A new framework is essential for evaluating nuclear risks in South Asia. This region is marked by perennial disputes, emerging rivalries and long-standing extra-regional interferences, suggesting that it must be considered as a complex geostrategic frame of reference, rather than as a mere geographic construct. As key variables, postures such as no first use and escalate to de-escalate, as well as technological advances may either mitigate or exacerbate nuclear risks. Due to this complexity, causes of instability, risks of conflict, escalation to nuclear use and prospects of restraints and risk reduction will need to engage key players. This must occur not simply in dyadic, but also in multilateral contexts, due to the cascading effects of interactions among them. Within this framework, this essay will explore the erosion of no first use, the potential pitfalls of escalate to de-escalate and technological advances pose significant and worrying challenges for nuclear risk reduction.