A 21st Century Classroom is a learning environment that incorporates current critical thinking, problem solving, communication, and collaboration skills into traditional core knowledge instruction. Fostering this space will enable students to integrate core subjects and lead to a deeper understanding of global awareness and greater economic, civic, health and environmental literacy. Skeptics have argued that transforming higher education, especially to attenuate its cost is something, which we know, but we cannot get it. However, information technology is a way to achieve this required transformation. This chapter explores explore how information technology might help achieve this transformation to advance higher education, and its prospects for success.