scholarly journals Screening of Biological Activities of Ligustrum lucidum Berries: A Comparative Approach

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301
Author(s):  
Teresa Delgado ◽  
Vanessa B. Paula ◽  
Maria Graça Campos ◽  
Nelson Farinha ◽  
André Caeiro ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Biological Properties ◽  
New Drugs ◽  
Comparative Approach ◽  
Chinese Traditional Medicine ◽  
Phenolic Profile ◽  
Ligustrum Lucidum ◽  
Geographic Origins ◽  
Boiled Water

Ligustrum lucidum Aiton including its berries have been used in Chinese Traditional Medicine for around 2000 years. Scientific studies developed on the last decades provided evidence on some biological properties of these products, mostly from particular geographic origins. In the present study, L. lucidium berries harvested in two regions of Portugal were considered. Extracts obtained with 100% ethanol, with 50% ethanol/water (v/v) and in boiled water were prepared and several parameters were assessed: antioxidant activity (using two methodologies), antimicrobial activity and phenolic profile. Results suggest that the different biological activities varied according to the region where samples were collected but also with the extraction methodology. Superior antioxidant potential was observed in water extracts, according to both assays, while for the remaining activities the ethanol 50% extracts had the highest activity. In these regions, the L. lucidum berries showed promising biological activities and may be interesting sources of compounds for the development of new drugs for diseases where oxidant reactive species and enzymatic disruption are believed to play a role as well as adjuvants for current antibiotic therapy.

scholarly journals Monoterpenes and Sesquiterpenes of Essential Oils from Psidium Species and Their Biological Properties

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 965
Author(s):  
Renan Campos e Silva ◽  
Jamile S. da Costa ◽  
Raphael O. de Figueiredo ◽  
William N. Setzer ◽  
Joyce Kelly R. da Silva ◽  
...  
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Biological Properties ◽  
Chemical Diversity ◽  
New Drugs ◽  
Natural Sources ◽  
Biological Potential ◽  
The World ◽  
Review Reports ◽  
Collection Sites

Psidium (Myrtaceae) comprises approximately 266 species, distributed in tropical and subtropical regions of the world. Psidium taxa have great ecological, economic, and medicinal relevance due to their essential oils’ chemical diversity and biological potential. This review reports 18 Psidium species growing around the world and the chemical and biological properties of their essential oils. Chemically, 110 oil records are reported with significant variability of volatile constituents, according to their seasonality and collection sites. Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents. The essential oils showed various biological activities, including antioxidant, antifungal, antibacterial, phytotoxic, larvicidal, anti-inflammatory, and cytotoxic properties. This review contributes to the Psidium species rational and economic exploration as natural sources to produce new drugs.

scholarly journals Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity

2020 ◽  
Vol 13 (12) ◽  
pp. 479
Author(s):  
Márcio Rodrigues ◽  
Ana Clara Lopes ◽  
Filipa Vaz ◽  
Melanie Filipe ◽  
Gilberto Alves ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Essential Oil ◽  
Biological Activities ◽  
Scientific Information ◽  
Biological Properties ◽  
Fusarium Spp ◽  
Candida Spp ◽  
Pharmaceutical Industries

Thymus mastichina has the appearance of a semishrub and can be found in jungles and rocky lands of the Iberian Peninsula. This work aimed to review and gather available scientific information on the composition and biological properties of T. mastichina. The main constituents of T. mastichina essential oil are 1,8-cineole (or eucalyptol) and linalool, while the extracts are characterized by the presence of flavonoids, phenolic acids, and terpenes. The essential oil and extracts of T. mastichina have demonstrated a wide diversity of biological activities. They showed antibacterial activity against several bacteria such as Escherichia coli, Proteus mirabilis, Salmonella subsp., methicillin-resistant and methicillin-sensitive Staphylococcus aureus, Listeria monocytogenes EGD, Bacillus cereus, and Pseudomonas, among others, and antifungal activity against Candida spp. and Fusarium spp. Additionally, it has antioxidant activity, which has been evaluated through different methods. Furthermore, other activities have also been studied, such as anticancer, antiviral, insecticidal, repellent, anti-Alzheimer, and anti-inflammatory activity. In conclusion, considering the biological activities reported for the essential oil and extracts of T. mastichina, its potential as a preservative agent could be explored to be used in the food, cosmetic, or pharmaceutical industries.

scholarly journals Propolis: A Complex Natural Product with a Plethora of Biological Activities That Can Be Explored for Drug Development

2015 ◽  
Vol 2015 ◽  
pp. 1-29 ◽  
Author(s):  
Ricardo Silva-Carvalho ◽  
Fátima Baltazar ◽  
Cristina Almeida-Aguiar
Keyword(s):  
Chemical Composition ◽  
Biological Activities ◽  
Clinical Effectiveness ◽  
Biological Properties ◽  
New Drugs ◽  
Published Data ◽  
Alternative Source ◽  
Scientific Attention

The health industry has always used natural products as a rich, promising, and alternative source of drugs that are used in the health system. Propolis, a natural resinous product known for centuries, is a complex product obtained by honey bees from substances collected from parts of different plants, buds, and exudates in different geographic areas. Propolis has been attracting scientific attention since it has many biological and pharmacological properties, which are related to its chemical composition. Severalin vitroandin vivostudies have been performed to characterize and understand the diverse bioactivities of propolis and its isolated compounds, as well as to evaluate and validate its potential. Yet, there is a lack of information concerning clinical effectiveness. The goal of this review is to discuss the potential of propolis for the development of new drugs by presenting published data concerning the chemical composition and the biological properties of this natural compound from different geographic origins.

scholarly journals Partial Purification and Characterization of Albain 1, a Triterpene with Antimicrobial Activity, from the Wood Extract of Avicennia alba Blume

2020 ◽  
pp. 38-48
Author(s):  
Moumita Choudhury ◽  
Kalishankar Mukherjee ◽  
Arnab De ◽  
Amalesh Samanta ◽  
Amit Roy
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
1H Nmr ◽  
Biological Activities ◽  
New Drugs ◽  
Partial Purification ◽  
Molecular Formula ◽  
Pharmaceutical Industries ◽  
Wood Extract ◽  
Avicennia Alba

Secondary metabolites of plants are important resources for development of new drugs. Mangrove plants are very well known sources of wide variety of secondary metabolites. Many of these secondary metabolites from mangroves have been found to possess significant biological activities where human health is concerned. Avicennia alba Blume is one such mangrove plant with reports of having many such secondary metabolites of clinical and commercial interests. Aim: To evaluate antimicrobial activity potential of A. alba wood extract and to isolate new bioactive constituent(s) responsible for such biological activity. Methodology: Preliminary screenings of antimicrobial activities in different organic solvent extracts of A. alba wood tissue were done by TLC-bioautography method and phytochemical nature of the antimicrobial constituent(s) in the extracts have been studied. One compound exhibiting significant antimicrobial activity, named as Albain 1, has been isolated. MIC value has been determined for Albain 1. The purity and structure of Albain 1 have been determined by HPLC, 1H NMR, FTIR and HRMS etc. analysis. Results: 1H NMR, FTIR and HRMS analysis have found out that the isolated compound Albain 1 is a triterpene and the molecular formula is C30H48O4. It has exhibited remarkable antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Bacillus pumilas (MIC 125 μg / ml). Conclusion: The observed antimicrobial activity of the isolated fraction of A. alba offer great potentials in pharmaceutical industries.

scholarly journals Enzyme Inhibitory Potential of Ligustrum lucidum Aiton Berries

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1283
Author(s):  
Vanessa Paula ◽  
Teresa Delgado ◽  
Maria Campos ◽  
Ofélia Anjos ◽  
Leticia Estevinho
Keyword(s):  
Traditional Medicine ◽  
Biological Activities ◽  
Acetylcholinesterase Inhibition ◽  
Chinese Traditional Medicine ◽  
Haemolytic Activity ◽  
Ligustrum Lucidum ◽  
Inhibitory Activities ◽  
Inhibitory Potential

Ligustrum lucidum Aiton and its berries have been used in Chinese traditional medicine for around two thousand years. In the present study, L. lucidium berries harvested in two regions of Portugal were studied. Haemolytic activity and inhibition of oxidative haemolysis as well as the enzyme inhibitory activities (α-amylase enzyme and acetylcholinesterase) were assessed. Results suggest that the different biological activities varied according to the region where samples were collected. Results demonstrated that the sample obtained from region R1 was the most efficient extract for all parameters evaluated, presenting the lowest values of IC50, 10.67 ± 0.46 μg/mL for the inhibition of erythrocyte oxidative haemolysis, 58.28 ± 3.77 μg/mL for the α-amylase enzyme and 67.67 ± 2.10 μg/mL for the acetylcholinesterase inhibition. L. Lucidum berries may be an interesting source of compounds for use in the development of the therapeutic armamentarium for diseases where enzymatic disruption is believed to play a role.

scholarly journals Synthesis and therapeutic potential of imidazole containing compounds

BMC Chemistry ◽  
2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ankit Siwach ◽  
Prabhakar Kumar Verma
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Properties ◽  
New Drugs ◽  
Hydrogen Atoms ◽  
Tautomeric Forms ◽  
Synthetic Routes ◽  
Derivatives Of ◽  
Heterocyclic Moiety ◽  
Antihistaminic Agent

Abstract Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. The imidazole name was reported by Arthur Rudolf Hantzsch (1857–1935) in 1887. 1, 3-diazole is an amphoteric in nature i.e. it shows both acidic and basic properties. It is a white or colorless solid that is highly soluble in water and other polar solvents. Due to the presence of a positive charge on either of two nitrogen atom, it shows two equivalent tautomeric forms. Imidazole was first named glyoxaline because the first synthesis has been made by glyoxal and ammonia. It is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The derivatives of 1, 3-diazole show different biological activities such as antibacterial, antimycobacterial, anti-inflammatory, antitumor, antidiabetic, anti-allergic, antipyretic, antiviral, antioxidant, anti-amoebic, antihelmintic, antifungal and ulcerogenic activities, etc. as reported in the literature. There are different examples of commercially available drugs in the market which contains 1, 3-diazole ring such as clemizole (antihistaminic agent), etonitazene (analgesic), enviroxime (antiviral), astemizole (antihistaminic agent), omeprazole, pantoprazole (antiulcer), thiabendazole (antihelmintic), nocodazole (antinematodal), metronidazole, nitroso-imidazole (bactericidal), megazol (trypanocidal), azathioprine (anti rheumatoid arthritis), dacarbazine (Hodgkin's disease), tinidazole, ornidazole (antiprotozoal and antibacterial), etc. This present review summarized some pharmacological activities and various kinds of synthetic routes for imidazole and their derived products.

Advances on Monosaccharides and Oligosaccharides: Structural Modifications and Bioactivities

2021 ◽  
Vol 21 ◽  
Author(s):  
Shaochen Li ◽  
Min Lv ◽  
Shaoyong Zhang ◽  
Hui Xu
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Biological Activities ◽  
Building Blocks ◽  
Biological Properties ◽  
Mechanisms Of Action ◽  
Biological Processes ◽  
Structural Modifications ◽  
Structure Activity ◽  
Derivatives Of

: Derivatives of monosaccharides and oligosaccharides play the important roles in biological processes. Monosaccharides are the single carbohydrate building blocks, such as glucose, xylose, and fructose. Oligosaccharides are composed of 2–10 monosaccharides including disaccharides and trisaccharides. Moreover, monosaccharides, oligosaccharides and their derivatives are vital molecules with various biological properties including anticancer activity, antiviral activity, insecticidal activity, antimicrobial activity, and antioxidant activity. This review covers a survey of structural modifications, biological activities, and mechanisms of action of monosaccharides, oligosaccharides and their derivatives. Additionally, their structure–activity relationships are also concluded.

Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives

2019 ◽  
Vol 16 (1) ◽  
pp. 17-37 ◽  
Author(s):  
Jaskirat Kaur ◽  
Divya Utreja ◽  
Ekta ◽  
Nisha Jain ◽  
Shivali Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Microbial Activity ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Indole Derivatives ◽  
Antimicrobial Drugs ◽  
Wide Range ◽  
Recent Developments

Background:Heterocyclic compounds containing nitrogen have been known to possess a very important role in the field of medicinal chemistry. Indole and its derivatives displayed a wide range of biological properties such as anti-inflammatory, analgesic, anti-microbial, anti-convulsant, antidepressant, anti-diabetic, antihelmintic and anti-allergic activities etc. The diverse biological activities exhibited by compounds containing indole moiety has provided the impetus to explore its anti-microbial activity in order to save the valuable life of patients. </P><P> Objective: The review focuses on the advances in the synthesis of indole derivatives and antimicrobial properties exhibited by them.Conclusion:A great deal of work has been done in order to synthesize indole derivatives and to evaluate antimicrobial potential, as indicated by the review. The information provided in this article may be helpful for the researchers for the development of efficient antimicrobial drugs.

scholarly journals Therapeutic potential of oxadiazole or furadiazole containing compounds

BMC Chemistry ◽  
2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Ankit Siwach ◽  
Prabhakar Kumar Verma
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Antiviral Drug ◽  
Biological Properties ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Methylene Groups ◽  
Synthetic Routes ◽  
Azole Ring ◽  
Derivatives Of

AbstractAs we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as oxadiazole. They are derived from furan by the replacement of two methylene groups (= CH) with two nitrogen (-N =) atoms. The aromaticity was reduced with the replacement of these groups in the furan ring to such an extent that it shows conjugated diene character. Four different known isomers of oxadiazole were existed such as 1,2,4-oxadiazole, 1,2,3-oxadiazole, 1,2,5-oxadiazole & 1,3,4-oxadiazole. Among them, 1,3,4-oxadiazoles & 1,2,4-oxadiazoles are better known and more widely studied by the researchers due to their broad range of chemical and biological properties. 1,3,4-oxadiazoles have become important synthons in the development of new drugs. The derivatives of the oxadiazole nucleus (1,3,4-oxadiazoles) show various biological activities such as antibacterial, anti-mycobacterial, antitumor, anti-viral and antioxidant activity, etc. as reported in the literature. There are different examples of commercially available drugs which consist of 1,3,4-oxadiazole ring such as nitrofuran derivative (Furamizole) which has strong antibacterial activity, Raltegravir as an antiviral drug and Nesapidil drug is used in anti-arrhythmic therapy. This present review summarized some pharmacological activities and various kinds of synthetic routes for 2, 5-disubstituted 1,3,4-oxadiazole, and their derived products.

Bioactive Metabolites from Pathogenic and Endophytic Fungi of Forest Trees

2018 ◽  
Vol 25 (2) ◽  
pp. 208-252 ◽  
Author(s):  
Marco Masi ◽  
Lucia Maddau ◽  
Benedetto Teodoro Linaldeddu ◽  
Bruno Scanu ◽  
Antonio Evidente ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Biological Activities ◽  
Terrestrial Ecosystems ◽  
Biological Properties ◽  
Research Literature ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
Bibliographic Databases ◽  
Forest Trees

Background: Fungi play an important role in terrestrial ecosystems interacting positively or negatively with plants. These interactions are complex and the outcomes are different depending on the fungal lifestyles, saprotrophic, mutualistic or pathogenic. Furthermore, fungi are well known for producing secondary metabolites, originating from different biosynthetic pathways, which possess biological properties of considerable biotechnological interest. Among the terrestrial ecosystems, temperate forests represent an enormous reservoir of fungal diversity. This review will highlight the goldmine of secondary metabolites produced by pathogenic and endophytic fungi of forest trees with focus on their biological activities. Methods: A structured search of bibliographic databases for peer-reviewed research literature was undertaken using a research discovery application providing access to a large and authoritative source of references. The papers selected were examined and the main results were reported and discussed. Results: Two hundred forthy-one papers were included in the review, outlined a large number of secondary metabolites produced by pathogenic and endophiltic fungi and their biological activities, including phytotoxic, antifungal, antioomycetes, antibacterial, brine shrimp lethality, mosquito biting deterrence and larvicidal, cytotoxic, antiproliferative and many other bioactivities. Conclusion: The findings of this review confirm the importance of secondary metabolites produced by pathogenic and endophytic fungi from forest plants growing in temperate regions as an excellent prospects to discover compounds with new bioactivities and mode of actions. In addition, the potential of some metabolites as a source of new drugs and biopesticides is underlined.

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