Hepatitis A and Non-A, Non-B Viral Hepatitis in São Paulo, Brazil: Epidemiological, Clinical, and Laboratory Comparisons in Hospitalized Patients

To evaluate the prevalence of antibody against hepatitis A in two socioeconomically distinct populations of a developing country, 540 serum specimens from children and adults living in São Paulo, Brazil, were tested for IgG anti HAV by a commercial radioimunoassay (Havab, Abbott Laboratories). The prevalence of anti-HAV in low socioeconomic level subjects was 75.0% in children 2-11 years old and 100.0% in adults, whereas in middle socioeconomic level significantly lower prevalences were observed (40.3% in chidren 2-11 years old and 91.9% in adults). Voluntary blood donors of middle socioeconomic level showed a prevalence of 90.4%. These data suggest that hepatitis A infection remains a highly endemic disease in São Paulo, Brazil.

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Hepatitis A Outbreaks and Environmental Circulation of Genotype IA Strains in the São Paulo City, 2017–2018

Food and Environmental Virology ◽

10.1007/s12560-021-09497-7 ◽

2021 ◽

Author(s):

Tatiana Prado ◽

Mikaela Renata Funada Barbosa ◽

Ronalda Silva Araújo ◽

Suzi Cristina Garcia ◽

Adalgisa Jesus Melo ◽

...

Keyword(s):

Hepatitis A ◽

Sao Paulo ◽

São Paulo

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EXPERIENCE IN THE EVALUATION OF CHILDREN WITH HEPATOSPLENOMEGALY AT A TEACHING AMBULATORY, SÃO PAULO, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651998000500001 ◽

1998 ◽

Vol 40 (5) ◽

pp. 269-275

Author(s):

Lucia F. BRICKS ◽

Ana Maria COCOZZA ◽

Rosa RESEGUE ◽

Ana Cecília S.L. SUCUPIRA ◽

Daleth RODRIGUES ◽

...

Keyword(s):

Weight Loss ◽

Urinary Tract ◽

Physical Examination ◽

Metabolic Disorders ◽

Hepatitis A ◽

Sao Paulo ◽

Deficiency Anemia ◽

São Paulo ◽

Neoplastic Disorders ◽

Age Range

Objectives: Describe cases of children with hepatosplenomegaly (HS) attended at the General Pediatric Teaching Ambulatory (AGER) of Instituto da Criança, São Paulo, identifying the main causes, evolution, necessity for hospitalization and/or referral to specialists. Methodology: Retrospective analysis of the records of children presenting HS on admission at AGER from September 1, 1993 to August 31, 1996. Results: Of the 89 children included (age range, 1 to 148 months; median, 24 months), 64 (72%) were referred from other services for HS investigation. Most common presenting complaints were: fever - 39 (44%); pallor - 26 (29%); weight loss - 21 (24%) and jaundice - 14 (16%). Main alterations noticed on physical examination were: pallor - 47 (53%) and short stature - 17 (19%). Anemia was diagnosed in 70 children (79%); 35 children (39%) had infections; 7 (8%) metabolic disorders and 5 (6%) neoplastic disorders. The most frequent infections were of the urinary tract - 9 (10%) and hepatitis A - 6 (7%).Thirty six children (40%) were referred to specialists, 17 of which were already diagnosed. Conclusions: Most of the children with HS present deficiency anemia associated with infections which the general pediatrician is able to diagnose. Persistence of unexplained HS for more than 2 months, especially when there is substantial volume enlargement or alteration in the organs consistency, is an indication for referral to specialists.

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Anti-hepatitis A virus frequency in adolescents at an outpatient clinic in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652006000100009 ◽

2006 ◽

Vol 48 (1) ◽

pp. 43-44 ◽

Cited By ~ 9

Author(s):

Maria Isabel Saraiva Dinelli ◽

Mauro Fisberg ◽

Maria Isabel de Moraes-Pinto

Keyword(s):

At Risk ◽

Outpatient Clinic ◽

Hepatitis A ◽

Hepatitis A Virus ◽

Age Groups ◽

Sao Paulo ◽

São Paulo ◽

Chi Square ◽

Chi Square Test ◽

Two Age Groups

The prevalence of hepatitis A virus (HAV) antibodies was assessed in adolescents (age ranging from 10.4 to 19.9 years) at an Adolescent Outpatient Clinic in São Paulo, Brazil. Anti-HAV was detected in 137 (54.2%) out of 253 individuals. When separated into two age groups, anti-HAV frequency was higher in the 15 to 19 year-old group (64%) in comparison to the 10 to 14 year-old group (46%) (Chi-square test: p = 0.004). These results suggest that adolescents in São Paulo are at risk of hepatitis A infection and are probably contracting HAV infection during this age period.

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COVID-19 in patients hospitalized and healthcare workers: what have changed after the first wave in a university hospital

10.1101/2021.05.11.21257011 ◽

2021 ◽

Author(s):

Luiz Vinicius Leao Moreira ◽

Gabriela Barbosa ◽

Luciano Kleber de Souza Luna ◽

Alberto Fernando Oliveira Justo ◽

Ana Paula Cunha Chaves ◽

...

Keyword(s):

Viral Load ◽

Healthcare Workers ◽

Sao Paulo ◽

Hospitalized Patients ◽

University Hospital ◽

São Paulo ◽

The Mean ◽

Wave Methods ◽

The Impact ◽

Pandemic Wave

Objective: To assess the COVID-19 frequency rates in hospitalized patients (HP) and healthcare workers (HCW), viral load inference, and the impact of vaccination and variants of concern (VOC) during the first pandemic wave. Methods: We evaluated the COVID-19 diagnostics at Hospital Sao Paulo, Brazil, from March 2020 to April 2021, in 10,202 samples (6,502 HP and 3,700 HCW) tested by RT-qPCR, inferring viral load by cycle threshold (Ct) values, and frequency rates. Results: SARS-CoV-2 was detected in 31.27% of individuals (32.23% HP and 29.80% HCW). The mean age of HP positives was 57.26 +/- 18.29 years (median = 59), with a mean Ct value of 25.55 +/- 6.07. Neither age nor Ct values in both groups have significantly differed during the first and second waves or even since the predominance of VOC P.1 on March 2021. Conclusions: The COVID-19 epidemic curves of HP and HCW accompanied the variations reported in Sao Paulo city, as well as the variation of hospitalization and occupancy of ICU beds. The VOC P.1 has no impact on the viral load, since its predominance in March 2021. The vaccination of HCW may have contributed to a decrease in the positivity rates, although more studies will provide a better understanding of the impact of immunization on the COVID-19 pandemic.

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Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.20-1598 ◽

2021 ◽

Author(s):

Patricia Vieira da Silva ◽

Silvano Barbosa de Oliveira ◽

Juan José Cortez Escalante ◽

Maria Almiron ◽

Daniel Henrique Tsuha ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Cardiovascular Disease ◽

Intensive Care ◽

Neurological Disease ◽

Clinical Characteristics ◽

Sao Paulo ◽

Hospitalized Patients ◽

São Paulo ◽

Elderly Individuals

São Paulo is a state in Brazil with one of the highest numbers of confirmed and severe cases of coronavirus disease (COVID-19), with an incidence of 294 hospitalizations per 100,000 inhabitants. We report the clinical characteristics and outcomes of 120,804 hospitalized patients with confirmed COVID-19 from February 26 to October 10, 2020, in São Paulo. Characteristics of patients who died and survived were compared using a survival analysis. The median age was 60 years (interquartile range [IQR], 47–72), 67,821 (56.1%) were men, and 61,659 (51.0%) were white. Most hospitalized patients (79,812; 66.1%) reported one or more comorbidities, 41,708 (34.5%) hospitalized patients were admitted to intensive care units, and 33,079 (27.4%) died. Men (hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.18–1.25), elderly individuals (HR, 3.85; 95% CI, 3.68–4.02), and patients with chronic cardiovascular disease including hypertension (HR, 1.05; 95% CI, 1.02–1.08), chronic lung disease (HR, 1.38; 95% CI, 1.31–1.45), diabetes mellitus (HR, 1.14; 95% CI, 1.11–1.18), and chronic neurological disease (HR, 1.48; 95% CI, 1.41–1.55) were at higher risk for death from COVID-19.

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Longitudinal study on occurrence of adenoviruses and hepatitis A virus in raw domestic sewage in the city of Limeira, São Paulo

Brazilian Journal of Microbiology ◽

10.1590/s1517-83822009000100017 ◽

2009 ◽

Vol 40 (1) ◽

pp. 102-107 ◽

Cited By ~ 12

Author(s):

Karina Medici Barrella ◽

Patrícia Garrafa ◽

Telma Alves Monezi ◽

Charlotte Marianna Hársi ◽

Cleber Salvi ◽

...

Keyword(s):

Longitudinal Study ◽

Hepatitis A ◽

Hepatitis A Virus ◽

Sao Paulo ◽

Domestic Sewage ◽

São Paulo ◽

The City

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Prevalence of depression and anxiety disorders in hospitalized patients at the dermatology clinical ward of a university hospital

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962012000300008 ◽

2012 ◽

Vol 87 (3) ◽

pp. 403-407 ◽

Cited By ~ 6

Author(s):

Maria Rita Polo Gascón ◽

Cristiana Mara Ribeiro ◽

Livia Maria de Araújo Bueno ◽

Glaucia Rosana Guerra Benute ◽

Mara Cristina Souza de Lucia ◽

...

Keyword(s):

Anxiety Disorders ◽

Sao Paulo ◽

Hospitalized Patients ◽

University Hospital ◽

São Paulo ◽

Depression And Anxiety ◽

Cross Sectional ◽

Clinical Ward ◽

Prevalence Of Depression ◽

Correlational Method

BACKGROUND: The objective of this study was to estimate the prevalence of depression and anxiety disorders in hospitalized patients at the dermatology ward at a university hospital in São Paulo, Brazil. OBJECTIVE: To assess the prevalence of mood and anxiety disorders in hospitalized patients at the dermatology ward at a university hospital in São Paulo. METHOD: A total of 75 patients, men and women, aged between 18 and 76 years, took part in the research. The study employed a descriptive, cross sectional and correlational method. The data was collected by means of a social demographic questionnaire and the PRIME-MD. RESULTS: It was found that 45.3 percent of the subjects presented with depressive symptoms, and 52 percent presented with symptoms of anxiety and that this survey showed moderate and high significant correlations (p<0,01; r= 0,616) for depression and anxiety. CONCLUSION: These facts could evidence the relationship between physical and psyche, just as the literature presents.

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