scholarly journals Electrospun Poly(ω-pentadecalactone-co-ε-caprolactone)/Gelatin/Chitosan Ternary Nanofibers with Antibacterial Activity for Treatment of Skin Infections

2022 ◽  
pp. 106113
Author(s):  
Cansu ULKER TURAN ◽  
Yuksel GUVENILIR
Keyword(s):  
Antibacterial Activity ◽  
Skin Infections

scholarly journals Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Jane Namukobe ◽  
Peter Sekandi ◽  
Robert Byamukama ◽  
Moses Murungi ◽  
Jennifer Nambooze ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Inhibitory Concentration ◽  
Antioxidant Properties ◽  
Sun Protection ◽  
Albino Rats ◽  
Skin Infections ◽  
Double Beam ◽  
Protection Potential ◽  
Bacterial Skin Infections

Abstract Background Rural populations in Uganda rely heavily on medicinal plants for the treatment of bacterial skin infections. However, the efficacy of these medicinal plants for their pharmacological action is not known. The study aimed at evaluating the antibacterial, antioxidant, and sun protection potential of Spermacoce princeae, Psorospermum febrifugum, Plectranthus caespitosus, and Erlangea tomentosa extracts. Methods The plant samples were extracted by maceration sequentially using hexane, dichloromethane, ethyl acetate, methanol, and distilled water. Antibacterial activity of each extract was carried out using an agar well diffusion assay against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonie, Streptococcus pyogenes, and Salmonella typhi. Acute dermal toxicity of the aqueous extract of S. princeae and P. febrifugum, and E. tomentosa was assessed in young adult healthy Wistar albino rats at a dose of 8000 and 10,000 mg/kg body weight. The antioxidant activity of each extract was carried out using a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The sun protection factor was determined using Shimadzu UltraViolet-Visible double beam spectrophotometer between 290 and 320 nm. Results The plant extracts showed good antibacterial activity against the tested bacterial strains with minimum inhibitory concentration (MIC) ranging between 3.12 and 12.5 mg/ml. There was no significant change in the levels of creatinine, alanine aminotransferase, and aspartate aminotransferase in the rats even at a higher dose of 10,000 mg/kg, which was related to the results of biochemical analysis of the blood samples from the treated and control groups. The aqueous and methanol extracts of S. princeae showed potential antioxidant properties, with half maximal inhibitory concentration (IC50) values of 59.82 and 61.20 μg/ml respectively. The organic and aqueous extracts of P. caespitosus showed high levels of protection against Ultraviolet light with sun protection potential values ranging between 30.67 and 37.84. Conclusions The study demonstrated that the selected medicinal plants possessed good antibacterial, antioxidant, and sun protection properties. Therefore, the plants are alternative sources of antibacterial, antioxidant, and sun protection agents in managing bacterial skin infections.

scholarly journals Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria

2018 ◽  
Vol 2018 ◽  
pp. 1-16
Author(s):  
Blessing O. Oyedemi ◽  
Sunday O. Oyedemi ◽  
Johnson V. Chibuzor ◽  
Ifeoma I. Ijeh ◽  
Roger M. Coopoosamy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Current Trend ◽  
Radical Scavenging ◽  
Herbal Remedies ◽  
Dependent Manner ◽  
Skin Infections ◽  
Antioxidant Power

Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased morbidity and premature death. The purpose of this study was to document medicinal plants used in the management of oral and skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the in vitro antioxidant and antibacterial activity. The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using a various solvent system of different polarity index. The antioxidant capacity of the plant extracts was evaluated using chemical-based methods, and its antibacterial effect was investigated using disc diffusion and microdilution methods. Sixty-one plant species belonging to 26 families were discovered, and the most frequently cited species are Euphorbiaceae (18.03%), Fabaceae (11.47%), and Asteraceae (11.47%). All the plant extracts showed a promising free radical scavenging activity and efficient ferric reducing antioxidant power in a concentration-dependent manner possibly due to their richness in polyphenol with TLC profiling showing maximum three bands of phytochemicals. Also, the plant extracts exhibited a mild to weak antibacterial activity against our panel of bacterial strains having MIC values ranging from 256 to > 512 μg/ mL reflected in their zone of inhibition at 10 μg/disc. The data obtained for Breynia nivosa (BN), Eleusine indica (EI), Cassia alata (CA), Chromolaena odorata (CO), and Acalypha hispida (AH) extracts substantiate the traditional use of these herbal remedies in the region and open the possibility for the development of cheaper and affordable drugs in the treatment of oral and skin infections. Further studies are needed to identify active ingredient with strong antibacterial and antioxidant capacities along with their molecular mechanisms.

scholarly journals ANTIBACTERIAL ACTIVITY TEST OF LEAVES KECOMBRANG (NICOLAIA SPECIOSA) ETHANOLIC EXTRACTS AGAINST STAPHYLOCOCCUS AUREUS

2020 ◽  
Vol 7 (2) ◽  
pp. 51-58
Author(s):  
Rinda Binugraheni ◽  
Ndaru Trisni Larasati
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Infectious Diseases ◽  
Leaf Extract ◽  
Diffusion Method ◽  
Skin Infections ◽  
Activity Test ◽  
Ethanolic Extracts ◽  
Made In ◽  
Data Result

Infectious diseases that often occur in humans are skin infections. One of the bacteria that cause infection in humans is Staphylococcus aureus. One of the plants used as an ingredient in traditional medicine and used as an anti-bacterial is a kecombrang plant. This research aims to test the antibacterial activity of leaf extract of kecombrang against Staphylococcus aureus. Kecombrang leaf obtained from Pandeglang Banten. Kecombrang leaves extracted with a maceration method using 96% ethanol solvent. Extracts of leaves are made in a various concentrations (100%, 75%, 50%, and 25%). The antibacterial activity test was performed by using the diffusion method to find out the large zone of diameter are formed to inhibiting Staphylococcus aureus bacteria.The results of the antibacterial activity of the leaves extract of kecombrang to Staphylococcus aureus at 25%, 50%, 75% and 100% concentrations respectively were 12.67 mm, 14.33 mm, 15.33 mm, and 17.00 mm. The data result showed, that leaf extract of kecombrang with 100% concentration had the largest inhibiting zone diameter of 17.00 mm, among other concentrations. This suggests that kecombrang leaf extract have antibacterial activity against Staphylococcus aureus.

scholarly journals Antibacterial Activity of Red yeast rice Extract against Propionibacterium acnes ATCC 11827 and Methicilin-Resistant Staphylococcus aureus ATCC BAA-1683

2021 ◽  
Vol 6 (2) ◽  
pp. 83
Author(s):  
Tiana Milanda ◽  
Ade Zuhrotun ◽  
Ulya Nabila ◽  
Vesara A. Gathera ◽  
Arif S.W Kusuma
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Propionibacterium Acnes ◽  
Ethyl Acetate Extract ◽  
Acne Vulgaris ◽  
Resistance Testing ◽  
Red Yeast Rice ◽  
Skin Infections ◽  
Red Yeast

Propionibacterium acnes ATCC 11827 and Methicillin-Resistant Staphylococcus aureus ATCC BAA-1683 are bacteria that cause skin infections, namely acne vulgaris and skin and soft tissue infection/SSTI. The increase in the number of resistant bacterial strains, such as MRSA,  requires the search for alternative antibiotics, including using natural ingredients. Red yeast rice is a product of rice fermentation by Monascus purpureus, which is known to have antibacterial, antifungal, antitumor, antioxidant, anti-inflammatory, anti-cholesterol and immunomodulator. This study aims to determine the antibacterial activity of several red yeast rice extracts against these bacteria that cause skin infections. The research was carried out through the stages of collecting materials and identifying the yeast isolates, extracting of red yeast rice, phytochemical screening of red yeast rice extract, confirmation of bacterial test, preparation of bacterial test suspension, testing for bacterial resistance, testing for antibacterial activity of red yeast rice extract and determining the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active extract. The results showed that the ethyl acetate and ethanol extracts had antibacterial activity against P. acnes ATCC 11827 and MRSA ATCC BAA-1683. Both extracts contain compounds from the polyphenols, flavonoids, quinones and saponins group. Ethyl acetate extract was the most active extract with MIC values against P. acnes ATCC 1182 and MRSA ATCC BAA-1683 of 50 mg/mL and 12.5 mg/mL. The MBC values of ethyl acetate extract against these bacterial tests were 100 mg/mL and 25 mg/mL. The ethyl acetate extract is more active against MRSA ATCC BAA-1683 than against P. acnes ATCC 11827. From the results of this study it is known that red yeast rice has activity against bacteria that cause skin infections, especially against MRSA

scholarly journals SIZE DEPENDENT APPLICATION OF BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES AGAINST BACTERIAL SKIN PATHOGENS

2017 ◽  
Vol 10 (10) ◽  
pp. 192 ◽  
Author(s):  
Patil Sunita ◽  
Muthusamy Palaniswamy
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Plant Extract ◽  
Skin Infections ◽  
Bacterial Strains ◽  
Extract Concentration ◽  
Childhood Morbidity ◽  
Common Skin ◽  
Staphylococcus Infections ◽  
Absorbance Peak

  Objective: Bacterial skin infection is one of the most common causes of childhood morbidity in India. Mostly, it is caused by Streptococcus and Staphylococcus infections. However, because of antibiotic resistance in bacterial strains, treatment of skin infections is becoming increasingly difficult. The objective of this research is to study the effect of plant extract concentration on synthesis and morphology of biological silver nanoparticles and investigation of their activity against bacterial skin pathogens.Methods: Biological silver nanoparticles were synthesized using two concentrations (5 and 10 ml) of Aegle marmelos fruit pulp extract. Ultraviolet (UV)-visible spectroscopy, field emission scanning microscopy (FESEM), and high resolution transmission electron microscopy (HRTEM) were used to analyze morphological features of nanoparticles. Antibacterial activity of synthesized silver nanoparticles was studied against the most common skin pathogens Staphylococcus aureus and Streptococcus pyogen, using a well diffusion method.Results: The silver nanoparticles synthesized from 5 ml extract showed UV-absorbance peak at 430 nm with 14-18 nm size, while silver nanoparticles synthesized from 10 ml extract was showed the absorbance at 427 nm with 4-8 nm size. FESEM and HRTEM analysis revealed that both the silver nanoparticles were spherical in shape. Both nanoparticles have shown antibacterial activity among them silver nanoparticles synthesized from 10 ml extract showed better antibacterial activity.Conclusion: This research confirms that plant extract concentration modulate the rate of synthesis, morphology, surface plasmon resonance, and activity of biological silver nanoparticles. Silver nanoparticles synthesized from 10 ml extract can be used efficiently in the treatment of bacterial skin infections.

scholarly journals ACTIVITY OF POLYHERBAL EXTRACT AGAINST BACTERIA CAUSING SKIN INFECTIONS IN DIABETIC PATIENTS.

2017 ◽  
Vol 10 (5) ◽  
pp. 147
Author(s):  
Chaitanya Sravanthi Kota ◽  
Chaitanya Sravanthi Kota ◽  
Chaitanya Sravanthi Kota
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Bacillus Subtilis ◽  
Diabetic Patients ◽  
Phytochemical Analysis ◽  
Skin Infections ◽  
Klebsiella Species ◽  
Standard Drug ◽  
Agar Diffusion

Objective   : - The objective of   this   study is to evaluate antibacterial activity of Polyherbal extract on few    microorganisms causing skin infections in most of the  diabetic patients  .Methods   : - Methanolic Polyherbal extract was prepared  from Acacia ferruginia (bark & fruit), Chloroxylon swietenia (bark, leaf, root), Casearia elliptica (bark), Terminalia alata (root, leaf). The preliminary phytochemical analysis was performed to identify the major phytoconstituents  in the extract.  Polyherbal extract was evaluated for antibacterial activity against bacteria   like Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa,   Escherichia coli, Proteus species, Klebsiella species causing skin infections , diabetic foot infections in diabetic patients. In-vitro method of agar diffusion disc method was used for the evaluation of antibacterial activity through zone of inhibition.  The standard drug used was Gentamicin. Minimum Inhibitory Concentration (MIC) of the extract was done  using broth dilution method.Results:  The polyherbal extract showed good antibacterial activity. The standard drug used was Gentamicin.  The Methanolic   Polyherbal extract showed   potent activityon all the selected microorganisms. The Polyherbal extract was active  against Pseudomonas aeruginosa (2.57 +  0.39) and E.coli (2.92 + 0.29) when compared with standard. The polyherbal extract showed potent activity  on Bacillus subtilis and  Proteus vulgaris.Conclusion : The polyherbal extract showed broad spectrum activity by being active against gram positive and gram negative microorganisms providing the scope for further analysis as a antibacterial preparation for the skin infections in diabetes patients. Keywords: Antibacterial activity, skin infections, diabetes, Polyherbal Extract, Agar diffusion disc.

scholarly journals Experimental Paper. Activity of essential oils against Staphylococcus aureus strains isolated from skin lesions in the course of staphylococcal skin infections

2017 ◽  
Vol 63 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Paweł Kwiatkowski ◽  
Magdalena Mnichowska-Polanowska ◽  
Agata Pruss ◽  
Małgorzata Dzięcioł ◽  
Helena Masiuk
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Essential Oils ◽  
Antimicrobial Agents ◽  
Skin Lesions ◽  
Dilution Method ◽  
Skin Infections ◽  
Staphylococcal Infections ◽  
Staphylococcal Skin Infections

SummaryIntroduction: Staphylococcus aureus is an important etiological agent of skin and soft tissue infections. Due to the increasing resistance of this bacterium to antimicrobial agents, treatment of staphylococcal infections remains a great challenge for clinicians and requires an alternative treatment options. Objective: The aim of the study was to determine the antimicrobial activity of essential oils: caraway (CEO), patchouli (PEO) and geranium (GEO) against S. aureus strains isolated from skin lesions in the course of staphylococcal skin infections. Methods: The antibacterial activity of essential oils was tested using the dilution method in Mueller-Hinton broth. Results: The antimicrobial effect of CEO, PEO and GEO was observed. The highest antimicrobial activity showed PEO (MIC = 1.7±0.8 µl/ml), the lower was observed for GEO (MIC = 5.4±2.0 µl/ml) and CEO (MIC = 18.8±10.3 µl/ml). Conclusion: All tested essential oils showed antibacterial activity against S. aureus strains isolated from skin lesions of patients with staphylococcal skin infections. Application of the CEO, PEO and GEO can become an alternative method of treatment of staphylococcal infections, but further microbiological tests and clinical trials should be assessed.

scholarly journals Development and Evaluation of Antibacterial Polyherbal Bath Soap

2021 ◽  
Vol 6 (5) ◽  
pp. 45-52
Author(s):  
Seema U. Shinde ◽  
Nikita D. Gidde ◽  
Jamir. A. Tamboli
Keyword(s):  
Antibacterial Activity ◽  
Curcuma Longa ◽  
Antibacterial Properties ◽  
Cost Effective ◽  
Skin Infections ◽  
E Coli ◽  
Diffusion Technique ◽  
Ongoing Care ◽  
Bacterial Skin Infections ◽  
Herbal Plant

Bacterial skin infections are the most prevalent among individuals, necessitating immediate treatment as well as ongoing care to preserve healthy skin. Because some herbal plant extracts have antibacterial properties, the goal of this research is to make an antibacterial poly herbal bath soap using curcuma longa[Turmeric] and Organum Vulgare [Oregano The antibacterial activity of prepared soap was evaluated against staphylococcus aureus, E. coli, and Aspergillus Niger using the agar well diffusion technique. The developed Polyherbal formulation had a good antibacterial activity, and it was analysed for several physicochemical parameters and whether it has good characteristics. Plants are easily obtainable, and their efficacy helps manufacturers in achieving cost-effective outcomes with few or no side effects.

scholarly journals Formulation and Evaluation of Antimicrobial Herbal Soap

2021 ◽  
Vol 71 (2) ◽  
Author(s):  
Seetha Devi Dr.A. ◽  
Sivani D.V. ◽  
Anusha D. ◽  
Sarath G. ◽  
Syed Meraj Sultana
Keyword(s):  
Antibacterial Activity ◽  
Cost Effective ◽  
Diffusion Method ◽  
Skin Infections ◽  
Ocimum Tenuiflorum ◽  
Bacterial Skin Infections ◽  
Herbal Plant ◽  
Significant Attention ◽  
Bacterial Effect ◽  
Agar Well Diffusion Method

Bacterial skin infections are most common amongst people, requiring significant attention for treatment and also for maintaining healthy skin. Some herbal plant extracts and their oils were found to have antibacterial activity. The aim and objective of the present study are to formulate and evaluate anti-bacterial herbal soap using Azadirachta indica, Ocimum tenuiflorum oils. The antibacterial activity of the prepared formulations was tested using the agar well diffusion method against the organisms Pseudomonas aeruginosa, Staphylococcus aureus and, Escherichia coli and they exhibited a good anti-bacterial effect. The prepared formulations were evaluated for various physicochemical parameters for which good characteristics were observed. The easy availability of plants and their effectiveness helps manufacturers with cost-effective benefits and with less or no side effects.

Sign in / Sign up

Export Citation Format

Share Document