Brodmann Areas

2006 ◽  
pp. 182-183
Keyword(s):  
Brodmann Areas

The frontal longitudinal system as revealed through the fiber microdissection technique: structural evidence underpinning the direct connectivity of the prefrontal-premotor circuitry

2020 ◽  
Vol 133 (5) ◽  
pp. 1503-1515 ◽  
Author(s):  
Spyridon Komaitis ◽  
Aristotelis V. Kalyvas ◽  
Georgios P. Skandalakis ◽  
Evangelos Drosos ◽  
Evgenia Lani ◽  
...  
Keyword(s):  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Frontal Area ◽  
Frontal Pole ◽  
Fiber System ◽  
Dorsolateral Prefrontal ◽  
Anterior Extension ◽  
Brodmann Areas ◽  
Longitudinal Fiber ◽  
Long Fibers

OBJECTIVEThe purpose of this study was to investigate the morphology, connectivity, and correlative anatomy of the longitudinal group of fibers residing in the frontal area, which resemble the anterior extension of the superior longitudinal fasciculus (SLF) and were previously described as the frontal longitudinal system (FLS).METHODSFifteen normal adult formalin-fixed cerebral hemispheres collected from cadavers were studied using the Klingler microdissection technique. Lateral to medial dissections were performed in a stepwise fashion starting from the frontal area and extending to the temporoparietal regions.RESULTSThe FLS was consistently identified as a fiber pathway residing just under the superficial U-fibers of the middle frontal gyrus or middle frontal sulcus (when present) and extending as far as the frontal pole. The authors were able to record two different configurations: one consisting of two distinct, parallel, longitudinal fiber chains (13% of cases), and the other consisting of a single stem of fibers (87% of cases). The fiber chains’ cortical terminations in the frontal and prefrontal area were also traced. More specifically, the FLS was always recorded to terminate in Brodmann areas 6, 46, 45, and 10 (premotor cortex, dorsolateral prefrontal cortex, pars triangularis, and frontal pole, respectively), whereas terminations in Brodmann areas 4 (primary motor cortex), 47 (pars orbitalis), and 9 were also encountered in some specimens. In relation to the SLF system, the FLS represented its anterior continuation in the majority of the hemispheres, whereas in a few cases it was recorded as a completely distinct tract. Interestingly, the FLS comprised shorter fibers that were recorded to interconnect exclusively frontal areas, thus exhibiting different fiber architecture when compared to the long fibers forming the SLF.CONCLUSIONSThe current study provides consistent, focused, and robust evidence on the morphology, architecture, and correlative anatomy of the FLS. This fiber system participates in the axonal connectivity of the prefrontal-premotor cortices and allegedly subserves cognitive-motor functions. Based in the SLF hypersegmentation concept that has been advocated by previous authors, the FLS should be approached as a distinct frontal segment within the superior longitudinal system.

scholarly journals Episodic Memory Encoding and Retrieval in Face-Name Paired Paradigm: An fNIRS Study

2021 ◽  
Vol 11 (7) ◽  
pp. 951
Author(s):  
Qian Yu ◽  
Boris Cheval ◽  
Benjamin Becker ◽  
Fabian Herold ◽  
Chetwyn C. H. Chan ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Neural Activity ◽  
Near Infrared ◽  
Clinical Settings ◽  
Functional Near Infrared Spectroscopy ◽  
Associate Learning ◽  
Brodmann Areas ◽  
Parietal Cortices ◽  
Increased Activity ◽  
Encoding And Retrieval

Background: Episodic memory (EM) is particularly sensitive to pathological conditions and aging. In a neurocognitive context, the paired-associate learning (PAL) paradigm, which requires participants to learn and recall associations between stimuli, has been used to measure EM. The present study aimed to explore whether functional near-infrared spectroscopy (fNIRS) can be employed to determine cortical activity underlying encoding and retrieval. Moreover, we examined whether and how different aspects of task (i.e., novelty, difficulty) affects those cortical activities. Methods: Twenty-two male college students (age: M = 20.55, SD = 1.62) underwent a face-name PAL paradigm under 40-channel fNIRS covering fronto-parietal and middle occipital regions. Results: A decreased activity during encoding in a broad network encompassing the bilateral frontal cortex (Brodmann areas 9, 11, 45, and 46) was observed during the encoding, while an increased activity in the left orbitofrontal cortex (Brodmann area 11) was observed during the retrieval. Increased HbO concentration in the superior parietal cortices and decreased HbO concentration in the inferior parietal cortices were observed during encoding while dominant activation of left PFC was found during retrieval only. Higher task difficulty was associated with greater neural activity in the bilateral prefrontal cortex and higher task novelty was associated with greater activation in occipital regions. Conclusion: Combining the PAL paradigm with fNIRS provided the means to differentiate neural activity characterising encoding and retrieval. Therefore, the fNIRS may have the potential to complete EM assessments in clinical settings.

Functional abnormalities in Broca’s area in adolescents with ADHD: A resting-state fMRI study

2015 ◽  
Vol 51 (1) ◽  
Author(s):  
Michał Pikusa ◽  
Rafał Jończyk
Keyword(s):  
Resting State ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Broca’S Area ◽  
Broca's Area ◽  
Hyperactivity Disorder ◽  
Spontaneous Neural Activity ◽  
Fmri Study ◽  
Brodmann Areas ◽  
Underlying Causes

AbstractThere is evidence that attention-deficit/hyperactivity disorder (ADHD) is associated with linguistic difficulties. However, the pathophysiology underlying these difficulties is yet to be determined. This study investigates functional abnormalities in Broca’s area, which is associated with speech production and processing, in adolescents with ADHD by means of resting-state fMRI. Data for the study was taken from the ADHD-200 project and included 267 ADHD patients (109 with combined inattentive/hyperactive subtype and 158 with inattentive subtype) and 478 typically-developing control (TDC) subjects. An analysis of fractional amplitude of low-frequency fluctuations (fALFF), which reflects spontaneous neural activity, in Broca’s area (Brodmann Areas 44/45) was performed on the data and the results were compared statistically across the participant groups. fALFF was found to be significantly lower in the ADHD inattentive group as compared to TDC in BA 44, and in the ADHD combined group as compared to TDC in BA 45. The results suggest that there are functional abnormalities in Broca’s area with people suffering from ADHD, and that the localization of these abnormalities might be connected to particular language deficits associated with ADHD subtypes, which we discuss in the article. The findings might help explore the underlying causes of specific language difficulties in ADHD.

Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfusion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis

2021 ◽  
Vol 19 ◽  
Author(s):  
Varvara Valotassiou ◽  
Nikolaos Sifakis ◽  
Chara Tzavara ◽  
Evi Lykou ◽  
Niki Tsinia ◽  
...  
Keyword(s):  
Partial Correlation ◽  
Motor Behavior ◽  
Neuropsychiatric Symptoms ◽  
Correlation Coefficients ◽  
Principal Component ◽  
Lewy Body Dementia ◽  
Brain Perfusion ◽  
Neuropsychiatric Inventory ◽  
Different Types ◽  
Brodmann Areas

Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in isolated NPSs or in specific forms of dementia. Objective: : The objective of this study is to evaluate the correlation of NPS in the NPI with Brodmann areas (BAs) perfusion, for revealing BAs involved in the pathogenesis of NPSs in dementia of various etiologies. Method: We studied 201 patients (82 with Alzheimer's disease, 75 with Frontotemporal dementia, 27 with Corticobasal Syndrome, 17 with Parkinson Disease/Lewy Body Dementia). Exploratory factor analysis was carried out to evaluate underlying groups of BAs, and Principal Component analysis was chosen as extraction method using Varimax rotation. Partial correlation coefficients were computed to explore the association of factors obtained from analysis and NPI items controlling for age, educational yeas, and ACE-R. Results: We found 6 BAs Factors(F); F1 (BAs 8,9,10,11,24,32,44,45,46,47, bilaterally), F2 (Bas 4,5,6,7,23,31, bilaterally), F3 (BAs 19,21,22,37,39,40, bilaterally), F4 (BAs 20,28,36,38, bilaterally), F5 (BAs 25, bilaterally) and F6 (BAs 17,18, bilaterally). Significant and negative correlation was found between NPI1 (delusions) and F3,F6, NPI2 (hallucinations) and F6, NPI7 (apathy) and F1,F4,F5, NPI3 (agitation) - NPI10 (aberrant motor behavior) - NPI12 (eating disorders) and F1. We did not find any significant correlation for NPI4,5,6,8,9,11 (depression, anxiety, euphoria, disinhibition, irritability, sleep disorders, respectively). Conclusion: Several NPSs share the same BAs among different types of dementia, while the manifestation of the rest may be attributed to different neural networks. These findings may have an impact on patients’ treatment.

Cortex: Topography and Organization

2021 ◽  
pp. 175-178
Author(s):  
Richard J. Caselli ◽  
David T. Jones
Keyword(s):  
Cerebral Cortex ◽  
Visual Cortex ◽  
Gray Matter ◽  
Striate Cortex ◽  
Neuronal Cell ◽  
Area 17 ◽  
Neuronal Cell Bodies ◽  
Brodmann Areas ◽  
Functional Components ◽  
Complex Activities

The cerebral cortex is involved in various simple and complex activities. It consists of layers of neuronal cell bodies (ie, gray matter) that are organized into gyri (convolutions).The cortex can be divided into functional components in several ways. Various schemes are based on function, cytoarchitecture, topography, or Brodmann areas. The terminology can be confusing because the same area of cortex could be designated by several names. For instance, Brodmann area 17 is also called the primary visual cortex, the striate cortex, and the calcarine cortex. Brodmann designated 52 regions of the cerebral cortex according to cytoarchitecture.

Characterization of the cerebral cortical representation of heartburn in GERD patients

2004 ◽  
Vol 286 (1) ◽  
pp. G174-G181 ◽  
Author(s):  
Mark Kern ◽  
Candy Hofmann ◽  
James Hyde ◽  
Reza Shaker
Keyword(s):  
Brain Regions ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Healthy Controls ◽  
Fmri Signal ◽  
Signal Characteristics ◽  
Average Maximum ◽  
Brodmann Areas ◽  
Perfusion Time ◽  
Cortical Regions

Although symptoms arising from the esophagus such as heartburn and pain can at times become challenging clinical problems, esophageal viscerosensation, especially with regard to chemical stimulation in humans, is incompletely understood. Our aims were 1) to characterize and ascertain the reproducibility of cerebral cortical registration of heartburn and 2) to elucidate the differences between these findings and those of esophageal subliminal acid stimulation in asymptomatic controls. We studied 11 gastroesophageal reflux disease (GERD) patients (9 males, 30–55 yr) and 15 healthy controls (8 males, 21–49 yr). Cerebral cortical functional magnetic resonance imaging (fMRI) activity was recorded twice in each subject, during two 5-min intervals of 0.1 N HCl, separated by 5 min of NaCl perfusion. Time from onset of acid perfusion to instant of fMRI signal increase and first report of heartburn averaged 1.60 ± 0.80 and 1.85 ± 0.60 min, respectively. Average maximum percent signal increase in the GERD patients (16.3 ± 3.5%) was significantly greater than that of healthy controls (3.8 ± 0.9%; P < 0.01). Temporal fMRI signal characteristics during heartburn were significantly different from those of subliminal acid stimulation in controls ( P < 0.01). Activated cortical regions included sensory/motor, parieto-occipital, cingulate and prefrontal regions, and the insula. There was 92% concordance between the activated Brodmann areas in repeated studies of GERD patients. Cortical activity associated with perceived and unperceived esophageal acid exposure in GERD patients and healthy controls, respectively, involves multiple brain regions but occurs more rapidly and with greater intensity in GERD patients than the activity in response to subliminal acid exposure in healthy controls. The cortical pain-processing pathway seems to be involved in perception of esophageal acid exposure and could explain the variations encountered in clinical practice defining this sensation.

Azure Machine Learning tools efficiency in the electroencephalographic signal P300 standard and target responses classification

2019 ◽  
Vol 15 (3) ◽  
Author(s):  
Grzegorz M. Wójcik ◽  
Andrzej Kawiak ◽  
Lukasz Kwasniewicz ◽  
Piotr Schneider ◽  
Jolanta Masiak
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Decision Tree ◽  
Event Related Potentials ◽  
Learning Tools ◽  
Mentally Disabled ◽  
Boosted Decision Tree ◽  
Brodmann Areas ◽  
Related Potentials ◽  
Somatosensory Responses

AbstractThe Event-Related Potentials were investigated on a group of 70 participants using the dense array electroencephalographic amplifier with photogrammetry geodesic station. The source localisation was computed for each participant. The activity of brodmann areas (BAs) involved in the brain cortical activity of each participant was measured. Then the mean electric charge flowing through particular areas was calculated. The five different machine learning tools (logistic regression, boosted decision tree, Bayes point machine, classic neural network and averaged perceptron classifier) from the Azure ecosystem were trained, and their accuracy was tested in the task of distinguishing standard and target responses in the experiment. The efficiency of each tool was compared, and it was found out that the best tool was logistic regression and the boosted decision tree in our task. Such an approach can be useful in eliminating somatosensory responses in experimental psychology or even in establishing new communication protocols with mildly mentally disabled subjects.

Concordance Between Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging (MRI) Derived Localization of Language in a Clinical Cohort

2020 ◽  
Vol 35 (6) ◽  
pp. 363-379
Author(s):  
Katherine Schiller ◽  
Asim F. Choudhri ◽  
Tamekia Jones ◽  
Christen Holder ◽  
James W. Wheless ◽  
...  
Keyword(s):  
Functional Mri ◽  
Odds Ratio ◽  
Magnetic Stimulation ◽  
Diagnostic Odds Ratio ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Clinical Cohort ◽  
Brodmann Areas ◽  
Magnetic Resonance Imaging Mri ◽  
Language Areas

Transcranial magnetic stimulation (TMS) is a newer noninvasive language mapping tool that is safe and well-tolerated by children. We examined the accuracy of TMS-derived language maps in a clinical cohort by comparing it against functional magnetic resonance imaging (MRI)–derived language map. The number of TMS-induced speech disruptions and the volume of activation during functional MRI tasks were localized to Brodmann areas for each modality in 40 patients with epilepsy or brain tumor. We examined the concordance between TMS- and functional MRI–derived language maps by deriving statistical performance metrics for TMS including sensitivity, specificity, accuracy, and diagnostic odds ratio. Brodmann areas 6, 44, and 9 in the frontal lobe and 22 and 40 in the temporal lobe were the most commonly identified language areas by both modalities. Overall accuracy of TMS compared to functional MRI in localizing language cortex was 71%, with a diagnostic odds ratio of 1.27 and higher sensitivity when identifying left hemisphere regions. TMS was more accurate in determining the dominant hemisphere for language with a diagnostic odds ratio of 6. This study is the first to examine the accuracy of the whole brain language map derived by TMS in the largest cohort examined to date. While this comparison against functional MRI confirmed that TMS reliably localizes cortical areas that are not essential for speech function, it demonstrated only slight concordance between TMS- and functional MRI–derived language areas. That the localization of specific language cortices by TMS demonstrated low accuracy reveals a potential need to use concordant tasks between the modalities and other avenues for further optimization of TMS parameters.

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