Fibrous Hamartoma of Infancy: Current Review

This review examines 197 cases of fibrous hamartoma of infancy (FHI) described in the literature and provides a detailed clinicopathologic analysis of what is known to date of this peculiar lesion of the subcutis and lower dermis. The vast majority of these cases occurred within the first year of life (91%). Twenty-three percent were congenital. There was a predilection for boys with a male/female ratio of 2.4. Males and females had similar anatomic distribution with the most common locations being the axillary region, upper arm, upper trunk, inguinal region, and external genital area. Most cases presented as solitary masses, but four cases of multiple separate synchronous lesions have been reported. Most lesions presented as a painless nodule, sometimes with rapid growth. A few cases had overlying skin changes, including alteration in pigmentation, eccrine gland hyperplasia, and increased hair. No lesions were reported to have familial or syndromic association, or to occur in combination with other hamartomas. Spontaneous regression has not been reported. The treatment of choice is local excision. Even with incomplete excision, FHI has a low recurrence rate. Criteria for histologic diagnosis include the presence of well-defined bundles of dense, uniform, fibrous connective tissue projecting into fat, primitive mesenchyme arranged in nests, concentric whorls or bands, and mature adipose tissue intimately admixed with the other components. Flow-cytometric and conventional cytogenetic studies have not been reported; these may clarify any relationship to other fibroblastic/myofibroblastic proliferations in children, resulting in better classification and terminology of this unique lesion.

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Immunophenotypic study of acute leukemia by flow cytometry at BPKMCH.

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i5.7856 ◽

2013 ◽

Vol 3 (5) ◽

pp. 345-350

Author(s):

S Shrestha ◽

J Shrestha ◽

CB Pun ◽

T Pathak ◽

S Bastola ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Acute Leukemia ◽

Acute Myelogenous Leukemia ◽

Lymphoblastic Leukemia ◽

Bone Marrow Examination ◽

Myelogenous Leukemia ◽

Female Ratio ◽

Flow Cytometric ◽

Male Female Ratio ◽

Acute Myelogenous

Background: Immunophenotyping of acute leukemia is one of the most important clinical applications of fl ow cytometry. The aim of this study was to determine the immunophenotyping profi le of acute leukemia, by means of a fl ow cytometric method, using monoclonal antibodies all marked with a fl uorochrome, in four colour systems to assess their distribution according to type of leukemia (lymphoid B or T / myeloid). Materials and Methods: We retrospectively collected data of immunophenotyping from 52 acute leukemia patients at the department of pathology in B.P. Koirala Memorial Cancer Hospital from January 2010 to December 2011. Diagnosis was based on peripheral blood and bone marrow examination for morphology, cytochemistry and immunophenotypic studies. Results: Out of total 52 cases of acute leukemia diagnosed by fl ow cytometry over a two year period, there were 31 cases (59.6 %) of acute lymphoblastic leukemia, 20 cases (38.4 %) of acute myelogenous leukemia and one case (1.9 %) of bi-phenotypic acute leukemia. Leukemia was diagnosed among adults in 44.2 % whereas among children with age less than or equal to 15 years in 55.7 %. Thirty eight (73%) were male and 14 (27 %) were female with a male: female ratio of 2.7:1. For acute myelogenous leukemia, it was found that M0 (5.0 %), M1 (20%), M2 (60%), M3 (15%), M4 (5.0 %) were detected. CD13 and CD33 were the most useful markers in the diagnosis of acute myelogenous leukemia. The most common subtype was AML-M2. Of the 31 cases with acute lymphoblastic leukemia, 20 cases (64.5 %) were identifi ed as B-ALL and 11 cases (35.5%) as T-ALL. Aside from cytoplasmic CD3 (cCD3) and CD7 were the most sensitive antigens present in all cases of T-ALL. All cases of B-ALL showed expression of pan B-cell markers CD19 and CD22, but 15 (75 %) of 20 cases expressed CD10. Conclusion: Flow cytometric immunophenotyping was found to be especially useful in the correct identifi cation and diagnosis of acute myeloid or lymphoblastic leukemia and its subtypes. In combination with French-American-British (FAB) morphology and immunophenotyping, we were able to diagnose and classify all patients with acute leukemia in this study. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 345-350 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7856

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Flow Cytometric Quantitation of Lymphocyte Subsets among HIV-infected and-uninfected Infants in the First Year of Life † 872

Pediatric Research ◽

10.1203/00006450-199804001-00893 ◽

1998 ◽

Vol 43 ◽

pp. 151-151

Author(s):

Tao-Zhen Lin ◽

Dana Stein ◽

Tammy Mui ◽

Thomas Denny ◽

Paul Palumbo

Keyword(s):

Lymphocyte Subsets ◽

First Year ◽

Flow Cytometric ◽

First Year Of Life

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Prevalence and risk factors for epilepsy in children with spastic cerebral palsy

Paediatrica Indonesiana ◽

10.14238/pi50.1.2010.11-7 ◽

2016 ◽

Vol 50 (1) ◽

pp. 11

Author(s):

Dedy Rahmat ◽

Irawan Mangunatmadja ◽

Bambang Tridjaja ◽

Taralan Tambunan ◽

Rulina Suradi

Keyword(s):

Risk Factors ◽

Central Nervous System ◽

Nervous System ◽

Cerebral Palsy ◽

Central Nervous System Infection ◽

First Year ◽

Genetic Syndrome ◽

Female Ratio ◽

Increased Risk ◽

First Year Of Life

Background Epilepsy in cerebral palsy (CP) is usually difficult to treat and can lead to poor prognosis due to increased risk for motor and cognitive disorders. The prevalence and risk factors of epilepsy in children with CP vary among studies.Objective To determine the prevalence and risk factors for epilepsy in spastic CP.Methods We performed a retrospective study using medical records of patients with spastic CP at the Departement of Child Health, Cipto Mangunkusumo Hospital from January 2003 until December 2008. Prevalence ratio was calculated by comparing the prevalence of epilepsy in subjects with and without risk factors. We excluded patients with metabolic disorder, genetic syndrome, and onset of CP after 3 years of age.Results Two hundred thirty six out of 238 spastic CP patients were analyzed. The mean age at diagnosis of spastic CP was 28.8 months. Male to female ratio was 1.4:1. The prevalence of epilepsy in spastic CP was 39%. The risk factors for epilepsy in spastic CP were central nervous system infection, the ocurrence of seizure in the first year of life, and abnormality of EE G.Conclusions The prevalence of epilepsy in spastic CP is 39%. The risk factors for epilepsy in spastic CP are post central nervous system infection, and ocurrence of seizure in the first year of life. [Paediatr Indones. 2010;50:11-7].

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Cranial ontogenetic variability, sex ratio and age structure of the Red fox

Open Life Sciences ◽

10.2478/s11535-010-0093-2 ◽

2010 ◽

Vol 5 (6) ◽

pp. 894-907 ◽

Cited By ~ 1

Author(s):

Martina Hartová-Nentvichová ◽

Miloš Anděra ◽

Vlastimil Hart

Keyword(s):

Sex Ratio ◽

Age Structure ◽

Growth Pattern ◽

Red Fox ◽

Growth Patterns ◽

First Year ◽

Red Foxes ◽

Female Ratio ◽

One Year ◽

First Year Of Life

AbstractDescribing the sex ratio, age structure of the population and ontogenetic variability of Red fox, Vulpes vulpes (Canidae, Carnivora) skull parameters, this study is based on 416 male and 289 female skulls collected in the Czech Republic. The skulls analysed came from feral individuals, that were shot by hunters. The male to female ratio was 1:0.69 regarding the whole population. Individuals younger than one year prevailed in the population (54% males, 48% females were in their first year of life). Four growth patterns of skull dimensions were described. The first group included mainly skull length dimensions (e.g. condylobasal length). They grew rapidly until the sixth month of life, becoming stabilised afterwards. The second group comprised parameters that were stable throughout the life (e.g. cheek tooth rows). Measurements representing the third growth pattern showed continual growth (mainly width dimensions, e.g. zygomatic breadth). Conversely, smaller dimensions of postorbital breadth were observed after the sixth month of life. Postorbital breadth represented the fourth growth pattern. It was concluded, that male and female Red foxes had similar ontogenetic skull development, even though there were some differences, e.g. in jugular breadth, which increased after the age of six months in males unlike in females.

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Mycosis Fungoides in Iranian Population: An Epidemiological and Clinicopathological Study

Journal of Skin Cancer ◽

10.1155/2015/306543 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Farahnaz Fatemi Naeini ◽

Bahareh Abtahi-Naeini ◽

Hamidreza Sadeghiyan ◽

Mohammad Ali Nilforoushzadeh ◽

Jamshid Najafian ◽

...

Keyword(s):

Mycosis Fungoides ◽

Disease Onset ◽

Clinical Information ◽

University Hospital ◽

Histologic Diagnosis ◽

Female Ratio ◽

Male Predominance ◽

Female Predominance ◽

Single Center Study ◽

Male Female Ratio

Background. Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Extensive studies on Iranian MF patients are absent. The present study aimed to produce updated clinical information on Iranian MF patients.Methods. This was a retrospective, descriptive, single-center study, including all cases of MF seen in the Department of Dermatology, University Hospital of Isfahan, Iran, between 2003 and 2013. Data systematically recorded for each patient included clinical, biological, histological, and molecular findings.Results. Eighty-six patients with clinical and histologic diagnosis of MF were included in the study. Thirty-nine patients (45.3%) were male. Female predominance was observed in patients (male : female ratio is 1 : 1.2). Patients were between 7 and 84 years of age (median: 41). The interval from disease onset to diagnosis ranged from 0 to 55 years (median: 1 year). Eighteen cases (20.9%) had unusual variants of MF. The most common types included hypopigmented and poikilodermatous MF. Childhood cases of MF constituted 5.8% (5/86) of all patients. The early stages were seen in 82 cases (95.34%).Conclusion. The major differences in epidemiologic characteristics of MF in Iran are the lack of male predominance and the lower age of patients at the time of diagnosis.

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Outcome of Rhabdomyosarcoma in First Year of Life: Children’s Cancer Hospital 57357 Egypt

Sarcoma ◽

10.1155/2013/439213 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Enas El Nadi ◽

Emad A. H. Moussa ◽

Wael Zekri ◽

Hala Taha ◽

Alaa Yones ◽

...

Keyword(s):

Overall Survival ◽

Survival Rate ◽

Multimodality Treatment ◽

Treatment Modalities ◽

First Year ◽

Female Ratio ◽

Free Survival ◽

Cancer Hospital ◽

One Year ◽

First Year Of Life

Background. Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. Fifty percent of RMS cases occur in the first 10 years of life and less commonly in infants younger than one-year old. These infants require adapted multimodality treatment approaches.Patients and Methods. We analyzed patients’ characteristics, treatment modalities, and the outcome for RMS infants treated at Children’s Cancer Hospital Egypt (CCHE) between July 2007 and December 2010 and compared them to patients above one year treated on the same protocol.Results. Out of the 126 RMS treated during this period, 18 were below the age of one year. The male: female ratio was 1.25 : 1. The median age at diagnosis was 0.7 ± 0.2 years. Most of the cases (27.8%) were presented in head and neck regions. The estimated 4-years failure-free survival and overall survival for infants were 49 ± 12% and 70 ± 12%, respectively. These failure-free survival rate and overall survival rate did not differ from those for older patients (P=0.2).Conclusion. Infants with RMS are a unique group of RMS who needs special concerns in tailoring treatment in addition to concerns regarding toxicity and morbidity in infants.Corrigendum to “Outcome of Rhabdomyosarcoma in First Year of Life: Children’s Cancer Hospital 57357 Egypt”

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The Prevalence of Symptoms of Life-Threatening Events in Infants of the First Year of Life: a Cross-Sectional Population Study

Вопросы современной педиатрии ◽

10.15690/vsp.v18i2.2013 ◽

2019 ◽

Vol 18 (2) ◽

pp. 109-117 ◽

Cited By ~ 1

Author(s):

Natalya N. Korableva ◽

Ekaterina N. Pershina ◽

Vladimir A. Gusev

Keyword(s):

Risk Factors ◽

Muscle Tone ◽

First Year ◽

Hospital Data ◽

Cross Sectional ◽

Skin Changes ◽

Life Threatening ◽

Second Year ◽

First Year Of Life ◽

Irregular Breathing

Background.The prevalence of symptoms of life-threatening events in infants was previously studied using hospital data. However, not all parents in the event of such symptoms seek medical help in the hospital.Objective.Our aim was to identify the prevalence and risk factors of life-threatening events in infants in the first year of life.Methods.In the period from November 2017 to February 2018, we interviewed mothers who have children in their second year of life who are registered at children's outpatient clinics in Syktyvkar. Respondents noted episodes of absent, infrequent or irregular breathing, blanching or cyanosis of the skin, changes in muscle tone (hypo- or hypertonia), changes in the level of responses that occurred in infancy. The prevalence of symptoms of life-threatening events was estimated based on the total number of infants in the first year of life (n = 3088) who lived in Syktyvkar as of January 1, 2018.Results.At least one symptom of life-threatening events in infancy was reported by 43 (4.3%) of the 1001 mothers surveyed. The prevalence of symptoms was 429.5 [95% confidence interval (CI) 321–574] per 10,000 children of the corresponding age. Independent predictors of life-threatening events in children of the first year of life were sudden deaths of relatives under the age of 50 years [odds ratio (OR) 2.4; 95% CI 1.1–5.3], cases of pre-syncope or syncope in relatives (OR 4.4, 95% CI 2.1–9.0), artificial feeding of infants (OR 4.0, 95% CI 1.5–11.2). The sensitivity of the model, which took into account the presence of at least one of the three predictors, was 19% (8/43), specificity — 99% (2/958).Conclusion.The issue of the occurrence of life-threatening events in an infant can impact every 25th family. In every fifth infant, the occurrence of symptoms of life-threatening events can be predicted based on risk factors.

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An audit of foeticide, neonaticide and infanticide: A retrospective study in the Department of Forensic Medicine, King Edward Medical University, Lahore

Medico-Legal Journal ◽

10.1177/00258172211038103 ◽

2022 ◽

pp. 002581722110381

Author(s):

Qasim Mehmood ◽

Fatima Yasin ◽

Arif Rasheed Malik

Keyword(s):

Mental Illness ◽

Retrospective Study ◽

Head Injury ◽

First Year ◽

Female Ratio ◽

Causative Factors ◽

Socioeconomic Stress ◽

First Year Of Life ◽

Medical University ◽

Male To Female

The deliberate killing of a foetus in the womb, or a child from the first 24 h of birth to one month of age, or within the first year of life, is called foeticide, neonaticide and infanticide, respectively. Socioeconomic stress, mental illness, gender selection, shame or fear of punishment of adultery or illegitimacy, grudge and jealousy with parents and negligent delivery by dai are major causative factors in such cases. This is a retrospective, descriptive, observational study, and the sample pool consisted of 35 cases. Foeticide cases were 42.9% of the total and the same percentage of cases were neonaticides, while 14.3% of cases were of infanticide. The male-to-female ratio was 1.26:1 and the major cause of death was head injury. The study shows a prevalence of foeticide and neonaticide as compared to infanticide. It also displays the prevalence of males in overall cases and a higher number of unknown cases in our setting.

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Moscas de las frutas (Díptera: Tephritidae) y parasitoides asociados con Psidium guajava L. y Coffea arabica L. en tres municipios de la Provincia de Vélez (Santander, Colombia). Parte 1: Índices de infestación y daño por moscas de la frutas

Ciencia y Tecnología Agropecuaria ◽

10.21930/rcta.vol5_num1_art:16 ◽

2004 ◽

Vol 5 (1) ◽

pp. 5 ◽

Cited By ~ 1

Author(s):

Ligia Núñez Bueno ◽

Raúl Gómez Santos ◽

Giovanni Guarín ◽

Guillermo León

Keyword(s):

Host Plant ◽

Coffea Arabica ◽

Psidium Guajava ◽

Fruit Flies ◽

Crop Damage ◽

First Year ◽

Female Ratio ◽

Male Female Ratio ◽

Total Damage ◽

Coffea Arabica L

La investigación se realizó en la Provincia de Vélez (5° 33’ – 5° 88’ Norte y 73° 42’ – 73° 48’ Oeste) en el Departamento de Santander (Colombia) en los municipios de Guavatá, Puente Nacional y Jesús María (1.650 – 1.890 msnm, 17,8° C; 1.800-2.500 ml de precipitación por año; 93% de humedad relativa) en Psidium guajava L. y Coffea arabica L., con el objeto de identificar y cuantificar el daño causado por moscas de las frutas. Se tomaron frutas maduras del árbol en tres fincas de cada localidad, una vez por mes durante los años 2000 y 2001. Las muestras se procesaron y analizaron y se contó el número de larvas del tercer instar, pupas y adultos de moscas emergidas. Éstas se agruparon por especie y sexo y se analizaron los datos promedios anuales por localidad y especie. Se analizaron 216 muestras de cada planta hospedante, equivalentes a 217,42 kg de guayaba y 213,75 kg de café. Emergieron las especies Anastrepha striata Schiner y A. fraterculus (Wied). En guayaba la relación fue del 91,72% de A. striata y 8,26% de A. fraterculus. En café 0,85% de A. striata y 99,18% de A. fraterculus. La relación de sexos de cada especie se mantuvo en 1:1. El porcentaje de frutas dañadas, promedio total anual, fue de 99,86% en el año 2000 y de 96,20% en el año 2001. No hubo diferencias significativas entre años ni localidades. Los índices de infestación (L3/kg de fruta) fueron de 153,3 en el año 2000 y de 214,9 en el año 2001 y hubo diferencias significativas entre años y localidades. En café, el porcentaje de daño y el índice de infestación fueron significativamente inferiores respecto a los de guayaba, y el promedio total anual fue de 18,93% en el año 2000 y de 22,23% en el año 2001. La infestación L3/kg) en el primer año fue de 110,6 y de 120,83 en el segundo año. Se observaron diferencias significativas entre localidades. Fruits flies (Diptera: Tephritidae) and parasitoids associated with Psidium guajava L. and Coffea Arabica L. in three municipalities of Vélez County (Santander, Colombia). Part 1: Fruit flies (Diptera: Tephritidae) infestation and damage indexes. This research took place in the Province of Velez in Santander, Colombia (5° 33’ – 5°88’ N and 73° 42’ – 73° 48’ W) in the municipalities of Guavatá, Puente Nacional and Jesús María (1.650 – 1.890 masl, 17,8° C; 1800- 2500 ml of rain/year; 93% of HR) in crops of Psidium guajava L. and Coffea arabica L. The objective was to identify and measure the crop damage caused by fruit flies on both species. Sampling was carried out for two years. Samples of mature fruits from each host plant were monthly taken from the trees, in three plots per location. Fruits were separately evaluated for the presence of larvae. The number of third instar larvae (L3), pupae and adults per sample was registered by species and sex. A total of 216 samples were analyzed per host plant which corresponded to 217, 42 kg of guava and 213,75 kg of coffee. Results indicated the presence of Anastrepha striata Schiner and A. fraterculus (Wied) emerging from guava and coffee. The attack proportion in guava was 91,72% caused by A. striata and only 8,26% caused by A. fraterculus. In coffee A. striata caused 0,85% of the attack while A. fraterculus caused 99,15% of the attack. Male: female ratio was 1:1 for both species. Average percent of total damage per year was 99,86% in 2000 and of 96,20% in 2001 for guava; no statistical differences within years were found. The infestation index [L3/kg of fruit] was 153.3 in the first year and 214,9 in the second year, significant differences among years and localities were found. Percentage of fruit damage was lower in coffee when compared to guava (18,93% in the first year and 22,23% in the second). The infestation [L3/kg] in the first year was 110,6 and 120,83 in the second (P>0.05).

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Critical Analysis of PIM2 Score Applicability in a Tertiary Care PICU in Western India

International Journal of Pediatrics ◽

10.1155/2014/703942 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Vivek V. Shukla ◽

Somashekhar M. Nimbalkar ◽

Ajay G. Phatak ◽

Jaishree D. Ganjiwale

Keyword(s):

Tertiary Care ◽

Area Under The Curve ◽

First Year ◽

Western India ◽

Roc Curve Analysis ◽

Female Ratio ◽

Male Female Ratio ◽

Physiological Reserve ◽

Input Variables ◽

Indian Setting

Objective.Children have limited physiological reserve that deteriorates rapidly. Present study profiled patients admitted to PICU and determined PIM2 score applicability in Indian setting.Patients and Methods.Prospective observational study.Results.In 742 consecutive admissions, male : female ratio was 1.5 : 1, 35.6% patients were ventilated, observed mortality was 7%, and 26.4% were <1 year. The profile included septicemia and septic shock (29.6%), anemia (27.1%), pneumonia (19.6%), and meningitis and encephalitis (17.2%). For the first year, sensitivity of PIM2 was 65.8% and specificity was 71% for cutoff value at 1.9 by ROC curve analysis. The area under the curve was 0.724 (95% CI: 0.69, 0.76). This cutoff was validated for second year data yielding similar sensitivity (70.6%) and specificity (65%). Logistic regression analysis (LRA) over entire data revealed various variables independently associated with mortality along with PIM2 score. Another logistic model with same input variables except PIM2 yielded the same significant variables with NagelkerkeRsquare of 0.388 and correct classification of 78.5 revealing contribution of PIM2 in predicting mortality is meager.Conclusion.Infectious diseases were the commonest cause of PICU admission and mortality. PIM2 scoring did not explain the outcome adequately, suggesting need for recalibration. Following PALS/GEM guidelines was associated with better outcome.

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