Extrusion improves the phenolic profile and biological activities of hempseed (Cannabis sativa L.) hull

2021 ◽  
Vol 346 ◽  
pp. 128606
Author(s):  
William Leonard ◽  
Pangzhen Zhang ◽  
Danyang Ying ◽  
Yun Xiong ◽  
Zhongxiang Fang
Keyword(s):  
Cannabis Sativa ◽  
Biological Activities ◽  
Phenolic Profile

scholarly journals Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 942
Author(s):  
Emilie Isidore ◽  
Hamza Karim ◽  
Irina Ioannou
Keyword(s):  
Phenolic Compounds ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Operating Conditions ◽  
Extraction Techniques ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Whole Plant ◽  
Conventional Solvent Extraction ◽  
By Products

Cannabis sativa L. is a controversial crop due to its high tetrahydrocannabinol content varieties; however, the hemp varieties get an increased interest. This paper describes (i) the main categories of phenolic compounds (flavonoids, stilbenoids and lignans) and terpenes (monoterpenes and sesquiterpenes) from C. sativa by-products and their biological activities and (ii) the main extraction techniques for their recovery. It includes not only common techniques such as conventional solvent extraction, and hydrodistillation, but also intensification and emerging techniques such as ultrasound-assisted extraction or supercritical CO2 extraction. The effect of the operating conditions on the yield and composition of these categories of phenolic compounds and terpenes was discussed. A thorough investigation of innovative extraction techniques is indeed crucial for the extraction of phenolic compounds and terpenes from cannabis toward a sustainable industrial valorization of the whole plant.

Phenolic profile and investigation of biological activities of Allium scorodoprasum L. subsp. rotundum

2022 ◽  
pp. 101548
Author(s):  
Tuğba Demir ◽  
Özlem Akpınar ◽  
Haki Kara ◽  
Hüseyin Güngör
Keyword(s):  
Biological Activities ◽  
Phenolic Profile ◽  
Allium Scorodoprasum

scholarly journals Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3266 ◽  
Author(s):  
Gokhan Zengin ◽  
Luigi Menghini ◽  
Antonella Di Sotto ◽  
Romina Mancinelli ◽  
Francesca Sisto ◽  
...  
Keyword(s):  
Essential Oil ◽  
Galleria Mellonella ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Methodological Approach ◽  
Volatile Component ◽  
Biologically Active ◽  
Antioxidant Compounds

Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, α-amylase, α-glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.

Cannabis Phenolics and their Bioactivities

2018 ◽  
Vol 25 (10) ◽  
pp. 1160-1185 ◽  
Author(s):  
Federica Pollastro ◽  
Alberto Minassi ◽  
Luigia Grazia Fresu
Keyword(s):  
Biological Activity ◽  
Phenolic Compounds ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Bibliographic Databases ◽  
Systematic Research ◽  
Prenylated Flavonoids ◽  
Beneficial Effects ◽  
Almost All

Background: Although Cannabis sativa L. is one of the most versatile plant species with multipurpose use both as medical, alimentary source and as psychoactive abuse, its biomedical relevance focused the attention on major cannabinoids. Phytochemical characterization of cannabis highlights the presence of various non-cannabinoids constituents including flavonoids, spiroindans, dihyrostilbenes, dihydrophenanthrenes, lignanamides, steroids and alkaloids. This review aims to identify polyphenols present in this plant, their biosynthesis, their bioactivities and their synthesis, when this occurred. Methods: We undertook a systematic research focused on bibliographic databases including all noncannabinoids phenolics in various C. sativa strains from their isolation, structural elucidation, their biological activity to their synthesis. Result: Nevertheless, attention has so far been focused only on cannabinoids (more than one hundred isolated), cannabis is a complex plant able to produce more than 480 chemical entities that represent almost all of the different biogenetic classes. Regarding phenolic compounds, the plant biosynthesises a plethora of unique non-cannabinoids second metabolites, such as prenylated flavonoids, stilbenoids derivatives and lignanammides. Conclusion: Cannabis is a plant with high pharmacological and nutrition values, its potentialities and applications are not only circumscribed to cannabinoids biological activities, but also defined by noncannabinoid compounds. The combination of other cannabinoids together with noncannabinoid components could enhance the beneficial effects of THC and could reduce undesirable side effects.

scholarly journals Characterization and Phytotoxicity Assessment of Essential Oils from Plant Byproducts

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2941 ◽  
Author(s):  
Antonella Smeriglio ◽  
Domenico Trombetta ◽  
Laura Cornara ◽  
Marco Valussi ◽  
Vincenzo De Feo ◽  
...  
Keyword(s):  
Essential Oils ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Lolium Multiflorum ◽  
Chemical Characterization ◽  
Zingiber Officinale ◽  
Lepidium Sativum ◽  
Cupressus Sempervirens ◽  
Wide Range

The present work describes the chemical characterization and the phytotoxicity assessment of essential oils (EOs) obtained from spent materials or pruning waste of four plant species: Zingiber officinale Roscoe used in the juicing industry, Pistacia vera L. var. Bronte used in the food industry, discarded material of industrial hemp (Cannabis sativa L. var. Futura 75), and pruning waste from Cupressus sempervirens L. The phytochemical profile of the EOs was evaluated by gas chromatographic flame ionization detection (GC-FID) and GC-MS analyses, which highlighted the presence of several compounds with a wide range of biological activities. Among them, application possibilities in agriculture were evaluated by studying the phytotoxic activity in vitro against germination and initial radical growth of several seeds such as Raphanus sativus L., Lepidium sativum L., Lactuca sativa L., Solanum lycopersicum L., Lolium multiflorum Lam., and Portulaca oleracea L.

scholarly journals ANTIMICROBIAL AND OTHER BIOACTIVE CONSTITUENTS OF Cannabis sativus ROOTS FROM PAKISTAN

2021 ◽  
Vol 27 (3) ◽  
pp. 359-368
Author(s):  
Arshad Javaid ◽  
Iqra Haider Khan ◽  
Malik F.H. Ferdosi
Keyword(s):  
Methyl Ester ◽  
Cannabis Sativa ◽  
Biological Activities ◽  
Octadecenoic Acid ◽  
Acid Methyl Ester ◽  
Biologically Active ◽  
Root Extract ◽  
Bioactive Constituents ◽  
Acid Methyl ◽  
Tetracosanoic Acid

Hemp (Cannabis sativa L.), a medicinal plant of family Cannabaceae, growing wildly in most of the rainfed areas of Punjab, Pakistan. In this study, phytochemical profile of methanolic extract of root was assessed through GC-MS analysis and various biologically active compounds were identified through literature survey. There were 14 compounds in the root extract. The most abundant compounds were γ-sitosterol (27.08%) and 9,12-octadecadienoic acid (Z,Z)-, methyl ester (24.09%) and hexadecanoic acid, methyl ester (21.81%). Other identified compounds were methyl stearate (5.51%), stigmasterol (5.12%), campesterol (4.19%), phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-(2.52%), 11-octadecenoic acid, methyl ester (2.10%), squalene (1.89%), β-amyrin (1.88%), eicosanoic acid, methyl ester (0.85%), tetracosanoic acid, methyl ester (0.88%), dronabinol (1.02%) and 2-methoxy-4-vinylphenol (0.96%). Most of the identified compounds possess one or more biological activities viz. antitumor, antifungal, antibacterial, antioxidant, anticancer, anti-inflammatory, antidiabetic, and/or analgesic.

scholarly journals LC-PDA-ESI/MS Identification of the Phenolic Components of Three Compositae Spices: Chamomile, Tarragon, and Mexican Arnica

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Long-Ze Lin ◽  
James M. Harnly
Keyword(s):  
Human Health ◽  
Biological Activities ◽  
Matricaria Chamomilla ◽  
Phenolic Profile ◽  
Phenol Compounds ◽  
Artemisia Dracunculus ◽  
Esi Ms ◽  
Phenolic Components ◽  
The Us

Chamomile ( Matricaria chamomilla L.), tarragon ( Artemisia dracunculus L.) and Mexican arnica ( Heterotheca inuoides) are common compositae spices and herbs found in the US market. They contain flavonoids and hydroxycinnamates that are potentially beneficial to human health. A standardized LC-PDA-ESI/MS profiling method was used to identify 51 flavonoids and 17 hydroxycinnamates. Many of the identifications were confirmed with authentic standards or through references in the literature or the laboratory's database. More than half of the phenol compounds for each spice had not been previously reported. The phenolic profile can be used for plant authentication and to correlate with biological activities.

scholarly journals Screening of Biological Activities of Ligustrum lucidum Berries: A Comparative Approach

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301
Author(s):  
Teresa Delgado ◽  
Vanessa B. Paula ◽  
Maria Graça Campos ◽  
Nelson Farinha ◽  
André Caeiro ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Biological Properties ◽  
New Drugs ◽  
Comparative Approach ◽  
Chinese Traditional Medicine ◽  
Phenolic Profile ◽  
Ligustrum Lucidum ◽  
Geographic Origins ◽  
Boiled Water

Ligustrum lucidum Aiton including its berries have been used in Chinese Traditional Medicine for around 2000 years. Scientific studies developed on the last decades provided evidence on some biological properties of these products, mostly from particular geographic origins. In the present study, L. lucidium berries harvested in two regions of Portugal were considered. Extracts obtained with 100% ethanol, with 50% ethanol/water (v/v) and in boiled water were prepared and several parameters were assessed: antioxidant activity (using two methodologies), antimicrobial activity and phenolic profile. Results suggest that the different biological activities varied according to the region where samples were collected but also with the extraction methodology. Superior antioxidant potential was observed in water extracts, according to both assays, while for the remaining activities the ethanol 50% extracts had the highest activity. In these regions, the L. lucidum berries showed promising biological activities and may be interesting sources of compounds for the development of new drugs for diseases where oxidant reactive species and enzymatic disruption are believed to play a role as well as adjuvants for current antibiotic therapy.

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