Influence of the Topography on the Long-Term Average Concentration Computed by Dispersion Models

Abstract Background Prior studies have investigated the association of PM2.5 exposure with arterial stiffness measured by ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV), of which conclusions are inconsistent. Moreover, limited evidence is available on the contributory role of PM2.5 exposure on the arterial stiffness index. Methods We used the population data from the Beijing Health Management Cohort and conducted a longitudinal analysis. The annual average concentration of PM2.5 for 35 air pollutant monitoring sites in Beijing from 2014 to 2018 was used to estimate individual exposure by different interpolation methods. Multivariate logistic regression and linear regression were conducted to assess the association of annual average PM2.5 concentration with the incidence of higher baPWV, the progression of ABI, and baPWV, respectively. Results The association between PM2.5 exposure and incidence of higher baPWV was not significant (OR = 1.11, 95% CI: 0.82–1.50, P = 0.497). There was − 0.16% (95% CI: − 0.43-0.11%) decrease in ABI annually and 1.04% (95% CI: 0.72–1.37%) increase in baPWV annually with each increment of 10 μg/m3 average PM2.5 concentration. Conclusions Long-term exposure to PM2.5 was associated with the progression of arterial stiffness in Beijing. This study suggests that improvement of air quality may help to prevent arterial stiffness.

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Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

Veterinární Medicína ◽

10.17221/1581-vetmed ◽

2011 ◽

Vol 56 (No. 2) ◽

pp. 63-74 ◽

Cited By ~ 13

Author(s):

L. Pavlata ◽

M. Chomat ◽

A. Pechova ◽

L. Misurova ◽

R. Dvorak

Keyword(s):

Blood Plasma ◽

Whole Blood ◽

Average Concentration ◽

The Other ◽

Control Group ◽

Selenium Yeast ◽

Hair Samples ◽

The Impact ◽

Se Status

This paper evaluates the impact of long-term supplementation of different forms of zinc (Zn) and selenium (Se) on the content of these substances in the blood and hair of goats. Two analogous supplementation experiments were performed. 37 goats divided into four groups were used in the first trial with the Zn supplementation. Group A (n = 10) was a control group (with no Zn administered). A further three groups (B, C, D) were supplemented with Zn in various forms. Group B (n = 9) with zinc oxide, Group C (n = 9) with zinc lactate and Group D (n = 9) with zinc chelate. The second trial with Se supplementation was carried out on 20 goats divided into four groups. Group E (n = 5) was a control group. The other three groups were administered Se. Group F (n = 5) was supplied with a selenium lactate-protein complex, Group G (n = 5) with sodium selenite and Group H (n = 5) with selenium yeast. Three months later blood and hair samples were taken from all animals and Zn and Se concentrations were determined in whole blood, plasma, and hair. Glutathione peroxidase (GSH-Px) activity was determined in the Se supplementation trial group. At the end of the trial the Zn concentrations in plasma and whole blood were without major differences between the groups. The plasma concentration of Zn did not increase from the initial value at the start of the trial. In hair the average concentration of Zn was 95.2–100.0 mg/kg in all groups. No conclusive relation was confirmed between the values of Zn in hair and its concentration in blood. The Se concentration in whole blood (µg/l) at the end of trial in supplemented groups (F – 188.8 ± 24.6; G – 197.2 ± 10.9; H – 190.1 ± 26.3) was significantly higher (P < 0.01) than in the control group (E – 103.1 ± 23.5). Similarly, the activity of GSH-Px (µkat/l) was significantly higher in all supplemented groups (F – 872.3 ± 94.8; G – 659.5 ± 176.4; H – 839.8 ± 150.8) than in the control group (E – 379.1 ± 63.5). Se content in hair (µg/kg) was higher also in all trial groups (F – 242.3 ± 41.5; G – 200.5 ± 46.9; H – 270.0 ± 106.8) than in the control group (E – 174.7 ± 38.0). However, it was significantly (P < 0.05) higher only in Group F. A conclusive correlation was identified between the Se concentration in whole blood and its content in hair (r = 0.54; P < 0.05; n = 20). Based on the results it can be concluded that none of the supplemented forms of Zn increased its concentration in blood, plasma and hair. On the other hand, the administration of Se led to an increase in the Se concentration in blood, increased the activity of GSH-Px in whole blood and the Se content in hair. Based on the proven correlation and regression relation between the Se concentration in blood and its content in hair, hair can be considered as a suitable material for the diagnosis of long-term Se status in goats. Goats with sufficient Se status are those that have more than 160 µg/kg of Se in hair dry weight.

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Arsenic trioxide: Pharmacokinetics in acute promyelocytic leukemia (APL) patients.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.7055 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 7055-7055

Author(s):

Cristina Maria Ghiuzeli ◽

Anthony Calabro ◽

Randall Jesse Saunders ◽

Daniel R. Budman ◽

Miroslav Styblo ◽

...

Keyword(s):

Arsenic Trioxide ◽

Hydride Generation ◽

Absorption Spectrometry ◽

Average Concentration ◽

Biologically Active ◽

Automated Method ◽

Key Enzyme ◽

Electron Reduction ◽

Therapeutic Doses

7055 Background: Arsenic (As) has significantly increased survival for APL patients. As and its metabolites’ effects on cell proliferation, apoptosis, and methylation, especially long term, remain largely unknown. It is imperative to study the pharmacokinetics of As at therapeutic doses in order to limit untoward effects resulting from treatment. Arsenic trioxide (ATO), available as arsenous acid (iAsIII), is readily metabolized through sequential methyl group additions and electron reduction steps: iAsIII →MAsV →MAsIII →DMAsV →DMAsIII →TMAsVO →TMAsIII. iAsIII, MAsIII and DMAsIII are more biologically active and more toxic than pentavalent forms. The key enzyme involved is arsenic methyltransferase, and polymorphisms contribute to metabolic differences between individuals. Methods: Cancer patients not treated with ATO (controls) had one collection of blood and urine samples, while APL patients receiving therapeutic doses of ATO had collections immediately prior to and at 1, 2, 4, 6, and 24 hours, days 4, 8, 15, and 4 weeks after ATO-free interval. Total iAs (iAsIII+iAsV), MAs (MAsIII+MAsV) and DMAs (DMAsIII+DMAsV) were measured in plasma using hydride generation cryotrapping atomic absorption spectrometry, a sensitive automated method of arsine detection. The same As species were measured in urine and in exfoliated bladder cells isolated from urine. Results: We report data on ten control patients and six treated patients (ATO 0.15 mg/kg/day). Initial average As concentrations in treated patients (0.051 ng/ml) were similar at baseline to the controls (0.046 ng/ml). We observed that iAs is quickly metabolized from a peak average plasma concentration of 32 ng As/ml to a trough of 10 ng As/ml within six hours from infusion, remaining unchanged for at least 24 hours. MAs and DMAs concentrations begin to increase at six hours, and continue to rise by day 4 to an average concentration of 8.5 and 10.4 ng As/ml respectively, followed by decline to baseline 4 weeks after final ATO infusion. Conclusions: Treatment with ATO leads to the formation of MAs and DMAs whose long term toxicity in APL patients is poorly understood. Studies involving analysis of As metabolites are needed to assess possible long term toxicities on non-targeted organs.

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Long term Impacts of Effluents on Quality of the Kosi River Water at District Rampur, Uttar Pradesh, India

Biosciences Biotechnology Research Asia ◽

10.13005/bbra/2896 ◽

2021 ◽

Vol 18 (1) ◽

pp. 59-69

Author(s):

Gulrez Nizami ◽

Shifa Rehman ◽

R. Z. Sayyed ◽

Ummul Khair Fatma ◽

Hesham El Enshasy

Keyword(s):

River Water ◽

Physicochemical Parameters ◽

Copper Content ◽

Uttar Pradesh ◽

Zinc Content ◽

Average Concentration ◽

Total Hardness ◽

Ph Values

The present study was aimed to analyze the influence of industrial and agricultural wastes on quality ofKosi river water, Rampur, UP, India. The results of the present study revealed pH values of between 7.2 and 6.3 (neutral to slightly acidic), the electrical conductivity between 129.4 μs/cmto399.3 μs/cm. The maximum EC value was observed at S5 in spring season. The turbidity of each was 0.4 to 7.067 NTU. The highest turbidity observed at S5 in winters. Total hardness of 73 (mg/L) and 506.33 (mg/L) were evident at S4 and S7 sites respectively. The BOD values ranged from 10.5 (mg/L) at S4 to 137.4 (mg/L) at S5. Higher BOD values at each site are reflecting the great extent of pollution. The minimum COD recorded at S3 (32.60 mg/L) however maximum recorded at S5 (168.65 mg/L). The results of the heavy metals showed a significant increase in the concentration of Pb, Zn, Cu, Hg and As at S5 as compared to the other sites. The As concentration was 0.04, 0.08, 0.85, 0.72 and 0.71 at S2, S3, S5, S6, and S7 respectively. These values were higher than the value of Arsenic as per WHO guidelines.The average concentration of Zn obtained was 0.05, 0.786, 0.413, 0.06, 3.26,0.97 and 0.53 mg/L at S1, S2, S3, S4, S5, S6, and S7 respectively. The highest value of Zn was recorded at S5 (SDP) as compared to other sites. Only at S5 the zinc content is exceeding the normal value. The copper content found to be lower (1.0 mg/Ll) than permissible value according to WHO. The Cu concentration was 0.01, 0.06 0.01 at S4, S5 and S6 respectively, at S1,S2, S3 and S7 zero. The changed physicochemical parameters and occurrence of heavy metal ions indicated a significant level of pollution in Kosi River.

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Association between air pollution and COVID-19 mortality and morbidity

Internal and Emergency Medicine ◽

10.1007/s11739-021-02834-5 ◽

2021 ◽

Author(s):

Karolina Semczuk-Kaczmarek ◽

Anna Rys-Czaporowska ◽

Janusz Sierdzinski ◽

Lukasz Dominik Kaczmarek ◽

Filip Marcin Szymanski ◽

...

Keyword(s):

Air Pollution ◽

Respiratory Diseases ◽

Average Concentration ◽

Cumulative Number ◽

Annual Average ◽

Mortality And Morbidity ◽

Increased Risk ◽

Annual Average Concentration ◽

Official Data

AbstractCoronavirus disease (COVID-19) pandemic is affecting the world unevenly. One of the highest numbers of cases were recorded in the most polluted regions worldwide. The risk factors for severe COVID-19 include diabetes, cardiovascular, and respiratory diseases. It has been known that the same disease might be worsened by chronic exposure to air pollution. The study aimed to determine whether long-term average exposure to air pollution is associated with an increased risk of COVID-19 cases and deaths in Poland. The cumulative number of COVID-19 cases and deaths for each voivodeship (the main administrative level of jurisdictions) in Poland were collected from March 4, 2020, to May 15, 2020. Based on the official data published by Chief Inspectorate of Environmental Protection voivodeship-level long-term exposure to main air pollution: PM2.5, PM10, NO2, SO2, O3 (averaged from 2013 to 2018) was established. There were statistically significant correlation between COVID-19 cases (per 100,000 population) and annual average concentration of PM2.5 (R2 = 0.367, p = 0.016), PM10 (R2 = 0.415, p = 0.009), SO2 (R2 = 0.489, p = 0.003), and O3 (R2 = 0.537, p = 0.0018). Moreover, COVID-19 deaths (per 100,000 population) were associated with annual average concentration of PM2.5 (R2 = 0.290, p = 0.038), NO2 (R2 = 0.319, p = 0.028), O3 (R2 = 0.452, p = 0.006). The long-term exposure to air pollution, especially PM2.5, PM10, SO2, NO2, O3 seems to play an essential role in COVID-19 prevalence and mortality. Long-term exposure to air pollution might increase the susceptibility to the infection, exacerbates the severity of SARS-CoV-2 infections, and worsens the patients’ prognosis. The study provides generalized and possible universal trends. Detailed analyzes of the phenomenon dedicated to a given region require taking into account data on comorbidities and socioeconomic variables as well as information about the long-term exposure to air pollution and COVID-19 cases and deaths at smaller administrative level of jurisdictions (community or at least district level).

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Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17239140 ◽

2020 ◽

Vol 17 (23) ◽

pp. 9140

Author(s):

Syuan-Yu Hong ◽

Lei Wan ◽

Hui-Ju Lin ◽

Cheng-Li Lin ◽

Chang-Ching Wei

Keyword(s):

Cohort Study ◽

Sulfur Dioxide ◽

Incidence Rate ◽

Air Pollutants ◽

Fine Particulate Matter ◽

Ambient Air ◽

Average Concentration ◽

Air Pollutant ◽

Research Database

Although studies have suggested environmental factors to be triggers of headache, the contribution of long-term air pollution exposure to recurrent headaches is poorly understood. Hence, we executed this nationwide cohort study to investigate associations between levels of ambient air pollutants and risks of recurrent headaches in children in Taiwan from 2000 to 2012. We used data from the Taiwan National Health Insurance Research Database and linked them to the Taiwan Air Quality Monitoring Database. Overall, 218,008 children aged < 18 were identified from 1 January 2000, and then followed until they were diagnosed by a physician for ≥3 times with recurrent headaches or until 31 December 2012. We categorized the annual average concentration of each air pollutant (fine particulate matter, total hydrocarbon, methane, sulfur dioxide, and nitrogen dioxide) into quartiles (Q1–Q4). We measured the incidence rate, hazard ratios (HRs), and the corresponding 95% confidence intervals for recurrent headaches. stratified by the quartiles. A total of 28,037 children (12.9%) were identified with recurrent headaches. The incidence rate and adjusted HR for recurrent headaches increased with higher-level exposure of air pollutants, except sulfur dioxide. We herein demonstrate that long-term ambient air pollutant exposure might be a risk factor for childhood recurrent headaches.

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Mercury background monitoring in the Lake Baikal region

10.5194/egusphere-egu21-3346 ◽

2021 ◽

Author(s):

Fidel Pankratov ◽

Alexander Mahura ◽

Valentin Popov ◽

Vladimir Masloboev

Keyword(s):

Northern Hemisphere ◽

Lake Baikal ◽

Baikal Region ◽

Background Level ◽

Average Concentration ◽

Monitoring Site ◽

Average Value ◽

Lake Baikal Region ◽

Mercury Analyzer

During 2013-2015 the gaseous elemental mercury (thereafter, mercury) measurements were carried out at two weather monitoring stations/sites (Listvyanka &#8211; from 25 July until 19 November 2013 and Tankhoj &#8211; from 27 July 2014 until 11 January 2015). The mercury analyzer Lumex RA-915AM was used for measurements. Although in the Northern Hemisphere the minimal average mercury concentration is about 1.5 ng m-3, the obtained results indicated that in the southern part of the Lake Baikal the lowest average concentration was about 1.18 ng m-3. Thus, the natural reserve territory of the Lake Baikal can be used as the main region to the background level of especially clean areas for monitoring heavy metals and persistent organic pollutants.For the Listvyanka measurements, the mercury analyzer was installed at 20 m distance from a shore of the lake. During July-November 2013, the average concentration value was about 1.41&#177;0.37 ng m-3 (with max - 4.81, min - 0.16). For the July-August period, the maximum variance distribution was estimates as 0.62 ng m-3. For the August-November period, the variance did not exceed the value of 0.38 ng m-3. Mercury from the atmosphere is deposited on the underlying surface, and with increasing intensity of total solar radiation the re-emission of mercury occurred resulting in increased concentrations of mercury at Listvyanka. A rather low mercury values were recorded during October-November 2013. Analysis of atmospheric transport during summer showed, that main sources of pollution are situated to the west of the lake, and it is a relatively larger area in the southwestern sector, and therefore, it is complex to identify exact locations of such pollution sources.For the Tankhoj site, in July 2014 the mercury analyzer was installed at about 100 m distance from a shore of the lake. It was for the first time, when the mercury monitoring was conducted for such long-term period of time in the Lake Baikal region. Note, that short-term measurements of mercury do not provide full understanding of the background level mercury and are insufficient to study dynamics. Analysis of obtained time-series showed that summer is characterized by a high variability of mercury (max - 2.86, min - 0.27, with an average 1.19&#177;0.27 ng m-3). In particular, in July an average value of 1.18 ng m-3 (max - 2.68, min - 0.43) was obtained, which corresponds to concentrations observed in the Northern Hemisphere. In August the average value of 1.22 ng m-3 (max - 2.86, min - 0.27) was obtained.Moreover, obtained results showed that location of the Tankhoj monitoring site can be used for long-term background monitoring of mercury.

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Distribution of fractions of zinc and their contribution towards availability and plant uptake of zinc under long-term maize (Zea mays L.) - wheat (Triticum aestivum L.) cropping on an Inceptisol

Soil Research ◽

10.1071/sr07073 ◽

2008 ◽

Vol 46 (1) ◽

pp. 83 ◽

Cited By ~ 16

Author(s):

Sanjib Kumar Behera ◽

Dhyan Singh ◽

B. S. Dwivedi ◽

Sarjeet Singh ◽

K. Kumar ◽

...

Keyword(s):

Agricultural Research ◽

Soil Depth ◽

Indian Agricultural Research Institute ◽

Triticum Aestivum L ◽

Average Concentration ◽

Wheat Crop ◽

Manganese Carbonate ◽

Intensive Farming ◽

Zn Uptake

Intensive farming with high yielding cultivars, application of high analysis NPK fertilisers, and reduced use of organic manures caused a decrease in the availability of zinc (Zn) in Indian soils. We collected soil and plant samples from an ongoing long-term experiment at Indian Agricultural Research Institute, New Delhi, to study the distribution of different fractions of Zn in an Inceptisol and their contribution towards the Zn availability in soil and Zn uptake in maize–wheat crop rotation. The treatments used for the study were NPK, NPK + FYM, NPK + Zn, and control (no fertiliser or manure). The DTPA-Zn concentration in soil was higher where Zn had been applied and declined with an increase in soil depth. The distribution of different fractions of Zn under various treatments and depths was inconsistent, and varied in a cropping year. The average concentration of total Zn (mg/kg) was 183, 183, 171, and 211 in 0–0.15, 0.15–0.30, 0.30–0.45, and 0.45–0.60 m depth, respectively. Residual Zn was the dominant portion of total Zn at all soil depths. Grain and stover yield of maize ranged from 1.10 to 2.43 t/ha and 1.22 to 2.46 t/ha, respectively, under different treatments, whereas, the yield of wheat grain varied from 2.25 to 4.69 t/ha and that of wheat straw from 2.56 to 5.20 t/ha. Highest uptake of Zn by both the crops occurred in Zn-treated plots. Zinc associated with easily reducible manganese, carbonate and iron and aluminum oxides contributed directly towards DTPA-extractable Zn. Sorbed Zn (SORB-Zn) and Zn associated with organic matter (OM-Zn) contributed significantly towards Zn uptake by the 2 crops.

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The influence of different recultivation techniques on primary production processes in a degraded urban lake

Oceanological and Hydrobiological Studies ◽

10.2478/s13545-014-0135-x ◽

2014 ◽

Vol 43 (3) ◽

Cited By ~ 3

Author(s):

Jolanta Grochowska ◽

Renata Brzozowska ◽

Katarzyna Parszuto

Keyword(s):

Organic Phosphorus ◽

Water Layer ◽

Average Concentration ◽

Lake District ◽

Chemical Parameters ◽

Protection Measures ◽

Artificial Aeration ◽

Phosphorus Inactivation ◽

The 1960S

AbstractThe study was conducted in Lake Długie located in Olsztyn, the Masurian Lake District. In the 1950s and in the 1960s, Lake Długie was used for 20 years as a collector of raw domestic and storm sewage. This has led to complete degradation of the lake. After preliminary protection measures implemented in the catchment, the lake was restored by artificial aeration and phosphorus inactivation methods. Long-term recultivation of the reservoir resulted in a significant and long-lasting improvement of the water quality. Before restoration, the average concentration of organic phosphorus in the surface water layer amounted to 0.166 mg Porg l−1 and of organic nitrogen — to 3.0 mg Norg l−1. After restoration, these values decreased to 0.058 mg Porg l−1 and 2.0 mg Norg l−1. The results obtained eight years after the recultivation of Lake Długie are extremely interesting. The amounts of chlorophyll a did not exceed 7 μg l−1, water transparency remained at a depth of 2.9 m, and BOD5 did not exceed 2 mg O2 l−1. These observations show that during implementation of recultivation treatments, only chemical parameters of the water significantly changed, while biological elements reacted to the treatments with some delay.

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Paraquat in Surface Water of Some Streams in Mai Chau Province, the Northern Vietnam: Concentrations, Profiles, and Human Risk Assessments

Journal of Chemistry ◽

10.1155/2018/8521012 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Nguyen Thi Hue ◽

Thi Phuong Mai Nguyen ◽

Hoang Nam ◽

Nguyen Hoang Tung

Keyword(s):

Hazard Index ◽

Life Quality ◽

Average Concentration ◽

Risk Assessments ◽

Minimum Risk ◽

Northern Vietnam ◽

Human Risk ◽

Herbicide Concentration ◽

Dry And Rainy Seasons

The concentrations and profiles of paraquat, a kind of herbicide, were studied in water samples taken from a stream flowing through five villages of Mai Chau province, the Northern Vietnam, during dry and rainy seasons. In this study, paraquat was found at almost the sampling sites and showed an average concentration for paraquat to be 30.69 μg/L and with a maximum of 134.08 μg/L. The herbicide concentration tended to be the highest on the dry season because of the least rainfall and also the highest evaporation rate of water in the stream. For risk assessment of human health, a hazard index (HI) value was calculated for estimating the risk towards the residents. HQ in the dry and rainy season is from 0.0001 to 0.2448 and from 0.0001 to 0.0279, respectively. The results showed a minimum risk; however, there are concerns toward the danger of long-term exposure to the residents from the stream that could affect their life quality.

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