Recent approaches and success of liposome-based nanodrug carriers for the treatment of brain tumor

: Brain tumors are nothing but a collection of neoplasms originated either from areas within the brain or from systemic metastasized tumors of other organs that have spread to the brain. It is a leading cause of death worldwide. The presence of the blood-brain barrier (BBB), blood-brain tumor barrier (BBTB), and some other factors may limit the entry of many potential therapeutics into the brain tissues in tumor area at the therapeutic concentration required for satisfying effectiveness. Liposomes are taking an active role in delivering many drugs through the BBB into the tumor due to their nanosize and their physiological compatibility. Further, this colloidal carrier can encapsulate both lipophilic and hydrophilic drugs due to its unique structure. The surface of the liposomes can be modified with various ligands that are very specific to the numerous receptors overexpressed onto the BBB as well as onto the diseased tumor surface site (i.e., BBTB) to deliver selective drugs into the tumor site. Moreover, the enhanced permeability and retention (EPR) effect can be an added advantage for nanosize liposomes to concentrate into the tumor microenvironment through relatively leaky vasculature of solid tumor in the brain where no restriction of penetration applies compared to normal BBB. Here in this review, we have tried to compilethe recent advancement along with the associated challenges of liposomes containing different anticancer chemotherapeutics across the BBB/BBTB for the treatment of gliomas that will be very helpful for the readers for better understanding of different trends of brain tumor targeted liposomes-based drug delivery and for pursuing fruitful research on the similar research domain.

Value Configurations for Data and Connectivity Solutions in Digitalized Future Factories

The ongoing Industry 4.0 transformation places significant pressures on how businesses create and capture value. Technological advancements such as next-generation mobile communications are reshaping the business ecosystem of Industry 4.0, resulting in emerging business opportunities for new players, such as local operators, to collaborate and compete with mobile communications companies that are implementing I4.0. These changes raise the need to explore emerging business opportunities concerning the digitalization of future factories. New data and connectivity services are introduced to serve the needs of rapidly increasing machine-type communications that rely on connectivity, primarily through the fifth generation (5G) mobile solutions provided by local operators. Thus, this paper outlines the potential value configurations for data and connectivity solutions by identifying, matching, and bridging the utilizable resources and addressable needs within the factory processes. The research applies an exploratory approach and uses the Gioia method to analyze qualitative data of a single case. The study follows the connectivity-content-context-commerce typology (4C) of Internet business models to structure, analyze, and classify the identified needs and resources in future factories from the perspective of the local operator. The findings show that the content layer of 4C business model typology is the most dominant among data and connectivity-based needs and resources of future factories. The paper contributes by presenting four alternative value configurations for digitalization for local operators in the future factory context: the product, component, platform, and complementary businesses. The results suggest content- and context-specific businesses carries foremost business potential for local operators, however quantitative validation will bring fruitful research avenues. Multiple case studies and different data collection methods may also be considered in future studies.

Imagination and evolution of taste

Taste is a complex biological, cultural and even psychological phenomenon. We can trace both significant differences and significant similarities in taste quite easily, if we observe human communities in different regions, countries and continents. For example, it is no surprise that most of us share a passion for sweet taste and might dislike bitter or sour. At different ages, people appreciate a variety of foods and drinks and preferences usually change due to physical and social exposure to a given diet. One thing that remains clear is that our taste constantly evolves, notwithstanding whether we discuss taste as a personal system of preferences or if we analyze it as a social convention of favoured sensory experiences. The evolution of taste is a multidirectional process and its roots can be traced back to biology, geography, cultural and social studies, religion, etc. However, in the current paper we will focus on a less examined perspective which seems to offer a fruitful research direction. How does thinking and creativity influence the evolution of taste? How important is our imagination in the taste formation process? Are we able to create an unprecedented dish or we are obliged to follow certain rules and predispositions in our creative culinary experiments? In order to answer these questions, we will start by looking at imagination itself. We will trace this idea back to Aristotle and Kant to define the essence of this controversial philosophical concept and to specify its function in reasoning. Then we will analyze certain aspects of creativity in taste, in order to observe the evolution of certain culinary tendencies. Last but not least we will focus on the influence of social media and the digital communication. Does digital living today improve the culinary imagination or not? Is the culinary evolution in the XXI century triggered by the social media and ease of access to information online?

Research Progress in the Interconversion, Turnover and Degradation of Chlorophyll

Chlorophylls (Chls, Chl a and Chl b) are tetrapyrrole molecules essential for photosynthetic light harvesting and energy transduction in plants. Once formed, Chls are noncovalently bound to photosynthetic proteins on the thylakoid membrane. In contrast, they are dismantled from photosystems in response to environmental changes or developmental processes; thus, they undergo interconversion, turnover, and degradation. In the last twenty years, fruitful research progress has been achieved on these Chl metabolic processes. The discovery of new metabolic pathways has been accompanied by the identification of enzymes associated with biochemical steps. This article reviews recent progress in the analysis of the Chl cycle, turnover and degradation pathways and the involved enzymes. In addition, open questions regarding these pathways that require further investigation are also suggested.

A review of literature directions regarding the impact of fintech firms on the banking industry

Purpose This paper aims to provide a review of literature directions regarding the potential impact of fintech operators on the financial services market globally. This paper reviews the literature to identify possible benefits or challenges that fintech firms can have for the traditional banking system. Design/methodology/approach This paper is based on a review of published research papers related to fintech and digital finance. The Scopus database, SSRN database and google scholar were used to find relevant research papers. The final sample included impactful papers about the effect of fintech activities on the banking and financial services industry. Findings The current paper indicated that while fintech firms would take some market share away from banks, it is not expected that fintech firms would substitute banks. However, banks are required to accelerate their adoption of innovations and advanced technology to compete with fintech firms. It is also proposed that strategic partnerships and cooperation could happen between banks and fintech companies in a way that benefits both sides. Originality/value The present paper adds to the understanding of the effect of the fintech firms’ growth on the banking industry in light of the emerging opportunities and threats for the financial sector. The paper also provides guidance for fruitful research on the impact of fintech activities on social and economic welfare in the future.

Identifying Factors Associated with Consumers’ Adoption of e-Mobility—A Systematic Literature Review

Electrification of road transport—replacing internal combustion engine vehicles with new energy vehicles such as electric vehicles (EVs)—seems to be a promising step towards achieving sustainable urban development, yet the diffusion of EVs is proceeding slowly. Investigating this phenomenon, researchers have provided numerous findings. However, these findings also created a fragmented and heterogeneous body of literature. This article applies a systematic literature review to establish a status quo of factors associated with the adoption of EVs. A total of 49 articles were identified and analyzed in detail for their contribution to EV adoption. The results from the systematic literature review were synthesized. The article ends with implications for policymakers and suggests fruitful research avenues for future investigations.

On the issue of diaphragmatic hernias

The issue of diaphragmatic hernias has been the subject of persistent and fruitful research since the last half of the last century. Until that time, the more or less developed doctrine of diaphragm hernias, one might say, did not exist at all - if individual cases of this kind of hernias were described, then the number of these descriptions was not so great, and these descriptions were of a purely casuistic nature.

Learning to Frame Complex Sustainability Challenges in Place: Explorations Into a Transdisciplinary “Challenge Lab” Curriculum

Complex sustainability challenges may never be fully solved, rather requiring continuous, adaptive, and reflexive responses over time. Engagement of this nature departs from well-structured problems that entail expected solutions; here, focus shifts toward ill-structured or ill-defined issues characterized by wickedness. In the context of complex challenges, inadequate or absent framing has performative implications on action. By overlooking the value of framing, eventual responses may not only fall short; they may even displace, prolong, or exacerbate situations by further entrenching unsustainability. In educational settings, we know little about how curriculum designs support challenge framing, and how students experience and learn framing processes. In this paper we explore a transdisciplinary “Challenge Lab” (C-Lab) curriculum from a perspective of challenge framing. When considering framing in higher education, we turn to the agenda in education for, as and with sustainable development to be problem-solving, solutions-seeking or challenge-driven. We introduce framing as a boundary object for transformative praxis, where sustainability is held to be complex and contextual. This study is qualitative and case-based, designed to illuminate processes of and experiences into sustainability challenge framing in a transdisciplinary learning setting. Methodologically, we draw from student reflective diaries that span the duration of a curriculum design. We structure our results with the support of three consecutive lenses for understanding “curriculum”: intended, enacted, and experienced curriculum. First, we present and describe a C-Lab approach at the level of ambition and design. Here it is positioned as a student-centered space, process, and institutional configuration, working with framing and re-framing complex sustainability challenges in context. Second, we present a particular C-Lab curriculum design that unfolded in 2020. Third, we illustrate the lived experiences and practical realities of participating in C-Lab as students and as teachers. We reflect upon dilemmas that accompany challenge framing in C-Lab and discuss the methodological implications of this study. Finally, we point toward fruitful research avenues that may extend understandings of challenge framing in higher education.

Even More Effort Towards Improved Bounds and Fixed-Parameter Tractability for Multiwinner Rules

Multiwinner elections have proven to be a fruitful research topic with many real world applications. We contribute to this line of research by improving the state of the art regarding the computational complexity of computing good committees. More formally, given a set of candidates C, a set of voters V, each ranking the candidates according to their preferences, and an integer k; a multiwinner voting rule identifies a committee of size k, based on these given voter preferences. In this paper we consider several utilitarian and egailitarian OWA (ordered weighted average) scoring rules, which are an extensively researched family of rules (and a subfamily of the family of committee scoring rules). First, we improve the result of Betzler et al. [JAIR, 2013], which gave a O(n^n) algorithm for computing winner under the Chamberlin Courant rule (CC), where n is the number of voters; to a running time of O(2^n), which is optimal. Furthermore, we study the parameterized complexity of the Pessimist voting rule and describe a few tractable and intractable cases. Apart from such utilitarian voting rules, we extend our study and consider egalitarian median and egalitarian mean (both committee scoring rules), showing some tractable and intractable results, based on nontrivial structural observations.

Accounting for (public) value(s): reconsidering publicness in accounting research and practice

PurposeThis paper aims to highlight the importance of (public) value(s) and publicness in accounting and accountability research. It pinpoints a range of issues that scholars need to contemplate when reconsidering publicness in accounting research and practice.Design/methodology/approachThe paper adopts an interdisciplinary literature review associated with a conceptual discussion of the actual and future challenges of public service accounting and accountability in considering public value(s).FindingsThe paper illustrates the centrality of (public) value(s) at the individual, organizational and societal levels in shaping and being shaped by calculative practices, and shows that looking at the interconnections between values and accounting is a fruitful research avenue. Moreover, it highlights the power of embracing interdisciplinary approaches to illuminate these interconnections and relate them to complex and current phenomena.Originality/valueThe paper’s originality lies in the reconsideration of (public) value(s) for public service accounting scholars, providing a critical reflection and setting new research avenues.