Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents

2020 ◽  
Vol 333 ◽  
pp. 127478 ◽  
Author(s):  
Gui-Lin Chen ◽  
Yong-Bing Xu ◽  
Jian-Lin Wu ◽  
Na Li ◽  
Ming-Quan Guo
Keyword(s):  
Moringa Oleifera ◽  
Chemical Constituents ◽  
Moringa Oleifera Leaves

scholarly journals The Chemical Composition of Egyptian Moringa Oleifera Grown in Different Agro-Ecological Regions

2018 ◽  
Vol 8 ◽  
pp. 1467-1475
Author(s):  
Samar Rhyem
Keyword(s):  
Chemical Composition ◽  
Sandy Soil ◽  
Moringa Oleifera ◽  
Ph Value ◽  
Chemical Constituents ◽  
Beta Carotene ◽  
Total Phenolic ◽  
Ecological Regions ◽  
Moringa Oleifera Leaves ◽  
Loam Soil

Moringa Oleifera plant is successfully grown in Egypt now their leaves are highly nutritious and can be eaten either fresh or cooked. Aim Evaluate chemical composition of Egyptian Moringa Oleifera leaves grown in different agro-ecological regions. Methods; Same age leaves were collected from private farm in Gharbiya governorate (loam soil) and from western dessert (sandy soil). Leaves were subjected to proximate, vitamin, minerals and antioxidants analysis. Results; soil types widely affect the results depending on the nutrients and ph value. Fresh leaves contain the highest moisture content and the lowest nutrients comparing to dried leaves. Moringa Oleifera grown in sandy soil had the highest content of ash, carbohydrate and minerals including; Ca, Zn, Na, K, Mg and Fe compared to which grown in loam soil. Vitamin C, beta carotene, total phenolic, total flavonoids, and total antioxidant capacity were higher in leaves cultivated from loam soil than sandy soil as  67.93, 1497, 58.9, 90.8 mg/g , 65% and 60.5, 1303.9, 50.4, 80.5mg/g, and 59% respectively. Variability in chemical composition is likely due to differences in soil, climate, and plant age. These relatively diverse chemical constituents may be responsible for the medicinal properties of Moringa Oleifera leaves

scholarly journals Comparative Analysis of Chemical Constituents of Moringa oleifera Leaves from China and India by Ultra-Performance Liquid Chromatography Coupled with Quadrupole-Time-Of-Flight Mass Spectrometry

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 942 ◽  
Author(s):  
Hongqiang Lin ◽  
Hailin Zhu ◽  
Jing Tan ◽  
Han Wang ◽  
Zhongyao Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Moringa Oleifera ◽  
Chemical Constituents ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Multivariate Statistical ◽  
Flight Mass Spectrometry ◽  
Moringa Oleifera Leaves ◽  
Potential Biomarkers

With the aim to discuss the similarities and differences of phytochemicals in Moringa oleifera leaves collected from China (CML) and India (IML) in mind, comparative ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-QTOF-MS) analysis was performed in this study. A screening analysis based on a UNIFI platform was first carried out to discuss the similarities. Next, untargeted metabolomic analysis based on multivariate statistical analysis was performed to discover the differences. As a result, a total of 122 components, containing 118 shared constituents, were characterized from CML and IML. The structure types included flavonoids, alkaloids, glyosides, organic acids and organic acid esters, iridoids, lignans, and steroids, etc. For CML, 121 compounds were characterized; among these, 18 potential biomarkers with higher contents enabled differentiation from IML. For IML, 119 compounds were characterized; among these, 12 potential biomarkers with higher contents enabled differentiation from CML. It could be concluded that both CML and IML are rich in phytochemicals and that CML is similar to IML in the kinds of the compounds it contains, except for the significant differences in the contents of some compounds. This comprehensive phytochemical profile study provides a basis for explaining the effect of different growth environments on secondary metabolites and exists as a reference for further research into or applications of CML in China.

Protective Effect of Moringa Oleifera Leaves Against TramadolInduced Nephrotoxicity in Mice

2017 ◽  
Vol 9 (02) ◽  
Author(s):  
Ashraf Albrakati
Keyword(s):  
Oral Dose ◽  
Moringa Oleifera ◽  
Treated Group ◽  
Control Group ◽  
Serum Urea ◽  
Kidney Function Tests ◽  
Mean Values ◽  
Intraperitoneal Dose ◽  
Moringa Oleifera Leaves ◽  
The Mean

Tramadol, a broadly in recent years, is an effective analgesic agent for the treatment of moderate to acute pain. Its metabolites are excreted by the kidney which may cause nephrotoxicity. Moringa oleifera leaves are commonly used to provide herbal and plant-derived medicinal products especially in developing nations. The present study was carried out to determine the biochemical and histopathological changes in the kidney of tramadol-treated albino mice and to evaluate the possible protective role of Moringa oleifera leaves against tramadol-induced nephrotoxicity. Twenty adult albino mice were divided into four groups. Control group (group i) received daily intraperitoneal injection of normal saline only, group ii received oral dose of Moringa oleifera leaves extract (20 mg/kg/bw) for three weeks, group iii received daily intraperitoneal dose of tramadol (0.3 mg/kg/bw) for the same period, group iv, received daily oral dose of Moringa oleifera leaves extract, (20 mg/kg/bw) three hours before injecting intraperitoneal dose of tramadol (0.3 mg/kg/bw), for the same period. Blood samples were withdrawn at the end of the experiment for kidney function tests and specimens from the kidney were processed for histological study. No significant differences in the mean values of the kidney function tests were noticed between Moringa oleifera group and control group. However, there was highly significant increase in the mean values of serum, urea and creatinine in tramadol-treated group as compared to the control group. Although tramadol + Moringa oleifera group revealed significant difference in the mean values of urea and creatinine when compared with tramadol-treated group. So, Moringa oleifera leaves extract have been shown to attenuate the renal dysfunction, improve the renal architecture, with nearly normalization of serum urea and creatinine levels which indicate improvement of renal function. In conclusion, in the light of biochemical results and histological findings, co-administration of Moringa oleifera leaves lessened the negative effects of tramadol-induced nephrotoxicity; possibly by its antioxidant action. Further investigation of these promising protective effects of Moringa oleifera leaves against tramadol-induced renal injury may have considerable impact on developing an adjunct therapy aiming to improve the therapeutic index of some nephrotoxic drugs.

Assessment on bioactive role of Moringa oleifera leaves as anthelmintic agent and improved growth performance in goats

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Juan Pedraza-Hernández ◽  
Mona M. M. Y. Elghandour ◽  
Ameer Khusro ◽  
Mohamed Z. M. Salem ◽  
Luis M. Camacho-Diaz ◽  
...  
Keyword(s):  
Growth Performance ◽  
Moringa Oleifera ◽  
Moringa Oleifera Leaves

scholarly journals Impact of Dietary Supplementation with Moringa oleifera Leaves on Performance, Meat Characteristics, Oxidative Stability, and Fatty Acid Profile in Growing Rabbits

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 248
Author(s):  
Shaimaa Selim ◽  
Mahmoud F. Seleiman ◽  
Mohamed M. Hassan ◽  
Ahmed A. Saleh ◽  
Mohamed A. Mousa
Keyword(s):  
Antioxidant Capacity ◽  
Nutritional Value ◽  
Moringa Oleifera ◽  
Live Weight ◽  
Dietary Supplementation ◽  
Serum Levels ◽  
Relative Content ◽  
Daily Weight Gain ◽  
Control Group ◽  
Moringa Oleifera Leaves

Moringa oleifera leaves (MOL) have gained great interest as a non-traditional feed ingredient due to their unique nutritional value. Therefore, the objective of the current study was to evaluate the effects of graded dietary supplementation levels with MOL on performance, carcass characteristics, antioxidant capacity, blood biochemical constituents, meat quality, and fatty acids profile of growing rabbits. A total of 120 weaned New Zealand white rabbits (6 weeks old) were randomly allotted into 4 dietary groups with 5 replicates each (n = 6), which were fed for 42 days with a basal diet as control or 3 experimental diets supplemented with 5, 10, or 15 g/kg MOL. The results showed that, compared to the control group, the dietary inclusion of MOL at a level of 10 and 15 g/kg DM linearly increased (p < 0.01) final live weight (2403.3 and 2498.2 vs. 2166.6) and average daily weight gain (36.5 and 35.51 g/d vs. 28.72 g/d), and enhanced feed conversion ratio (2.49 and 2.50 vs. 3.14). The dietary supplementation with MOL linearly increased dressing out percentage, spleen index, intestinal length, and decreased abdominal fat index (p < 0.01). Greater serum levels of total protein and globulin, but lower alanine aminotransferase and aspartate aminotransferase were observed in the MOL-fed rabbits (p < 0.01). Serum levels of total triglycerides, cholesterol, and low-density lipoprotein (p < 0.05) were decreased linearly and quadratically in the MOL groups compared with the control. Glutathione peroxidase activity increased (p < 0.01), whereas malondialdehyde decreased (p < 0.01) linearly and quadratically in both serum and meat, in response to dietary MOL supplementation. Dietary MOL supplementation increased the meat crude protein content but lowered the relative content of ether extract in the meat (p < 0.05). The relative content of the meat n-3 PUFA was increased by about 33.71%, 29.46%, and 24.36% for the MOL0.5%, MOL1%, and MOL1.5% groups compared to control. In conclusion, MOL could be used at a level of 1.5g/kg of the growing rabbits’ diets with beneficial impacts on performance, antioxidant capacity, and the nutritional value of the meat.

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