Association of calcium intake, lactose intolerance and physical activity with bone health assessed via quantitative ultrasound among young adults of a Malaysian university

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Noor Fairuzi Suhana Yahya ◽  
Norlida Mat Daud ◽  
Ika Aida Aprilini Makbul ◽  
Qurratul Aini Salma Abdul Aziz
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Quantitative Ultrasound ◽  
Bone Health ◽  
Calcium Intake ◽  
Lactose Intolerance

Body Composition and Its Relationship to Growth and Bone Mass in Patients with Thalassemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3890-3890
Author(s):  
Ellen Fung ◽  
Yan Xu ◽  
Janet Kwiatkowski ◽  
Sylvia Titi Singer ◽  
Ashutosh Lal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Nutritional Status ◽  
Bone Mass ◽  
Body Fat ◽  
Lean Mass ◽  
Bone Health ◽  
Calcium Intake ◽  
Z Score ◽  
Percentage Body Fat

Abstract Optimal nutritional status is imperative for achieving the genetic potential for growth and development in children as well as for robust immune function and bone health in adults. Patients with thalassemia (Thal) are known to have abnormal growth, altered development and immune function and deficits in bone mass. For children, weight and height is commonly used to assess overall nutritional status, whereas for adults, body composition is a gross marker of an individual’s overall nutritional health. Nutritional status and body composition has not been explored in patients with Thal. To examine this, we have assessed body composition (fat, lean) and bone density by dual energy x-ray absorptiometry (DXA, Hologic Delphi A) in 370 subjects enrolled in a cross-sectional study of the Thal Clinical Research Network (TCRN), a North American collaborative research group. In addition to DXA, weight and height were measured, medical history obtained and a brief calcium food frequency and physical activity questionnaire completed. The total sample was divided into 2 groups: (TxThal) 257 transfused thalassemia major and E-beta thal patients (23.7 ± 11 yr, 131 male), and (NTxThal) 113 never or minimally transfused patients with other thalassemia syndromes (21.3 ± 13 yr, 50 male). Body mass index (BMI) was calculated (kg/m2) and cutoffs determined for children (<17=underweight, ≥30 obese) and adults (<18.5=underweight, ≥30 obese). As expected there was a high correlation between BMI and fat and lean mass by DXA (r=0.7 to 0.86, p<0.001). 6.2% of adults and 39.3% of children were classified as underweight by BMI and nearly 1/3 of children with Thal had abnormally low percentage body fat; while only 3.4% of adults and 2.2% of children were considered obese. Compared to median data from NHANES, adult patients with Thal are much leaner (BMI: 22.8±0.4) compared to contemporary adult Americans (28.1±0.2, p<0.0001). TxThal had more total body fat mass (14.3 vs 11.4 g, p<0.0001) and percentage body fat (27.3% vs. 24.9% p=0.007) compared to NTxThal. As has been observed in epidemiological studies of healthy subjects, calcium intake was inversely related to fat mass (p=0.009) as well as lean mass (p=0.007) after controlling for the effects of age, gender and diagnosis. Current physical activity level was a strong predictor of reduced body fat (p=0.007), whereas hemoglobin level was positively related to lean mass (p=0.001). Moreover, body fat was a positive predictor for height Z-score (p<0.0001). Low bone mass (BMD Z-Score <−2.0) was found in 50% of subjects, and BMD Z-score was moderately correlated with height Z-score (p<0.0001) and weight Z-score (p<0.0001). Though the majority of patients with Thal were classified as having a healthy body composition with very few obese patients, nearly 40% of the children in this sample were underweight. NTxThal appear at particular risk for underweight. These results suggest that an adequate amount of body fat is necessary for optimal growth and bone health in patients with Thal, and that calcium intake is associated with optimal body composition. These preliminary findings support the need for more careful study of nutritional status and its relationship to overall health in patients with thalassemia.

scholarly journals Association between occupational physical activity and quantitative bone ultrasound in sawmill workers

Sigurnost ◽  
2021 ◽  
Vol 63 (4) ◽  
pp. 363-372
Author(s):  
Selma Cvijetić ◽  
Milica Gomzi ◽  
Jelena Macan
Keyword(s):  
Physical Activity ◽  
Bone Density ◽  
Quantitative Ultrasound ◽  
Bone Health ◽  
Physical Exertion ◽  
Physical Workload ◽  
Occupational Activity ◽  
Occupational Physical Activity ◽  
Cross Sectional ◽  
Sawmill Workers

A small number of studies have examined the relationship between bone health and level of physical load. We explored the effect of occupational physical activity on skeletal status in younger sawmill workers using ultrasonic indices of bone density. In a cross-sectional study, we measured bone density with quantitative ultrasound (QUS) in 128 sawmill workers (89 men and 39 women), mean age 39.1 +/- 10.8 years. Back strength was measured by dynamometry. Information on occupational and leisure physical activity, joint pain, education and smoking were obtained with the questionnaire. All QUS bone parameters and back strength were significantly higher in men than in women. A T score for quantitative ultrasound index (QUI) of − 2.2 or lower was found only in two men and one women. QUI did not significantly differ based on presence of parameters of physical occupational activity (carrying loads exceeding 5 kg, repetitive movements, physical exertion while working and non-sitting position at work). When controlling for age, gender and body mass index, participants with higher smoking index had significantly lower QUI (p=0.004). Physical workload was not significantly associated with QUI. In our working population, some lifestyle habits, such as smoking, had a greater impact on bone health than physical occupational activity.

scholarly journals Lactose Intolerance and Bone Health: The Challenge of Ensuring Adequate Calcium Intake

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 718 ◽  
Author(s):  
Joanna Hodges ◽  
Sisi Cao ◽  
Dennis Cladis ◽  
Connie Weaver
Keyword(s):  
Bone Health ◽  
Calcium Intake ◽  
Lactose Intolerance ◽  
Calcium Absorption ◽  
Fragility Fractures ◽  
Food Sources ◽  
Nutritional Deficiencies ◽  
Free Calcium ◽  
Lactase Deficiency ◽  
Dairy Consumption

Calcium is an important nutrient with impact upon many biological systems, most notably bone. Ensuring adequate calcium intake throughout the lifespan is essential to building and maintaining bone. Lactose intolerance may predispose individuals to low calcium intake as the number of lactose-free, calcium-rich food sources is limited. In this review, we summarize data from human and animal studies on the influence of lactose and lactase deficiency on calcium absorption and bone health. Based on the available evidence, neither dietary lactose nor lactase deficiency have a significant impact on calcium absorption in adult humans. However, lactose intolerance may lead to reduced bone density and fragility fractures when accompanied by decreased intake or avoidance of dairy. Recently published human trials and meta-analyses suggest a weak but significant association between dairy consumption and bone health, particularly in children. Given the availability of simple dietary approaches to building lactose tolerance and the nutritional deficiencies associated with dairy avoidance, multiple public health organizations recommend that all individuals—including those that are lactose intolerant—consume three servings of dairy per day to ensure adequate nutrient intakes and optimal bone health.

Predictors of bone mineral density in a convenience sample of young Caucasian adults living in southern Ontario

2012 ◽  
Vol 37 (4) ◽  
pp. 706-714 ◽  
Author(s):  
Laura E. Chouinard ◽  
Janis Randall Simpson ◽  
Andrea C. Buchholz
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Body Mass ◽  
Bone Mineral ◽  
Bone Health ◽  
Calcium Intake ◽  
Health Concern ◽  
Mineral Density ◽  
Southern Ontario ◽  
Men And Women

Osteoporosis is a major public health concern in Canada and worldwide. Although much is known about bone health in older adults, little is known about bone health in young, healthy Canadian men and women. The objectives of this research were to describe bone mineral density (BMD) of young, healthy adults living in southern Ontario, Canada, and to identify predictors of BMD in this population. Two-hundred and fifty-eight Caucasian men and women aged 18–33 years completed health and physical activity questionnaires along with a calcium and vitamin D specific food frequency questionnaire. Height and mass were measured. BMD of the total hip, femoral neck, spine, and total body was measured using dual energy X-ray absorptiometry. Among men, body mass, weight-bearing physical activity, and calcium intake were significant predictors of BMD. Among women, body mass, calcium intake, and family history of osteoporosis significantly predicted log BMD. The predictors of BMD in young Canadian men and women identified in this study may inform the development of longitudinal studies designed to examine the influence of lifestyle factors on BMD in young adults.

scholarly journals Greater Calcium Intake is Associated with Better Bone Health Measured by Quantitative Ultrasound of the Phalanges in Pediatric Patients Treated with Anticonvulsant Drugs

Nutrients ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 9908-9917 ◽  
Author(s):  
Vicente Vera ◽  
Jose Moran ◽  
Patricia Barros ◽  
Maria Canal-Macias ◽  
Rafael Guerrero-Bonmatty ◽  
...  
Keyword(s):  
Quantitative Ultrasound ◽  
Bone Health ◽  
Calcium Intake ◽  
Pediatric Patients ◽  
Anticonvulsant Drugs

The Effects of Body Composition, Dietary Intake, and Physical Activity on Calcaneus Quantitative Ultrasound in Spanish Young Adults

2016 ◽  
Vol 18 (4) ◽  
pp. 439-444 ◽  
Author(s):  
María Correa-Rodríguez ◽  
Jacqueline Schmidt Rio-Valle ◽  
Emilio González-Jiménez ◽  
Blanca Rueda-Medina
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Body Composition ◽  
Bone Mass ◽  
Dietary Intake ◽  
Lean Mass ◽  
Quantitative Ultrasound ◽  
Early Adulthood ◽  
Broadband Ultrasound Attenuation ◽  
Modifiable Factors

Identifying modifiable factors that influence bone gain during early adulthood in order to maximize peak bone mass (PBM) is a potential primary strategy in the prevention of osteoporosis in later life. The present study examined the relationships between body composition, dietary intake and physical activity (PA), and bone health measured by quantitative ultrasound (QUS) at the right calcaneus. The study population consisted of 781 Spanish men and women (age 19.1 ± 3.6). Body composition, dietary intake, PA, and bone strength were assessed. Calcaneus QUS was significantly correlated with age, height, weight, body mass index, lean mass, fat mass, protein intake, and moderate and high PA. No significant correlation between calcium intake and broadband ultrasound attenuation (BUA, dB/MHz) was detected. Linear regression analyses revealed that independent variables accounted for 18.8% of the total variance of calcaneus BUA ( p = .000). Lean mass and high PA were significant predictors of BUA variance in young adults ( p = .000 and p = .045, respectively). Results indicate that lifestyle choices and their consequences during early adulthood could influence bone mass, particularly PA and lean mass. Furthermore, this study provides novel data about bone mass as indicated by the QUS measurements at the time of PBM acquisition.

scholarly journals Genetic variants and physical activity interact to affect bone density in Hispanic children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruixue Hou ◽  
Shelley A. Cole ◽  
Mariaelisa Graff ◽  
Yujie Wang ◽  
Karin Haack ◽  
...  
Keyword(s):  
Physical Activity ◽  
Lumbar Spine ◽  
Bone Health ◽  
Calcium Intake ◽  
Genetic Variants ◽  
Genetic Risk ◽  
Polygenic Risk Score ◽  
Environment Interaction ◽  
Hispanic Children ◽  
Total Body

Abstract Background Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. Methods Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine BMD. Results We found evidence of statistically significant interaction effects between the PRS and MVPA on total body BMD and lumbar spine BMD (p < 0.05). Higher PRS was associated with a lower total body BMD (β = − 0.040 ± 0.009, p = 1.1 × 10− 5) and lumbar spine BMD (β = − 0.042 ± 0.013, p = 0.0016) in low MVPA group, as compared to high MVPA group (β = − 0.015 ± 0.006, p = 0.02; β = 0.008 ± 0.01, p = 0.4, respectively). Discussion The study indicated that calcium intake does not modify the relationship between genetic variants and BMD, while it implied physical activity interacts with genetic variants to affect BMD in Hispanic children. Due to limited sample size of our study, future research on gene by environment interaction on bone health and functional studies to provide biological insights are needed. Conclusions Bone health in Hispanic children with high genetic risk for low BMD is benefitted more by MVPA than children with low genetic risk. Our results may be useful to predict disease risk and tailor dietary and physical activity advice delivery to people, especially children.

scholarly journals Dietary Patterns of Greek Adults and Their Associations with Serum Vitamin D Levels and Heel Quantitative Ultrasound Parameters for Bone Health

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 123
Author(s):  
Effimia Grigoriou ◽  
George Trovas ◽  
Nikolaos Papaioannou ◽  
Ismene Dontas ◽  
Konstantinos Makris ◽  
...  
Keyword(s):  
Physical Activity ◽  
Dietary Patterns ◽  
Quantitative Ultrasound ◽  
Bone Health ◽  
Dietary Pattern ◽  
Dietary Habits ◽  
Univariate Analysis ◽  
Nutritional Habits ◽  
Vitamin D Levels ◽  
Greek Adults

The aim of this study is to investigate the dietary patterns which indicate the nutritional habits of Greek adults and their effects on serum 25(OH)D levels and quantitative ultrasound (QUS) parameters for bone health. This study is part of OSTEOS, an observational cross-sectional study. In total, 741 adults from rural and urban areas throughout Greece were recruited. A validated food frequency questionnaire (FFQ) was used for assessment of the population’s dietary habits. Serum 25(OH)D was measured by enzyme immunoassay; QUS parameters were assessed with an Achilles device. Principal component analysis (PCA) was carried out for dietary pattern determination, and univariate analysis of variance was used for the assessment of 25(OH)D, broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) determinants. Six dietary patterns explain 52.2% of the variability of Greek adults’ nutritional habits. The ‘vegetables–fruit’ dietary pattern explains the biggest rate of variability. Determinants of serum 25(OH)D are body mass index (BMI), elderly status, summer sun exposure, organized physical activity, a ‘healthy’ pattern in winter months, and adherence to a ‘sweet’ pattern. Determinants of QUS parameters are age, BMI, sedentary time, organized physical activity participation, and adherence to a ‘healthy’ pattern.

scholarly journals Factors Associated With Bone Health Status of Malaysian Pre-adolescent Children in the PREBONE-kids Study

2020 ◽  
Author(s):  
Chung Yuan Chang ◽  
Kanimolli Arasu ◽  
Soon Yee Wong ◽  
Shu Hwa Ong ◽  
Wai Yew Yang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Body Composition ◽  
Health Status ◽  
Bone Mineral ◽  
Lean Mass ◽  
Bone Health ◽  
Calcium Intake ◽  
Mineral Density ◽  
25 Oh Vitamin D

Abstract Background: Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study). Methods: Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ questionnaire, and serum 25(OH) vitamin D using LC-MS/MS. Results: The mean calcium intake was 348.8 ± 180.1 mg/day and mean serum 25-OH vitamin D level was 43.9 ± 14.5nmol/L. In boys, lean mass (LM) was significantly associated with LSBMC (β = 0.539, p<0.001), LSBMD (β=0.607, p<0.001), TBBMC (β=0.675, p<0.001) and TBBMD (β= 0.481, p<0.01). Height was significantly associated with LSBMC (β =0.346, p<0.001) and TBBMC (β =0.282, p<0.001) while fat mass (FM) (β=0.261, p=0.034) and MET score (β =0.163, p=0.026) were significant predictors of TBBMD. Among girls, LM was significantly associated with LSBMC (β = 0.620, p<0.001), LSBMD (β=0.700, p<0.001), TBBMC (β=0.542, p<0.001) and TBBMD (β= 0.747, p<0.001). Calcium intake was a significant predictor of LSBMC (β=0.102, p=0.034), TBBMC (β=0.122, p<0.001) and TBBMD (β=0.196, p=0.002) in girls. Lean mass (LM) was weakly correlated with MET scores (r = 0.205, p = 0.001) but not protein (r = 0.055, p = 0.393) or energy intake (r = 0.101, p = 0.117). MET score (β = 0.207, p = 0.043) was a significant predictor of LM in boys but no factor was found to predict LM in girls. Conclusion: LM is the major determinant of BMC and BMD among pre-adolescent Malaysian children and physical activity is a significant predictor of LM in boys. Encouraging physical activity, calcium intake and optimum diets that build lean body mass should be the focus for developing public health guidance to ensure optimal bone health status during rapid growth.

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