324-PA11 Treatment of multidrug-resistant pulmonary tuberculosis (MDR-TB) with scheme chemotherapy including ofloxacin, clofazimine and amikacin

1995 ◽  
Vol 76 ◽  
pp. 89
Author(s):  
M. Seiscento ◽  
F.A.F. Melo ◽  
J. Ide Neto ◽  
J.B. Affiune ◽  
A. Noronha
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Mdr Tb

scholarly journals Rifampicin and isoniazid drug resistance among patients diagnosed with pulmonary tuberculosis in southwestern Uganda

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0259221
Author(s):  
Lisa Nkatha Micheni ◽  
Kennedy Kassaza ◽  
Hellen Kinyi ◽  
Ibrahim Ntulume ◽  
Joel Bazira
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Bivariate Analysis ◽  
Newly Diagnosed ◽  
High Resolution Melt ◽  
Significant Control ◽  
Mdr Tb ◽  
Previously Treated ◽  
Southwestern Uganda

Multidrug-resistant tuberculosis (MDR-TB) has become a major threat to the control of tuberculosis globally. Uganda is among the countries with a relatively high prevalence of tuberculosis despite significant control efforts. In this study, the drug resistance of Mycobacterium tuberculosis to rifampicin (RIF) and isoniazid (INH) was investigated among patients diagnosed with pulmonary tuberculosis in Southwestern Uganda. A total of 283 sputum samples (266 from newly diagnosed and 17 from previously treated patients), collected between May 2018 and April 2019 at four different TB diagnostic centres, were assessed for RIF and INH resistance using high-resolution melt curve analysis. The overall prevalence of monoresistance to INH and RIF was 8.5% and 11% respectively, while the prevalence of MDR-TB was 6.7%. Bivariate analysis showed that patients aged 25 to 44 years were at a higher risk of developing MDR-TB (cOR 0.253). Furthermore, among the newly diagnosed patients, the prevalence of monoresistance to INH, RIF and MDR-TB was 8.6%, 10.2% and 6.4% respectively; while among the previously treated cases, these prevalence rates were 5.9%, 23.5% and 11.8%. These rates are higher than those reported previously indicating a rise in MTB drug resistance and may call for measures used to prevent a further rise in drug resistance. There is also a need to conduct frequent drug resistance surveys, to monitor and curtail the development and spread of drug-resistant TB.

scholarly journals KARAKTERISTIK PENDERITA TUBERKULOSIS PARU DENGAN MULTIDRUG-RESISTANT TUBERCULOSIS (MDR-TB) DI RSUD ULIN BANJARMASIN

2017 ◽  
Vol 13 (1) ◽  
pp. 23
Author(s):  
Gusti Andhika Azwar ◽  
Dewi Indah Noviana ◽  
FX. Hendriyono
Keyword(s):  
High School ◽  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
Senior High School ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Acid Fast Bacilli ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb

Abstract: Tuberculosis is the main health problem in the world and getting worse with Multidrug-Resistant Tuberculosis (MDR-TB) cases. Many research about MDR-TB patients is conducted to describe MDR-TB patients characteristics. This research aims to describe the characteristics of pulmonary tuberculosis MDR-TB at RSUD Ulin Banjarmasin on December 2015-May 2016. This was a descriptive research with crossectional approaches. Data were collected from clinical pathology laboratory and patients medical record. The Result indicate that as many as 19 pulmonary TB patients with MDR-TB at RSUD Ulin Banjarmasin on December 2015-May 2016 with characteristics were dominated by men 84,2% (16 subjects); age 45-54 years 35,8% (7 subjects); junior and senior high school both 21,1% (4 subjects); private employees 31,6% (6 subjects); came with TB relapses 68,4% (13 subjects); and the acid-fast bacilli examination showed negative and positive both 21,1% (4 subjects). In conclusion, the characteristics of pulmonary tuberculosis patients with Multidrug-Resistant Tuberculosis (MDR-TB) at RSUD Ulin Banjarmasin on December 2015-May 2016 are dominated by men, age 45-54 years old, junior and senior high school, private employees, from Banjarmasin, come with TB relapses and the acid-fast bacilli examination showed negative and positive. Keywords:     multidrug-resistant tuberculosis (MDR-TB), Tuberculosis patient’s characteristics, RSUD Ulin Banjarmasin Abstrak: Tuberkulosis merupakan masalah kesehatan utama di dunia dan bertambah berat dengan munculnya kasus multidrug-resistant tuberculosis (MDR-TB). Berbagai penelitian dilakukan untuk mengetahui karakteristik penderita MDR-TB. Oleh karena itu, penelitian ini bertujuan untuk mengetahui karakteristik penderita tuberkulosis paru dengan MDR-TB di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016. Penelitian  ini adalah penelitian deskriptif dengan rancangan cross-sectional. Data diambil dari Laboratorium Patologi Klinik dan rekam medis penderita. Hasil penelitian menunjukkan 19 penderita tuberkulosis paru dengan MDR-TB di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016 didominasi oleh laki-laki 84,2% (16 orang); usia 45-34 35,8% (7 orang); pendidikan SMP dan SMA masing-masing 21,1% (4 orang); pekerja swasta 31,6% (6 orang); berasal dari Banjarmasin 57,9% (11 orang); datang dengan keadaaan TB kasus relaps kategori 1 dan kategori 2 68,4% (13 orang); dan dengan hasil pemeriksaan sputum BTA positif dan negatif masing-masing 21,1% (4 orang). Kesimpulan penelitian ini adalah karakteristik penderita tuberkulosis paru dengan multidrug-resistant Tuberculosis (MDR-TB) di RSUD Ulin Banjarmasin periode Desember 2015-Mei 2016 didominasi oleh laki-laki, usia 45-54 tahun, pendidikan SMP dan SMA, pekerja swasta, berasal dari Banjarmasin, datang dengan keadaan kasus TB relaps dan hasil sputum BTA negatif dan positif. Kata-kata kunci:        Multidrug-resistant tuberculosis (MDR-TB), karakteristik penderita Tuberkulosis Paru

scholarly journals Efficiency of surgical treatment of multidrug-resistant Pulmonary Tuberculosis within the DOTS-PLUS program

2009 ◽  
Vol 8 (1) ◽  
pp. 85-91
Author(s):  
A. K. Strelis ◽  
A. A. Strelis ◽  
O. V. Anastasov ◽  
Ye. V. Nekrasov ◽  
V. K. Raskoshnykh ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Pulmonary Tuberculosis ◽  
Clinical Results ◽  
Multidrug Resistant ◽  
Positive Outcomes ◽  
Antituberculosis Drugs ◽  
Surgical Interventions ◽  
Tuberculosis Patients ◽  
Mdr Tb ◽  
Methods Of Treatment

Efficiency of the surgical treatment of pulmonary tuberculosis for multidrug-resistant (MDR TB) tuberculosis patients was analyzed. Seventy DOTS-PLUS patients with various clinical forms of pulmonary tuberculosis and Mycobacterium resistance from 3 to 8 antituberculosis drugs have been operated. Positive clinical results have been achieved for 65 (92,8%) patients. Indications for surgical treatment for patients with MDR TB have been developed. To ensure positive outcomes of the surgical interventions, main objective is the development of so-called a favorable preoperative environment during the preoperative phase. It includes switching on intensive chemotherapy and pathogenetic methods of treatment.

scholarly journals Comparison of Chest X-Ray Findings Between Primary and Secondary Multidrug Resistant Pulmonary Tuberculosis

2021 ◽  
Vol 5 (10) ◽  
pp. 903-910
Author(s):  
Ricky Septafianty ◽  
Anita Widyoningroem ◽  
M. Yamin S. S ◽  
Rosy Setiawati ◽  
Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
X Rays ◽  
Pulmonary Tb ◽  
X Ray ◽  
Pleural Thickening ◽  
Significant Difference ◽  
Record Data ◽  
Mdr Tb ◽  
Chest X Ray

Introduction: Radiological imaging has a key role in multidrug-resistant (MDR) pulmonary tuberculosis (TB) screening and diagnosis. However, new cases of MDR pulmonary TB are often overlooked; therefore, its transmission might continue before its diagnosis. The most widely used and affordable radiological modality is a chest radiograph. This study aims to describe the characteristics of primary and secondary MDR pulmonary TB chest x-ray findings for differential diagnosis. Methods: This study was an analytic observational study with a retrospective design. Researchers evaluated medical record data of primary and secondary MDR pulmonary TB patients who underwent chest x-ray examinations. The patient's chest x-rays were then evaluated. Evaluated variables were lung, pleural, and mediastinal abnormalities and severity category. Results: The most common chest x-ray finding in primary MDR pulmonary TB was consolidation (96.2%), which was mostly unilateral (52.0%), accompanied by cavities (71.2%), most of which were multiple (83.8%) with a moderate category of severity. The most common chest x-ray finding in secondary MDR pulmonary TB was consolidation (100%), which was mostly bilateral (60.4%), accompanied by cavities (80.2%), most of which were multiple (90.1%) with severe category of severity. Pleural thickening (47.5%) was also found. Conclusion: There was a significant difference between primary and secondary MDR pulmonary TB in terms of mild severity category, and pleural thickening. Mild severity category is mostly found in primary MDR-TB and pleural thickening is mostly found in secondary TB.

scholarly journals Genetic variability in multidrug-resistant Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in North India

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ajay Vir Singh ◽  
Suman Singh ◽  
Anjali Yadav ◽  
Shweta Kushwah ◽  
Rajbala Yadav ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Mycobacterium Tuberculosis ◽  
Genetic Variability ◽  
Pulmonary Tuberculosis ◽  
Control Strategies ◽  
Multidrug Resistant ◽  
North India ◽  
Drug Resistant ◽  
High Genetic Diversity ◽  
Mdr Tb

Abstract Background Information on the genetic variability of drug resistant isolates of Mycobacterium tuberculosis is of paramount importance to understand transmission dynamics of disease and to improve TB control strategies. Despite of largest number of multidrug-resistant (MDR) tuberculosis cases (1, 30,000; 27% of the global burden), strains responsible for the expansion or development of drug-resistant Mycobacterium tuberculosis infections have been poorly characterized in India. Present study was aimed to investigate the genetic diversity in MDR isolates of Mycobacterium tuberculosis in North India. Results Spacer oligonucleotide typing (spoligotyping) was performed on 293 clinical MDR isolates of Mycobacterium tuberculosis recovered from cases of pulmonary tuberculosis from North India. Spoligotyping identified 74 distinct spoligotype patterns. Comparison with an international spoligotype database (spoldb4 database) showed that 240 (81.91%) and 32 (10.92%) strains displayed known and shared type patterns, while 21 (7.16%) strains displayed unique spoligotype patterns. Among the phylogeographic lineages, lineage 3 (East African-Indian) was found most predominant lineage (n = 159, 66.25%), followed by lineage 2 (East Asian; n = 34, 14.16%), lineage 1 (Indo-Oceanic; n = 30, 12.50%) and lineage 4 (Euro American; n = 17, 7.08%). Overall, CAS1_DEL (60.41%; SITs 2585, 26, 2694, 309, 381, 428, 1401, 141, 25, 1327) was found most pre-dominant spoligotype pattern followed by Beijing (14.16%; SITs255, 260, 1941, 269) and EAI3_IND (5.00%; SITs 298, 338, 11). The demographic and clinical characteristics were not found significantly associated with genotypic lineages of MDR-M.tuberculosis isolates recovered from pulmonary TB patients of North India. Conclusions Present study reveals high genetic diversity among the Mycobacterium tuberculosis isolates and highlights that SIT141/CAS1_Del followed by SIT26/ Beijing lineage is the most common spoligotype responsible for the development and transmission of MDR-TB in North India. The high presence of shared type and unique spoligotype patterns of MDR strains indicates epidemiological significance of locally evolved strains in ongoing transmission of MDR-TB within this community which needs to be further monitored using robust molecular tools with high discriminatory power.

scholarly journals TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

2021 ◽  
Vol 17 (9) ◽  
pp. e1009941
Author(s):  
Jeffrey M. Collins ◽  
Dean P. Jones ◽  
Ashish Sharma ◽  
Manoj Khadka ◽  
Ken H. Liu ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Pulmonary Tuberculosis ◽  
Metabolic Response ◽  
Tca Cycle ◽  
Multidrug Resistant ◽  
Pulmonary Tb ◽  
Metabolic Remodeling ◽  
Mdr Tb ◽  
Key Driver ◽  
Tca Cycle Intermediates

The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1β-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of the proinflammatory metabolite succinate and decreased concentrations of the anti-inflammatory metabolite itaconate. This inflammatory metabolic response was particularly active in persons with multidrug-resistant (MDR)-TB that received at least 2 months of ineffective treatment and was only reversed after 1 year of appropriate anti-TB chemotherapy. Both succinate and IL-1β were significantly associated with proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids. Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1β-mediated proinflammatory eicosanoid signaling in pulmonary TB disease. These findings support host metabolic remodeling as a key driver of pathologic inflammation in human TB disease.

scholarly journals TCA cycle remodeling is associated with IL-1β-mediated proinflammatory eicosanoid signaling in humans with pulmonary tuberculosis

2021 ◽  
Author(s):  
Jeffrey M. Colins ◽  
Dean P. Jones ◽  
Ashish Sharma ◽  
Manoj Khadka ◽  
Ken Liu ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Inflammation ◽  
Tca Cycle ◽  
Multidrug Resistant ◽  
Inflammatory Signaling ◽  
Pulmonary Tb ◽  
Mdr Tb ◽  
Tca Cycle Intermediates ◽  
Cytokine Profiling

AbstractThe metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1β-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of TCA cycle intermediates such as succinate and decreases in itaconate. This inflammatory metabolic network was particularly active in persons with multidrug-resistant (MDR)-TB after receiving 2 months of ineffective treatment and was only reversed after 1 year of appropriate anti-TB chemotherapy. Both succinate and IL-1β were closely associated with increases in proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids. Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates are important drivers of IL-1β-mediated proinflammatory eicosanoid signaling in humans with pulmonary TB disease. Host-directed therapies that mitigate such metabolic reprograming may have potential to limit excessive pulmonary inflammation and tissue damage.

scholarly journals Comparison of Chest X-Ray Findings Between Primary and Secondary Multidrug Resistant Pulmonary Tuberculosis

2021 ◽  
Vol 5 (4) ◽  
pp. 855-862
Author(s):  
Ricky Septafianty ◽  
Anita Widyoningroem ◽  
M. Yamin S. S ◽  
Rosy Setiawati ◽  
Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
X Rays ◽  
Pulmonary Tb ◽  
X Ray ◽  
Pleural Thickening ◽  
Significant Difference ◽  
Record Data ◽  
Mdr Tb ◽  
Chest X Ray

Introduction: Radiological imaging has a key role in multidrug-resistant (MDR) pulmonary tuberculosis (TB) screening and diagnosis. However, new cases of MDR pulmonary TB are often overlooked; therefore, its transmission might continue before its diagnosis. The most widely used and affordable radiological modality is a chest radiograph. This study aims to describe the characteristics of primary and secondary MDR pulmonary TB chest x-ray findings for differential diagnosis. Methods: This study was an analytic observational study with a retrospective design. Researchers evaluated medical record data of primary and secondary MDR pulmonary TB patients who underwent chest x-ray examinations. The patient's chest x-rays were then evaluated. Evaluated variables were lung, pleural, and mediastinal abnormalities and severity category. Results: The most common chest x-ray finding in primary MDR pulmonary TB was consolidation (96.2%), which was mostly unilateral (52.0%), accompanied by cavities (71.2%), most of which were multiple (83.8%) with a moderate category of severity. The most common chest x-ray finding in secondary MDR pulmonary TB was consolidation (100%), which was mostly bilateral (60.4%), accompanied by cavities (80.2%), most of which were multiple (90.1%) with severe category of severity. Pleural thickening (47.5%) was also found. Conclusion: There was a significant difference between primary and secondary MDR pulmonary TB in terms of mild severity category, and pleural thickening. Mild severity category is mostly found in primary MDR-TB and pleural thickening is mostly found in secondary TB.

scholarly journals Laboratory evaluation of the efficacy of Liastene application in complex therapy of multiresistant pulmonary tuberculosis

2021 ◽  
pp. 25-31
Author(s):  
I.L. Platonova ◽  
M.I. Sakhelashvili ◽  
G.D. Shtybel ◽  
O.I. Sakhelashvili-Bil
Keyword(s):  
Pulmonary Tuberculosis ◽  
Dynamic Balance ◽  
Multidrug Resistant ◽  
Redox Activity ◽  
Laboratory Evaluation ◽  
Phagocytic Index ◽  
Control Group ◽  
Treatment Regimens ◽  
Mdr Tb ◽  
Experimental Group

OBJECTIVE. Evaluating according to laboratory tests the effectiveness of Liasten in the treatment of patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). MATERIALS AND METHODS. Evaluation of the effectiveness of etiotropic and etiopathogenetic therapy in 57 patients with MDR-TB was performed. According to the treatment schemes, patients were divided into groups. The control group (n=22) received individualized antimycobacterial therapy (AMBT) regimens. The experimental group (n=35) received AMBT in combination with Liasten. Evaluation of the effectiveness of treatment regimens was performed on the basis of indicators of general clinical blood tests, immunological and bacteriological studies. RESULTS AND DISCUSSION. In patients of the experimental group, compared with the control in 1.5 times more often found positive changes in the hemogram of blood and ESR (p<0.05-0.001), the establishment of a dynamic balance between the pools of lymphocyte cells CD4+ and СD8+ (immunoregulatory index, p<0.05), an increase in the number of phagocytosis active cells (phagocytic index, p<0.05), the content of cationic lysosomal proteins of granulocyte leukocytes (p<0.05), a 1.4-fold decrease in the cytochemical coefficient of neutrophils (p<0.05), the number of proliferated under the action of PPD-L lymphocytes (p<0.05), normalization of phagocytic counts and total redox activity of neutrophils (p<0.05), increase in frequency and reduction of anesthesia was stated. CONCLUSIONS. Restoration of the body’s immune status, blood hemogram, increase in frequency and reduction of the time of decontamination were more active and occurred 1.5 times more often in patients receiving a complex combination of AMBT with Liasten.

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