Study of the technological properties of excipients in the development of the composition of orally dispersible tablets

Introduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment. Samples of excipients were analyzed according to such pharmacopoeial indicators as description, flowability, bulk density, compressibility, fractional composition, solubility in water.Aim. The aim of the work is to create a list and study the technological properties of candidate substances for the role of auxiliary substances in the composition being developed by the ODT.Materials and methods. The technological properties of excipient samples were studied according to the methods of the State Pharmacopoeia of the XIV edition using the flowability tester GTL (ERWEKA, Germany), the bulk density tester SVM 221 (ERWEKA, Germany), the tablet press PGR-10 (LabTools, Russia) and the tablet hardness tester TBH 125 TDP (ERWEKA, Germany).Results and discussion. As a result of the study, experimental data on the technological properties of excipient samples were collected, and the selected samples were compared according to pharmaceutical and technological indicators.Conclusion. In the course of the study, a list of auxiliary substances for the development of the composition of ODT was formed and studies of their technological properties were carried out. The obtained experimental data will allow to develop an optimal matrix of a multifactorial experiment for the development of the composition of ODT and justify the choice of excipients.

Monitoring and charging level alignment system for a vehicle hybrid power unit battery pack

The article is devoted to the actual problem of developing effective means of control and charging level alignment of the vehicle hybrid power unit (HPU) accumulators. A description of the automatic control and charging level alignment system of the battery pack for hybrid power unit developed by the authors, while simultaneously controlling the temperature of each battery, the originality of which is protected by patents of the Russian Federation, is provided.The device is distinguished by the simplicity of the circuit design, its own low energy consumption and potentially low cost. To check the efficiency of the proposed device the computer simulation and experimental study were carried out. As a result of the provided multifactorial experiment, a regression function was obtained, which allows, by the value of the obtained coefficients, to reveal the degree of inhomogeneity of the monitored batteries in terms of electrical parameters and the temperature of influence, as well as to take into account the effects of pair and quadratic interactions.

INFLUENCE OF ROAD POLLUTION COMPONENTS FOR WATER ABSORPTION OF ANTI-CORROSIVE FILM

Проблема и цель. Для достижения цели исследования и ответа на поставленные вопросы было проведено изучение влияния компонентов загрязнения поверхности автомобильной дороги на влагопоглощение пленки пластизольной мастики Д-11А, которое влияет на долговечность ее защитных свойств. Методология. Пробы загрязнений дорожной поверхности показали, что основными коррозионноагрессивными компонентами в них являются ионы хлора , аммония нитратов и сульфатов . Одним из основных свойств противокоррозионной пленки является сплошность, т.е. отсутствие в структуре микро- и макропор, о чем можно судить по ее влагопоглощению. Влияние выявленных компонентов на влагопоглощение пластизольной пленки исследовали по методу многофакторного эксперимента плана N = 2⁴. Последовательность проведения экспериментов была следующей: на аналитических весах ВЛА-200 г-М с точностью 0,0001 г взвешивали подготовленные образцы из стали 08кп до и после нанесения покрытия, высушивали и помещали в химические стаканы емкостью 900 мл с 16 вариантами растворов. Растворы готовили исходя из концентрации активных ионов загрязнений, растворяя в 1 л дистиллированной воды NaCl – 1,404 г, NH4OH – 0,0068 г, NaNO3 – 0,051 г, Na2SO4 – 0,3905 г. Через 24, 72, 120 и 240 ч образцы вынимали из растворов, высушивали, взвешивали и гравиметрическим методом определяли влагопоглощение пленки. Результаты. По результатам экспериментов были получены уравнения зависимости влагопоглощения от коррозионно-активных компонентов загрязнения дорожной поверхности. Заключение. Анализ уравнений показал, что при одиночном воздействии факторов на влагопоглощение наибольшее влияние оказывают ионы и . . Ионы и менее агрессивны к защитной пленке. Сочетание ионов хлора и сульфатов повышает влагоемкость пленки. Ионы нитратов и сульфатов частично тормозят влагопоглощение пленки, а в сочетании с ионами существенно повышают влагоемкость покрытий. Problem and purpose. To achieve the goal of the study and answer the questions posed, a study was made of the infuence of the components of the road surface pollution on the moisture absorption of the D-11A plastisol mastic flm, which afects the durability of its protective properties. Methodology. Samples of road surface contamination showed that the main corrosive components in them are ions of chlorine, ammonium, nitrates and sulfates. One of the main properties of anti-corrosive flms is continuity, i.e. the absence of micro- and macropores in the structure, which can be judged by its moisture absorption. The infuence of the identifed components on the moisture absorption of the plastisol flm was investigated by the method of a multifactorial experiment of the design N = 24. The sequence of experiments was as follows: on an analytical balance VLA-200 g-M with an accuracy of 0.0001 g, prepared samples of 08kp steel were weighed before and after coating, dried and placed in beakers with a capacity of 900 ml with 16 solutions. The solutions were prepared based on the concentration of active ions of contaminants, dissolving in 1 liter of distilled water NaCl - 1.404 g, NH4OH - 0.0068 g, NaNO3 - 0.051 g, Na2SO4 - 0.3905 g. After 24, 72, 120 and 240 h, the samples were taken out from solutions, dried, weighed, and the moisture absorption of the flm was determined by the gravimetric method. Results. Based on the results of the experiments, equations were obtained for the dependence of moisture absorption on the corrosive components of road surface pollution. Conclusion. Analysis of the equations showed that with a single efect of factors on moisture absorption, ions and have the greatest infuence. Ions and less aggressive to the protective flm. The combination of chlorine and sulfate ions increases the moisture holding capacity of the flm. Ions of nitrates and sulfates partially inhibit the moisture absorption of the flm, and in combination with ions signifcantly increases the moisture capacity of the coatings.

Optimization of the kinematic mode of operation of the tractor-driven tillage tool

A traction-driven tillage tool with low traction resistance has been developed. A decrease in the tractive resistance of the implement is achieved by transferring the main share of the power consumed by the implement to the process of loosening the soil through the tractor power take-off shaft (PTO) to the drive needle discs, which in turn create a pushing force. The efficiency of the technological process of soil cultivation depends on the kinematic mode of operation of each row of disk working bodies of the tractiondrive tillage implements. To optimize their kinematic mode of operation, a multifactorial experiment was carried out, which made it possible to establish the optimal values of such factors as the kinematic parameters of the 1st and 2nd rows of needle disks at the set operating speed of the unit.

PLANNING A MULTI-FACTOR EXPERIMENT FOR DETERMINING RATIONAL PARAMETERS OF THE VIBRATION MACHINE OPERATION

The approaches and methods of improving the quality and efficiency of agricultural machinery repair are of priority importance in Ukraine today. The tough competitive environment in the interstate and domestic market of technical services dictates its own terms. One of the promising research methods is the planning of an experiment in the optimization of multifactorial processes, such as vibration strengthening processing of agricultural machinery parts. The object of the research in this article was the technological process of finishing, cleaning and strengthening processing of parts of tillage machines with their surface plastic vibration deformation. The purpose of the work was to plan a multifactorial experiment for the theoretical determination of the compromise parameters of the operation of a vibration machine with an activator of the movement of the working medium for strengthening the treatment of the working bodies of tillage machines. The task of the work was to: analyze research and publications on the basics of probability theory, mathematical statistics, foundations of correlation, variance and regression analyzes, planning an optimal experiment; obtain the coefficients of complex equations of multiple regression of the 2nd order and plot the dependence of the consumed energy consumption by the developed installation on the amplitude of oscillations of the working chamber, the amplitude of oscillations of the activator, angular velocity of the drive shaft of the working chamber, angular velocity of the drive shaft of the activator, processing time; the height of microroughnesses from the vibration amplitude of the working chamber, the vibration amplitude of the activator, the angular velocity of the drive shaft of the working chamber, the angular velocity of the drive shaft of the activator, the processing time; surface hardness on the vibration amplitude of the working chamber, vibration amplitude of the activator, angular velocity of the drive shaft of the working chamber, angular velocity of the drive shaft of the activator, processing time; based on the results of the research and testing of the developed installation on the basis of the constructed response surfaces of the processes under study, to determine the rational technological parameters of its operation, the compromise value of which can be obtained by the Cramer method in the mathematical environment "Mathcad 15". The research methodology was based on mathematical statistics, correlation, variance and regression analyzes, planning an optimal experiment. In scientific work, based on the results of a multifactorial experiment, a mathematical model was obtained in the form of multiple second-order regression, which adequately describes the technological process under study. Compromise technological parameters of the investigated process were obtained, which are: the amplitude of oscillations of the working chamber - 2-4 mm; the vibration amplitude of the activator is 1.5-2.5 mm; the angular speed of the drive shaft of the working chamber - 115-120 rad/s; the angular speed of the drive shaft of the activator 130-145 rad/s; processing time - 80 min.

The use of zeolites for biogas purification in agricultural production

The article refers to studies related to the purification of biogas. Biogas is obtained by fermenting of native manure. Biogas is obtained as a result of fermentation of native manure with subsequent purification from unwanted impurities. After purification, the content of methane in biofuel rises, therefore the quality of alternative fuel improves. The results of studies on the use of natural zeolites of the Khonguruu deposit in the Suntarskyulus of the Republic of Sakha (Yakutia) as a filter material are presented. The device of the filter for biogas is described.The materials for planning a multifactorial experiment are briefly presented. The most significant factors of the biogas purification process have been specified: size of fractions, zeolite mass, ratio of the height of bulk material to the diameter of the filter. It is shown that the maximum efficiency of biogas purification was obtained with the ratio of the height and diameter of the filter H/d = 3.0: 4.2. The optimal average weighted diameter of the granules of the bulk filter material (zeolite) is 0.004 m. The optimum mass of the filter material is 0.75-0.8 kg. At the filter outlet, biogas with 93.3%of methane content wasobtained.

Application of fertilizers and growth stimulants for growing chickpeas in the dry steppe zone of the Middle Volga region

The results of the 2016–2017 studies are presented. Indicators of the crop structure, productivity and fodder values of chickpea varieties (Privo 1, Volgogradsky 10, Volzhanin) are determined. Different methods of crops treatment with growth stimulants Growth matrix, Megamix Profi, Aminokat + Raikat Development are described. The multifactorial experiment included two options of mineral nutrition (without and with fertilizers N12P52 (factor A); three varieties of chickpeas: “Privo 1”, “Volzhanin”, “Volgogradsky 10” (factor B); two options of vegetation treatment: without and with treatment using Growth Matrix, Megamix Profi, Aminokat + Raikat Development (factor C). The studies have shown that all treatment options f increased productivity of chickpeas and crops quality. The maximum yield was obtained by applying N12P52 for Volzhanin variety treated with Megamix Profi and Aminokat + Raikat Development (2.19 t/ha and 2.16 t/ha with a dry matter of 1.97-1.95 t/ha, digestible protein of 0.36-0.33 t/ ha and an exchange energy yield of 27.10-26.90 GJ/ha, respectively).