The Recurrent Nature of Central Starbursts

Krimi have been considered a major public health problem through out the world (WHO, 1967 Wandan, 1983 McLaren, 1984). In our country this problem is equally significant. It effects the children more frequently than adult (CCRAS 1987). Krimi hamper growth and development of a person, create malnutritional condition and decrease immunity thus the effective solution of this problem is necessary. Of all the herbs used in treating worm infestation, Vidanga is the best. So, Vidanga was selected for the present study. Whole plant of Embelia ribes Linn. were used as materials, as whole plants are used as medicine. Acharya Charaka describe Krimiroga in Vimanasthana. In most of patients, who are suffering from worm infestation have an Vivarnata (discolouration) on the face. “Vivarnata” had been described by Acharya Charaka under the Lakshana of Purishaja Krimi and it has been also described in Rasavaha Srotodusti Lakshana. Krimis robe the digestive nutritive assets through the intestinal wall, which we are making with high effort. So the deficiency of Rasa Dhatu create. According to Dhatu Poshana Nyaya if the Rasa Dhatu is not sufficient then other Dhatu can’t form properly and ultimate weak resistance and poor immunity develops and it is one cause of recurrent nature of disease. Prakriti Vighata and Nidana Parivarjana eradicate Krimiroga from the base.

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Towards Solving Health Inequities: A Method to Identify Ideological Operation in Global Health Programs

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094393 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4393

Author(s):

Hani Kim ◽

Uros Novakovic

Keyword(s):

Antimicrobial Resistance ◽

Global Health ◽

Case Studies ◽

Health Inequities ◽

Health Problems ◽

Health Programs ◽

Slavoj Zizek ◽

Slavoj Žižek ◽

Relations Of Power ◽

Recurrent Nature

The function of ideology is to naturalize and maintain unequal relations of power. Making visible how ideology operates is necessary for solving health inequities grounded in inequities of resources and power. However, discerning ideology is difficult because it operates implicitly. It is not necessarily explicit in one’s stated aims or beliefs. Philosopher Slavoj Žižek conceptualizes ideology as a belief in overarching unity or harmony that obfuscates immanent tension within a system. Drawing from Žižek’s conceptualization of ideology, we identify what may be considered as ‘symptoms’ of ideological practice: (1) the recurrent nature of a problem, and (2) the implicit externalization of the cause. Our aim is to illustrate a method to identify ideological operation in health programs on the basis of its symptoms, using three case studies of persistent global health problems: inequitable access to vaccines, antimicrobial resistance, and health inequities across racialized communities. Our proposed approach for identifying ideology allows one to identify ideological practices that could not be identified by particular ideological contents. It also safeguards us from an illusory search for an emancipatory content. Critiquing ideology in general reveals possibilities that are otherwise kept invisible and unimaginable, and may help us solve recalcitrant problems such as health inequities.

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Biofilm Biology and Vaccine Strategies for Otitis Media Due to Nontypeable Haemophilus influenzae

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0038-1660818 ◽

2018 ◽

Vol 14 (02) ◽

pp. 069-078 ◽

Cited By ~ 6

Author(s):

Laura Novotny ◽

Kenneth Brockman ◽

Elaine Mokrzan ◽

Joseph Jurcisek ◽

Lauren Bakaletz

Keyword(s):

Haemophilus Influenzae ◽

Otitis Media ◽

Middle Ear ◽

Causative Agent ◽

Upper Respiratory Tract ◽

Nontypeable Haemophilus Influenzae ◽

Physical Defenses ◽

Upper Respiratory ◽

Recurrent Nature ◽

Gain Access

AbstractOtitis media (OM) is one of the most common diseases of childhood, and nontypeable Haemophilus influenzae (NTHI) is the predominant causative agent of chronic and recurrent OM, as well as OM for which treatment has failed. Moreover, NTHI is now as important a causative agent of acute OM as the pneumococcus. NTHI colonizes the human nasopharynx asymptomatically. However, upon perturbation of the innate and physical defenses of the airway by upper respiratory tract viral infection, NTHI can replicate, ascend the Eustachian tube, gain access to the normally sterile middle ear space, and cause disease. Bacterial biofilms within the middle ear, including those formed by NTHI, contribute to the chronic and recurrent nature of this disease. These multicomponent structures are highly resistant to clearance by host defenses and elimination by traditional antimicrobial therapies. Herein, we review several strategies utilized by NTHI to persist within the human host and interventions currently under investigation to prevent and/or resolve NTHI-induced diseases of the middle ear and uppermost airway.

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Thrombotic Complications in Gliomas

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0039-1687892 ◽

2019 ◽

Vol 45 (04) ◽

pp. 326-333

Author(s):

Alexandra L. Czap ◽

Ashley Becker ◽

Patrick Y. Wen

Keyword(s):

Perceived Risk ◽

Perioperative Period ◽

High Grade Glioma ◽

Term Treatment ◽

Long Term Treatment ◽

High Incidence ◽

Risk Patients ◽

Thrombotic Complications ◽

Recurrent Nature

AbstractArterial and venous thromboses are common in glioma patients, both in the perioperative period and throughout the course of the disease. High-grade glioma patients harbor underlying hypercoagulability, which predisposes these high-risk patients with prolonged immobility and neurologic deficits to thrombotic events. Despite the high incidence and recurrent nature of these complications, there is no standardized approach to the management of glioma patients, and many challenges remain. Historically, the perceived risk of intracranial and intratumoral hemorrhage limited the use of anticoagulation, favoring nonpharmacological prophylaxis and treatment. Multiple studies have demonstrated the safety and efficacy of anticoagulation when indicated, with low molecular weight heparin as the preferred short- or long-term treatment. This review will discuss the epidemiology, risk factors, and therapeutic management of both venous and arterial thrombotic complications in glioma.

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Cicatricial Pemphigoid of the Larynx: A Case Report of Surgical Treatment

Ear Nose & Throat Journal ◽

10.1177/014556139607501007 ◽

1996 ◽

Vol 75 (10) ◽

pp. 658-668 ◽

Cited By ~ 5

Author(s):

Yousry El-Sayed ◽

Hamad Al-Muhaimeed

Keyword(s):

Case Report ◽

Surgical Treatment ◽

Special Reference ◽

Surgical Excision ◽

Cicatricial Pemphigoid ◽

Laryngeal Stenosis ◽

Laryngeal Lesions ◽

Recurrent Nature ◽

Laryngeal Airway

Although laryngeal stenosis caused by cicatricial pemphigoid (CP) is a well documented entity, reports about its surgical treatment are scant. This may be due to the reluctance of the surgeons to excise the scarring, knowing the recurrent nature of the disease. In this paper we report a case of severe laryngeal stenosis caused by CP which necessitated a tracheostomy. When the disease had stabilized, laryngeal airway was restored following open surgical excision and stenting. The historic, clinical, histologic, immunopathologic and therapeutic features of CP are presented with special reference to the laryngeal lesions.

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Predicting relapse after antidepressant withdrawal – a systematic review

Psychological Medicine ◽

10.1017/s0033291716002580 ◽

2016 ◽

Vol 47 (3) ◽

pp. 426-437 ◽

Cited By ~ 28

Author(s):

I. M. Berwian ◽

H. Walter ◽

E. Seifritz ◽

Q. J. M. Huys

Keyword(s):

Antidepressant Medication ◽

Recurrence Risk ◽

Relevant Information ◽

Main Diagnosis ◽

Major Depressive ◽

Relapse Risk ◽

Search Terms ◽

Recurrent Nature ◽

Course Of Depression

A substantial proportion of the burden of depression arises from its recurrent nature. The risk of relapse after antidepressant medication (ADM) discontinuation is high but not uniform. Predictors of individual relapse risk after antidepressant discontinuation could help to guide treatment and mitigate the long-term course of depression. We conducted a systematic literature search in PubMed to identify relapse predictors using the search terms ‘(depress* OR MDD*) AND (relapse* OR recurren*) AND (predict* OR risk) AND (discontinu* OR withdraw* OR maintenance OR maintain or continu*) AND (antidepress* OR medication OR drug)’ for published studies until November 2014. Studies investigating predictors of relapse in patients aged between 18 and 65 years with a main diagnosis of major depressive disorder (MDD), who remitted from a depressive episode while treated with ADM and were followed up for at least 6 months to assess relapse after part of the sample discontinued their ADM, were included in the review. Although relevant information is present in many studies, only 13 studies based on nine separate samples investigated predictors for relapse after ADM discontinuation. There are multiple promising predictors, including markers of true treatment response and the number of prior episodes. However, the existing evidence is weak and there are no established, validated markers of individual relapse risk after antidepressant cessation. There is little evidence to guide discontinuation decisions in an individualized manner beyond overall recurrence risk. Thus, there is a pressing need to investigate neurobiological markers of individual relapse risk, focusing on treatment discontinuation.

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Novel method of intralesional cidofovir injection into laryngotracheal papillomata

The Journal of Laryngology & Otology ◽

10.1017/s0022215110003014 ◽

2011 ◽

Vol 125 (4) ◽

pp. 402-404 ◽

Cited By ~ 2

Author(s):

R S Sahota ◽

F J Uddin ◽

J AL-Shukri ◽

A A Moir

Keyword(s):

Antiviral Activity ◽

Respiratory Tract ◽

Upper Respiratory Tract ◽

Laryngeal Papillomatosis ◽

Novel Technique ◽

Surgical Debulking ◽

Novel Method ◽

Upper Respiratory ◽

Surgical Treatments ◽

Recurrent Nature

AbstractLaryngeal papillomatosis is characterised by multiple papillomata affecting the upper respiratory tract. This condition is difficult to treat due to its recurrent nature. Treatment often involves surgical debulking. A number of non-surgical treatments have been reported. Intralesional cidofovir, a cytosine nucleoside analogue with antiviral activity, has been used in an attempt to manage the condition. We present a novel technique of administering cidofovir in a case of recurrent laryngotracheal papillomata.

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Bipolar Affective Disorder in Old Age

The British Journal of Psychiatry ◽

10.1192/bjp.136.1.26 ◽

1980 ◽

Vol 136 (1) ◽

pp. 26-32 ◽

Cited By ~ 133

Author(s):

Kenneth Shulman ◽

Felix Post

Keyword(s):

Retrospective Study ◽

Affective Disorder ◽

Old Age ◽

Bipolar Affective Disorder ◽

Bipolar Disorders ◽

Long Period ◽

Bipolar Patients ◽

Depressive Episodes ◽

Recurrent Nature

SummaryIn a retrospective study of 67 elderly bipolar patients the first manic attack occurred at about age 60, often after a long period from the time of the first affective episode, after which further depressive episodes occurred. This calls into question Perris’ criteria for unipolar diagnosis. Among the men, a preponderance of cerebral-organic disorders was found. The evidence for sub-classification of bipolar disorders into secondary or symptomatic manias is discussed. The recurrent nature of the illness in old age stresses the need for further evaluation of lithium prophylaxis.

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Exome Sequencing of Glioblastoma-Derived Cancer Stem Cells Reveals Rare Clinically Relevant Frameshift Deletion in MLLT1 Gene

10.21203/rs.3.rs-754227/v1 ◽

2021 ◽

Author(s):

Hany Marei ◽

Asmaa Althani ◽

Nahla Afifi ◽

Anwarul Hasan ◽

Thomas Caceci ◽

...

Keyword(s):

Stem Cells ◽

Cancer Stem Cells ◽

Allelic Frequency ◽

Common Variants ◽

Single Nucleotide Variants ◽

Single Nucleotide ◽

Frameshift Deletion ◽

Prognostic Outcome ◽

The Common ◽

Recurrent Nature

Abstract Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem cells (CSC) which confer resistance against standard chemo- and radiotherapeutics modalities. Two types of GBM-associated CSC were isolated from the same patient: tumor core- (c-CSC) and peritumor tissue-derived cancer stem cells (p-CSC).Methods: In the present study, potential differences in genetic variants between c-CSC versus p-CSC derived from four GBM patients were investigated with the aims of 1) comparing the exome sequences between all the c-CSC or p-CSC to identify the common variants; 2) identifying the variants affecting the function of genes known to be involved in cancer origin and development.Results: By comparative analyses, we identified common gene single nucleotide variants (SNV) in all GBM c-CSC and p-CSC, a potentially deleterious variant was a frameshift deletion at Gln461fs in the MLLT1 gene, that was encountered only in p-CSC samples with different allelic frequency.Conclusions: Our study supports the hypothesis that the varied genetic composition of GBM-associated c-CSC and p-CSC may be involved in different therapeutic responses or the recurrent nature of GBM.

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Pyogenic granuloma gravidarum: a case in the nasal cavity and the use of MRI as a preoperative surgical aide

BMJ Case Reports ◽

10.1136/bcr-2018-225803 ◽

2019 ◽

Vol 12 (5) ◽

pp. e225803 ◽

Cited By ~ 1

Author(s):

Farizeh Ahmed ◽

Maral J Rouhani ◽

Annakan Victor Navaratnam

Keyword(s):

Nasal Cavity ◽

Surgical Management ◽

Preoperative Planning ◽

Post Partum ◽

Pyogenic Granuloma ◽

Proliferative Lesion ◽

Recurrent Nature ◽

Uncommon Location

Pyogenic granuloma gravidarum is a benign fibrovascular proliferative lesion usually involving the oral gingivae in pregnant patients. While it also occurs, although less frequently, on other oral sites such as lips, tongue and palate, it is relatively unusual to find it in the nasal cavity. Furthermore, lesions normally involute spontaneously after childbirth. For persistent lesions requiring surgical management, imaging has historically been limited to CT. This case is notable not only for its uncommon location but also for its recurrent nature, failure to regress post partum and the use of MRI in the preoperative planning.

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