Improving the Laboratory Result Release Process in the Light of ISO 15189:2012 Standard

SummaryDuring the 20th century understanding for quality has changed and international and national requirements for quality have been published. Therefore also medical branches started to establish quality management systems. Quality assurance has always been important for medical laboratories. Certification according to the standard ISO 9001 and accreditation according to the standard ISO 17025 have been the proof of fulfilling quality requirements. The relatively new standard ISO 15189 is the first standard for medical laboratories. This standard includes technical and management requirements for the medical laboratory. The main focus is the proof of competence within the personnel. As this standard is accepted throughout the European Union an increase in accreditations of medical laboratories is predictable.

Download Full-text

A STUDY OF SOLUTIONS TO PREVENT THE EROSION OF THE MOSS GROWING ON ARCHITECTURES OF HUE IMPERIAL CITADEL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2012.4.9 ◽

2012 ◽

pp. 66-69

Author(s):

Nhan Duc Nguyen ◽

Cong Nho Luong ◽

Hoang Vu Nguyen

Keyword(s):

Citric Acid ◽

Key Words ◽

Environmentally Friendly ◽

Living Environment ◽

Laboratory Result ◽

Urgent Problem ◽

Funaria Hygrometrica ◽

Moss Species ◽

Measurement And Evaluation ◽

Scientific Name

Background: The erosion of mosses on the surface of Hue imperial citadel has caused a lot of harm and is currently an urgent problem to be solved. Objectives:1. Identifying some moss species growing on Hue relics. 2. Determining the cause of slipperiness and the living environment mosses. 3. Finding a solution to limit the intrusion of the mosses. Methods: The methods are: identifying scientific name by comparing patterns, identify mucus, pH measurement and evaluation of the effects of certain chemicals on the growth of mosses in the laboratory. Result: The moss species that develop popularly in Hue relics is Funaria hygrometrica, Bryum apiculatum, Trichostomum orthodontum, Fissidens lycopodioides. Funaria hygrometrica is the most popular moss. The cause of the slipperiness is mucus in moss cells released outside the moss after death. Mosses grow well in moist environments, clear and slightly acidic surface. After two days assessing the effect of citric acid 18%, 15%, 10% and 7% NaHCO3, 5%, 3% on the growth of moss, the mosses all died completely. Since then identified two types of chemicals have been found to completely dead moss, inexpensive, environmentally friendly and does not affect the surface of architectures are citric acid 10% solution and NaHCO3 3% solution. Keywords: The moss erosion, Funaria hygrometrica, mucus, citric acid, NaHCO3 Key words: The moss erosion, Funaria hygrometrica, mucus, citric acid, NaHCO 3

Download Full-text

Exploring siRNA Umpired Nanogels: A Tale of Barrier Combating Carrier

Current Pharmaceutical Design ◽

10.2174/1381612826666200417143800 ◽

2020 ◽

Vol 26 (27) ◽

pp. 3234-3250

Author(s):

Sushil K. Kashaw ◽

Prashant Sahu ◽

Vaibhav Rajoriya ◽

Pradeep Jana ◽

Varsha Kashaw ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Engineering ◽

Viral Infections ◽

Slow Release ◽

Molecular Level ◽

Release Kinetics ◽

Biologically Active ◽

Release Process ◽

Rapid Release ◽

Wide Range

Potential short interfering RNAs (siRNA) modulating gene expression have emerged as a novel therapeutic arsenal against a wide range of maladies and disorders containing cancer, viral infections, bacterial ailments and metabolic snags at the molecular level. Nanogel, in the current medicinal era, displayed a comprehensive range of significant drug delivery prospects. Biodegradation, swelling and de-swelling tendency, pHsensitive drug release and thermo-sensitivity are some of the renowned associated benefits of nanogel drug delivery system. Global researches have also showed that nanogel system significantly targets and delivers the biomolecules including DNAs, siRNA, protein, peptides and other biologically active molecules. Biomolecules delivery via nanogel system explored a wide range of pharmaceutical, biomedical engineering and agro-medicinal application. The siRNAs and DNAs delivery plays a vivacious role by addressing the hitches allied with chronic and contemporary therapeutic like generic possession and low constancy. They also incite release kinetics approach from slow-release while mingling to rapid release at the targets will be beneficial as interference RNAs delivery carriers. Therefore, in this research, we focused on the latest improvements in the delivery of siRNA loaded nanogels by enhancing the absorption, stability, sensitivity and combating the hindrances in cellular trafficking and release process.

Download Full-text

Dual Release Model to Evaluate Dissolution Profiles from Swellable Drug Polyelectrolyte Matrices

Current Drug Delivery ◽

10.2174/1567201817666200512093115 ◽

2020 ◽

Vol 17 (6) ◽

pp. 511-522 ◽

Cited By ~ 2

Author(s):

Alicia Graciela Cid ◽

María Verónica Ramírez-Rigo ◽

María Celeste Palena ◽

Elio Emilio Gonzo ◽

Alvaro Federico Jimenez-Kairuz ◽

...

Keyword(s):

Experimental Data ◽

Drug Release ◽

Inflection Point ◽

Release Profile ◽

Experimental Point ◽

Extended Model ◽

Release Process ◽

Proposed Model ◽

Dual Release ◽

Release Model

Background: Mathematical modeling in modified drug release is an important tool that allows predicting the release rate of drugs in their surrounding environment and elucidates the transport mechanisms involved in the process. Objective: The aim of this work was to develop a mathematical model that allows evaluating the release profile of drugs from polymeric carriers in which the swelling phenomenon is present. Methods: Swellable matrices based on ionic complexes of alginic acid or carboxymethylcellulose with ciprofloxacin were prepared and the effect of adding the polymer sodium salt on the swelling process and the drug release was evaluated. Experimental data from the ciprofloxacin release profiles were mathematically adjusted, considering the mechanisms involved in each stage of the release process. Results: A proposed model, named “Dual Release” model, was able to properly fit the experimental data of matrices presenting the swelling phenomenon, characterized by an inflection point in their release profile. This entails applying the extended model of Korsmeyer-Peppas to estimate the percentage of drug released from the first experimental point up to the inflection point and then a model called Lumped until the final time, allowing to adequately represent the complete range of the drug release profile. Different parameters of pharmaceutical relevance were calculated using the proposed model to compare the profiles of the studied matrices. Conclusion: The “Dual Release” model proposed in this article can be used to predict the behavior of complex systems in which different mechanisms are involved in the release process.

Download Full-text

Design and Experiment of Capacitive Micromachined Ultrasonic Transducer Array for High-Frequency Underwater Imaging

Recent Advances in Electrical & Electronic Engineering (Formerly Recent Patents on Electrical & Electronic Engineering) ◽

10.2174/2352096513999201026225123 ◽

2020 ◽

Vol 13 ◽

Author(s):

Yuanyu Yu ◽

Jiujiang Wang ◽

Xin Liu ◽

Sio Hang Pun ◽

Weibao Qiu ◽

...

Keyword(s):

Ultrasound Imaging ◽

High Frequency ◽

Ultrasonic Transducer ◽

Center Frequency ◽

Design Parameters ◽

Underwater Imaging ◽

Release Process ◽

Steel Wires ◽

Capacitive Micromachined Ultrasonic Transducer ◽

Frequency Ultrasound

Background:: Ultrasound is widely used in the applications of underwater imaging. Capacitive micromachined ultrasonic transducer (CMUT) is a promising candidate to the traditional piezoelectric ultrasonic transducer. In underwater ultrasound imaging, better resolutions can be achieved with a higher frequency ultrasound. Therefore, a CMUT array for high-frequency ultrasound imaging is proposed in this work. Methods:: Analytical methods are used to calculate the center frequency in water and the pull-in voltage for determining the operating point of CMUT. Finite element method model was developed to finalize the design parameters. The CMUT array was fabricated with a five-mask sacrificial release process. Results:: The CMUT array owned an immersed center frequency of 2.6 MHz with a 6 dB fractional bandwidth of 123 %. The pull-in voltage of the CMUT array was 85 V. An underwater imaging experiment was carried out with the target of three steel wires. Conclusion:: In this study, we have developed CMUT for high-frequency underwater imaging. The experiment showed that the CMUT can detect the steel wires with the diameter of 100 μm and the axial resolution was 0.582 mm, which is close to one wavelength of ultrasound in 2.6 MHz.

Download Full-text

Assessment of laboratory errors and best laboratory practices

International Journal of Bioassays ◽

10.21746/ijbio.2016.07.008 ◽

2016 ◽

Vol 5 (07) ◽

pp. 4704

Author(s):

Syed Riaz Mehdi* ◽

Sharique Ahmad ◽

Noorin Zaidi

Keyword(s):

External Quality Control ◽

External Quality ◽

Iso 15189 ◽

Laboratory Errors ◽

Control Programs ◽

Medical Laboratories ◽

Laboratory Error ◽

Active Communication ◽

Total Testing Process ◽

Five Phases

Laboratory error is defined by ISO 22367 as “Failure of planned actions to be completed as intended or use a wrong plan to achieve an aim”. Lundeberg in 1981 outlined the concept of Total Testing Process (TTP) and Plebani elaborated it further and classified the whole testing process into five phases of Pre-Pre Analytic, Pre Analytic, Analytic, Post Analytic and Post - Post Analytic. The errors have to be identified and resolved in each phase of the process. The medical laboratories have to run Internal and External Quality Control programs and abide by the guidelines of ISO 15189 in order to be accredited by bodies like JCI, CAP or NABL. Active communication and regular interaction between the clinicians and the laboratory is recommended during Pre Analytic and Post Analytic phases of TTP in order to achieve the target of Best Laboratory Practices.

Download Full-text

Research on the Ignition Height and Reaction Flame Temperature of PTFE/Al/Si/CuO with Different Mass Ratios of PTFE/Si

Materials ◽

10.3390/ma14133464 ◽

2021 ◽

Vol 14 (13) ◽

pp. 3464

Author(s):

Xuan Zou ◽

Jingyuan Zhou ◽

Xianwen Ran ◽

Yiting Wu ◽

Ping Liu ◽

...

Keyword(s):

Energy Release ◽

High Speed ◽

Flame Temperature ◽

Sintering Process ◽

Release Process ◽

Reactive Material ◽

Temperature Changes ◽

Release Capacity ◽

Mass Ratios ◽

The Relationship

Recent studies have shown that the energy release capacity of Polytetrafluoroethylene (PTFE)/Al with Si, and CuO, respectively, is higher than that of PTFE/Al. PTFE/Al/Si/CuO reactive materials with four proportions of PTFE/Si were designed by the molding–sintering process to study the influence of different PTFE/Si mass ratios on energy release. A drop hammer was selected for igniting the specimens, and the high-speed camera and spectrometer systems were used to record the energy release process and the flame spectrum, respectively. The ignition height of the reactive material was obtained by fitting the relationship between the flame duration and the drop height. It was found that the ignition height of PTFE/Al/Si/CuO containing 20% PTFE/Si is 48.27 cm, which is the lowest compared to the ignition height of other Si/PTFE ratios of PTFE/Al/Si/CuO; the flame temperature was calculated from the flame spectrum. It was found that flame temperature changes little for the same reactive material at different drop heights. Compared with the flame temperature of PTFE/Al/Si/CuO with four mass ratios, it was found that the flame temperature of PTFE/Al/Si/CuO with 20% PTFE/Si is the highest, which is 2589 K. The results show that PTFE/Al/Si/CuO containing 20% PTFE/Si is easier to be ignited and has a stronger temperature destruction effect.

Download Full-text

Distributed Thermal Energy Storage Configuration of an Urban Electric and Heat Integrated Energy System Considering Medium Temperature Characteristics

Energies ◽

10.3390/en14102924 ◽

2021 ◽

Vol 14 (10) ◽

pp. 2924

Author(s):

Wei Wei ◽

Yusong Guo ◽

Kai Hou ◽

Kai Yuan ◽

Yi Song ◽

...

Keyword(s):

Energy Storage ◽

Thermal Energy ◽

Thermal Energy Storage ◽

Internal Heat ◽

Configuration Model ◽

Electric Heater ◽

Heat Network ◽

Release Process ◽

Medium Temperature ◽

Temperature Characteristics

Distributed thermal energy storage (DTES) provides specific opportunities to realize the sustainable and economic operation of urban electric heat integrated energy systems (UEHIES). However, the construction of the theory of the model and the configuration method of thermal storage for distributed application are still challenging. This paper analyzes the heat absorption and release process between the DTES internal heat storage medium and the heat network transfer medium, refines the relationship between heat transfer power and temperature characteristics, and establishes a water thermal energy storage and electric heater phase change thermal energy storage model, considering medium temperature characteristics. Combined with the temperature transmission delay characteristics of a heat network, a two-stage optimal configuration model of DTES for UEHIES is proposed. The results show that considering the temperature characteristics in the configuration method can accurately reflect the performance of DTES, enhance wind power utilization, improve the operation efficiency of energy equipment, and reduce the cost of the system.

Download Full-text