Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers

Abstract Purpose Serum erythropoietin (EPO) concentration is increased following static apnoea-induced hypoxia. However, the acute erythropoietic responses to a series of dynamic apnoeas in non-divers (ND) or elite breath-hold divers (EBHD) are unknown. Methods Participants were stratified into EBHD (n = 8), ND (n = 10) and control (n = 8) groups. On two separate occasions, EBHD and ND performed a series of five maximal dynamic apnoeas (DYN) or two sets of five maximal static apnoeas (STA). Control performed a static eupnoeic (STE) protocol to control against any effects of water immersion and diurnal variation on EPO. Peripheral oxygen saturation (SpO2) levels were monitored up to 30 s post each maximal effort. Blood samples were collected at 30, 90, and 180 min after each protocol for EPO, haemoglobin and haematocrit concentrations. Results No between group differences were observed at baseline (p > 0.05). For EBHD and ND, mean end-apnoea SpO2 was lower in DYN (EBHD, 62 ± 10%, p = 0.024; ND, 85 ± 6%; p = 0.020) than STA (EBHD, 76 ± 7%; ND, 96 ± 1%) and control (98 ± 1%) protocols. EBHD attained lower end-apnoeic SpO2 during DYN and STA than ND (p < 0.001). Serum EPO increased from baseline following the DYN protocol in EBHD only (EBHD, p < 0.001; ND, p = 0.622). EBHD EPO increased from baseline (6.85 ± 0.9mlU/mL) by 60% at 30 min (10.82 ± 2.5mlU/mL, p = 0.017) and 63% at 180 min (10.87 ± 2.1mlU/mL, p = 0.024). Serum EPO did not change after the STA (EBHD, p = 0.534; ND, p = 0.850) and STE (p = 0.056) protocols. There was a significant negative correlation (r = − 0.49, p = 0.003) between end-apnoeic SpO2 and peak post-apnoeic serum EPO concentrations. Conclusions The novel findings demonstrate that circulating EPO is only increased after DYN in EBHD. This may relate to the greater hypoxemia achieved by EBHD during the DYN.

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SIALIC ACID IN THE PRIMARY AND DIFFERENTIAL DIAGNOSIS OF LUNG CANCER

Problems in oncology ◽

10.37469/0507-3758-2017-63-6-926-932 ◽

2017 ◽

Vol 63 (6) ◽

pp. 926-932

Author(s):

Lyudmila Belskaya ◽

Viktor Kosenok ◽

Ж. Массард

Keyword(s):

Lung Cancer ◽

Enzyme Activity ◽

Optimization Problems ◽

Primary Lung Cancer ◽

Nonparametric Test ◽

Nonsmall Cell Lung Cancer ◽

Group Differences ◽

Diagnosis Of Lung Cancer ◽

And Control ◽

Control Study

So far optimization problems for diagnostics and prognostication aids remained relevant for lung cancer as a leader in the structure of cancers. Objective: a search for regularities of changes in the saliva enzyme activity in patients with nonsmall cell lung cancer. In the case-control study, 505 people took part, divided into 2 groups: primary (lung cancer, n=290) and control (conventionally healthy, n=215). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured with spectrophotometry. Between-group differences were measured with the nonparametric test. It was shown that in terms of lung cancer, we observe metabolic changes, described with the decreased de Ritis coefficient (p

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Serum Endocrine Profile in Relation to Estrus Synchronization in Surti Does

THE INDIAN JOURNAL OF VETERINARY SCIENCES AND BIOTECHNOLOGY ◽

10.21887/ijvsbt.v13i03.10609 ◽

2018 ◽

Vol 13 (03) ◽

Author(s):

M. M. Chaudhary ◽

C. T. Khasatiya ◽

S. B. Patel ◽

S. S. Chaudhary ◽

V. B. Atara ◽

...

Keyword(s):

Jugular Vein ◽

Estrus Synchronization ◽

Progesterone Concentration ◽

Serum Progesterone ◽

Blood Samples ◽

Group Iii ◽

Group I ◽

Endocrine Profile ◽

Group Ii ◽

And Control

The serum progesterone and estradiol profiles during synchronization of estrus by buck effect and PGF2α treatments were monitored in Surti does. Total eighteen non-pregnant does selected were evenly divided into 3 groups, 6 does in each group. The does of Group I were teased with a sexuallyactive- apronized buck; and those of Group II were treated with PGF2α, i.e., Inj. Lutalyse® @ 7.5 mg/doe IM twice 11 days apart, while the Group III served as untreated control. Blood samples were collected from all the animals on day 0 (before 1st PGF2α injection), 3rd day (during treatment), 11th day (before 2nd PGF2α injection), 14th day (after treatment) and 40th day (post-service) by jugular vein puncture. The serum separated was stored at -20°C till further analysis. In all the three groups, 83.33% does, conceived at first service in the sampling cycle. The overall mean serum progesterone concentration of Group I does (5.82±0.72 ng/ml) was significantly higher (p less than 0.01) as compared to Group II (2.93±0.38 ng/ml) and III (2.88±0.30 ng/ml). Similarly, the overall mean serum progesterone concentration of Surti does on day 0 (2.65±0.46 ng/ml), 3rd (2.56±0.80 ng/ml), 11th (4.45±0.84 ng/ml) and 14th (3.40±0.63 ng/ml) did not differ significantly, but the overall mean level at day 40 (6.31±0.45 ng/ml) was significantly (p less than 0.01) higher, because most of animals became pregnant at that time. The overall mean serum oestradiol-17β levels of Group I (24.40±2.98 pg/ ml) was significantly higher (p less than 0.01) than in Group II (15.77±1.77 pg/ml) and III (12.21±1.45 pg/ ml). On the other hand, the overall mean serum oestradiol-17β levels of Surti does on day 0 (12.89±1.21 pg/ml), 3rd (15.84±1.74 pg/ml), 11th (14.81±1.96 pg/ml), 14th (22.15±2.97 pg/ml) and 40th (21.64±5.16 pg/ml) did not differ significantly (p>0.05) and the slightly higher overall mean level found at 40th day might be the influence of the non-pregnant does at first service in the cumulative animals. The hormonal profile reflected the initiation of cyclicity and establishment of pregnancy in treated and control animals.

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Multi-Objective Optimization of Integrated Civilian-Military Scheduling of Medical Supplies for Epidemic Prevention and Control

Healthcare ◽

10.3390/healthcare9020126 ◽

2021 ◽

Vol 9 (2) ◽

pp. 126

Author(s):

Hai-Feng Ling ◽

Zheng-Lian Su ◽

Xun-Lin Jiang ◽

Yu-Jun Zheng

Keyword(s):

Prevention And Control ◽

Large Scale ◽

Medical Services ◽

The Novel ◽

Multi Objective ◽

Medical Supplies ◽

Problem Instances ◽

Novel Coronavirus ◽

And Control ◽

Minimum Ratio

In a large-scale epidemic, such as the novel coronavirus pneumonia (COVID-19), there is huge demand for a variety of medical supplies, such as medical masks, ventilators, and sickbeds. Resources from civilian medical services are often not sufficient for fully satisfying all of these demands. Resources from military medical services, which are normally reserved for military use, can be an effective supplement to these demands. In this paper, we formulate a problem of integrated civilian-military scheduling of medical supplies for epidemic prevention and control, the aim of which is to simultaneously maximize the overall satisfaction rate of the medical supplies and minimize the total scheduling cost, while keeping a minimum ratio of medical supplies reservation for military use. We propose a multi-objective water wave optimization (WWO) algorithm in order to efficiently solve this problem. Computational results on a set of problem instances constructed based on real COVID-19 data demonstrate the effectiveness of the proposed method.

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Salmonella Bacterin Vaccination Decreases Shedding and Colonization of Salmonella Typhimurium in Pigs

Microorganisms ◽

10.3390/microorganisms9061163 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1163

Author(s):

Eduarda Alexandra Gonçalves de Oliveira Moura ◽

Daniela Gomes da Silva ◽

Caio Henrique Turco ◽

Thainara Vitoria Carnevalli Sanches ◽

Gabriel Yuri Storino ◽

...

Keyword(s):

Salmonella Typhimurium ◽

Blood Count ◽

Control Strategies ◽

Control Group ◽

Blood Samples ◽

Commercial Vaccine ◽

Serum Igg ◽

And Control ◽

Experimental Group ◽

Over Time

Since the occurrence of swine salmonellosis has increased over time and control strategies other than biosecurity are highly recommended, the present study aimed to evaluate the efficacy of vaccination with Salmonella Choleraesuis and Salmonella Typhimurium bacterins in pigs. Two experimental groups were formed: G1, animals immunized with two doses of a commercial vaccine (n = 20); G2, control group (n = 20). After vaccination, all pigs were orally challenged (D0) with 108 CFU of Salmonella Typhimurium and evaluated for 40 days. Every 10 days after D0, five piglets from each experimental group were euthanized and submitted to the necroscopic examination, when organ samples were collected. Blood samples and rectal swabs were collected before the first dose of the vaccine (D−42), before the second dose (D−21), before the challenge (D0), and thereafter, every three days until D39. Blood count, serum IgG measurement by ELISA, and the excretion of Salmonella Typhimurium in feces were evaluated. While the results from blood count and serum IgG concentration did not differ, the detection and excretion of Salmonella between G1 and G2 differed (p < 0.05). Therefore, it was observed that this vaccine partially protected the animals against experimental infection with Salmonella Typhimurium, reducing the excretion of bacteria in feces.

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Local cooling during hot water immersion improves perceptions without inhibiting the acute interleukin-6 response

European Journal of Applied Physiology ◽

10.1007/s00421-021-04616-5 ◽

2021 ◽

Author(s):

R. G. Mansfield ◽

S. P. Hoekstra ◽

J. J. Bill ◽

Christof A. Leicht

Keyword(s):

Thermal Comfort ◽

Interleukin 6 ◽

Water Immersion ◽

Hot Water ◽

Upper Body ◽

Healthy Male ◽

Local Cooling ◽

Blood Samples ◽

Body Cooling ◽

Hot Water Immersion

Abstract Purpose Passive elevation of body temperature can induce an acute inflammatory response that has been proposed to be beneficial; however, it can be perceived as uncomfortable. Here, we investigate whether local cooling of the upper body during hot water immersion can improve perception without inhibiting the interleukin-6 (IL-6) response. Methods Nine healthy male participants (age: 22 ± 1 years, body mass: 83.4 ± 9.4 kg) were immersed up to the waist for three 60-min water immersion conditions: 42 °C hot water immersion (HWI), 42 °C HWI with simultaneous upper-body cooling using a fan (FAN), and 36 °C thermoneutral water immersion (CON). Blood samples to determine IL-6 plasma concentration were collected pre- and post-water immersion; basic affect and thermal comfort were assessed throughout the intervention. Results Plasma IL-6 concentration was higher for HWI and FAN when compared with CON (P < 0.01) and did not differ between HWI and FAN (P = 0.22; pre to post, HWI: 1.0 ± 0.6 to 1.5 ± 0.7 pg·ml−1, FAN: 0.7 ± 0.5 to 1.1 ± 0.5 pg·ml−1, CON: 0.5 ± 0.2 to 0.5 ± 0.2 pg·ml−1). At the end of immersion, basic affect was lowest for HWI (HWI: − 1.8 ± 2.0, FAN: 0.2 ± 1.6, CON 1.0 ± 2.1, P < 0.02); thermal comfort for HWI was in the uncomfortable range (3.0 ± 1.0, P < 0.01 when compared with FAN and CON), whereas FAN (0.7 ± 0.7) and CON (-0.2 ± 0.7) were in the comfortable range. Conclusion Local cooling of the upper body during hot water immersion improves basic affect and thermal comfort without inhibiting the acute IL-6 response.

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Design of a Multi-Arm Robot for Mandible Reconstruction Surgery

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.654.187 ◽

2014 ◽

Vol 654 ◽

pp. 187-190 ◽

Cited By ~ 1

Author(s):

Hong Hua Zhao ◽

Jian Ying Tian ◽

Dong Song Li ◽

Chang Sheng Ai

Keyword(s):

Mechanical Design ◽

The Novel ◽

Robot System ◽

Mandible Reconstruction ◽

3D Navigation ◽

Reconstruction Surgery ◽

And Control ◽

Robotic Surgical System ◽

Surgical System ◽

Poor Stability

Clinical treatment for mandible defects is Mandible Reconstruction Surgery (MRS) including bone grafts, distraction osteogenesis and bone tissue engineering, however, MRS is operated by doctors without 3D navigation at present which leads to lots of disadvantages such as bad operational control, low positioning accuracy and poor stability. Therefore, a robotic surgical system was designed to assist surgeons on manipulating. For this study, the robot system was given in brief, then mechanical design and control system of the novel three-arm robot.And experiment results in this study show that the robot works stably and accurately. The development of this medical robot system contributes to the promotion and popularization of the MRS in clinics.

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Soft Spherical Tensegrity Robot Design Using Rod-Centered Actuation and Control

Volume 5A: 40th Mechanisms and Robotics Conference ◽

10.1115/detc2016-60550 ◽

2016 ◽

Cited By ~ 11

Author(s):

Lee-Huang Chen ◽

Kyunam Kim ◽

Ellande Tang ◽

Kevin Li ◽

Richard House ◽

...

Keyword(s):

Degrees Of Freedom ◽

Low Cost ◽

Space Exploration ◽

Robot Design ◽

The Novel ◽

Flexible Design ◽

Spherical Robot ◽

Potential Benefits ◽

And Performance ◽

And Control

This paper presents the design, analysis and testing of a fully actuated modular spherical tensegrity robot for co-robotic and space exploration applications. Robots built from tensegrity structures (composed of pure tensile and compression elements) have many potential benefits including high robustness through redundancy, many degrees of freedom in movement and flexible design. However to fully take advantage of these properties a significant fraction of the tensile elements should be active, leading to a potential increase in complexity, messy cable and power routing systems and increased design difficulty. Here we describe an elegant solution to a fully actuated tensegrity robot: The TT-3 (version 3) tensegrity robot, developed at UC Berkeley, in collaboration with NASA Ames, is a lightweight, low cost, modular, and rapidly prototyped spherical tensegrity robot. This robot is based on a ball-shaped six-bar tensegrity structure and features a unique modular rod-centered distributed actuation and control architecture. This paper presents the novel mechanism design, architecture and simulations of TT-3, the first untethered, fully actuated cable-driven six-bar tensegrity spherical robot ever built and tested for mobility. Furthermore, this paper discusses the controls and preliminary testing performed to observe the system’s behavior and performance.

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Increased Delay Discounting on a Novel Real-Time Task among Girls, but not Boys, with ADHD

Journal of the International Neuropsychological Society ◽

10.1017/s1355617715001071 ◽

2015 ◽

Vol 22 (1) ◽

pp. 12-23 ◽

Cited By ~ 21

Author(s):

Keri S. Rosch ◽

Stewart H. Mostofsky

Keyword(s):

Real Time ◽

Delay Discounting ◽

Diagnostic Group ◽

Group Differences ◽

The Novel ◽

Typically Developing ◽

Subjective Ratings ◽

Time Discounting ◽

Children With Adhd ◽

Girls With Adhd

AbstractThe aim of this study was to examine delay discounting in girls and boys with ADHD-Combined type (ADHD-C) relative to typically developing (TD) children on two tasks that differ in the extent to which the rewards and delays were experienced by participants. Children ages 8–12 years with ADHD-C (n=65; 19 girls) and TD controls (n=55; 15 girls) completed two delay discounting tasks involving a series of choices between smaller, immediate and larger, delayed rewards. The classic delay discounting task involved choices about money at delays of 1–90 days and only some of the outcomes were actually experienced by the participants. The novel real-time discounting task involved choices about an immediately consumable reward (playing a preferred game) at delays of 25–100 s, all of which were actually experienced by participants. Participants also provided subjective ratings of how much they liked playing the game and waiting to play. Girls with ADHD-C displayed greater delay discounting compared to boys with ADHD-C and TD girls and boys on the real-time discounting task. Diagnostic group differences were not evident on the classic discounting task. In addition, children with ADHD-C reported wanting to play the game more and liking waiting to play the game less than TD children. This novel demonstration of greater delay discounting among girls with ADHD-C on a discounting task in which the rewards are immediately consumable and the delays are experienced in real-time informs our understanding of sex differences and motivational processes in children with ADHD. (JINS, 2016, 22, 12–23)

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Dynamic Analysis and Control of an Automatic Transmission for Start-Stop Function and Efficiency Improvement

Mathematical Problems in Engineering ◽

10.1155/2015/209276 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13

Author(s):

Yang Liu ◽

Shuhan Wang ◽

Peng Dong ◽

Xiangyang Xu

Keyword(s):

Control Strategies ◽

Automatic Transmission ◽

Simulation Method ◽

Transmission Efficiency ◽

The Novel ◽

Test Results ◽

Test Environment ◽

Pump System ◽

Oil Pump ◽

And Control

An electric oil pump (EOP) was integrated into the hydraulic system and an automatic transmission (AT) mechanical oil pump (MOP) was downsized. These processes were performed to combine a start-stop function with the AT and further improve the transmission efficiency. Furthermore, this study established a dynamics model of power loss and leakage of an 8-speed AT; a flow-based control algorithm of the EOP was then developed to realize the start-stop function and support the MOP to meet the flow requirement of the system. Based on a driving simulation method, sizes of the MOP and EOP that ensured optimal fuel economy were selected. A control strategy for the starting clutch was also developed to minimize the starting delay of the test vehicle. A test environment on a rig and prototype vehicle was established to verify the feasibility of the proposed control strategies. The test results indicated that the transmission functioned favorably with the novel two-pump system presented, and a quick and smooth starting performance was achieved when the engine was restarted. The findings in this study are extremely valuable for forward designs of an AT for realizing start-stop function and improving efficiency.

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Simple mathematical models for controlling COVID-19 transmission through social distancing and community awareness

Zeitschrift für Naturforschung C ◽

10.1515/znc-2021-0004 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Ahmed S. Elgazzar

Keyword(s):

Mathematical Models ◽

Virus Transmission ◽

Small World ◽

Vaccination Rate ◽

The Novel ◽

Social Distancing ◽

Community Awareness ◽

Sufficient Degree ◽

And Control

Abstract The novel COVID-19 pandemic is a current, major global health threat. Up till now, there is no fully approved pharmacological treatment or a vaccine. Also, its origin is still mysterious. In this study, simple mathematical models were employed to examine the dynamics of transmission and control of COVID-19 taking into consideration social distancing and community awareness. Both situations of homogeneous and nonhomogeneous population were considered. Based on the calculations, a sufficient degree of social distancing based on its reproductive ratio is found to be effective in controlling COVID-19, even in the absence of a vaccine. With a vaccine, social distancing minimizes the sufficient vaccination rate to control the disease. Community awareness also has a great impact in eradicating the virus transmission. The model is simulated on small-world networks and the role of social distancing in controlling the infection is explained.

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