fact that a certain number of professional situations can be better understood if we consider them through the prism of liminality - an intermediate state between otherness and norms, approaches to this concept are considered. Arnold van Gennep's views that life is characterized by transitions from one social group or situation to another. Victor Turner, expanding the understanding of liminality and describing its relevance to both traditional and modern societies. The works of Homi Bhabha, in which liminality is put forward as a state that allows self-construction through the rejection of imposed forms. The three-phase structure of the liminality of L.I. Fusu. Liminality in modern psychology is a state that occurs at the moment of transition from one stage of development to another, that is, associated with life changes or developmental crises, with changes in general, or with a situation of uncertainty. The article concludes that the problem of the development of subjective vitality is interconnected with the presence of the state of liminality and the conditions of the liminal situation. Liminality acts as a psychological condition for a change in the level of subjective vitality, leading to the need to revise the attitude to life, spiritual foundations and the system of values.

“Wiedergeburt” Society of Russian Germans in the Republic of Khakassia in the 1990s–2010s

This article examines the “Wiedergeburt” Society of Russian Germans in the Republic of Khakassia over the period from 1990s to 2010s relying on the archival sources. The object of this research is the “Wiedergeburt” Society of Russian Germans in the 1990s–2010s. The subject is the “Rebirth” Society of Russian Germans in the Republic of Khakassia. The goal of the publication consists in analysis of the history of establishment and development of “Wiedergeburt” Society in the Republic of Khakassia. The author aims to trace the history of creation of “Wiedergeburt” Society in the Russian Federation, namely in the Republic of Khakassia; as well as analyze the role of “Rebirth” Society in Germany-Russia relations. The article employs historical-comparative, chronological, and retrospective methods. The scientific novelty lies in the comparative analysis of the processes of creation and development of “Wiedergeburt” Society on the national level and on the level of the Republic of Khakassia; summary and systematization of  the related material using the historical-comparative and system-functional method for examination of the tasks faced by “Rebirth” Society in the Republic of Khakassia; examination of the regional branch of “Wiedergeburt” Society in Abakan within the system of nonprofit organization of Russian Germans; use of archival sources. The conclusion is made that “Wiedergeburt” Society in the Republic of Khakassia is part of the system of nonprofit organization of Russian Germans, and the regional branch of “Rebirth” Society in Abakan slightly differed from the central All-Union Society of Russian Germans “Wiedergeburt”. In pursuit of its goals, the organization was focused on the cultural-educational activity, preservation of culture and traditions, and development of the German language.

Comparative efficacy of genetically engineered biological drugs in real clinical practice according to the Moscow Unified Arthritis Registry (MUAR) data

Background: the list expansion of genetically engineered biological drugs (GEBD) used for the treatment of ankylosing spondylitis (AS) determines the relevance of studies aimed at comparing them and determining their place in this disease treatment. Real clinical practice studies are the preferred source of this data type. Aim: to evaluate the efficacy of various GEBD in patients with AS according to the Moscow Unified Arthritis Registry (MUAR). Material and methods: the analysis of the MUAR data was carried out. These included clinical cases with GEBD, for which there were data of a completed visit after 6 months or more after the treatment initiation. Parameters values achieved during treatment with various drugs were analyzed. The comparison was conducted during a multivariate analysis with adjustments for the identified confounders. Non-clinical parameters that were reliably and independently associated with the achieved BASDAI index (CRP) values were considered as confounders. Results: the study included 363 treatment episodes with GEBP in 361 patients. As mutually independent significant predictors of the achieved ASDAS (confounders) values, GEBD treatment duration were established until the evaluation of indicators (p<0.001) and the age of the patient (p=0.006). Significant association between the established values of the studied parameters and the used GEBD were found for the achieved ASDAS (p=0.033) and ESR (p=0.007) values. In a pairwise drug comparison using the conservative Šidák correction, the achieved values of ASDAS and ESR during infliximab and adalimumab administration were significantly less than during certolizumab pegol administration. Conclusion: infliximab, adalimumab, etanercept, certolizumab pegol, golimumab, secukinumab in real clinical practice demonstrate generally similar clinical efficacy in the treatment of AS. The effect of golimumab and secukinumab, recently introduced into clinical practice, does not significantly differ from the effect produced by long-term TNF-α inhibitors. Certain disease activity preservation in a significant part of patients gives grounds to continue the search for new treatment methods. KEYWORDS: ankylosing spondylitis, genetically engineered biological drugs, tumor necrosis factor inhibitors, C-reactive protein, confounders, registry. FOR CITATION: Rosochkina E.A., Lukina G.V., Koltsova E.N. et al. Comparative efficacy of genetically engineered biological drugs in real clinical practice according to the Moscow Unified Arthritis Registry (MUAR) data. Russian Medical Inquiry. 2021;5(2):58–63. DOI: 10.32364/2587-6821-2021-5-2-58-63.

TOTAL-DIGITAL CONTROL ON THE DIFFUSION OF STATE POLICY IN CONDITIONS OF EMERGENCY SITUATIONS

Issues related to the implementation of tasks related to countering threats to national security in the field of state policy of electronic and total control are considered. Particular attention is paid to the issue of interdisciplinary convergence of leading industries of modern technologies, their synergetic relationship and impact on humans in today's security environment. The current views of scientists and practitioners on the transition from a system of state supervision (control) in the field of cybersecurity to a system of emergency prevention, as well as advances in science and technology to increase the capacity of state defense forces to respond to emergencies. It is argued that it is quantum reorientation that would promote the formation of more humane communications at all levels of government, would form new scientific imperatives in modern periods of international emergencies. It is outlined that when a global pandemic is ripe as an epidemic of a historically cyclical nature, the "state in the smartphone" acquires a specific weight. To this end, the need for further growth in computing power is justified. Emphasis is placed on the current state of security of the individual, state and society, in particular on revising the existing attitude to security issues through the formation of a new mass culture – security culture, when every Ukrainian consciously chooses a position, acquires the necessary knowledge and skills in security. time the state creates favorable conditions for its vital activity, preservation of health and working capacity. Emphasis is placed on the lack of a comprehensive state policy for the formation and implementation of a strategy for the implementation of a culture of security, which would cover all areas of human activity; lack of a supra-departmental coordination and methodological center, which will facilitate the implementation of organizational approaches to improve the situation regarding the formation of a culture of security. There is a lack of attention to security, health, education and science.

Suppression of β1-Adrenoceptor Autoantibodies is Involved in the Antiarrhythmic Effects of Omega-3 Fatty Acids in Male and Female Hypertensive Rats

The arrhythmogenic potential of β1-adrenoceptor autoantibodies (β1-AA), as well as antiarrhythmic properties of omega-3 in heart diseases, have been reported while underlying mechanisms are poorly understood. We aimed to test our hypothesis that omega-3 (eicosapentaenoic acid-EPA, docosahexaenoic acid-DHA) may inhibit matrix metalloproteinase (MMP-2) activity to prevent cleavage of β1-AR and formation of β1-AA resulting in attenuation of pro-arrhythmic connexin-43 (Cx43) and protein kinase C (PKC) signaling in the diseased heart. We have demonstrated that the appearance and increase of β1-AA in blood serum of male and female 12-month-old spontaneously hypertensive rats (SHR) was associated with an increase of inducible ventricular fibrillation (VF) comparing to normotensive controls. In contrast, supplementation of hypertensive rats with omega-3 for two months suppressed β1-AA levels and reduced incidence of VF. Suppression of β1-AA was accompanied by a decrease of elevated myocardial MMP-2 activity, preservation of cardiac cell membrane integrity and Cx43 topology. Moreover, omega-3 abrogated decline in expression of total Cx43 as well as its phosphorylated forms at serine 368 along with PKC-ε, while decreased pro-fibrotic PKC-δ levels in hypertensive rat heart regardless the sex. The implication of MMP-2 in the action of omega-3 was also demonstrated in cultured cardiomyocytes in which desensitization of β1-AR due to permanent activation of β1-AR with isoproterenol was prevented by MMP-2 inhibitor or EPA. Collectively, these data support the notion that omega-3 via suppression of β1-AA mechanistically controlled by MMP-2 may attenuate abnormal of Cx43 and PKC-ε signaling; thus, abolish arrhythmia substrate and protect rats with an advanced stage of hypertension from malignant arrhythmias.

Can uterine secretion of modified histones alter blastocyst implantation, embryo nutrition, and transgenerational phenotype?

Extracellular histones support rodent and human embryo development in at least two ways. First, these molecules in uterine secretions protect embryos from inflammation caused by pathogens that gain access to the reproductive tract. Also, histones in uterine secretions likely support penetration of the uterine epithelium by blastocysts during embryo implantation. Extracellular histones seem to preserve amino acid transport system B0,+ in blastocysts by inhibiting its activity. Preservation of system B0,+ is needed because, at the time of invasion of the uterine epithelium by motile trophoblasts, system B0,+ is likely reactivated to help remove tryptophan from the implantation chamber. If tryptophan is not removed, T-cells proliferate and reject the implanting blastocyst. Epigenetic modification of histones could alter their promotion of normal implantation through, say, incomplete tryptophan removal and, thus, allow partial T-cell rejection of the conceptus. Such partial rejection could impair placental development, embryonal/fetal nutrition, and weight gain prior to birth. Small-for-gestational-age offspring are predisposed to developing metabolic syndrome, obesity, and associated complications as adults. Shifting expression of these phenotypes might contribute to transgenerational variation and evolution. The spectrum of possible extracellular histone targets in early development warrant new research, especially since the effects of epigenetic histone modifications might be transgenerational.